Publications by authors named "Cynthia A Afshari"

42Publications

Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Toxicol Sci 2015 Jun 9;145(2):283-95. Epub 2015 Mar 9.

*Amgen Inc., Comparative Biology and Safety Sciences, Department of Discovery Toxicology, Thousand Oaks, California 91320 and Amgen Research GmbH, 93053 Regensburg, Germany

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June 2015

The evolution of bioinformatics in toxicology: advancing toxicogenomics.

Toxicol Sci 2011 Mar 22;120 Suppl 1:S225-37. Epub 2010 Dec 22.

Department of Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, California 91320, USA.

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March 2011

Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors.

Chem Res Toxicol 2010 Jun;23(6):1025-33

Comparative Biology and Safety Sciences, and Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA.

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June 2010

Insight into redox-regulated gene networks in vascular cells.

Bioinformation 2007 Apr 10;1(10):379-83. Epub 2007 Apr 10.

Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky 40292, USA.

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April 2007

Integrating phenotypic and expression profiles to map arsenic-response networks.

Genome Biol 2004 29;5(12):R95. Epub 2004 Nov 29.

Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.

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October 2005

Exploration of low-dose estrogen effects: identification of No Observed Transcriptional Effect Level (NOTEL).

Toxicol Pathol 2004 Jul-Aug;32(4):482-92

National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

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February 2005

Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.

Proc Natl Acad Sci U S A 2004 May 21;101(18):7199-204. Epub 2004 Apr 21.

Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

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May 2004

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program.

Cancer Cell 2004 Mar;5(3):263-73

Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA.

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March 2004

Identification of platform-independent gene expression markers of cisplatin nephrotoxicity.

Environ Health Perspect 2004 Mar;112(4):488-94

Center for Drug Evaluation and Research, Division of Applied Pharmacology Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Life Sciences Building 64, Silver Spring, MD 20993, USA.

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March 2004