Curtis Gumbs

Curtis Gumbs

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Curtis Gumbs

Curtis Gumbs

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35Publications

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Clonal Dynamics and Clinical Implications of Post-Remission Clonal Hematopoiesis in Acute Myeloid Leukemia (AML).

Authors:
Tomoyuki Tanaka Kiyomi Morita Feng Wang Latasha Little Curtis Gumbs Jairo Matthews Courtney D DiNardo Tapan M Kadia Farhad Ravandi Marina Y Konopleva Hagop M Kantarjian Richard E Champlin Guillermo Garcia-Manero P Andrew Futreal Koichi Takahashi

Blood 2019 Nov;134(Supplement_1):17

Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1182/blood-2019-122274DOI Listing
November 2019

Immune and circulating tumor DNA profiling following radiation treatment for oligometastatic NSCLC; translational correlatives from a mature randomized phase II trial.

Authors:
Chad Tang Won-Chul Lee Alexandre Reuben Lianpeng Chang Hai Tran Latasha Little Curtis Gumbs Jennifer Wargo Andrew Futreal Zhongxing Liao Xuefeng Xia Xin Yi Steven G Swisher John V Heymach Daniel Gomez Jianjun Zhang

Int J Radiat Oncol Biol Phys 2019 Oct 30. Epub 2019 Oct 30.

Genomic Medicine; Thoracic/Head and Neck Medical Oncology. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2019.10.038DOI Listing
October 2019

Multi-region exome sequencing reveals genomic evolution from preneoplasia to lung adenocarcinoma.

Authors:
Xin Hu Junya Fujimoto Lisha Ying Junya Fukuoka Kazuto Ashizawa Wenyong Sun Alexandre Reuben Chi-Wan Chow Nicholas McGranahan Runzhe Chen Jinlin Hu Myrna C Godoy Kazuhiro Tabata Kishio Kuroda Lei Shi Jun Li Carmen Behrens Edwin Roger Parra Latasha D Little Curtis Gumbs Xizeng Mao Xingzhi Song Samantha Tippen Rebecca L Thornton Humam Kadara Paul Scheet Emily Roarty Edwin Justin Ostrin Xu Wang Brett W Carter Mara B Antonoff Jianhua Zhang Ara A Vaporciyan Harvey Pass Stephen G Swisher John V Heymach J Jack Lee Ignacio I Wistuba Waun Ki Hong P Andrew Futreal Dan Su Jianjun Zhang

Nat Commun 2019 07 5;10(1):2978. Epub 2019 Jul 5.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-019-10877-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611767PMC
July 2019

Late relapse in acute myeloid leukemia (AML): clonal evolution or therapy-related leukemia?

Authors:
Musa Yilmaz Feng Wang Sanam Loghavi Carlos Bueso-Ramos Curtis Gumbs Latasha Little Xingzhi Song Jianhua Zhang Tapan Kadia Gautam Borthakur Elias Jabbour Naveen Pemmaraju Nicholas Short Guillermo Garcia-Manero Zeev Estrov Hagop Kantarjian Andrew Futreal Koichi Takahashi Farhad Ravandi

Blood Cancer J 2019 01 16;9(2). Epub 2019 Jan 16.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.nature.com/articles/s41408-019-0170-3
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http://dx.doi.org/10.1038/s41408-019-0170-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335405PMC
January 2019

Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes.

Authors:
Koichi Takahashi Feng Wang Kiyomi Morita Yuanqing Yan Peter Hu Pei Zhao Abdallah Abou Zhar Chang Jiun Wu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Marcus Coyle Marisela Mendoza Erika Thompson Jianhua Zhang Courtney D DiNardo Nitin Jain Farhad Ravandi Jorge E Cortes Guillermo Garcia-Manero Steven Kornblau Michael Andreeff Elias Jabbour Carlos Bueso-Ramos Akifumi Takaori-Kondo Marina Konopleva Keyur Patel Hagop Kantarjian P Andrew Futreal

Nat Commun 2018 07 10;9(1):2670. Epub 2018 Jul 10.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-018-04924-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039465PMC
July 2018

Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia.

