Publications by authors named "Cuicui Wang"

187 Publications

Improved Auditory Function Caused by Music Versus Foreign Language Training at School Age: Is There a Difference?

Cereb Cortex 2021 Jul 16. Epub 2021 Jul 16.

State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

In adults, music and speech share many neurocognitive functions, but how do they interact in a developing brain? We compared the effects of music and foreign language training on auditory neurocognition in Chinese children aged 8-11 years. We delivered group-based training programs in music and foreign language using a randomized controlled trial. A passive control group was also included. Before and after these year-long extracurricular programs, auditory event-related potentials were recorded (n = 123 and 85 before and after the program, respectively). Through these recordings, we probed early auditory predictive brain processes. To our surprise, the language program facilitated the children's early auditory predictive brain processes significantly more than did the music program. This facilitation was most evident in pitch encoding when the experimental paradigm was musically relevant. When these processes were probed by a paradigm more focused on basic sound features, we found early predictive pitch encoding to be facilitated by music training. Thus, a foreign language program is able to foster auditory and music neurocognition, at least in tonal language speakers, in a manner comparable to that by a music program. Our results support the tight coupling of musical and linguistic brain functions also in the developing brain.
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http://dx.doi.org/10.1093/cercor/bhab194DOI Listing
July 2021

Significance of miR-141 and miR-340 in cervical squamous cell carcinoma.

Open Med (Wars) 2021 16;16(1):864-872. Epub 2021 Jun 16.

Department of Pathology, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang, China.

Background: We investigated the expression and clinical significance of miR-141 and miR-340 in cervical squamous cell carcinoma (CSCC).

Methods: Expression of miR-141 and miR-340 in CSCC, high-grade squamous intraepithelial lesion (HSIL), and normal cervical squamous epithelium were detected by qRT-PCR. PTEN was assessed by immunohistochemistry. Their relationship with clinicopathological features was analyzed.

Results: The changes of miR-141 and miR-340 were different in CSCC, HSIL, and normal squamous epithelium ( = 0.030). miR-141 expression was statistically significant in gross type, differentiation, uterine corpus invasion, nerve invasion, vagina invasion, and FIGO stage in CSCC ( < 0.05). miR-340 expression was related to tumor size, differentiation, nerve invasion, lymph node metastasis, and FIGO stage in CSCC ( < 0.05). miR-141 and miR-340 expressions were statistically significant in different ages ( < 0.05) in HSIL. The AUC of miR-141 in CSCC diagnosis and that of miR-340 in HSIL diagnosis were 0.893 and 0.764, respectively. The sensitivity and the specificity of miR-141 for diagnosis of CSCC were 95.0% and 60.8%, respectively, while those of miR-340 for diagnosis of HSIL were 90.0 and 48.6%, respectively. miR-141 and miR-340 expressions are associated with PTEN expression ( = 0.002 and < 0.001).

Conclusion: miR-141 and miR-340 may be associated with their target gene PTEN and involved in the carcinogenesis of cervical squamous epithelium.
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http://dx.doi.org/10.1515/med-2021-0281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209411PMC
June 2021

MiR-342 inhibits proliferation and apoptosis of liver cancer cells via targeting LGR5 via regulating Wnt/β-Catenin signaling pathway.

Minerva Gastroenterol (Torino) 2021 Jun 23. Epub 2021 Jun 23.

Department of pathology, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, China.

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http://dx.doi.org/10.23736/S2724-5985.21.02906-5DOI Listing
June 2021

Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis.

Front Immunol 2021 28;12:691559. Epub 2021 May 28.

Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China.

Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases. Compared with other IL-17 cytokine family members, IL-25 has relatively low sequence similarity to IL-17A and exhibits a distinct function from other IL-17 cytokines. IL-25 binds to its receptor composed of IL-17 receptor A (IL-17RA) and IL-17 receptor B (IL-17RB) for signal transduction. IL-25 has been implicated as a type 2 cytokine and can induce the production of IL-4, IL-5 and IL-13, which in turn inhibits the differentiation of T helper (Th) 17. In addition to its anti-inflammatory properties, IL-25 also exhibits a pro-inflammatory effect in the pathogenesis of Th17-dominated diseases. Here, we review recent advances in the roles of IL-25 in the pathogenesis of inflammation and autoimmune diseases.
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http://dx.doi.org/10.3389/fimmu.2021.691559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194343PMC
May 2021

Melatonin ameliorates hypertension in hypertensive pregnant mice and suppresses the hypertension-induced decrease in Ca-activated K channels in uterine arteries.

Hypertens Res 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Zibo Central Hospital, Zibo, Shandong, China.

Decreased secretion of melatonin was reported to be associated with an enhanced risk of hypertension and diabetes. However, the effect of melatonin on gestational hypertension (GH) and the underlying mechanism remain unclear. A GH mouse model was established via electrical stimulation. The hypertensive phenotypes were indicated by systolic blood pressure (SBP) and urinary protein levels. Uterine artery (UtA) endothelial function was detected by relaxation, peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI) and pulsatility index (PI). Protein expression levels were determined using immunochemistry and Western blots. Pregnancy outcomes were indicated by the fetal live ratio, fetal weight and placental weight. Melatonin supplementation ameliorated hypertensive phenotypes in the mice with GH and enhanced UtA endothelial response to acetylcholine. The BK potassium channel was involved in the effect of melatonin on UtA endothelial function, and melatonin promoted BK potassium channel expression and function in UtAs. Finally, melatonin improved pregnancy outcomes in pregnant mice. In conclusion, melatonin ameliorates hypertension in hypertensive pregnant mice and suppresses hypertension-induced decreases in Ca-activated K channels in uterine arteries.
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http://dx.doi.org/10.1038/s41440-021-00675-5DOI Listing
June 2021

Targeting angiogenesis for fracture nonunion treatment in inflammatory disease.

