Cynthia E Dunbar

Cynthia E Dunbar

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Cynthia E Dunbar

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Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag.

Authors:
Thomas Winkler Xing Fan James Cooper Ronan Desmond David J Young Danielle M Townsley Phillip Scheinberg Sophia Grasmeder Andre Larochelle Marie Desierto Janet Valdez Jennifer Lotter Colin Wu Ruba N Shalhoub Katherine R Calvo Neal S Young Cynthia E Dunbar

Blood 2019 Jun 16;133(24):2575-2585. Epub 2019 Apr 16.

Translational Stem Cell Biology Branch and.

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http://dx.doi.org/10.1182/blood.2019000478DOI Listing
June 2019

CRISPR/Cas9 gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs.

Authors:
Tae-Hoon Shin Eun Jung Baek Marcus A F Corat Shirley Chen Jean-Yves Metais Aisha A AlJanahi Yifan Zhou Robert E Donahue Kyung-Rok Yu Cynthia E Dunbar

Blood 2019 Jun 19;133(23):2542-2545. Epub 2019 Apr 19.

Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood.2019000800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557622PMC
June 2019

Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque.

Authors:
Diego A Espinoza Xing Fan Di Yang Stefan F Cordes Lauren L Truitt Katherine R Calvo Idalia M Yabe Selami Demirci Kristin J Hope So Gun Hong Allen Krouse Mark Metzger Aylin Bonifacino Rong Lu Naoya Uchida John F Tisdale Xiaolin Wu Suk See DeRavin Harry L Malech Robert E Donahue Chuanfeng Wu Cynthia E Dunbar

Mol Ther 2019 Jun 9;27(6):1074-1086. Epub 2019 Apr 9.

Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554657PMC
June 2019

Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model.

Authors:
Naoya Uchida Tina Nassehi Claire M Drysdale Jackson Gamer Morgan Yapundich Aylin C Bonifacino Allen E Krouse Nathaniel Linde Matthew M Hsieh Robert E Donahue Cynthia E Dunbar Leslie S Kean John F Tisdale

Mol Ther 2019 Jun 5. Epub 2019 Jun 5.

Cellular and Molecular Therapeutics Branch, National Heart Lung and Blood Institutes (NHLBI)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.05.022DOI Listing
June 2019

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ.

Authors:
Luigi J Alvarado Heather D Huntsman Hai Cheng Danielle M Townsley Thomas Winkler Xingmin Feng Cynthia E Dunbar Neal S Young Andre Larochelle

Blood 2019 May 25;133(19):2043-2055. Epub 2019 Feb 25.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2018-11-884486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509545PMC
May 2019

GATA2 deficiency and human hematopoietic development modeled using induced pluripotent stem cells.

Authors:
Moonjung Jung Stefan Cordes Jizhong Zou Shiqin J Yu Xavi Guitart So Gun Hong Vinh Dang Elaine Kang Flavia S Donaires Sergio A Hassan Maher Albitar Amy P Hsu Steven M Holland Dennis D Hickstein Danielle Townsley Cynthia E Dunbar Thomas Winkler

Blood Adv 2018 12;2(23):3553-3565

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD.

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http://dx.doi.org/10.1182/bloodadvances.2018017137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290105PMC
December 2018

Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity.

Authors:
Idalia M Yabe Lauren L Truitt Diego A Espinoza Chuanfeng Wu Samson Koelle Sandhya Panch Marcus A F Corat Thomas Winkler Kyung-Rok Yu So Gun Hong Aylin Bonifacino Allen Krouse Mark Metzger Robert E Donahue Cynthia E Dunbar

Mol Ther Methods Clin Dev 2018 Dec 25;11:143-154. Epub 2018 Oct 25.

Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23290501183010
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http://dx.doi.org/10.1016/j.omtm.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258888PMC
December 2018

Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets.

Authors:
Chuanfeng Wu Diego A Espinoza Samson J Koelle Di Yang Lauren Truitt Heinrich Schlums Bernard A Lafont Jan K Davidson-Moncada Rong Lu Amitinder Kaur Quirin Hammer Brian Li Sandhya Panch David A Allan Robert E Donahue Richard W Childs Chiara Romagnani Yenan T Bryceson Cynthia E Dunbar

Sci Immunol 2018 Nov;3(29)

Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.

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http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
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http://dx.doi.org/10.1126/sciimmunol.aat9781DOI Listing
November 2018

An Introduction to the Analysis of Single-Cell RNA-Sequencing Data.

Authors:
Aisha A AlJanahi Mark Danielsen Cynthia E Dunbar

Mol Ther Methods Clin Dev 2018 Sep 2;10:189-196. Epub 2018 Aug 2.

Translational Stem Cell Biology Branch, NHLBI, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.omtm.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072887PMC
September 2018

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes.

Authors:
Sandhya R Panch Michael E Bozik Thomas Brown Michelle Makiya Calman Prussin Donald G Archibald Gregory T Hebrank Mary Sullivan Xiaoping Sun Lauren Wetzler JeanAnne Ware Michael P Fay Cynthia E Dunbar Steven I Dworetzky Paneez Khoury Irina Maric Amy D Klion

Blood 2018 08 8;132(5):501-509. Epub 2018 May 8.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-02
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http://dx.doi.org/10.1182/blood-2018-02-835330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073324PMC
August 2018

Genotoxic Lemons Become Epigenomic Lemonade.

Authors:
Stefan F Cordes Cynthia E Dunbar

Cell Stem Cell 2018 07;23(1):9-10

Hematology Branch, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.06.007DOI Listing
July 2018

Bone Marrow as a Source of Cells for Paroxysmal Nocturnal Hemoglobinuria Detection.

