Cristina Mecucci

Cristina Mecucci

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Cristina Mecucci

Cristina Mecucci

Publications by authors named "Cristina Mecucci"

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Identification of two independent clones underlying the co-existence of myelodysplastic syndrome with excess of blasts type 2 and isolated 5q- and smouldering multiple myeloma.

Cytopathology 2019 Jul 11. Epub 2019 Jul 11.

Department of Medicine, Section of Hematology and Center for Hemato-Oncology Research CREO, Cytogenetics and Molecular Medicine Laboratory, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1111/cyt.12752DOI Listing
July 2019

Lenalidomide treatment of myelodysplastic syndromes with chromosome 5q deletion: Results from the National Registry of the Italian Drug Agency.

Eur J Haematol 2018 Jul 22;101(1):78-85. Epub 2018 May 22.

Department of Medicine, Institute of Hematology and Center for Hemato-Oncology Research (C.R.E.O.), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1111/ejh.13067DOI Listing
July 2018

Cytogenetic/mutation profile of chronic lymphocytic leukemia/malignant melanoma collision tumors of the skin.

Mol Cytogenet 2018 16;11. Epub 2018 Jan 16.

1Molecular Medicine Laboratory, Hematology and Bone Marrow Transplantation Unit, University of Perugia, Hospital S. Maria della Misericordia, Piazzale Menghini n.9, 06132 Perugia, Italy.

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http://dx.doi.org/10.1186/s13039-017-0353-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771154PMC
January 2018

Involvement of a member of the histone cluster 1 at 6p21 in NUP98-positive MDS/AML.

Leuk Lymphoma 2017 11 9;58(11):2765-2767. Epub 2017 May 9.

a Molecular Medicine Laboratory, Department of Medicine , CREO, University of Perugia , Perugia , Italy.

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http://dx.doi.org/10.1080/10428194.2017.1312375DOI Listing
November 2017

Clinical-Grade-Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell-Dependent Graft-versus-Leukemia Effect in Murine Models.

Biol Blood Marrow Transplant 2017 Nov 17;23(11):1847-1851. Epub 2017 Jul 17.

Department of Hematology, Transfusion Medicine and Biotechnologies, Ospedale Civile, Pescara, Italy; Department of Medicine and Aging Sciences, University of Chieti-Pescara, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2017.07.009DOI Listing
November 2017

Unraveling the mechanisms behind iron overload and ineffective hematopoiesis in myelodysplastic syndromes.

Leuk Res 2017 11 5;62:108-115. Epub 2017 Oct 5.

Università degli Studi di Bologna, Via Massarenti 9, 40138, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2017.10.001DOI Listing
November 2017

Sensitivity of cutaneous chronic myelomonocytic leukaemia lesions to hypomethylating treatment.

Eur J Dermatol 2017 10;27(5):540-542

Institute of Hematology and Hemato-Oncology Research Centre (CREO), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1684/ejd.2017.3068DOI Listing
October 2017

Practical considerations for diagnosis and management of patients and carriers.

Semin Hematol 2017 04 6;54(2):69-74. Epub 2017 Apr 6.

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2017.04.002DOI Listing
April 2017

The Molecular Spectrum of β- and α-Thalassemia Mutations in Non-Endemic Umbria, Central Italy.

Hemoglobin 2016 Nov;40(6):371-376

c Dipartimento di Scienze Cliniche e Biologiche , Università degli Studi di Torino, Azienda Ospedaliera Universitaria San Luigi Gonzaga , Torino , Italia.

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http://dx.doi.org/10.1080/03630269.2017.1289101DOI Listing
November 2016

Nucleoporin genes in human diseases.

Eur J Hum Genet 2016 10 13;24(10):1388-95. Epub 2016 Apr 13.

Department of Medicine, Laboratory of Molecular Medicine, CREO, University of Perugia, Perugia, Italy.

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http://www.nature.com/articles/ejhg201625
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http://dx.doi.org/10.1038/ejhg.2016.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027676PMC
October 2016

Expanding the role of the splicing USB1 gene from Poikiloderma with Neutropenia to acquired myeloid neoplasms.