Authors:
Kiyomi Morita Hagop M Kantarjian Feng Wang Yuanqing Yan Carlos Bueso-Ramos Koji Sasaki Ghayas C Issa Sa Wang Jeffrey Jorgensen Xingzhi Song Jianhua Zhang Samantha Tippen Rebecca Thornton Marcus Coyle Latasha Little Curtis Gumbs Naveen Pemmaraju Naval Daver Courtney D DiNardo Marina Konopleva Michael Andreeff Farhad Ravandi Jorge E Cortes Tapan Kadia Elias Jabbour Guillermo Garcia-Manero Keyur P Patel P Andrew Futreal Koichi Takahashi

J Clin Oncol 2018 06 27;36(18):1788-1797. Epub 2018 Apr 27.

Kiyomi Morita, Hagop M. Kantarjian, Feng Wang, Yuanqing Yan, Carlos Bueso-Ramos, Koji Sasaki, Ghayas C. Issa, Sa Wang, Jeffrey Jorgensen, Xingzhi Song, Jianhua Zhang, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Latasha Little, Curtis Gumbs, Naveen Pemmaraju, Naval Daver, Courtney D. DiNardo, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Jorge E. Cortes, Tapan Kadia, Elias Jabbour, Guillermo Garcia-Manero, Keyur P. Patel, P. Andrew Futreal, and Koichi Takahash, The University of Texas MD Anderson Cancer Center, Houston, TX; Kiyomi Morita, The University of Tokyo, Tokyo; and Koichi Takahashi, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1200/JCO.2017.77.6757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008108PMC
June 2018

KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary.

Authors:
R Tyler Hillman Joseph Celestino Christopher Terranova Hannah C Beird Curtis Gumbs Latasha Little Tri Nguyen Rebecca Thornton Samantha Tippen Jianhua Zhang Karen H Lu David M Gershenson Kunal Rai Russell R Broaddus P Andrew Futreal

Nat Commun 2018 06 27;9(1):2496. Epub 2018 Jun 27.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1038/s41467-018-04950-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021426PMC
June 2018

Clinical implications of cancer gene mutations in patients with chronic lymphocytic leukemia treated with lenalidomide.

Authors:
Koichi Takahashi Boyu Hu Feng Wang Yuanqing Yan Ekaterina Kim Candida Vitale Keyur P Patel Paolo Strati Curtis Gumbs Latasha Little Samantha Tippen Xingzhi Song Jianhua Zhang Nitin Jain Philip Thompson Guillermo Garcia-Manero Hagop Kantarjian Zeev Estrov Kim-Anh Do Michael Keating Jan A Burger William G Wierda P Andrew Futreal Alessandra Ferrajoli

Blood 2018 04 22;131(16):1820-1832. Epub 2018 Jan 22.

Department of Leukemia and.

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http://dx.doi.org/10.1182/blood-2017-11-817296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909764PMC
April 2018

Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin.

Authors:
Hannah C Beird Chia-Chin Wu Davis R Ingram Wei-Lien Wang Asrar Alimohamed Curtis Gumbs Latasha Little Xingzhi Song Barry W Feig Christina L Roland Jianhua Zhang Robert S Benjamin Patrick Hwu Alexander J Lazar P Andrew Futreal Neeta Somaiah

Cold Spring Harb Mol Case Stud 2018 04 2;4(2). Epub 2018 Apr 2.

Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/mcs.a002386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880260PMC
April 2018

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.

Authors:
Alexandre Reuben Rachel Gittelman Jianjun Gao Jiexin Zhang Erik C Yusko Chang-Jiun Wu Ryan Emerson Jianhua Zhang Christopher Tipton Jun Li Kelly Quek Vancheswaran Gopalakrishnan Runzhe Chen Luis M Vence Tina Cascone Marissa Vignali Junya Fujimoto Jaime Rodriguez-Canales Edwin R Parra Latasha D Little Curtis Gumbs Marie-Andrée Forget Lorenzo Federico Cara Haymaker Carmen Behrens Sharon Benzeno Chantale Bernatchez Boris Sepesi Don L Gibbons Jennifer A Wargo William N William Stephen Swisher John V Heymach Harlan Robins J Jack Lee Padmanee Sharma James P Allison P Andrew Futreal Ignacio I Wistuba Jianjun Zhang

Cancer Discov 2017 10 21;7(10):1088-1097. Epub 2017 Jul 21.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-17-0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628137PMC
October 2017

Copy number alterations detected as clonal hematopoiesis of indeterminate potential.

