Cristina Vilaplana

Cristina Vilaplana

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Cristina Vilaplana

Publications by authors named "Cristina Vilaplana"

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How Far Are we Away From an Improved Vaccine For Tuberculosis? Current Efforts and Future Prospects.

Arch Bronconeumol 2019 Jul 26;55(7):373-377. Epub 2018 Dec 26.

Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Can Ruti Campus, Badalona, Catalonia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S03002896183044
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http://dx.doi.org/10.1016/j.arbres.2018.11.002DOI Listing
July 2019

A Beneficial Effect of Low-Dose Aspirin in a Murine Model of Active Tuberculosis.

Front Immunol 2018 23;9:798. Epub 2018 Apr 23.

Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Spain.

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http://dx.doi.org/10.3389/fimmu.2018.00798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924809PMC
June 2019

Latent TB Infection (LTBI) - Mycobacterium tuberculosis pathogenesis and the dynamics of the granuloma battleground.

Int J Infect Dis 2019 Mar 26;80S:S58-S61. Epub 2019 Feb 26.

Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal; Department of Haematology and Oncology, Krankenhaus Nordwest, Frankfurt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2019.02.035DOI Listing
March 2019

Does long-term care subsidization reduce hospital admissions and utilization?

J Health Econ 2018 03 31;58:43-66. Epub 2018 Jan 31.

University of Murcia, Spain.

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http://dx.doi.org/10.1016/j.jhealeco.2018.01.002DOI Listing
March 2018

Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review.

Front Immunol 2017 30;8:772. Epub 2017 Jun 30.

Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Badalona, Catalonia, Spain.

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http://dx.doi.org/10.3389/fimmu.2017.00772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492311PMC
June 2017

A literary approach to tuberculosis: lessons learned from Anton Chekhov, Franz Kafka, and Katherine Mansfield.

Int J Infect Dis 2017 Mar 16;56:283-285. Epub 2016 Dec 16.

Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Edifici Laboratoris de Recerca, Can Ruti Campus, Crtra, de Can Ruti, Camí de les Escoles, s/n, 08916, Badalona, Catalonia, Spain; CIBER Enfermedades Respiratorias. Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0. 28029, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2016.12.012DOI Listing
March 2017

Retrospective study of clinical and lesion characteristics of patients undergoing surgical treatment for Pulmonary Tuberculosis in Georgia.

Int J Infect Dis 2017 Mar 19;56:200-207. Epub 2016 Dec 19.

Experimental Tuberculosis Unit (UTE). Fundació Institut Germans Trias i Pujol (IGTP). Universitat Autònoma de Barcelona (UAB). Edifici Laboratoris de Recerca. Can Ruti Campus. Crtra. de Can Ruti, Camí de les Escoles, s/n. 08916, Badalona, Catalonia; Spain; CIBER Enfermedades Respiratorias, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0. 28029, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ijid.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660856PMC
March 2017

Local Inflammation, Dissemination and Coalescence of Lesions Are Key for the Progression toward Active Tuberculosis: The Bubble Model.

Front Microbiol 2016 2;7:33. Epub 2016 Feb 2.

Departament de Física i Enginyeria Nuclear, Escola Superior d'Agricultura de Barcelona, Universitat Politècnica de Catalunya - BarcelonaTech Castelldefels, Spain.

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http://dx.doi.org/10.3389/fmicb.2016.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736263PMC
February 2016

Oral Administration of Heat-Killed Mycobacterium manresensis Delays Progression toward Active Tuberculosis in C3HeB/FeJ Mice.

Front Microbiol 2015 5;6:1482. Epub 2016 Jan 5.

Unitat de Tuberculosi Experimental, Fundació Institut Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona Badalona, Spain.

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http://journal.frontiersin.org/Article/10.3389/fmicb.2015.01
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http://dx.doi.org/10.3389/fmicb.2015.01482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700139PMC
January 2016

Individual-Based Modeling of Tuberculosis in a User-Friendly Interface: Understanding the Epidemiological Role of Population Heterogeneity in a City.

Front Microbiol 2015 12;6:1564. Epub 2016 Jan 12.

Departament de Física, Escola Superior d'Agricultura de Barcelona, Universitat Politècnica de Catalunya-BarcelonaTech Barcelona, Spain.

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http://dx.doi.org/10.3389/fmicb.2015.01564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709466PMC
January 2016

To achieve an earlier IFN-γ response is not sufficient to control Mycobacterium tuberculosis infection in mice.