Authors:
Alina E Dulau-Florea Neal S Young Irina Maric Katherine R Calvo Cynthia E Dunbar Danielle M Townsley Thomas Winkler Mariela Monreal Chunjie Jiang Elaine K Jordan Raul C Braylan

Am J Clin Pathol 2018 Jul 5. Epub 2018 Jul 5.

Hematology Laboratory, Department of Laboratory Medicine, Bethesda, MD.

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http://dx.doi.org/10.1093/ajcp/aqy053DOI Listing
July 2018

Eltrombopag mobilizes iron in patients with aplastic anemia.

Authors:
Zhen Zhao Qian Sun Lori J Sokoll Michael Streiff Zhe Cheng Sophie Grasmeder Danielle M Townsley Neal S Young Cynthia E Dunbar Thomas Winkler

Blood 2018 05 9;131(21):2399-2402. Epub 2018 Apr 9.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2018-01-826784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969382PMC
May 2018

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.

Authors:
Miriam Y Kim Kyung-Rok Yu Saad S Kenderian Marco Ruella Shirley Chen Tae-Hoon Shin Aisha A Aljanahi Daniel Schreeder Michael Klichinsky Olga Shestova Miroslaw S Kozlowski Katherine D Cummins Xinhe Shan Maksim Shestov Adam Bagg Jennifer J D Morrissette Palak Sekhri Cicera R Lazzarotto Katherine R Calvo Douglas B Kuhns Robert E Donahue Gregory K Behbehani Shengdar Q Tsai Cynthia E Dunbar Saar Gill

Cell 2018 05 31;173(6):1439-1453.e19. Epub 2018 May 31.

Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183059
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http://dx.doi.org/10.1016/j.cell.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003425PMC
May 2018

Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs.

Authors:
Yongshun Lin Huimin Liu Michael Klein John Ostrominski So Gun Hong Ravi Chandra Yada Guibin Chen Keron Navarengom Robin Schwartzbeck Hong San Zu-Xi Yu Chengyu Liu Kaari Linask Jeanette Beers Lugui Qiu Cynthia E Dunbar Manfred Boehm Jizhong Zou

Sci Rep 2018 Apr 12;8(1):5907. Epub 2018 Apr 12.

iPSC Core, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://www.nature.com/articles/s41598-018-24074-y
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http://dx.doi.org/10.1038/s41598-018-24074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897327PMC
April 2018

The impact of aging on primate hematopoiesis as interrogated by clonal tracking.

Authors:
Kyung-Rok Yu Diego A Espinoza Chuanfeng Wu Lauren Truitt Tae-Hoon Shin Shirley Chen Xing Fan Idalia M Yabe Sandhya Panch So Gun Hong Samson Koelle Rong Lu Aylin Bonifacino Allen Krouse Mark Metzger Robert E Donahue Cynthia E Dunbar

Blood 2018 03 2;131(11):1195-1205. Epub 2018 Jan 2.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2017-08-802033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855019PMC
March 2018

Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia.

Authors:
Xin Zhao Xingmin Feng Zhijie Wu Thomas Winkler Ronan Desmond Matthew Olnes Bogdan Dumitriu Danielle M Townsley Cynthia E Dunbar Neal S Young

Exp Hematol 2018 02 20;58:39-43. Epub 2017 Sep 20.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1016/j.exphem.2017.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815891PMC
February 2018

Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation.

Authors:
Chuanfeng Wu Diego A Espinoza Samson J Koelle E Lake Potter Rong Lu Brian Li Di Yang Xing Fan Robert E Donahue Mario Roederer Cynthia E Dunbar

J Exp Med 2018 01 15;215(1):217-232. Epub 2017 Nov 15.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1084/jem.20171341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748860PMC
January 2018

Gene therapy comes of age.

Authors:
Cynthia E Dunbar Katherine A High J Keith Joung Donald B Kohn Keiya Ozawa Michel Sadelain

Science 2018 01;359(6372)

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1126/science.aan4672DOI Listing
January 2018

CRISPR/Cas9-Based Safe-Harbor Gene Editing in Rhesus iPSCs.

Authors:
Ravi Chandra Yada John W Ostrominski Ilker Tunc So Gun Hong Jizhong Zou Cynthia E Dunbar

Curr Protoc Stem Cell Biol 2017 11 15;43:5A.11.1-5A.11.14. Epub 2017 Nov 15.

Hematology Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cpsc.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709051PMC
November 2017

Transcriptome analysis reveals similarities between human blood CD3 CD56 cells and mouse CD127 innate lymphoid cells.

Authors:
David S J Allan Ana Sofia Cerdeira Anuisa Ranjan Christina L Kirkham Oscar A Aguilar Miho Tanaka Richard W Childs Cynthia E Dunbar Jack L Strominger Hernan D Kopcow James R Carlyle

Sci Rep 2017 06 14;7(1):3501. Epub 2017 Jun 14.

Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-017-03256-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471261PMC
June 2017

Two Decades of ASGCT: Dreams Become Reality.

Authors:
Cynthia E Dunbar

Mol Ther 2017 05 20;25(5):1057-1058. Epub 2017 Apr 20.

Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417834PMC
May 2017

Rhesus Macaque iPSC Generation and Maintenance.

Authors:
Ravi Chandra Yada So Gun Hong Yongshun Lin Thomas Winkler Cynthia E Dunbar

Curr Protoc Stem Cell Biol 2017 May 16;41:4A.11.1-4A.11.13. Epub 2017 May 16.