Authors:
Koichi Takahashi Feng Wang Hagop Kantarjian Xingzhi Song Keyur Patel Sattva Neelapu Curtis Gumbs Latasha Little Samantha Tippen Rebecca Thornton Courtney D DiNardo Farhad Ravandi Carlos Bueso-Ramos Jianhua Zhang Xifeng Wu Guillermo Garcia-Manero P Andrew Futreal

Blood Adv 2017 Jun 19;1(15):1031-1036. Epub 2017 Jun 19.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1182/bloodadvances.2017007922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728325PMC
June 2017

Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma.

Authors:
Alexandre Reuben Christine N Spencer Peter A Prieto Vancheswaran Gopalakrishnan Sangeetha M Reddy John P Miller Xizeng Mao Mariana Petaccia De Macedo Jiong Chen Xingzhi Song Hong Jiang Pei-Ling Chen Hannah C Beird Haven R Garber Whijae Roh Khalida Wani Eveline Chen Cara Haymaker Marie-Andrée Forget Latasha D Little Curtis Gumbs Rebecca L Thornton Courtney W Hudgens Wei-Shen Chen Jacob Austin-Breneman Robert Szczepaniak Sloane Luigi Nezi Alexandria P Cogdill Chantale Bernatchez Jason Roszik Patrick Hwu Scott E Woodman Lynda Chin Hussein Tawbi Michael A Davies Jeffrey E Gershenwald Rodabe N Amaria Isabella C Glitza Adi Diab Sapna P Patel Jianhua Hu Jeffrey E Lee Elizabeth A Grimm Michael T Tetzlaff Alexander J Lazar Ignacio I Wistuba Karen Clise-Dwyer Brett W Carter Jianhua Zhang P Andrew Futreal Padmanee Sharma James P Allison Zachary A Cooper Jennifer A Wargo

NPJ Genom Med 2017 7;2. Epub 2017 Apr 7.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/s41525-017-0013-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557036PMC
April 2017

Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance.

Authors:
Whijae Roh Pei-Ling Chen Alexandre Reuben Christine N Spencer Peter A Prieto John P Miller Vancheswaran Gopalakrishnan Feng Wang Zachary A Cooper Sangeetha M Reddy Curtis Gumbs Latasha Little Qing Chang Wei-Shen Chen Khalida Wani Mariana Petaccia De Macedo Eveline Chen Jacob L Austin-Breneman Hong Jiang Jason Roszik Michael T Tetzlaff Michael A Davies Jeffrey E Gershenwald Hussein Tawbi Alexander J Lazar Patrick Hwu Wen-Jen Hwu Adi Diab Isabella C Glitza Sapna P Patel Scott E Woodman Rodabe N Amaria Victor G Prieto Jianhua Hu Padmanee Sharma James P Allison Lynda Chin Jianhua Zhang Jennifer A Wargo P Andrew Futreal

Sci Transl Med 2017 03;9(379)

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aah3560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819607PMC
March 2017

Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study.

Authors:
Koichi Takahashi Feng Wang Hagop Kantarjian Denaha Doss Kanhav Khanna Erika Thompson Li Zhao Keyur Patel Sattva Neelapu Curtis Gumbs Carlos Bueso-Ramos Courtney D DiNardo Simona Colla Farhad Ravandi Jianhua Zhang Xuelin Huang Xifeng Wu Felipe Samaniego Guillermo Garcia-Manero P Andrew Futreal

Lancet Oncol 2017 01 3;18(1):100-111. Epub 2016 Dec 3.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30626-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405697PMC
January 2017

Clinical implications of TP53 mutations in myelodysplastic syndromes treated with hypomethylating agents.