Br J Haematol 2015 Nov 25;171(4):557-65. Epub 2015 Aug 25.

Medical Cytogenetics and Molecular Genetics Laboratory, Centro di Ricerche e Tecnologie Biomediche IRCCS, Istituto Auxologico Italiano, Milan, Italy.

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http://dx.doi.org/10.1111/bjh.13651DOI Listing
November 2015

4q12 translocations with GSX2 expression identify a CD7(+) acute myeloid leukaemia subset.

Br J Haematol 2015 Oct 30;171(1):141-5. Epub 2015 Mar 30.

Department of Medicine, Section of Haematology, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1111/bjh.13368DOI Listing
October 2015

CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q).

Br J Haematol 2015 Oct 18;171(2):210-214. Epub 2015 Jun 18.

LLR Molecular Haematology Unit, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.13563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744770PMC
October 2015

NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias.

Leuk Res 2015 Jul 7;39(7):769-72. Epub 2015 May 7.

Laboratory of Molecular Medicine, CREO, University of Perugia and A.O. Perugia, 06132 Perugia, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01452126150012
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http://dx.doi.org/10.1016/j.leukres.2015.04.014DOI Listing
July 2015

Metachronous cardiac and cerebral sarcomas: case report with focus on molecular findings and review of the literature.

Hum Pathol 2015 Mar 9;46(3):482-7. Epub 2014 Dec 9.

Department of Experimental Medicine, Pathological Anatomy and Histology Unit, Medical School, University of Perugia, I-06129 Perugia, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177140048
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http://dx.doi.org/10.1016/j.humpath.2014.10.028DOI Listing
March 2015

The GNAS1 gene in myelodysplastic syndromes (MDS).

Leuk Res 2014 Jul 29;38(7):804-7. Epub 2014 Mar 29.

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2014.03.017DOI Listing
July 2014

Blast crisis Ph+ chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2.

Mol Cytogenet 2014 20;7:42. Epub 2014 Jun 20.

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Polo Unico S. Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1186/1755-8166-7-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071805PMC
June 2014

Clustering of genomic breakpoints at the MLL locus in therapy-related acute leukemia with t(4;11)(q21;q23).

Genes Chromosomes Cancer 2014 Mar 5;53(3):248-54. Epub 2013 Dec 5.

Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; Laboratorio di Neuro-Oncoematologia, Fondazione Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1002/gcc.22135DOI Listing
March 2014

[Diagnosis and prognosis in myelodysplastic syndromes. The impact of cytogenetics].

Authors:
Cristina Mecucci

Recenti Prog Med 2014 Mar;105(3):110-4

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http://dx.doi.org/10.1701/1434.15871DOI Listing
March 2014

Subclonal evolution of a classical Hodgkin lymphoma from a germinal center B-cell-derived mantle cell lymphoma.

Int J Cancer 2014 Feb 29;134(4):832-43. Epub 2013 Aug 29.

Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1002/ijc.28422DOI Listing
February 2014

NUP98 fusion oncoproteins promote aneuploidy by attenuating the mitotic spindle checkpoint.

Cancer Res 2014 Feb 26;74(4):1079-90. Epub 2013 Dec 26.

Authors' Affiliations: Department of Life Sciences, University of Modena and Reggio Emilia, Modena; and Department of Hematology, University of Perugia, University Hospital S. Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0912DOI Listing
February 2014

New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.

Blood 2013 Jun 14;121(25):5064-7. Epub 2013 May 14.

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2013-02-487256DOI Listing
June 2013

Acute leukemia with PICALM-MLLT10 fusion gene: diagnostic and treatment struggle.

Cancer Genet Cytogenet 2010 Oct;202(2):129-32

Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.07.126DOI Listing
October 2010

A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement.

Cancer Genet Cytogenet 2009 Sep;193(2):109-11

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Ematologia e Trapianto di Midollo Osseo, Ospedale S.M. della Misericordia, (Padiglione B, piano -2), S. Andrea delle Fratte, 06156 Perugia, Italy.

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http://dx.doi.org/10.1016/j.cancergencyto.2009.04.015DOI Listing
September 2009

RABGAP1L gene rearrangement resulting from a der(Y)t(Y;1)(q12;q25) in acute myeloid leukemia arising in a child with Klinefelter syndrome.