Hematology Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cpsc.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434708PMC
May 2017

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.

Authors:
Marcus A F Corat Heinrich Schlums Chuanfeng Wu Jakob Theorell Diego A Espinoza Stephanie E Sellers Danielle M Townsley Neal S Young Yenan T Bryceson Cynthia E Dunbar Thomas Winkler

Blood 2017 04 30;129(14):1940-1946. Epub 2016 Nov 30.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2016-08-734285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383870PMC
April 2017

Adaptive NK cells can persist in patients with mutation depleted of stem and progenitor cells.

Authors:
Heinrich Schlums Moonjung Jung Hongya Han Jakob Theorell Venetia Bigley Samuel C C Chiang David S J Allan Jan K Davidson-Moncada Rachel E Dickinson Tim D Holmes Amy P Hsu Danielle Townsley Thomas Winkler Weixin Wang Pål Aukrust Ingvild Nordøy Katherine R Calvo Steve M Holland Matthew Collin Cynthia E Dunbar Yenan T Bryceson

Blood 2017 04 16;129(14):1927-1939. Epub 2017 Feb 16.

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1182/blood-2016-08-734236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383869PMC
April 2017

Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

Authors:
Danielle M Townsley Phillip Scheinberg Thomas Winkler Ronan Desmond Bogdan Dumitriu Olga Rios Barbara Weinstein Janet Valdez Jennifer Lotter Xingmin Feng Marie Desierto Harshraj Leuva Margaret Bevans Colin Wu Andre Larochelle Katherine R Calvo Cynthia E Dunbar Neal S Young

N Engl J Med 2017 04;376(16):1540-1550

From the Hematology Branch (D.M.T., T.W., R.D., B.D., O.R., B.W., J.V., J.L., X.F., M.D., H.L., A.L., C.E.D., N.S.Y.) and the Office of Biostatistics Research (C.W.), National Heart, Lung, and Blood Institute, and the Nursing Research and Translational Science Section, Department of Nursing (M.B.), and the Hematology Section, Department of Laboratory Medicine (K.R.C.), Clinical Center - all at the National Institutes of Health, Bethesda, MD; and the Division of Clinical Hematology, Antônio Ermírio de Moraes Cancer Center, Hospital A Beneficência Portuguesa de São Paulo, São Paulo (P.S.).

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http://dx.doi.org/10.1056/NEJMoa1613878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548296PMC
April 2017

Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants.

Authors:
Samson J Koelle Diego A Espinoza Chuanfeng Wu Jason Xu Rong Lu Brian Li Robert E Donahue Cynthia E Dunbar

Blood 2017 03 13;129(11):1448-1457. Epub 2017 Jan 13.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2016-07
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http://dx.doi.org/10.1182/blood-2016-07-728691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356453PMC
March 2017

iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.

Authors:
Erika M Kwon John P Connelly Nancy F Hansen Frank X Donovan Thomas Winkler Brian W Davis Halah Alkadi Settara C Chandrasekharappa Cynthia E Dunbar James C Mullikin Paul Liu

Proc Natl Acad Sci U S A 2017 02 6;114(8):1964-1969. Epub 2017 Feb 6.

Oncogenesis and Development Section, National Human Genome Research Institute, NIH, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1616035114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338363PMC
February 2017

Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers.

Authors:
So Gun Hong Ravi Chandra Yada Kyujoo Choi Arnaud Carpentier T Jake Liang Randall K Merling Colin L Sweeney Harry L Malech Moonjung Jung Marcus A F Corat Aisha A AlJanahi Yongshun Lin Huimin Liu Ilker Tunc Xujing Wang Maryknoll Palisoc Stefania Pittaluga Manfred Boehm Thomas Winkler Jizhong Zou Cynthia E Dunbar

Mol Ther 2017 01 4;25(1):44-53. Epub 2017 Jan 4.

Hematology Branch, National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda, MD 20892, USA.

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http://www.cell.com/molecular-therapy-family/molecular-thera
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http://linkinghub.elsevier.com/retrieve/pii/S152500161645361
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http://dx.doi.org/10.1016/j.ymthe.2016.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363312PMC
January 2017

Gene Editing of Human Hematopoietic Stem and Progenitor Cells: Promise and Potential Hurdles.

Authors:
Kyung-Rok Yu Hannah Natanson Cynthia E Dunbar

Hum Gene Ther 2016 10 2;27(10):729-740. Epub 2016 Aug 2.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035911PMC
http://dx.doi.org/10.1089/hum.2016.107DOI Listing
October 2016

The Role of Nonhuman Primate Animal Models in the Clinical Development of Pluripotent Stem Cell Therapies.

Authors:
So Gun Hong Yongshun Lin Cynthia E Dunbar Jizhong Zou

Mol Ther 2016 08;24(7):1165-9

iPSC Core, Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2016.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088755PMC
August 2016

Gene and Cell Therapies in Expansion Mode: ASGCT 2016.

Authors:
Cynthia E Dunbar

Mol Ther 2016 08;24(8):1333-4

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http://dx.doi.org/10.1038/mt.2016.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023373PMC
August 2016

Blood's 70th anniversary: CARs on the Blood highway.

Authors:
Cynthia E Dunbar

Blood 2016 07;128(1):1-3

Editor-in-Chief, Blood, 2008-2012.

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http://www.bloodjournal.org/content/128/1/1.full.pdf
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http://dx.doi.org/10.1182/blood-2015-10-635334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937353PMC
July 2016

Thrombopoietic status of patients on haemodialysis.