Authors:
Koichi Takahashi Keyur Patel Carlos Bueso-Ramos Jianhua Zhang Curtis Gumbs Elias Jabbour Tapan Kadia Michael Andreff Marina Konopleva Courtney DiNardo Naval Daver Jorge Cortes Zeev Estrov Andrew Futreal Hagop Kantarjian Guillermo Garcia-Manero

Oncotarget 2016 Mar;7(12):14172-87

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://www.oncotarget.com/fulltext/7290
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http://dx.doi.org/10.18632/oncotarget.7290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924706PMC
March 2016

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing.

Authors:
Jianjun Zhang Junya Fujimoto Jianhua Zhang David C Wedge Xingzhi Song Jiexin Zhang Sahil Seth Chi-Wan Chow Yu Cao Curtis Gumbs Kathryn A Gold Neda Kalhor Latasha Little Harshad Mahadeshwar Cesar Moran Alexei Protopopov Huandong Sun Jiabin Tang Xifeng Wu Yuanqing Ye William N William J Jack Lee John V Heymach Waun Ki Hong Stephen Swisher Ignacio I Wistuba P Andrew Futreal

Science 2014 Oct;346(6206):256-9

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Honorary Faculty, Wellcome Trust Sanger Institute, Hinxton, UK CB10 1SA.

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http://dx.doi.org/10.1126/science.1256930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354858PMC
October 2014

Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

Authors:
Sam Behjati Patrick S Tarpey Helen Sheldon Inigo Martincorena Peter Van Loo Gunes Gundem David C Wedge Manasa Ramakrishna Susanna L Cooke Nischalan Pillay Hans Kristian M Vollan Elli Papaemmanuil Hans Koss Tom D Bunney Claire Hardy Olivia R Joseph Sancha Martin Laura Mudie Adam Butler Jon W Teague Meena Patil Graham Steers Yu Cao Curtis Gumbs Davis Ingram Alexander J Lazar Latasha Little Harshad Mahadeshwar Alexei Protopopov Ghadah A Al Sannaa Sahil Seth Xingzhi Song Jiabin Tang Jianhua Zhang Vinod Ravi Keila E Torres Bhavisha Khatri Dina Halai Ioannis Roxanis Daniel Baumhoer Roberto Tirabosco M Fernanda Amary Chris Boshoff Ultan McDermott Matilda Katan Michael R Stratton P Andrew Futreal Adrienne M Flanagan Adrian Harris Peter J Campbell

Nat Genet 2014 Apr 16;46(4):376-379. Epub 2014 Mar 16.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.

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http://dx.doi.org/10.1038/ng.2921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032873PMC
April 2014

De novo mutations in ATP1A3 cause alternating hemiplegia of childhood.

Authors:
Erin L Heinzen Kathryn J Swoboda Yuki Hitomi Fiorella Gurrieri Sophie Nicole Boukje de Vries F Danilo Tiziano Bertrand Fontaine Nicole M Walley Sinéad Heavin Eleni Panagiotakaki Stefania Fiori Emanuela Abiusi Lorena Di Pietro Matthew T Sweney Tara M Newcomb Louis Viollet Chad Huff Lynn B Jorde Sandra P Reyna Kelley J Murphy Kevin V Shianna Curtis E Gumbs Latasha Little Kenneth Silver Louis J Ptáček Joost Haan Michel D Ferrari Ann M Bye Geoffrey K Herkes Charlotte M Whitelaw David Webb Bryan J Lynch Peter Uldall Mary D King Ingrid E Scheffer Giovanni Neri Alexis Arzimanoglou Arn M J M van den Maagdenberg Sanjay M Sisodiya Mohamad A Mikati David B Goldstein

Nat Genet 2012 Sep 29;44(9):1030-4. Epub 2012 Jul 29.

Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA.

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http://dx.doi.org/10.1038/ng.2358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442240PMC
September 2012

Using ERDS to infer copy-number variants in high-coverage genomes.