Bone Res 2021 Jun 7;9(1):29. Epub 2021 Jun 7.

Department of Orthopaedic Surgery, School of Medicine, Washington University, St. Louis, MO, USA.

Atrophic fracture nonunion poses a significant clinical problem with limited therapeutic interventions. In this study, we developed a unique nonunion model with high clinical relevance using serum transfer-induced rheumatoid arthritis (RA). Arthritic mice displayed fracture nonunion with the absence of fracture callus, diminished angiogenesis and fibrotic scar tissue formation leading to the failure of biomechanical properties, representing the major manifestations of atrophic nonunion in the clinic. Mechanistically, we demonstrated that the angiogenesis defect observed in RA mice was due to the downregulation of SPP1 and CXCL12 in chondrocytes, as evidenced by the restoration of angiogenesis upon SPP1 and CXCL12 treatment in vitro. In this regard, we developed a biodegradable scaffold loaded with SPP1 and CXCL12, which displayed a beneficial effect on angiogenesis and fracture repair in mice despite the presence of inflammation. Hence, these findings strongly suggest that the sustained release of SPP1 and CXCL12 represents an effective therapeutic approach to treat impaired angiogenesis and fracture nonunion under inflammatory conditions.
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http://dx.doi.org/10.1038/s41413-021-00150-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184936PMC
June 2021

lncRNA MIR210HG promotes the progression of endometrial cancer by sponging miR-337-3p/137 via the HMGA2-TGF-β/Wnt pathway.

Mol Ther Nucleic Acids 2021 Jun 16;24:905-922. Epub 2021 Apr 16.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Epithelial-mesenchymal transition (EMT) promotes tumorigenesis and metastasis and increases tumor tolerance to treatment intervention. Abnormal activation of transforming growth factor β (TGF-β) and Wnt pathway induces EMT. Long non-coding RNAs (lncRNAs) significantly influence EMT regulation. Herein, we show that MIR210HG is overexpressed in endometrial cancer tissues, which is associated with poor prognosis. MIR210HG silencing significantly inhibited proliferation, migration, invasion, and EMT phenotype formation as well as tumorigenesis . Mechanistically, bioinformatics analyses, RNA binding protein immunoprecipitation (RIP) assays, and luciferase assays showed that MIR210HG acts as a molecular sponge of miR-337-3p and miR-137 to regulate the expression of HMGA2. Additionally, MIR210HG overexpression significantly enriched the Wnt/β-catenin and TGF-β/Smad3 signaling pathway genes, while MIR210HG or HMGA2 knockdown suppressed the Wnt/β-catenin and TGF-β/Smad3 signaling pathway. Our findings on the MIR210HG-miR-337-3p/137-HMGA2 axis illustrate its potential as a target for endometrial cancer therapeutic development.
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http://dx.doi.org/10.1016/j.omtn.2021.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141672PMC
June 2021

Dose optimisation based on pharmacokinetic/pharmacodynamic target of tigecycline.

J Glob Antimicrob Resist 2021 06 4;25:315-322. Epub 2021 May 4.

Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Huaiyin District, Jinan 250021, China; Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address:

Tigecycline, a new first-in-class glycylcycline antibiotic, has shown promising efficacy against a broad range of micro-organisms. It is widely prescribed for various infections, with most prescriptions being considered for off-label use. However, only a few years after its approval by the US Food and Drug Administration (FDA), tigecycline is suspected of increasing all-cause mortality. Some clinicians have suggested such unfavourable outcomes correlate with inadequate drug exposure at the infection site. The pharmacokinetic/pharmacodynamic (PK/PD) profile of a drug plays an important role in predicting its antibiotic effect, which for tigecycline is determined as the ratio of area under the concentration-time curve (AUC) to minimum inhibitory concentration (MIC). In this study, PK/PD targets based on infection sites, bacterial isolates and patient populations are discussed. Generally, a higher dosage of tigecycline for the treatment of serious infections has been recommended in previous reports. However, the latest finding of tigecycline's atypical protein binding property requires consideration when recommending further use. In addition, combination therapy with other antibiotics provides another option by potentially lowering the MICs of multidrug-resistant bacteria.
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http://dx.doi.org/10.1016/j.jgar.2021.04.006DOI Listing
June 2021

New Trends in Pharmacological Treatments for Osteoarthritis.

Front Pharmacol 2021 15;12:645842. Epub 2021 Apr 15.

Department of Rheumatology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Osteoarthritis (OA) is the leading cause of function loss and disability among the elderly, with significant burden on the individual and society. It is a severe disease for its high disability rates, morbidity, costs, and increased mortality. Multifactorial etiologies contribute to the occurrence and development of OA. The heterogeneous condition poses a challenge for the development of effective treatment for OA; however, emerging treatments are promising to bring benefits for OA management in the future. This narrative review will discuss recent developments of agents for the treatment of OA, including potential disease-modifying osteoarthritis drugs (DMOADs) and novel therapeutics for pain relief. This review will focus more on drugs that have been in clinical trials, as well as attractive drugs with potential applications in preclinical research. In the past few years, it has been realized that a complex interaction of multifactorial mechanisms is involved in the pathophysiology of OA. The authors believe there is no miracle therapeutic strategy fitting for all patients. OA phenotyping would be helpful for therapy selection. A variety of potential therapeutics targeting inflammation mechanisms, cellular senescence, cartilage metabolism, subchondral bone remodeling, and the peripheral nociceptive pathways are expected to reshape the landscape of OA treatment over the next few years. Precise randomized controlled trials (RCTs) are expected to identify the safety and efficacy of novel therapies targeting specific mechanisms in OA patients with specific phenotypes.
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http://dx.doi.org/10.3389/fphar.2021.645842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085504PMC
April 2021

Analysis of the postharvest storage characteristics of the new red-fleshed apple cultivar 'meihong'.

Food Chem 2021 Aug 8;354:129470. Epub 2021 Mar 8.