Authors:
Taha Bat Betul E Bat Ahmed El-Moghraby Samir Patel Xingmin Feng Cynthia E Dunbar Erdal Sarac

Br J Haematol 2016 Mar 16;172(6):954-7. Epub 2016 Feb 16.

Western Reserve Health Education, Northeastern Ohio Medical University (NEOMED), Youngstown, OH, USA.

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http://dx.doi.org/10.1111/bjh.13918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785056PMC
March 2016

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells.

Authors:
Chen Glait-Santar Ronan Desmond Xingmin Feng Taha Bat Jichun Chen Elisabeth Heuston Benjamin Mizukawa James C Mulloy David M Bodine Andre Larochelle Cynthia E Dunbar

Stem Cells 2015 Dec 5;33(12):3635-42. Epub 2015 Oct 5.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/stem.2208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713243PMC
December 2015

Modeling Human Bone Marrow Failure Syndromes Using Pluripotent Stem Cells and Genome Engineering.

Authors:
Moonjung Jung Cynthia E Dunbar Thomas Winkler

Mol Ther 2015 Dec 5;23(12):1832-42. Epub 2015 Oct 5.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2015.180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700116PMC
December 2015

Human hematopoietic stem cells from mobilized peripheral blood can be purified based on CD49f integrin expression.

Authors:
Heather D Huntsman Taha Bat Hai Cheng Ayla Cash Patali S Cheruku Jian-Fei Fu Keyvan Keyvanfar Richard W Childs Cynthia E Dunbar Andre Larochelle

Blood 2015 Sep;126(13):1631-3

National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1182/blood-2015-07-660670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582339PMC
September 2015

Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib.

Authors:
Chan Y Cheah Kate Burbury Jane F Apperley Francoise Huguet Vincenzo Pitini Martine Gardembas David M Ross Donna Forrest Philippe Genet Philippe Rousselot Nigel Patton Graeme Smith Cynthia E Dunbar Sawa Ito Ricardo C T Aguiar Olatoyosi Odenike Alla Gimelfarb Nicholas C P Cross John F Seymour

Blood 2014 Jun 31;123(23):3574-7. Epub 2014 Mar 31.

Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia; University of Melbourne, Parkville, VIC, Australia;

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http://dx.doi.org/10.1182/blood-2014-02-555607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047496PMC
June 2014

An AAVS1-targeted minigene platform for correction of iPSCs from all five types of chronic granulomatous disease.

Authors:
Randall K Merling Colin L Sweeney Jessica Chu Aaron Bodansky Uimook Choi Debra Long Priel Douglas B Kuhns Hongmei Wang Sam Vasilevsky Suk See De Ravin Thomas Winkler Cynthia E Dunbar Jizhong Zou Kol A Zarember John I Gallin Steven M Holland Harry L Malech

Mol Ther 2015 Jan 7;23(1):147-57. Epub 2014 Oct 7.

Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2014.195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426805PMC
January 2015

Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.

Authors:
Arun Balakumaran Prasun J Mishra Edyta Pawelczyk Sayuri Yoshizawa Brian J Sworder Natasha Cherman Sergei A Kuznetsov Paolo Bianco Neelam Giri Sharon A Savage Glenn Merlino Bogdan Dumitriu Cynthia E Dunbar Neal S Young Blanche P Alter Pamela G Robey

Blood 2015 Jan 12;125(5):793-802. Epub 2014 Dec 12.

Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research.

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http://dx.doi.org/10.1182/blood-2014-06-566810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311227PMC
January 2015

Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.

Authors:
Arun Balakumaran Prasun J Mishra Edyta Pawelczyk Sayuri Yoshizawa Brian J Sworder Natasha Cherman Sergei A Kuznetsov Paolo Bianco Neelam Giri Sharon A Savage Glenn Merlino Bogdan Dumitriu Cynthia E Dunbar Neal S Young Blanche P Alter Pamela G Robey

Blood 2015 Jan 12;125(5):793-802. Epub 2014 Dec 12.

Skeletal Biology Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research.

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http://dx.doi.org/10.1182/blood-2014-06-566810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311227PMC
January 2015

IFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.

Authors:
José Medina-Echeverz Lydia A Haile Fei Zhao Jaba Gamrekelashvili Chi Ma Jean-Yves Métais Cynthia E Dunbar Veena Kapoor Michael P Manns Firouzeh Korangy Tim F Greten

Eur J Immunol 2014 Aug 16;44(8):2457-67. Epub 2014 Jun 16.

GI-Malignancy Section, Thoracic and GI-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/eji.201444497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140991PMC
August 2014

In vivo clonal tracking of hematopoietic stem and progenitor cells marked by five fluorescent proteins using confocal and multiphoton microscopy.

Authors:
Daniela Malide Jean-Yves Métais Cynthia E Dunbar

J Vis Exp 2014 Aug 6(90):e51669. Epub 2014 Aug 6.

Hematology Branch, NHLBI/NIH.

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http://dx.doi.org/10.3791/51669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540089PMC
August 2014

Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib.

Authors:
Chan Y Cheah Kate Burbury Jane F Apperley Francoise Huguet Vincenzo Pitini Martine Gardembas David M Ross Donna Forrest Philippe Genet Philippe Rousselot Nigel Patton Graeme Smith Cynthia E Dunbar Sawa Ito Ricardo C T Aguiar Olatoyosi Odenike Alla Gimelfarb Nicholas C P Cross John F Seymour

Blood 2014 Jun 31;123(23):3574-7. Epub 2014 Mar 31.

