Publications by authors named "Cristina Rada"

44Publications

Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues.

Mol Ther Methods Clin Dev 2019 Sep 4;14:77-89. Epub 2019 Jun 4.

Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

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http://dx.doi.org/10.1016/j.omtm.2019.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606965PMC
September 2019

Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE.

J Exp Med 2017 01 19;214(1):183-196. Epub 2016 Dec 19.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, England, UK

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http://dx.doi.org/10.1084/jem.20161056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206502PMC
January 2017

Harnessing mutation: The best of two worlds.

Science 2016 09;353(6305):1206-7

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.aai8233DOI Listing
September 2016

Molecular fine-tuning of affinity maturation in germinal centers.

J Clin Invest 2016 Jan 14;126(1):32-4. Epub 2015 Dec 14.

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http://dx.doi.org/10.1172/JCI85627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701570PMC
January 2016

Directed evolution of human scFvs in DT40 cells.

Protein Eng Des Sel 2016 Feb 30;29(2):39-48. Epub 2015 Oct 30.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK

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http://dx.doi.org/10.1093/protein/gzv058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840456PMC
February 2016

Mutagenesis by AID: Being in the Right Place at the Right Time.

Authors:
Cristina Rada

PLoS Genet 2015 Sep 10;11(9):e1005489. Epub 2015 Sep 10.

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1005489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565633PMC
September 2015

Active RNAP pre-initiation sites are highly mutated by cytidine deaminases in yeast, with AID targeting small RNA genes.

Elife 2014 Sep 19;3:e03553. Epub 2014 Sep 19.

Protein and Nucleic Acid Chemistry Division, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.03553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359381PMC
September 2014

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis.

Elife 2013 Apr 16;2:e00534. Epub 2013 Apr 16.

Protein and Nucleic Acid Chemistry Division , Medical Research Council Laboratory of Molecular Biology , Cambridge , United Kingdom.

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http://dx.doi.org/10.7554/eLife.00534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628087PMC
April 2013

The cytoplasmic AID complex.

Semin Immunol 2012 Aug 13;24(4):273-80. Epub 2012 Jun 13.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.smim.2012.05.004DOI Listing
August 2012

REG-γ associates with and modulates the abundance of nuclear activation-induced deaminase.

J Exp Med 2011 Nov 31;208(12):2385-91. Epub 2011 Oct 31.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1084/jem.20110856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256965PMC
November 2011

Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).

Proc Natl Acad Sci U S A 2011 Nov 31;108(45):18366-71. Epub 2011 Oct 31.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1106729108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215039PMC
November 2011

CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.

J Biol Chem 2011 May 8;286(19):17091-102. Epub 2011 Mar 8.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.208769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089553PMC
May 2011

A high-throughput assay for DNA deaminases.

Methods Mol Biol 2011 ;718:171-84

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1007/978-1-61779-018-8_11DOI Listing
June 2011

The dependence of Ig class-switching on the nuclear export sequence of AID likely reflects interaction with factors additional to Crm1 exportin.

Eur J Immunol 2011 Feb 23;41(2):485-90. Epub 2010 Dec 23.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1002/eji.201041011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437479PMC
February 2011

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID.

J Exp Med 2010 Jan 4;207(1):141-53. Epub 2010 Jan 4.

Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 0QH, England, UK.

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http://dx.doi.org/10.1084/jem.20092238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812546PMC
January 2010

Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy.

J Biol Chem 2010 Mar 17;285(10):7111-8. Epub 2009 Dec 17.

Department of Bioscience and Biotechnology, Graduate School of Agriculture, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.052977
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http://dx.doi.org/10.1074/jbc.M109.052977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844160PMC
March 2010

The AKV murine leukemia virus is restricted and hypermutated by mouse APOBEC3.

J Virol 2009 Nov 2;83(22):11550-9. Epub 2009 Sep 2.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, United Kingdom CB2 0QH.

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http://dx.doi.org/10.1128/JVI.01430-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772689PMC
November 2009

AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity.

Nat Struct Mol Biol 2009 Jul 21;16(7):769-76. Epub 2009 Jun 21.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.1038/nsmb.1623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851237PMC
July 2009

The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence.

Proc Natl Acad Sci U S A 2009 Apr 7;106(16):6736-41. Epub 2009 Apr 7.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0810808106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672500PMC
April 2009

AID and RPA: PKA makes the connection local.

Authors:
Cristina Rada

Nat Immunol 2009 Apr;10(4):367-9

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http://dx.doi.org/10.1038/ni0409-367DOI Listing
April 2009

Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.

J Virol 2008 Nov 10;82(22):10998-1008. Epub 2008 Sep 10.

Department of Immunology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.1128/JVI.01311-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573259PMC
November 2008

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

Mol Cell 2008 Aug;31(4):474-84

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK.

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http://dx.doi.org/10.1016/j.molcel.2008.07.009DOI Listing
August 2008

Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.

J Exp Med 2007 Jan 26;204(1):7-10. Epub 2006 Dec 26.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1084/jem.20062409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118430PMC
January 2007

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.

J Exp Med 2006 Sep 7;203(9):2085-94. Epub 2006 Aug 7.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.

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http://www.jem.org/lookup/doi/10.1084/jem.20061067
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http://dx.doi.org/10.1084/jem.20061067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118391PMC
September 2006

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.

EMBO J 2006 Feb 12;25(3):585-95. Epub 2006 Jan 12.

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/sj.emboj.7600939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383525PMC
February 2006

Mice deficient in APOBEC2 and APOBEC3.

Mol Cell Biol 2005 Aug;25(16):7270-7

Medical Research Council Laboratory of Molecular Biology, Division of PNAC, Cambridge, UK.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.25.16.7270-7277.2005
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http://dx.doi.org/10.1128/MCB.25.16.7270-7277.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190257PMC
August 2005

Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.

Nat Rev Immunol 2005 02;5(2):171-8

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1038/nri1553DOI Listing
February 2005

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.

Mol Cell 2004 Oct;16(2):163-71

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650400613
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http://dx.doi.org/10.1016/j.molcel.2004.10.011DOI Listing
October 2004

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

Curr Biol 2002 Oct;12(20):1748-55

Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/s0960-9822(02)01215-0DOI Listing
October 2002

AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.

Proc Natl Acad Sci U S A 2002 May;99(10):7003-8

Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.092160999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124518PMC
May 2002

Epigenetics: monoallelic expression in the immune system.

Curr Biol 2002 Feb;12(3):R108-10

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1016/s0960-9822(02)00674-7DOI Listing
February 2002