State Key Laboratory of Crop Biology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an 271018, Shandong, PR China; Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production in Shandong, Tai'an 271018, Shandong, PR China. Electronic address:

This study examined the effects of postharvest storage conditions on the fruit quality of a new red-fleshed apple cultivar ('Meihong'). Mature 'Meihong' and 'Golden delicious' apples were exposed to room temperature, low temperature, and low temperature and 1-MCP, after which several fruit characteristics were evaluated (i.e., firmness, ethylene release rate, relative content of aroma components, phenolic compounds and antioxidant capacity, fruit softening-related enzyme activities, and related gene expression). Both 'Meihong' and 'Golden delicious' were ACS1-1/-2 heterozygotes, but the ethylene release rate in 'Meihong' fruits was lower than that in 'Golden delicious' fruits during storage. Therefore, 'Meihong' fruits are more conducive to storage. The low temperature storage with and without 1-MCP delayed fruit softening, decreased the ethylene release rate and ester aroma component content, and maintained total flavonoid and anthocyanin contents. Therefore, storage at low temperatures with 1-MCP or other preservatives may be useful for maintaining the 'Meihong' fruit quality.
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http://dx.doi.org/10.1016/j.foodchem.2021.129470DOI Listing
August 2021

Ambient PM species and ultrafine particle exposure and their differential metabolomic signatures.

Environ Int 2021 06 24;151:106447. Epub 2021 Feb 24.

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02129, USA; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

Background: The metabolomic signatures of short- and long-term exposure to PM have been reported and linked to inflammation and oxidative stress. However, little is known about the relative contribution of the specific PM species (hence sources) that drive these metabolomic signatures.

Objectives: We aimed to determine the relative contribution of the different species of PM exposure to the perturbed metabolic pathways related to changes in the plasma metabolome.

Methods: We performed mass-spectrometry based metabolomic profiling of plasma samples among men from the Normative Aging Study to identify metabolic pathways associated with PM species. The exposure windows included short-term (one, seven-, and thirty-day moving average) and long-term (one year moving average). We used linear mixed-effect regression with subject-specific intercepts while simultaneously adjusting for PM, NO, O, temperature, relative humidity, and covariates and correcting for multiple testing. We also used independent component analysis (ICA) to examine the relative contribution of patterns of PM species.

Results: Between 2000 and 2016, 456 men provided 648 blood samples, in which 1158 metabolites were quantified. We chose 305 metabolites for the short-term and 288 metabolites for the long-term exposure in this analysis that were significantly associated (p-value < 0.01) with PM to include in our PM species analysis. On average, men were 75.0 years old and their body mass index was 27.7 kg/m. Only 3% were current smokers. In the adjusted models, ultrafine particles (UFPs) were the most significant species of short-term PM exposure followed by nickel, vanadium, potassium, silicon, and aluminum. Black carbon, vanadium, zinc, nickel, iron, copper, and selenium were the significant species of long-term PM exposure. We identified several metabolic pathways perturbed with PM species including glycerophospholipid, sphingolipid, and glutathione. These pathways are involved in inflammation, oxidative stress, immunity, and nucleic acid damage and repair. Results were overlapped with the ICA.

Conclusions: We identified several significant perturbed plasma metabolites and metabolic pathways associated with exposure to PM species. These species are associated with traffic, fuel oil, and wood smoke. This is the largest study to report a metabolomic signature of PM species' exposure and the first to use ICA.
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http://dx.doi.org/10.1016/j.envint.2021.106447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994935PMC
June 2021

Deep learning model for classifying endometrial lesions.

J Transl Med 2021 01 6;19(1):10. Epub 2021 Jan 6.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110021, People's Republic of China.

Background: Hysteroscopy is a commonly used technique for diagnosing endometrial lesions. It is essential to develop an objective model to aid clinicians in lesion diagnosis, as each type of lesion has a distinct treatment, and judgments of hysteroscopists are relatively subjective. This study constructs a convolutional neural network model that can automatically classify endometrial lesions using hysteroscopic images as input.

Methods: All histopathologically confirmed endometrial lesion images were obtained from the Shengjing Hospital of China Medical University, including endometrial hyperplasia without atypia, atypical hyperplasia, endometrial cancer, endometrial polyps, and submucous myomas. The study included 1851 images from 454 patients. After the images were preprocessed (histogram equalization, addition of noise, rotations, and flips), a training set of 6478 images was input into a tuned VGGNet-16 model; 250 images were used as the test set to evaluate the model's performance. Thereafter, we compared the model's results with the diagnosis of gynecologists.

Results: The overall accuracy of the VGGNet-16 model in classifying endometrial lesions is 80.8%. Its sensitivity to endometrial hyperplasia without atypia, atypical hyperplasia, endometrial cancer, endometrial polyp, and submucous myoma is 84.0%, 68.0%, 78.0%, 94.0%, and 80.0%, respectively; for these diagnoses, the model's specificity is 92.5%, 95.5%, 96.5%, 95.0%, and 96.5%, respectively. When classifying lesions as benign or as premalignant/malignant, the VGGNet-16 model's accuracy, sensitivity, and specificity are 90.8%, 83.0%, and 96.0%, respectively. The diagnostic performance of the VGGNet-16 model is slightly better than that of the three gynecologists in both classification tasks. With the aid of the model, the overall accuracy of the diagnosis of endometrial lesions by gynecologists can be improved.

Conclusions: The VGGNet-16 model performs well in classifying endometrial lesions from hysteroscopic images and can provide objective diagnostic evidence for hysteroscopists.
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http://dx.doi.org/10.1186/s12967-020-02660-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788977PMC
January 2021

Association Between Preoperative Blood Transfusion and Postoperative Venous Thromboembolism: Review Meta-Analysis.

Ann Vasc Surg 2021 May 28;73:463-472. Epub 2020 Dec 28.