Department of Haematology, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia; University of Melbourne, Parkville, VIC, Australia;

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http://dx.doi.org/10.1182/blood-2014-02-555607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047496PMC
June 2014

Path to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model.

Authors:
So Gun Hong Thomas Winkler Chuanfeng Wu Vicky Guo Stefania Pittaluga Alina Nicolae Robert E Donahue Mark E Metzger Sandra D Price Naoya Uchida Sergei A Kuznetsov Tina Kilts Li Li Pamela G Robey Cynthia E Dunbar

Cell Rep 2014 May 15;7(4):1298-1309. Epub 2014 May 15.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1016/j.celrep.2014.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058889PMC
May 2014

Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study.

Authors:
Sanggu Kim Namshin Kim Angela P Presson Mark E Metzger Aylin C Bonifacino Mary Sehl Samson A Chow Gay M Crooks Cynthia E Dunbar Dong Sung An Robert E Donahue Irvin S Y Chen

Cell Stem Cell 2014 Apr;14(4):473-85

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; UCLA AIDS Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009343PMC
April 2014

Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.

Authors:
Chuanfeng Wu Brian Li Rong Lu Samson J Koelle Yanqin Yang Alexander Jares Alan E Krouse Mark Metzger Frank Liang Karin Loré Colin O Wu Robert E Donahue Irvin S Y Chen Irving Weissman Cynthia E Dunbar

Cell Stem Cell 2014 Apr;14(4):486-499

Hematology Branch; National Heart, Lung and Blood Institute; National Institutes of Health, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091400050
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http://dx.doi.org/10.1016/j.stem.2014.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979461PMC
April 2014

Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.

Authors:
Ronan Desmond Danielle M Townsley Bogdan Dumitriu Matthew J Olnes Phillip Scheinberg Margaret Bevans Ankur R Parikh Kinneret Broder Katherine R Calvo Colin O Wu Neal S Young Cynthia E Dunbar

Blood 2014 Mar 17;123(12):1818-25. Epub 2013 Dec 17.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-10-53
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http://dx.doi.org/10.1182/blood-2013-10-534743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962161PMC
March 2014

No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.

Authors:
Stephanie E Sellers Bogdan Dumitriu Mary J Morgan William M Hughes Colin O Wu Nalini Raghavarchari Yanqin Yang Naoya Uchida John F Tisdale Dong S An Irvin S Chen Peiman Hematti Robert E Donahue Andre Larochelle Neal S Young Rodrigo T Calado Cynthia E Dunbar

Mol Ther 2014 Jan 18;22(1):52-8. Epub 2013 Jul 18.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2013.168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978805PMC
January 2014

Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.

Authors:
Naoya Uchida Molly E Evans Matthew M Hsieh Aylin C Bonifacino Allen E Krouse Mark E Metzger Stephanie E Sellers Cynthia E Dunbar Robert E Donahue John F Tisdale

Mol Ther Nucleic Acids 2013 Sep 17;2:e122. Epub 2013 Sep 17.

Molecular and Clinical Hematology Branch, National Heart Lung and Blood Institutes (NHLBI)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mtna.2013.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098567PMC
September 2013

Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes.

Authors:
Danielle M Townsley Ronan Desmond Cynthia E Dunbar Neal S Young

Int J Hematol 2013 Jul 21;98(1):48-55. Epub 2013 May 21.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, CRC 3-5140, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s12185-013-1352-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144663PMC
July 2013

Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion.

Authors:
Taha Bat Susan F Leitman Katherine R Calvo Donna Chauvet Cynthia E Dunbar

Transfusion 2013 Jun 9;53(6):1201-4. Epub 2012 Oct 9.

Hematology Branch, National Heart, Lung, and BloodInstitute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1111/j.1537-2995.2012.03918.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543490PMC
June 2013

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs.

Authors:
Thomas Winkler So Gun Hong Jake E Decker Mary J Morgan Chuanfeng Wu William M Hughes Yanqin Yang Danny Wangsa Hesed M Padilla-Nash Thomas Ried Neal S Young Cynthia E Dunbar Rodrigo T Calado

J Clin Invest 2013 May 15;123(5):1952-63. Epub 2013 Apr 15.

Hematology Branch, National Heart Lung and Blood Institute (NHLBI), NIH, Bethesda, Maryland 0892-1202, USA.

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http://dx.doi.org/10.1172/JCI67146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635755PMC
May 2013

BCL2A1a over-expression in murine hematopoietic stem and progenitor cells decreases apoptosis and results in hematopoietic transformation.

Authors:
Jean-Yves Métais Thomas Winkler Julia T Geyer Rodrigo T Calado Peter D Aplan Michael A Eckhaus Cynthia E Dunbar

PLoS One 2012 30;7(10):e48267. Epub 2012 Oct 30.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0048267PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484072PMC
April 2013

Hematopoietic stem cell gene therapy:assessing the relevance of preclinical models.

Authors:
Andre Larochelle Cynthia E Dunbar

Semin Hematol 2013 Apr;50(2):101-30

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http://dx.doi.org/10.1053/j.seminhematol.2013.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761403PMC
April 2013

Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells.

Authors:
So Gun Hong Cynthia E Dunbar Thomas Winkler

Mol Ther 2013 Feb 4;21(2):272-81. Epub 2012 Dec 4.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/mt.2012.255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594024PMC
February 2013

High efficiency restriction enzyme-free linear amplification-mediated polymerase chain reaction approach for tracking lentiviral integration sites does not abrogate retrieval bias.