Authors:
Mingfu Zhu Anna C Need Yujun Han Dongliang Ge Jessica M Maia Qianqian Zhu Erin L Heinzen Elizabeth T Cirulli Kimberly Pelak Min He Elizabeth K Ruzzo Curtis Gumbs Abanish Singh Sheng Feng Kevin V Shianna David B Goldstein

Am J Hum Genet 2012 Sep 30;91(3):408-21. Epub 2012 Aug 30.

Center for Human Genome Variation, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511991PMC
September 2012

Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.

Authors:
Erin L Heinzen Chantal Depondt Gianpiero L Cavalleri Elizabeth K Ruzzo Nicole M Walley Anna C Need Dongliang Ge Min He Elizabeth T Cirulli Qian Zhao Kenneth D Cronin Curtis E Gumbs C Ryan Campbell Linda K Hong Jessica M Maia Kevin V Shianna Mark McCormack Rodney A Radtke Gerard D O'Conner Mohamad A Mikati William B Gallentine Aatif M Husain Saurabh R Sinha Krishna Chinthapalli Ram S Puranam James O McNamara Ruth Ottman Sanjay M Sisodiya Norman Delanty David B Goldstein

Am J Hum Genet 2012 Aug 2;91(2):293-302. Epub 2012 Aug 2.

Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415540PMC
August 2012

Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia.

Authors:
Anna C Need Joseph P McEvoy Massimo Gennarelli Erin L Heinzen Dongliang Ge Jessica M Maia Kevin V Shianna Min He Elizabeth T Cirulli Curtis E Gumbs Qian Zhao C Ryan Campbell Linda Hong Peter Rosenquist Anu Putkonen Tero Hallikainen Eila Repo-Tiihonen Jari Tiihonen Deborah L Levy Herbert Y Meltzer David B Goldstein

Am J Hum Genet 2012 Aug 2;91(2):303-12. Epub 2012 Aug 2.

Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA.

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http://dx.doi.org/10.1016/j.ajhg.2012.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415532PMC
August 2012

Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function.

Authors:
Yuki Hitomi Elizabeth T Cirulli Jacques Fellay John G McHutchison Alexander J Thompson Curtis E Gumbs Kevin V Shianna Thomas J Urban David B Goldstein

Gastroenterology 2011 Apr 1;140(4):1314-21. Epub 2011 Jan 1.

Center for Human Genome Variation, School of Medicine, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.12.038DOI Listing
April 2011

The characterization of twenty sequenced human genomes.

Authors:
Kimberly Pelak Kevin V Shianna Dongliang Ge Jessica M Maia Mingfu Zhu Jason P Smith Elizabeth T Cirulli Jacques Fellay Samuel P Dickson Curtis E Gumbs Erin L Heinzen Anna C Need Elizabeth K Ruzzo Abanish Singh C Ryan Campbell Linda K Hong Katharina A Lornsen Alexander M McKenzie Nara L M Sobreira Julie E Hoover-Fong Joshua D Milner Ruth Ottman Barton F Haynes James J Goedert David B Goldstein

PLoS Genet 2010 Sep 9;6(9):e1001111. Epub 2010 Sep 9.

Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936541PMC
September 2010

Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene.

Authors:
Nara L M Sobreira Elizabeth T Cirulli Dimitrios Avramopoulos Elizabeth Wohler Gretchen L Oswald Eric L Stevens Dongliang Ge Kevin V Shianna Jason P Smith Jessica M Maia Curtis E Gumbs Jonathan Pevsner George Thomas David Valle Julie E Hoover-Fong David B Goldstein

PLoS Genet 2010 Jun 17;6(6):e1000991. Epub 2010 Jun 17.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pgen.1000991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887469PMC
June 2010

Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.