Department of Transfusion Medicine, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China. Electronic address:

Background: Several studies have shown that preoperative blood transfusion is associated with postoperative venous thromboembolism (VTE). In this study, a meta-analysis was performed to explore the relationship between preoperative blood transfusion and postoperative VTE.

Methods: Published articles were identified through a comprehensive review of PubMed and EMBASE. Data from studies reporting relative risks, odds ratios, or hazard ratios comparing the risk of postoperative VTE among participants who had preoperative blood transfusion versus those without preoperative blood transfusion were analyzed. A random-effect model was used to calculate pooled odds ratios and 95% confident intervals (CIs).

Results: Eight studies, which included 3,504,778 participants, aligned with our inclusion criteria and were included in the meta-analysis. Pooled analysis showed an association between preoperative blood transfusion and postoperative VTE, with an odds ratio of 2.95 (95% CI: 1.65-5.30; I = 89.1%). In subgroup analyses, the positive association between preoperative blood transfusion and postoperative VTE was still exist in studies with confounders adjustment. Sensitivity analysis by one-study-removed analysis confirmed the robustness of our results.

Conclusions: Our study indicated that preoperative blood transfusion was associated with higher odds of postoperative VTE. Further large-scale prospective cohort studies are needed to investigate the causality between preoperative blood transfusion and postoperative VTE.
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http://dx.doi.org/10.1016/j.avsg.2020.11.033DOI Listing
May 2021

Analysis of Pathogen Distribution and Its Antimicrobial Resistance in Bloodstream Infections in Hospitalized Children in East China, 2015-2018.

J Trop Pediatr 2021 01;67(1)

Medical Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.

This study analyzed the pathogen distribution in bloodstream-infected (BSI) children hospitalized in Shandong Province from 2015 to 2018, to identify prevention strategies and select empiric antimicrobial therapy for BSI in children. Blood sample data from 14 107 children from 162 hospitals of Shandong Province were obtained from the China Antimicrobial Resistance Surveillance System and analyzed with WHONET 5.6 software. The results of the blood culture test showed the growth of 70.6% Gram-positive and 29.4% Gram-negative bacteria. Of the 14 107 blood isolates, 59.3% were collected from males and 40.7% were from females. Coagulase-negative staphylococci (47.1%) were the most commonly distributed pathogens. The distribution of pathogens varied according to age group and season. All Staphylococcus isolates were susceptible to vancomycin, teicoplanin and linezolid. Clinically, significant declines in penicillin-resistant Streptococcus pneumonia and carbapenem-resistant Escherichia coli were observed during the study period; however, detection rates of carbapenem-resistant Klebsiella pneumoniae increased over time (p < 0.05). Empiric antimicrobial therapy should be prescribed according to corresponding regional pediatric antimicrobial-resistant data.
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http://dx.doi.org/10.1093/tropej/fmaa077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7948388PMC
January 2021

Rural and urban disparities in selective attention in Chinese young adults: An event-related potential study.

Appl Neuropsychol Adult 2020 Dec 21:1-7. Epub 2020 Dec 21.

School of Psychology, Northwest Normal University, Lanzhou, China.

Previous studies showed that attention system and its underlying neural mechanisms were profound affected by social inequalities. However, previous studies on social inequalities were mainly focused on family-based factors, such as parental education, parental occupation, and household income. In the present study, we investigated the neural mechanisms underlying more broader social context (e.g., rural verse urban) disparities in selective attention among young adults in China. Event-related potentials (ERPs) were recorded from 22 college students who had born and grown up in rural areas and 22 students who had born and grown up in urban areas during an auditory selective attention task. Although behavioral performance was not significantly different between groups, attentional differences in the negativity difference (Nd) were significantly larger in the urban group than the rural group. Whole sample analysis with hierarchical regression showed that rural/urban status still made a significant contribution to the prediction of Nd amplitudes even after the effects of age, sex, and various family SES measures (include parents' educational levels and annual household income) were controlled for. These findings represent a first step toward understanding the ways in which broad social environmental factors shape the neural basis of selective attention.
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http://dx.doi.org/10.1080/23279095.2020.1861617DOI Listing
December 2020

DNA methylation-based biomarkers of age acceleration and all-cause death, myocardial infarction, stroke, and cancer in two cohorts: The NAS, and KORA F4.

EBioMedicine 2021 Jan 3;63:103151. Epub 2020 Dec 3.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, 401 Park Drive, West of Landmark Center, Boston, MA 02215, United States.

Background: DNA methylation (DNAm) may play a role in age-related outcomes. It is not yet known which DNAm-based biomarkers of age acceleration (BoAA) has the strongest association with age-related endpoints.

Methods: We collected the blood samples from two independent cohorts: the Normative Ageing Study, and the Cooperative Health Research in the Region of Augsburg cohort. We measured epigenome-wide DNAm level, and generated five DNAm BoAA at baseline. We used Cox proportional hazards model to analyze the relationships between BoAA and all-cause death. We applied the Fine and Gray competing risk model to estimate the risk of BoAA on myocardial infarction (MI), stroke, and cancer, accounting for death of other reasons as the competing risks. We used random-effects meta-analyses to pool the individual results, with adjustment for multiple testing.

Findings: The mean chronological ages in the two cohorts were 74, and 61, respectively. Baseline GrimAgeAccel, and DNAm-related mortality risk score (DNAmRS) both had strong associations with all-cause death, MI, and stroke, independent from chronological age. For example, a one standard deviation (SD) increment in GrimAgeAccel was significantly associated with increased risk of all-cause death [hazard ratio (HR): 2.01; 95% confidence interval (CI), 1.15, 3.50], higher risk of MI (HR: 1.44; 95% CI, 1.16, 1.79), and elevated risk of stroke (HR: 1.42; 95% CI, 1.06, 1.91). There were no associations between any BoAA and cancer.

Interpretation: From the public health perspective, GrimAgeAccel is the most useful tool for identifying at-risk elderly, and evaluating the efficacy of anti-aging interventions.