Authors:
Chuanfeng Wu Alexander Jares Thomas Winkler Jianjun Xie Jean-Yves Metais Cynthia E Dunbar

Hum Gene Ther 2013 Jan 26;24(1):38-47. Epub 2012 Oct 26.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1089/hum.2012.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555095PMC
January 2013

Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy.

Authors:
Daniela Malide Jean-Yves Métais Cynthia E Dunbar

Blood 2012 Dec 20;120(26):e105-16. Epub 2012 Sep 20.

Light Microscopy Core Facility. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2012-06-440636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537316PMC
December 2012

An educational infusion: more synergy between Blood and the American Society of Hematology.

Authors:
Cynthia E Dunbar

Blood 2012 Nov;120(23):4449

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http://dx.doi.org/10.1182/blood-2012-10-461673DOI Listing
November 2012

High efficiency restriction enzyme-free linear amplification-mediated polymerase chain reaction approach for tracking lentiviral integration sites does not abrogate retrieval bias.

Authors:
Chuanfeng Wu Alexander Jares Thomas Winkler Jianjun Xie Jean-Yves Metais Cynthia E Dunbar

Hum Gene Ther 2013 Jan 26;24(1):38-47. Epub 2012 Oct 26.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1089/hum.2012.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555095PMC
January 2013

Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.

Authors:
Federico Mingozzi Yifeng Chen Samuel L Murphy Shyrie C Edmonson Alex Tai Sandra D Price Mark E Metzger Shangzhen Zhou J Fraser Wright Robert E Donahue Cynthia E Dunbar Katherine A High

Mol Ther 2012 Jul 8;20(7):1410-6. Epub 2012 May 8.

Division of Hematology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/mt.2012.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392987PMC
July 2012

Eltrombopag and improved hematopoiesis in refractory aplastic anemia.

Authors:
Matthew J Olnes Phillip Scheinberg Katherine R Calvo Ronan Desmond Yong Tang Bogdan Dumitriu Ankur R Parikh Susan Soto Angelique Biancotto Xingmin Feng Jay Lozier Colin O Wu Neal S Young Cynthia E Dunbar

N Engl J Med 2012 Jul;367(1):11-9

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1056/NEJMoa1200931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422737PMC
July 2012

Hematopoietic stem cell engineering at a crossroads.

Authors:
Isabelle Rivière Cynthia E Dunbar Michel Sadelain

Blood 2012 Feb 17;119(5):1107-16. Epub 2011 Nov 17.

Center for Cell Engineering, Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2011-09-349993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277348PMC
February 2012

Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain.

Authors:
Andre Larochelle Jennifer M Gillette Ronan Desmond Brian Ichwan Amy Cantilena Alexandra Cerf A John Barrett Alan S Wayne Jennifer Lippincott-Schwartz Cynthia E Dunbar

Blood 2012 Feb 6;119(8):1848-55. Epub 2012 Jan 6.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-08-37
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http://dx.doi.org/10.1182/blood-2011-08-371583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293639PMC
February 2012

Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice.

Authors:
Inho Kim Yoo-Jin Kim Jean-Yves Métais Cynthia E Dunbar Andre Larochelle

Exp Hematol 2012 Jan 20;40(1):84-91. Epub 2011 Oct 20.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.exphem.2011.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237729PMC
January 2012

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.

Authors:
Chuanfeng Wu Cynthia E Dunbar

Front Med 2011 Dec 27;5(4):356-71. Epub 2011 Dec 27.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s11684-011-0159-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508510PMC
December 2011

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.

Authors:
Annette Deichmann Martijn H Brugman Cynthia C Bartholomae Kerstin Schwarzwaelder Monique M A Verstegen Steven J Howe Anne Arens Marion G Ott Dieter Hoelzer Reinhard Seger Manuel Grez Salima Hacein-Bey-Abina Marina Cavazzana-Calvo Alain Fischer Anna Paruzynski Richard Gabriel Hanno Glimm Ulrich Abel Claudia Cattoglio Fulvio Mavilio Barbara Cassani Alessandro Aiuti Cynthia E Dunbar Christopher Baum H Bobby Gaspar Adrian J Thrasher Christof von Kalle Manfred Schmidt Gerard Wagemaker

Mol Ther 2011 Nov 23;19(11):2031-9. Epub 2011 Aug 23.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/mt.2011.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222531PMC
November 2011

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.

Authors:
Georg Aue Yang Du Susan M Cleveland Stephen B Smith Utpal P Davé Delong Liu Marc A Weniger Jean Yves Metais Nancy A Jenkins Neal G Copeland Cynthia E Dunbar

Blood 2011 Oct 30;118(17):4674-81. Epub 2011 Aug 30.

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1182/blood-2011-04-351528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208283PMC
October 2011

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.

Authors:
Ayelet Dar Amir Schajnovitz Kfir Lapid Alexander Kalinkovich Tomer Itkin Aya Ludin Wei-Ming Kao Michela Battista Melania Tesio Orit Kollet Neta Netzer Cohen Raanan Margalit Eike C Buss Francoise Baleux Shinya Oishi Nobutaka Fujii Andre Larochelle Cynthia E Dunbar Hal E Broxmeyer Paul S Frenette Tsvee Lapidot

Leukemia 2011 Aug 15;25(8):1286-1296. Epub 2011 Apr 15.

Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

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http://www.nature.com/articles/leu201162
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http://dx.doi.org/10.1038/leu.2011.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175714PMC
August 2011

Contributions of gene marking to cell and gene therapies.