PLoS One 2014 24;9(6):e100830. Epub 2014 Jun 24.

Unitat de Tuberculosi Experimental (UTE), Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES, Badalona, Catalonia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100830PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069189PMC
November 2015

Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis.

Vaccine 2015 Mar 2;33(11):1353-9. Epub 2015 Feb 2.

Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland; Nationales Zentrum für Mykobakterien, Gloriastrasse 30/32, 8006 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.vaccine.2015.01.058DOI Listing
March 2015

Multiple consecutive infections might explain the lack of protection by BCG.

PLoS One 2014 16;9(4):e94736. Epub 2014 Apr 16.

Unitat de Tuberculosi Experimental, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Catalonia, Spain; Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain; Centro de Investigaciones Biomédicas En Red Enfermedades Respiratorias (CIBERES), Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094736PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989258PMC
February 2015

Will we be treating tuberculosis with vaccines in the XXI century?

Arch Bronconeumol 2014 Sep 30;50(9):373-4. Epub 2014 Apr 30.

Unitat de Tuberculosi Experimental, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, España.

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http://dx.doi.org/10.1016/j.arbres.2014.03.001DOI Listing
September 2014

The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies.

Front Microbiol 2014 14;5:55. Epub 2014 Feb 14.

Unitat de Tuberculosi Experimental, Fundació Institut Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias Badalona, Spain.

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http://dx.doi.org/10.3389/fmicb.2014.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924323PMC
June 2014

Damaging role of neutrophilic infiltration in a mouse model of progressive tuberculosis.

Tuberculosis (Edinb) 2014 Jan 19;94(1):55-64. Epub 2013 Sep 19.

Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES, Unitat de Tuberculosi Experimental, Crtra. de Can Ruti, Camí de les Escoles, s/n, 08916 Badalona, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2013.09.004DOI Listing
January 2014

Evolution and role of corded cell aggregation in Mycobacterium tuberculosis cultures.

Tuberculosis (Edinb) 2013 Nov 13;93(6):690-8. Epub 2013 Aug 13.

Unitat de Tuberculosi Experimental (UTE), Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES, Crtra. de Can Ruti, Camí de les Escoles s/n, Edifici Escoles, 08916 Badalona, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S14729792130015
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http://dx.doi.org/10.1016/j.tube.2013.08.003DOI Listing
November 2013

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials.

Vaccine 2013 Oct 17;31(42):4867-73. Epub 2013 Aug 17.

Grupo de Genética de Micobacterias, Dpto. Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, C/ Domingo Miral s/n, 50009 Zaragoza, Spain; CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1016/j.vaccine.2013.07.051DOI Listing
October 2013

Ibuprofen therapy resulted in significantly decreased tissue bacillary loads and increased survival in a new murine experimental model of active tuberculosis.

J Infect Dis 2013 Jul 5;208(2):199-202. Epub 2013 Apr 5.

Unitat de Tuberculosi Experimental, Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERES.

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http://dx.doi.org/10.1093/infdis/jit152DOI Listing
July 2013

Chemo-enzymatic synthesis and glycosidase inhibitory properties of DAB and LAB derivatives.

Org Biomol Chem 2013 Mar 5;11(12):2005-21. Epub 2013 Feb 5.

Dept Química Biológica y Modelización Molecular, Instituto de Química Avanzada de Cataluña, IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.

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http://dx.doi.org/10.1039/c3ob27343aDOI Listing
March 2013

Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols.

Org Biomol Chem 2012 Aug 26;10(31):6309-21. Epub 2012 Jun 26.

Dept Biological Chemistry and Molecular Modeling, Instituto de Química Avanzada de Cataluña, IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.

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http://dx.doi.org/10.1039/c2ob25943eDOI Listing
August 2012

Low dose aerosol fitness at the innate phase of murine infection better predicts virulence amongst clinical strains of Mycobacterium tuberculosis.

PLoS One 2012 3;7(1):e29010. Epub 2012 Jan 3.

Unitat de Tuberculosi Experimental, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029010PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250398PMC
May 2012

[The social value of informal care provided to elderly dependent people in Spain].

Gac Sanit 2011 Dec 12;25 Suppl 2:108-14. Epub 2011 Nov 12.

Universidad de Castilla-La Mancha, Toledo, España.

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http://dx.doi.org/10.1016/j.gaceta.2011.09.005DOI Listing
December 2011

[Immunodiagnosis and biomarkers in tuberculosis].