Funding: National Institute of Environmental Health Sciences of U.S., Harvard Chan-NIEHS Center for Environmental Health, German Federal Ministry of Education and Research, and the State of Bavaria in Germany.
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http://dx.doi.org/10.1016/j.ebiom.2020.103151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724153PMC
January 2021

FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis.

Proc Natl Acad Sci U S A 2020 12 16;117(48):30488-30497. Epub 2020 Nov 16.

Department of Orthopaedic Surgery, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110;

Transforming growth factor-β (TGF-β) signaling is a critical regulator for articular cartilage tissue maintenance and chondrocyte homeostasis. Nonetheless, the regulatory networks and downstream signaling pathways that govern the chondroprotective function of TGF-β in the context of osteoarthritis (OA) are not fully defined. Recent studies reveal that mice with postnatal deletion of triple forkhead box class Os (FoxOs) (1, 3, and 4) spontaneously develop OA-like pathologies. The OA phenotype largely recapitulates that observed in mice with loss of TGF-βR2. In the present study, we investigated the role of FoxOs as downstream mediators of TGF-β signaling and define their role in articular cartilage homeostasis. Among the three FoxOs (1, 3, and 4), TGF-β signaling exclusively regulates FoxO1 in a TGF-β activated kinase 1 (TAK1)-dependent manner. Furthermore, FoxO1 was genetically ablated in mice in a tissue-specific manner in articular cartilage or overexpressed in adult cartilage immediately followed by meniscal/ligament injury (MLI). Histological and microcomputed tomography (micro-CT) analyses demonstrated that loss of FoxO1 postnatally in articular cartilage leads to OA-like pathologies, and gain of FoxO1 in adult cartilage has both preventative and therapeutic effects on surgically induced OA. Mechanistically, FoxO1 was found to maintain articular chondrocyte homeostasis through induction of anabolic and autophagy-related gene expressions. Importantly, overexpression of FoxO1 markedly rescued the OA phenotypes caused by deficiency in TGF-β signaling in chondrocytes. Our study identifies that TGF-β/TAK1-FoxO1 is a key signaling cascade in regulation of articular cartilage autophagy and homeostasis and is a potentially important therapeutic target for OA-like joint diseases.
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http://dx.doi.org/10.1073/pnas.2017056117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720227PMC
December 2020

Musical experience may help the brain respond to second language reading.

Neuropsychologia 2020 11 14;148:107655. Epub 2020 Oct 14.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, 611731, China; School of Life Science and Technology, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.

A person's native language background exerts constraints on the brain's automatic responses while learning a second language. It remains unclear, however, whether and how musical experience may help the brain overcome such constraints and meet the requirements of a second language. This study compared native Chinese English learners who were musicians, non-musicians and native English readers on their automatic brain automatic integration of English letter-sounds with an ERP cross-modal audiovisual mismatch negativity paradigm. The results showed that native Chinese-speaking musicians successfully integrated English letters and sounds, but their non-musician peers did not, despite of their comparable English learning experience and proficiency level. However, native Chinese-speaking musicians demonstrated enhanced cross-modal MMN for both synchronized and delayed letter-sound integration, while native English readers only showed enhanced cross-modal MMN for synchronized integration. Moreover, native Chinese-speaking musicians showed stronger theta oscillations when integrating English letters and sounds, suggesting that they had better top-down modulation. In contrast, native English readers showed stronger delta oscillations for synchronized integration, and their cross-modal delta oscillations significantly correlated with English reading performance. These findings suggest that long-term professional musical experience may enhance the top-down modulation, then help the brain efficiently integrating letter-sounds required by the second language. Such benefits from musical experience may be different from those from specific language experience in shaping the brain's automatic responses to reading.
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http://dx.doi.org/10.1016/j.neuropsychologia.2020.107655DOI Listing
November 2020

A follow-up study of a Chinese family with Waardenburg syndrome type II caused by a truncating mutation of MITF gene.

Mol Genet Genomic Med 2020 12 12;8(12):e1520. Epub 2020 Oct 12.

Center for Medical Genetics, Southwest Hospital, Army Medical University, Chongqing, China.

Background: Waardenburg syndrome (WS) is a highly clinically and genetically heterogeneous disease. The core disease phenotypes of WS are sensorineuronal hearing loss and pigmentary disturbance, which are usually caused by the absence of neural crest cell-derived melanocytes. At present, four subtypes of WS have been defined, which are caused by seven genes. Waardenburg syndrome type 2 (WS2) is one of the most common forms. Two genes, MITF and SOX10, have been found to be responsible for majority of WS2.

Methods: In this study, we performed a clinical longitudinal follow-up and mutation screening for a Chinese family with Waardenburg syndrome type II.

Results: A diversity of clinical manifestations was observed in this WS2 family. In addition to the congenital hearing loss of most affected family members, progressive hearing loss was also found in some WS2 patients. A nonsense mutation of c.328C>T (p.R110X) in MITF was identified in all affected family members. This mutation results in a truncated MITF protein, which is considered to be a disease-causing mutation.

Conclusion: These findings offer a better understanding of the spectrum of MITF mutations and highlight the necessity of continuous hearing assessment in WS patients.
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http://dx.doi.org/10.1002/mgg3.1520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767564PMC
December 2020

Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.