Authors:
Cecilia N Barese Cynthia E Dunbar

Hum Gene Ther 2011 Jun 5;22(6):659-68. Epub 2011 May 5.

Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20852, USA.

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http://dx.doi.org/10.1089/hum.2010.237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120086PMC
June 2011

CD9 up-regulation on CD34+ cells with ingenol 3,20-dibenzoate does not improve homing in NSG mice.

Authors:
Ronan Desmond Ashley Dunfee Frederick Racke Cynthia E Dunbar Andre Larochelle

Blood 2011 May;117(21):5774-6

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http://dx.doi.org/10.1182/blood-2011-01-332031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110034PMC
May 2011

Patients, hematologists, and time.

Authors:
Lawrence A Solberg Cynthia E Dunbar

Blood 2011 Mar;117(10):2753-4

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http://dx.doi.org/10.1182/blood-2011-02-334854DOI Listing
March 2011

Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.

Authors:
Andre Larochelle Michael Savona Michael Wiggins Stephanie Anderson Brian Ichwan Keyvan Keyvanfar Sean J Morrison Cynthia E Dunbar

Blood 2011 Feb 16;117(5):1550-4. Epub 2010 Dec 16.

National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2009-03-212803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318774PMC
February 2011

Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after transplantation.

Authors:
Stephanie Sellers Theotonius J Gomes Andre Larochelle Rebecca Lopez Rima Adler Allen Krouse Robert E Donahue Richard W Childs Cynthia E Dunbar

Mol Ther 2010 Sep 22;18(9):1633-9. Epub 2010 Jun 22.

Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892-1290, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152500161630839
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http://dx.doi.org/10.1038/mt.2010.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956935PMC
September 2010

Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.

Authors:
Jianjun Xie Andre Larochelle Irina Maric Marion Faulhaber Robert E Donahue Cynthia E Dunbar

Hum Gene Ther 2010 Jun;21(6):695-703

Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.liebertpub.com/doi/10.1089/hum.2009.191
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http://dx.doi.org/10.1089/hum.2009.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938356PMC
June 2010

No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells.

Authors:
Thomas Winkler Amy Cantilena Jean-Yves Métais Xiuli Xu Anh-Dao Nguyen Bhavesh Borate Jessica E Antosiewicz-Bourget Tyra G Wolfsberg James A Thomson Cynthia E Dunbar

Stem Cells 2010 Apr;28(4):687-94

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/stem.322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173982PMC
April 2010

Gene therapy activates EVI1, destabilizes chromosomes.

Authors:
Cynthia E Dunbar Andre Larochelle

Nat Med 2010 Feb;16(2):163-5

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http://dx.doi.org/10.1038/nm0210-163DOI Listing
February 2010

Keeping up with Blood: introducing our CME program.

Authors:
Georgia B Vogelsang Cynthia E Dunbar

Blood 2010 Jan;115(4):756

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http://dx.doi.org/10.1182/blood-2010-01-263004DOI Listing
January 2010

The yin and yang of stem cell gene therapy: insights into hematopoiesis, leukemogenesis, and gene therapy safety.

Authors:
Cynthia E Dunbar

Hematology Am Soc Hematol Educ Program 2007 :460-5

Hematology Branch, NIH, Building 10, Room 7C103, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/asheducation-2007.1.460DOI Listing
July 2009

In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.

Authors:
Andre Larochelle Uimook Choi Yan Shou Nora Naumann Natalia A Loktionova Joshua R Clevenger Allen Krouse Mark Metzger Robert E Donahue Elizabeth Kang Clinton Stewart Derek Persons Harry L Malech Cynthia E Dunbar Brian P Sorrentino

J Clin Invest 2009 Jul 8;119(7):1952-63. Epub 2009 Jun 8.

National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.jci.org/articles/view/37506
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http://dx.doi.org/10.1172/JCI37506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701865PMC
July 2009

Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cells.

Authors:
Yoo-Jin Kim Yoon-Sang Kim Andre Larochelle Gabriel Renaud Tyra G Wolfsberg Rima Adler Robert E Donahue Peiman Hematti Bum-Kee Hong Jean Roayaei Keiko Akagi Janice M Riberdy Arthur W Nienhuis Cynthia E Dunbar Derek A Persons

Blood 2009 May 1;113(22):5434-43. Epub 2009 Apr 1.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, MD 20852, USA.

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http://dx.doi.org/10.1182/blood-2008-10-185199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689045PMC
May 2009

Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.

Authors:
Caroline Soulas Robert E Donahue Cynthia E Dunbar Derek A Persons Xavier Alvarez Kenneth C Williams

Am J Pathol 2009 May 6;174(5):1808-17. Epub 2009 Apr 6.

Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA.

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http://dx.doi.org/10.2353/ajpath.2009.081010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671269PMC
May 2009

Introducing "e-Blood".

Authors:
Grover C Bagby Cynthia E Dunbar

Blood 2009 May;113(19):4488

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http://dx.doi.org/10.1182/blood-2009-01-200865DOI Listing
May 2009

Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche.

Authors:
Jennifer M Gillette Andre Larochelle Cynthia E Dunbar Jennifer Lippincott-Schwartz

Nat Cell Biol 2009 Mar 8;11(3):303-11. Epub 2009 Feb 8.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncb1838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748410PMC
March 2009

More frequent Blood transfusions.

Authors:
Cynthia E Dunbar

Blood 2009 Jan;113(1)

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January 2009

'Ghostbusting' at blood.