Authors:
Erin L Heinzen Rodney A Radtke Thomas J Urban Gianpiero L Cavalleri Chantal Depondt Anna C Need Nicole M Walley Paola Nicoletti Dongliang Ge Claudia B Catarino John S Duncan Dalia Kasperaviciūte Sarah K Tate Luis O Caboclo Josemir W Sander Lisa Clayton Kristen N Linney Kevin V Shianna Curtis E Gumbs Jason Smith Kenneth D Cronin Jessica M Maia Colin P Doherty Massimo Pandolfo David Leppert Lefkos T Middleton Rachel A Gibson Michael R Johnson Paul M Matthews David Hosford Reetta Kälviäinen Kai Eriksson Anne-Mari Kantanen Thomas Dorn Jörg Hansen Günter Krämer Bernhard J Steinhoff Heinz-Gregor Wieser Dominik Zumsteg Marcos Ortega Nicholas W Wood Julie Huxley-Jones Mohamad Mikati William B Gallentine Aatif M Husain Patrick G Buckley Ray L Stallings Mihai V Podgoreanu Norman Delanty Sanjay M Sisodiya David B Goldstein

Am J Hum Genet 2010 May 15;86(5):707-18. Epub 2010 Apr 15.

Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA.

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http://dx.doi.org/10.1016/j.ajhg.2010.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869004PMC
May 2010

Host determinants of HIV-1 control in African Americans.

Authors:
Kimberly Pelak David B Goldstein Nicole M Walley Jacques Fellay Dongliang Ge Kevin V Shianna Curtis Gumbs Xiaojiang Gao Jessica M Maia Kenneth D Cronin Shehnaz K Hussain Mary Carrington Nelson L Michael Amy C Weintrob

J Infect Dis 2010 Apr;201(8):1141-9

Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA.

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http://dx.doi.org/10.1086/651382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838940PMC
April 2010

ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.

Authors:
Jacques Fellay Alexander J Thompson Dongliang Ge Curtis E Gumbs Thomas J Urban Kevin V Shianna Latasha D Little Ping Qiu Arthur H Bertelsen Mark Watson Amelia Warner Andrew J Muir Clifford Brass Janice Albrecht Mark Sulkowski John G McHutchison David B Goldstein

Nature 2010 Mar 21;464(7287):405-8. Epub 2010 Feb 21.

Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA.

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http://www.nature.com/doifinder/10.1038/nature08825
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http://dx.doi.org/10.1038/nature08825DOI Listing
March 2010

Common genetic variation and the control of HIV-1 in humans.

Authors:
Jacques Fellay Dongliang Ge Kevin V Shianna Sara Colombo Bruno Ledergerber Elizabeth T Cirulli Thomas J Urban Kunlin Zhang Curtis E Gumbs Jason P Smith Antonella Castagna Alessandro Cozzi-Lepri Andrea De Luca Philippa Easterbrook Huldrych F Günthard Simon Mallal Cristina Mussini Judith Dalmau Javier Martinez-Picado José M Miro Niels Obel Steven M Wolinsky Jeremy J Martinson Roger Detels Joseph B Margolick Lisa P Jacobson Patrick Descombes Stylianos E Antonarakis Jacques S Beckmann Stephen J O'Brien Norman L Letvin Andrew J McMichael Barton F Haynes Mary Carrington Sheng Feng Amalio Telenti David B Goldstein

PLoS Genet 2009 Dec 24;5(12):e1000791. Epub 2009 Dec 24.

Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA.

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https://dx.plos.org/10.1371/journal.pgen.1000791
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http://dx.doi.org/10.1371/journal.pgen.1000791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791220PMC
December 2009

CCL3L1 and HIV/AIDS susceptibility.

Authors:
Thomas J Urban Amy C Weintrob Jacques Fellay Sara Colombo Kevin V Shianna Curtis Gumbs Margalida Rotger Kimberly Pelak Kristen K Dang Roger Detels Jeremy J Martinson Stephen J O'Brien Norman L Letvin Andrew J McMichael Barton F Haynes Mary Carrington Amalio Telenti Nelson L Michael David B Goldstein

Nat Med 2009 Oct;15(10):1110-2

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http://www.nature.com/articles/nm1009-1110
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http://dx.doi.org/10.1038/nm1009-1110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821825PMC
October 2009

Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study.