J Gerontol A Biol Sci Med Sci 2021 Apr;76(5):760-769

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

One-carbon metabolism is an important contributor to aging-related diseases; nevertheless, relationships of one-carbon metabolites with novel DNA methylation-based measures of biological aging remain poorly characterized. We examined relationships of one-carbon metabolites with 3 DNA methylation-based measures of biological aging: DNAmAge, GrimAge, and PhenoAge. We measured plasma levels of 4 common one-carbon metabolites (vitamin B6, vitamin B12, folate, and homocysteine) in 715 VA Normative Aging Study participants with at least 1 visit between 1999 and 2008 (observations = 1153). DNA methylation age metrics were calculated using the HumanMethylation450 BeadChip. We utilized Bayesian Kernel Machine Regression models adjusted for chronological age, lifestyle factors, age-related diseases, and study visits to determine metabolites important to the aging outcomes. Bayesian Kernel Machine Regression models allowed for the estimation of the relationships of single metabolites and the cumulative metabolite mixture with methylation age. Log vitamin B6 was selected as important to PhenoAge (β = -1.62 years, 95% CI: -2.28, -0.96). Log folate was selected as important to GrimAge (β = 0.75 years, 95% CI: 0.41, 1.09) and PhenoAge (β = 1.62 years, 95% CI: 0.95, 2.29). Compared to a model where each metabolite in the mixture is set to its 50th percentile, the log cumulative mixture with each metabolite at its 30th (β = -0.13 years, 95% CI: -0.26, -0.005) and 40th percentile (β = -0.06 years, 95% CI: -0.11, -0.005) was associated with decreased GrimAge. Our results provide novel characterizations of the relationships between one-carbon metabolites and DNA methylation age in a human population study. Further research is required to confirm these findings and establish their generalizability.
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http://dx.doi.org/10.1093/gerona/glaa257DOI Listing
April 2021

Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes.

JCI Insight 2020 09 17;5(18). Epub 2020 Sep 17.

Department of Rheumatology and Immunology and.

Fibroblast-like synoviocytes (FLSs) are critical to joint inflammation and destruction in rheumatoid arthritis (RA). Increased glycolysis in RA FLSs contributes to persistent joint damage. SUMOylation, a posttranslational modification of proteins, plays an important role in initiation and development of many diseases. However, the role of small ubiquitin-like modifier-activating (SUMO-activating) enzyme 1 (SAE1)/ubiquitin like modifier activating enzyme 2 (UBA2) in regulating the pathogenic FLS behaviors is unknown. Here, we found an increased expression of SAE1 and UBA2 in FLSs and synovial tissues from patients with RA. SAE1 or UBA2 knockdown by siRNA and treatment with GA, an inhibitor of SAE1/UBA2-mediated SUMOylation, resulted in reduced glycolysis, aggressive phenotype, and inflammation. SAE1/UBA2-mediated SUMOylation of pyruvate kinase M2 (PKM2) promoted its phosphorylation and nuclear translocation and decreased PK activity. Moreover, inhibition of PKM2 phosphorylation increased PK activity and suppressed glycolysis, aggressive phenotype, and inflammation. We further demonstrated that STAT5A mediated SUMOylated PKM2-induced glycolysis and biological behaviors. Interestingly, GA treatment attenuated the severity of arthritis in mice with collagen-induced arthritis and human TNF-α transgenic mice. These findings suggest that an increase in synovial SAE1/UBA2 may contribute to synovial glycolysis and joint inflammation in RA and that targeting SAE1/UBA2 may have therapeutic potential in patients with RA.
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http://dx.doi.org/10.1172/jci.insight.135935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526534PMC
September 2020

Rbm24 regulates inner-ear-specific alternative splicing and is essential for maintaining auditory and motor coordination.

RNA Biol 2021 04 20;18(4):468-480. Epub 2020 Sep 20.

The Institute of Stem Cell and Regenerative Medicine, School of Medicine, Xiamen University, Xiamen, China.

Tissue-specific alternative splicing (AS) is emerging as one of the most exciting types of mechanisms associated with organ development and disease. In the auditory system, many hearing-related genes undergo AS, and errors in this process result in syndromic or non-syndromic hearing loss. However, little is known about the factors and mechanisms directing AS in the inner ear. In the present study, we identified a novel RNA-binding protein, Rbm24, which was critically involved in regulating inner-ear-specific AS. Rbm24 deletion resulted in hearing loss and defects in motor coordination. Global splicing analysis showed Rbm24 was required for correct splicing of a subset of pre-mRNA transcripts with essential roles in stereocilia integrity and survival of hair cells. Furthermore, we identified that Rbm24 directly regulated the splicing of Cdh23, a known disease gene responsible for human Usher syndrome 1D and non-syndromic autosomal recessive deafness DFNB12. In conclusion, our findings demonstrated that Rbm24 was a critical factor in regulating inner-ear-specific splicing and maintaining the hearing and motor coordination function of the inner ear. Our data not only offer mechanistic insights but also provide functional annotation of Rbm24 splicing targets that contribute to hearing loss.
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http://dx.doi.org/10.1080/15476286.2020.1817265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971244PMC
April 2021

Effects of Various Doses of Caffeine Ingestion on Intermittent Exercise Performance and Cognition.

Brain Sci 2020 Aug 28;10(9). Epub 2020 Aug 28.

School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.

To date, no study has examined the effects of caffeine on prolonged intermittent exercise performance that imitates certain team-sports, and the suitable concentration of caffeine for improved intermittent exercise performance remains elusive. The purpose of the present cross-over, double-blind preliminary study was to investigate effects of low, moderate, and high doses of caffeine ingestion on intermittent exercise performance and cognition. Ten males performed a familiarization session and four experimental trials. Participants ingested capsules of placebo or caffeine (3, 6, or 9 mg/kg) at 1 h before exercise, rested quietly, and then performed cycling for 2 × 30 min. The cycling protocol consisted of maximal power pedaling for 5 s (mass × 0.075 kp) every minute, separated by unloaded pedaling for 25 s and rest for 30 s. At pre-ingestion of capsules, 1 h post-ingestion, and post-exercise, participants completed the Stroop task. The mean power-output (MPO), peak power-output (PPO), and response time (RT) in the Stroop task were measured. Only 3 mg/kg of caffeine had positive effects on the mean PPO and MPO; 3 mg/kg caffeine decreased RTs significantly in the incongruent and congruent conditions. These results indicate that the ingestion of low-dose caffeine had greater positive effects on the participants' physical strength during prolonged intermittent exercise and cognition than moderate- or high-dose caffeine.
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http://dx.doi.org/10.3390/brainsci10090595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564618PMC
August 2020

Association of the Total White Blood Cell, Neutrophils, and Monocytes Count With the Presence, Severity, and Types of Carotid Atherosclerotic Plaque.