Virchows Arch 2009 Mar 28;454(3):311-6. Epub 2009 Jan 28.

Cytogenetics and Molecular Genetics, Bambino Gesù Children's Hospital, Piazza S. Onofrio 4, 00165, Rome, Italy.

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http://dx.doi.org/10.1007/s00428-009-0732-zDOI Listing
March 2009

t(3;11)(q12;p15)/NUP98-LOC348801 fusion transcript in acute myeloid leukemia.

Haematologica 2008 Sep 4;93(9):1398-401. Epub 2008 Jul 4.

IbiT Foundation, Fondazione IRCCS Biotecnologie nel Trapianto, Hematology, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.3324/haematol.12945DOI Listing
September 2008

Comparative genomic hybridization identifies 17q11.2 approximately q12 duplication as an early event in cutaneous T-cell lymphomas.

Cancer Genet Cytogenet 2008 Jul;184(1):48-51

Cytogenetics and Molecular Genetics Laboratory, Hematology and Bone Marrow Transplantation Unit, IBiT Foundation, University of Perugia, via Brunamonti 51, 06123 Perugia, Italy.

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http://dx.doi.org/10.1016/j.cancergencyto.2008.03.007DOI Listing
July 2008

Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature.

Cancer Genet Cytogenet 2007 Oct;178(1):42-8

Department of Pathology and Laboratory, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room 4711, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.06.012DOI Listing
October 2007

Molecular cytogenetic findings in a four-way t(1;12;5;12)(p36;p13;q33;q24) underlying the ETV6-PDGFRB fusion gene in chronic myelomonocytic leukemia.

Cancer Genet Cytogenet 2007 Jul;176(1):67-71

Department of Hematology, University of Perugia, IBiT Foundation (Fondazione IRCCS Biotecnologie nel Trapianto), via Brunamonti 51, 06122 Perugia, Italy.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.03.004DOI Listing
July 2007

A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma.

Cancer Genet Cytogenet 2007 May;175(1):73-6

Department of Hematology, University of Perugia, IBiT Foundation, Fondazione IRCCS Biotecnologie nel Trapianto, via Brunamonti 51, 06122 Perugia, Italy.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.01.011DOI Listing
May 2007

Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias.

Haematologica 2007 Apr;92(4):519-32

Section of Haematology and Immunology, University of Perugia, IBit Foundation, Perugia, Italy.

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http://dx.doi.org/10.3324/haematol.11007DOI Listing
April 2007

Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.

Blood 2007 Feb 28;109(3):874-85. Epub 2006 Sep 28.

Institute of Hematology, University of Perugia, Italy.

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http://dx.doi.org/10.1182/blood-2006-07-012252DOI Listing
February 2007

Cryptic chromosome 9q34 deletion generates TAF-Ialpha/CAN and TAF-Ibeta/CAN fusion transcripts in acute myeloid leukemia.

Haematologica 2007 Feb;92(2):232-5

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Policlinico Monteluce, via Brunamonti 51, 06122 Perugia, Italy.

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http://dx.doi.org/10.3324/haematol.10538DOI Listing
February 2007

Chronic lymphocytic leukaemia Is terminal del(14)(q24) a new marker for prognostic stratification?

Leuk Res 2006 Dec 2;30(12):1569-72. Epub 2006 May 2.

Hematology and Bone Marrow Transplantation Unit, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.leukres.2006.03.019DOI Listing
December 2006

Fusion of ETV6 to GOT1 in a case with myelodysplastic syndrome and t(10;12)(q24;p13).

Haematologica 2006 Jul 1;91(7):949-51. Epub 2006 Jun 1.

Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium.

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July 2006

Nucleophosmin and cancer.

Nat Rev Cancer 2006 Jul;6(7):493-505

Cancer Biology & Genetics Program, Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nrc1885DOI Listing
July 2006

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.

Blood 2005 Dec 2;106(12):3733-9. Epub 2005 Aug 2.

Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilian's University, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2005-06-2248DOI Listing
December 2005