Authors:
Iris Grossman Patrick F Sullivan Nicole Walley Youfang Liu Jeffrey R Dawson Curtis Gumbs Andrea Gaedigk J Steven Leeder Joseph P McEvoy Michael E Weale David B Goldstein

Genet Med 2008 Oct;10(10):720-9

Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina, USA.

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http://dx.doi.org/10.1097/GIM.0b013e3181863239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697113PMC
October 2008

Failure to replicate effect of Kibra on human memory in two large cohorts of European origin.

Authors:
Anna C Need Deborah K Attix Jill M McEvoy Elizabeth T Cirulli Kristen N Linney Ana Patricia Wagoner Curtis E Gumbs Ina Giegling Hans-Jürgen Möller Clyde Francks Pierandrea Muglia Allen Roses Greg Gibson Mike E Weale Dan Rujescu David B Goldstein

Am J Med Genet B Neuropsychiatr Genet 2008 Jul;147B(5):667-8

Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1002/ajmg.b.30658DOI Listing
July 2008

Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.

Authors:
Gianpiero L Cavalleri Michael E Weale Kevin V Shianna Rinki Singh John M Lynch Bronwyn Grinton Cassandra Szoeke Kevin Murphy Peter Kinirons Deirdre O'Rourke Dongliang Ge Chantal Depondt Kristl G Claeys Massimo Pandolfo Curtis Gumbs Nicole Walley James McNamara John C Mulley Kristen N Linney Leslie J Sheffield Rodney A Radtke Sarah K Tate Stephanie L Chissoe Rachel A Gibson David Hosford Alice Stanton Tracey D Graves Michael G Hanna Kai Eriksson Anne-Mari Kantanen Reetta Kalviainen Terence J O'Brien Josemir W Sander John S Duncan Ingrid E Scheffer Samuel F Berkovic Nicholas W Wood Colin P Doherty Norman Delanty Sanjay M Sisodiya David B Goldstein

Lancet Neurol 2007 Nov;6(11):970-80

Department of Clinical Neurological Sciences and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland Research Institute, and Division of Neurology, Beaumont Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1016/S1474-4422(07)70247-8DOI Listing
November 2007

A whole-genome association study of major determinants for host control of HIV-1.

Authors:
Jacques Fellay Kevin V Shianna Dongliang Ge Sara Colombo Bruno Ledergerber Mike Weale Kunlin Zhang Curtis Gumbs Antonella Castagna Andrea Cossarizza Alessandro Cozzi-Lepri Andrea De Luca Philippa Easterbrook Patrick Francioli Simon Mallal Javier Martinez-Picado José M Miro Niels Obel Jason P Smith Josiane Wyniger Patrick Descombes Stylianos E Antonarakis Norman L Letvin Andrew J McMichael Barton F Haynes Amalio Telenti David B Goldstein

Science 2007 Aug 19;317(5840):944-7. Epub 2007 Jul 19.

Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.

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http://www.gxe2010.org/Speakers/pubs/Goldstein_2007.pdf
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http://www.sciencemag.org/cgi/doi/10.1126/science.1143767
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http://dx.doi.org/10.1126/science.1143767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1991296PMC
August 2007

Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation.

Authors:
Sanjay M Sisodiya Pamela J Thompson Anna Need Sarah E Harris Michael E Weale Susan E Wilkie Michel Michaelides Samantha L Free Nicole Walley Curtis Gumbs Dianne Gerrelli Piers Ruddle Lawrence J Whalley John M Starr David M Hunt David B Goldstein Ian J Deary Anthony T Moore

J Med Genet 2007 Jun 19;44(6):373-80. Epub 2007 Jan 19.

Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

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http://dx.doi.org/10.1136/jmg.2006.047407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740882PMC
June 2007

Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.

Authors:
Takayuki Akimoto Steven C Pohnert Ping Li Mei Zhang Curtis Gumbs Paul B Rosenberg R Sanders Williams Zhen Yan

J Biol Chem 2005 May 14;280(20):19587-93. Epub 2005 Mar 14.

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M408862200DOI Listing
May 2005