Med Clin (Barc) 2011 Oct 5;137(9):408-13. Epub 2010 Nov 5.

Center for Molecular Microbiology and Infection and Division of Medicine, Imperial College London, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00257753100088
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http://dx.doi.org/10.1016/j.medcli.2010.09.008DOI Listing
October 2011

Prophylactic effect of a therapeutic vaccine against TB based on fragments of Mycobacterium tuberculosis.

PLoS One 2011 24;6(5):e20404. Epub 2011 May 24.

Unitat de Tuberculosi Experimental, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Crta Badalona, Catalonia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020404PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101251PMC
September 2011

Granuloma encapsulation is a key factor for containing tuberculosis infection in minipigs.

PLoS One 2010 Apr 6;5(4):e10030. Epub 2010 Apr 6.

Unitat de Tuberculosi Experimental (UTE), Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010030PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850319PMC
April 2010

Tuberculin immunotherapy: its history and lessons to be learned.

Microbes Infect 2010 Feb 4;12(2):99-105. Epub 2009 Nov 4.

Unitat de Tuberculosi Experimental, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.

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http://dx.doi.org/10.1016/j.micinf.2009.10.006DOI Listing
February 2010

Evolution of foamy macrophages in the pulmonary granulomas of experimental tuberculosis models.

Tuberculosis (Edinb) 2009 Mar 24;89(2):175-82. Epub 2008 Dec 24.

Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Catalonia, Spain.

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http://dx.doi.org/10.1016/j.tube.2008.11.001DOI Listing
March 2009

Enhanced gamma interferon responses of mouse spleen cells following immunotherapy for tuberculosis relapse.

Clin Vaccine Immunol 2008 Nov 30;15(11):1742-4. Epub 2008 Sep 30.

Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.

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http://dx.doi.org/10.1128/CVI.00255-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583524PMC
November 2008

Induction of a specific strong polyantigenic cellular immune response after short-term chemotherapy controls bacillary reactivation in murine and guinea pig experimental models of tuberculosis.

Clin Vaccine Immunol 2008 Aug 4;15(8):1229-37. Epub 2008 Jun 4.

Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Catalonia, Spain.

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http://dx.doi.org/10.1128/CVI.00094-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519306PMC
August 2008

Intragranulomatous necrosis in pulmonary granulomas is not related to resistance against Mycobacterium tuberculosis infection in experimental murine models induced by aerosol.

Int J Exp Pathol 2006 Apr;87(2):139-49

Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol and Universitat Autònoma de Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1111/j.0959-9673.2006.00472.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517358PMC
April 2006

Intragranulomatous necrosis in lungs of mice infected by aerosol with Mycobacterium tuberculosis is related to bacterial load rather than to any one cytokine or T cell type.

Microbes Infect 2006 Mar 13;8(3):628-36. Epub 2006 Jan 13.

Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol and Universitat Autònoma de Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1016/j.micinf.2005.08.014DOI Listing
March 2006

Immunotherapy with fragmented Mycobacterium tuberculosis cells increases the effectiveness of chemotherapy against a chronical infection in a murine model of tuberculosis.

Vaccine 2005 Feb;23(11):1393-8

Unitat de Tuberculosi Experimental, Department of Microbiology, Fundació Institut per a la Investigació en Ciències de la Salut "Germans Trias i Pujol", Universitat Autònoma de Barcelona, 08916 Badalona, Catalonia, Spain.

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http://dx.doi.org/10.1016/j.vaccine.2004.09.008DOI Listing
February 2005

Catalase-peroxidase activity has no influence on virulence in a murine model of tuberculosis.

Tuberculosis (Edinb) 2003 ;83(6):351-9

Unitat de Tuberculosi Experimental, Department of Microbiology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Crta del Canyet s/n, Badalona, 08916 Catalonia, Spain.

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March 2004

Widespread bronchogenic dissemination makes DBA/2 mice more susceptible than C57BL/6 mice to experimental aerosol infection with Mycobacterium tuberculosis.

Infect Immun 2003 Oct;71(10):5845-54

Unitat de Tuberculosi Experimental, Department of Microbiology, Hospital Universitari Germans Trias i Pujol, Ctra del Canyet s/n, 08916 Badalona, Catalonia, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC201050PMC
http://dx.doi.org/10.1128/iai.71.10.5845-5854.2003DOI Listing
October 2003