Front Med (Lausanne) 2020 21;7:313. Epub 2020 Jul 21.

Department of Physical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Previous studies have indicated that white blood cells (WBCs) might contribute to the development of atherosclerosis. However, the associations of WBCs and WBC subgroups with carotid atherosclerotic plaque (CAP) have not been compared. A cross-sectional study including 3,569 healthy Chinese adults was conducted between January 2016 and December 2018 in Zhengzhou, China, to explore the associations of WBC and WBC subtypes with the presence, severity, and types of CAPs. Fasting peripheral venous blood was collected for measurement of the total WBC and WBC subtype counts. The size, composition, and types of CAPs in the common carotid artery, the internal carotid artery, and the external carotid artery were measured bilaterally using B-mode ultrasound. The total WBC, neutrophil, and monocyte counts showed significant associations with the presence of CAPs in men, but not in women, with the adjusted odds ratios (95% CI) in the highest (compared to the lowest) quartile 1.99 (1.33-2.97), 1.65 (1.10-2.47), and 2.17 (1.41-3.18) ( = 0.004, = 0.004, and < 0.001), respectively. The three leukocyte counts were also significantly associated with the severity of CAPs, as judged by the count of CAPs, maximal internal carotid plaque thickness, and the plaque score (all < 0.01, < 0.05). Compared with individuals without CAPs, those with echolucent plaques had significantly increased total WBC and neutrophil counts, whereas those with polytype plaques had a significantly increased monocyte count. WBC, neutrophil, and monocyte counts were significantly associated with the presence, severity, and types of CAPs in a healthy Chinese population.
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http://dx.doi.org/10.3389/fmed.2020.00313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385072PMC
July 2020

Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies.

Aging (Albany NY) 2020 08 3;12(16):16539-16554. Epub 2020 Aug 3.

Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC 27709, USA.

Chronic obstructive pulmonary disease (COPD) is a frequent diagnosis in older individuals and contributor to global morbidity and mortality. Given the link between lung disease and aging, we need to understand how molecular indicators of aging relate to lung function and disease. Using data from the population-based KORA (Cooperative Health Research in the Region of Augsburg) surveys, we associated baseline epigenetic (DNA methylation) age acceleration with incident COPD and lung function. Models were adjusted for age, sex, smoking, height, weight, and baseline lung disease as appropriate. Associations were replicated in the Normative Aging Study. Of 770 KORA participants, 131 developed incident COPD over 7 years. Baseline accelerated epigenetic aging was significantly associated with incident COPD. The change in age acceleration (follow-up - baseline) was more strongly associated with COPD than baseline aging alone. The association between the change in age acceleration between baseline and follow-up and incident COPD replicated in the Normative Aging Study. Associations with spirometric lung function parameters were weaker than those with COPD, but a meta-analysis of both cohorts provide suggestive evidence of associations. Accelerated epigenetic aging, both baseline measures and changes over time, may be a risk factor for COPD and reduced lung function.
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http://dx.doi.org/10.18632/aging.103784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485704PMC
August 2020

Differential Effects of Monetary and Social Rewards on Product Online Rating Decisions in E-Commerce in China.

Front Psychol 2020 3;11:1440. Epub 2020 Jul 3.

School of Management, Hefei University of Technology, Hefei, China.

Humans can change their behaviors to obtain environmental rewards (e.g., money, food, and sex). However, our knowledge regarding how rewards affect human behaviors by priming and whether there are differences among types of rewards is limited. This study focused on whether monetary and social rewards have different priming effects on product rating decisions in e-commerce by using a behavioral experiment and event-related potentials (ERPs). Using cash/discount coupons as a monetary reward and greeting cards as a social reward, the behavioral data showed that unsatisfactory products with a monetary reward induced a less negative consumer attitude than those with a social reward or no reward; additionally, such products were associated with a longer reaction time while rating products than those with a social reward, reflecting that monetary rewards made it more difficult for the subjects to rate unsatisfactory products than social rewards. The P2, N2, and P3 components of the ERP data were evaluated. Unsatisfactory products caused negative emotion, which could be compensated more by the monetary reward than the social reward as reflected by a smaller P2 amplitude. Due to the compensation effect of the monetary reward, unsatisfactory products were associated with more decision conflict than the social reward as reflected by a more negative N2 amplitude, which is consistent with the behavioral results. However, in the subsequent controlled process, regardless of whether the products were satisfactory or unsatisfactory, the monetary reward caused more attention reallocation and was more motivating than the social reward as reflected by a larger P3 component. These findings have implications for the marketing strategy of online sellers and value of online reviews and suggest attaching importance to ethical issues induced by monetary rewards in rating behaviors.
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http://dx.doi.org/10.3389/fpsyg.2020.01440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362955PMC
July 2020

Comorbid diabetes and the risk of disease severity or death among 8807 COVID-19 patients in China: A meta-analysis.

Diabetes Res Clin Pract 2020 Aug 22;166:108346. Epub 2020 Jul 22.

Faculty of Medicine, Federal University of Ceará (FAMED-UFC), Brazil; Faculty of Health Sciences, NORD University, Bodø, Norway; International Diabetes Federation. 166 Chaussee de La Hulpe B-1170, Brussels, Belgium.

Aims: Diabetes mellitus has been reported to be one of the most prevalent comorbidity in patients with Coronavirus Disease 2019 (COVID-19). We aimed to assess the association of comorbid diabetes with COVID-19 severity or mortality in China.