Authors:
Cynthia E Dunbar Martin S Tallman

Blood 2009 Jan;113(3):502-3

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http://dx.doi.org/10.1182/blood-2008-10-184952DOI Listing
January 2009

Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.

Authors:
Antonis Voutetakis Changyu Zheng Mark Metzger Ana P Cotrim Robert E Donahue Cynthia E Dunbar Bruce J Baum

Hum Gene Ther 2008 Dec;19(12):1401-5

Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Department of Health and Human Services, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940457PMC
December 2008

Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population.

Authors:
Sumithira Vasu Susan F Leitman John F Tisdale Matthew M Hsieh Richard W Childs A John Barrett Daniel H Fowler Michael R Bishop Elizabeth M Kang Harry L Malech Cynthia E Dunbar Hanh M Khuu Robert Wesley Yu Y Yau Charles D Bolan

Blood 2008 Sep 3;112(5):2092-100. Epub 2008 Jun 3.

Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2008-03-143677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518908PMC
September 2008

Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors.

Authors:
Jingqiong Hu Gabriel Renaud Theotonius J Gomes Theotonius Golmes Andrea Ferris Paul C Hendrie Robert E Donahue Stephen H Hughes Tyra G Wolfsberg David W Russell Cynthia E Dunbar

Mol Ther 2008 Sep 24;16(9):1617-23. Epub 2008 Jun 24.

Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, Blood Institute, National Institute of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2008.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561952PMC
September 2008

HOXB4 and retroviral vectors: adding fuel to the fire.

Authors:
Andre Larochelle Cynthia E Dunbar

J Clin Invest 2008 Apr;118(4):1350-3

Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI35326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268881PMC
April 2008

The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy.

Authors:
Jean-Yves Métais Cynthia E Dunbar

Mol Ther 2008 Mar 29;16(3):439-49. Epub 2008 Jan 29.

Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/sj.mt.6300372DOI Listing
March 2008

Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI.

Authors:
Erik M Shapiro Laura N Medford-Davis Tarek M Fahmy Cynthia E Dunbar Alan P Koretsky

Contrast Media Mol Imaging 2007 May-Jun;2(3):147-53

Molecular and Cellular Imaging Laboratory, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA.

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January 2008

Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing.

Authors:
Amy D Klion Jamie Robyn Irina Maric Weiming Fu Laura Schmid Steven Lemery Pierre Noel Melissa A Law Marilyn Hartsell Cheryl Talar-Williams Michael P Fay Cynthia E Dunbar Thomas B Nutman

Blood 2007 Nov 20;110(10):3552-6. Epub 2007 Aug 20.

Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2007-07-100164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077306PMC
November 2007

No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells.

Authors:
Farastuk Bozorgmehr Stefanie Laufs Stephanie E Sellers Ingo Roeder Walter J Zeller Werner J Zeller Cynthia E Dunbar Stefan Fruehauf

Stem Cells 2007 Oct 5;25(10):2610-8. Epub 2007 Jul 5.

Research Group Pharmacology of Cancer Treatment, German Cancer Research Center, Heidelberg, Germany.

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October 2007

Hematopoietic stem-cell behavior in nonhuman primates.

Authors:
Bryan E Shepherd Hans-Peter Kiem Peter M Lansdorp Cynthia E Dunbar Geraldine Aubert Andre LaRochelle Ruth Seggewiss Peter Guttorp Janis L Abkowitz

Blood 2007 Sep 25;110(6):1806-13. Epub 2007 May 25.

Department of Biostatistics, Vanderbilt University, Nashville, TN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976353PMC
September 2007

Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors.

Authors:
Jingqiong Hu Andrea Ferris Andre Larochelle Allen E Krouse Mark E Metzger Robert E Donahue Stephen H Hughes Cynthia E Dunbar

Hum Gene Ther 2007 Aug;18(8):691-700

Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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August 2007

Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.

Authors:
Ruth Seggewiss Karin Loré F Javier Guenaga Stefania Pittaluga Joseph Mattapallil Catherine K Chow Richard A Koup Kevin Camphausen Martha C Nason Martin Meier-Schellersheim Robert E Donahue Bruce R Blazar Cynthia E Dunbar Daniel C Douek

Blood 2007 Jul 20;110(1):441-9. Epub 2007 Mar 20.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2006-12-065623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1975851PMC
July 2007

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.

Authors:
Cary Hsu Stephanie A Jones Cyrille J Cohen Zhili Zheng Keith Kerstann Juhua Zhou Paul F Robbins Peter D Peng Xinglei Shen Theotonius J Gomes Cynthia E Dunbar David J Munroe Claudia Stewart Kenneth Cornetta Danny Wangsa Thomas Ried Steven A Rosenberg Richard A Morgan

Blood 2007 Jun 12;109(12):5168-77. Epub 2007 Mar 12.

Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1182/blood-2006-06-029173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890824PMC
June 2007

Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.

Authors:
Antonis Voutetakis Changyu Zheng Fumi Mineshiba Ana P Cotrim Corinne M Goldsmith Michael Schmidt Sandra Afione Nienke Roescher Mark Metzger Michael A Eckhaus John A Chiorini Cynthia E Dunbar Robert E Donahue Bruce J Baum

Hum Gene Ther 2007 Feb;18(2):142-50

Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Department of Human Health Services, Bethesda, MD 20892, USA.

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February 2007

Large animal models for stem and progenitor cell analysis.

Authors:
Robert E Donahue Ken Kuramoto Cynthia E Dunbar

Curr Protoc Immunol 2005 Nov;Chapter 22:Unit 22A.1

National Institutes of Health, Bethesda, Maryland, USA.

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November 2005