Methods: We performed a systematic literature search from six electronic databases on diabetes and COVID-19. The outcome of interest was disease severity or mortality. Heterogeneity among the studies was assessed by the Cochran Q test and the I statistic. A random effects model was applied to calculate the pooled risk ratio (RR) with 95% confidence interval (CI).

Results: Nine studies from different provinces/cities were identified according to the predefined inclusion and exclusion criteria. There were a total of 1070 patients with diabetes, out of the 8807 COVID-19 cases. The majority of the cases were derived from Hubei Province. A low degree of heterogeneity in the risk estimates was observed in the included studies. Meta-analysis showed that there was a significant association of preexisting diabetes with disease severity or death. The pooled RR was 2.96 (95% CI: 2.31-3.79; p < 0.001). Sensitivity analysis demonstrated no significant changes in the pooled estimates.

Conclusions: Comorbid diabetes was associated with an increased risk of disease severity or death in Chinese COVID-19 patients.
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http://dx.doi.org/10.1016/j.diabres.2020.108346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375287PMC
August 2020

NO attenuation in flue gas by OH/SO-based advanced oxidation processes.

Environ Sci Pollut Res Int 2020 Oct 17;27(30):37468-37487. Epub 2020 Jul 17.

College of Resources and Environment, University of Chinese Academy of Sciences, Beijing, 100049, China.

The combustion of fossil fuels has resulted in rapidly increasing emissions of nitrogen oxide (NO), which has caused serious human health and environmental problems. NO capture has become a research focus in gas purification because NO accounts for more than 90% of NO and is difficult to remove. Advanced oxidation processes (AOPs), features the little secondary pollution and the broad-spectrum strong oxidation of hydroxyl radicals (OH), are effective and promising strategies for NO removal from coal-fired flue gas. This review provides the state of the art of NO removal by AOPs, highlighting several methods for producing OH and SO. According to the main radicals responsible for NO removal, these processes are classified into two categories: hydroxyl radical-based AOPs (HR-AOPs) and sulfate radical-based AOPs (SR-AOPs). This paper also reviews the mechanisms of NO capture by reactive oxygen species (ROS) and SO in various AOPs. A HiGee (high-gravity) enhanced AOP process for improving NO removal, characterized by intensified gas-liquid mass transfer and efficient micro-mixing, is then proposed and discussed in brief. We believe that this review will be useful for workers in this field. Graphical abstract.
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http://dx.doi.org/10.1007/s11356-020-09782-1DOI Listing
October 2020

Biomarkers of aging and lung function in the normative aging study.

Aging (Albany NY) 2020 06 19;12(12):11942-11966. Epub 2020 Jun 19.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis in the Normative Aging Study using linear mixed-effect models. We generated GrimAgeAccel, PhenoAgeAccel, extrinsic and intrinsic epigenetic age acceleration using a publically available online calculator. We calculated Zhang's DNAmRiskScore based on 10 CpGs. We measured telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) using quantitative real-time polymerase chain reaction. A pulmonary function test was performed measuring forced expiratory volume in 1 second / forced vital capacity (FEV/FVC), FEV, and maximum mid-expiratory flow (MMEF). Epigenetic-based BoA were associated with lower lung function. For example, a one-year increase in GrimAgeAccel was associated with a 13.64 mL [95% confidence interval (CI), 5.11 to 22.16] decline in FEV; a 0.2 increase in Zhang's DNAmRiskScore was associated with a 0.009 L/s (0.005 to 0.013) reduction in MMEF. No association was found between TL/mtDNA-CN and lung function. Overall, this paper shows that epigenetics might be a potential mechanism underlying pulmonary dysfunction in the elderly.
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http://dx.doi.org/10.18632/aging.103363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343502PMC
June 2020

Necessity of personal sampling for exposure assessment on specific constituents of PM: Results of a panel study in Shanghai, China.

Environ Int 2020 08 17;141:105786. Epub 2020 May 17.

School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China; Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission, Shanghai Institute of Planned Research, Institute of Reproduction and Development, Fudan University, Shanghai, China. Electronic address:

Many epidemiological studies have evaluated the health risks of ambient fine particulate matter (PM). However, few studies have investigated the potential exposure misclassification caused by using ambient PM concentrations as proxy for individual exposure to PM in regions with high-level of air pollution. This study aimed to compare the differences between personal and ambient PM constituent concentrations, and to predict the personal exposure of sixteen PM constituents. We collected 141 72-h personal exposure filter samples from a panel of 36 healthy non-smoking college students in Shanghai, China. We then used the liner mixed effects models to predict personal constituent-specific exposure using ambient observations and several possible influencing factors including time-activity patterns, temporal variables, and meteorological conditions. The final model of each component was further evaluated by determination coefficient (R) and root mean square error (RMSE) from leave-one-out-cross-validation (LOOCV). We observed ambient concentrations were higher than personal concentrations for all PM components except for Mn, Fe, Ca, and V. Especially, ambient NH, As, and NO concentrations were 3.65, 5.65 and 7.33-fold higher than their corresponding personal concentrations, respectively. The ambient level was the strongest predictor of their corresponding personal PM components with the highest marginal R (R: 0.081 ~ 0.901), meteorological conditions (R: 0.000 ~ 0.357), time-activity pattern (R: 0.000 ~ 0.083) and temporal indicators (R: 0.031 ~ 0.562) were also important predictors. Our final models predicted at least 50% of the variance of all personal PM constituents and even over 90% for K, Pb, and SO. LOOCV analysis showed that R and RMSE ranged from 0.251 to 0.907 and 0.000 to 0.092 μg/m, respectively. Our results showed that ambient concentration of most PM constituents along with time-activity patterns, temporal variables, and meteorological conditions, could adequately predict personal exposure concentration. Prediction models of individual PM constituent may help to improve the accuracy of exposure measurement in future epidemiological studies.
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http://dx.doi.org/10.1016/j.envint.2020.105786DOI Listing
August 2020
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