Cristina Fillat

Cristina Fillat

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Cristina Fillat

Publications by authors named "Cristina Fillat"

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Bioselection Reveals miR-99b and miR-485 as Enhancers of Adenoviral Oncolysis in Pancreatic Cancer.

Mol Ther 2019 01 27;27(1):230-243. Epub 2018 Sep 27.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 08036 Barcelona, Spain; Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona (UB), 08036 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318784PMC
January 2019

Zeb1 in Stromal Myofibroblasts Promotes -Driven Development of Pancreatic Cancer.

Cancer Res 2018 05 28;78(10):2624-2637. Epub 2018 Feb 28.

Gastrointestinal and pancreatic oncology research group, Hospital Clinic, Barcelona, CiberEHD, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1882DOI Listing
May 2018

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

Cell Rep 2018 05;23(6):1867-1878

Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.04.008DOI Listing
May 2018

Deciphering microRNA targets in pancreatic cancer using miRComb R package.

Oncotarget 2018 Jan 8;9(5):6499-6517. Epub 2018 Jan 8.

Gastrointestinal & Pancreatic Oncology Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.18632/oncotarget.24034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814228PMC
January 2018

Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth.

Diabetes 2017 12 2;66(12):3029-3040. Epub 2017 Oct 2.

Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

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http://dx.doi.org/10.2337/db16-1569DOI Listing
December 2017

Implications of MicroRNAs in Oncolytic Virotherapy.

Front Oncol 2017 4;7:142. Epub 2017 Jul 4.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.3389/fonc.2017.00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495989PMC
July 2017

Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies.

Nat Commun 2017 03 16;8:14833. Epub 2017 Mar 16.

Gene Therapy and Cancer, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-153, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1038/ncomms14833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357308PMC
March 2017

Codon optimization of the adenoviral fiber negatively impacts structural protein expression and viral fitness.

Sci Rep 2016 06 9;6:27546. Epub 2016 Jun 9.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1038/srep27546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899721PMC
June 2016

Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges.

BMC Genomics 2015 Nov 6;16:907. Epub 2015 Nov 6.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Rosselló 149-153, 08036, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12864-015-2160-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636806PMC
November 2015

AduPARE1A and gemcitabine combined treatment trigger synergistic antitumor effects in pancreatic cancer through NF-κB mediated uPAR activation.

Mol Cancer 2015 Jul 31;14:146. Epub 2015 Jul 31.

Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Rosselló 149-153, Barcelona, 08036, Spain.

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http://dx.doi.org/10.1186/s12943-015-0413-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521493PMC
July 2015

Combining oncolytic virotherapy and cytotoxic therapies to fight cancer.

Curr Pharm Des 2014 ;20(42):6513-21

Institut d'Investigacions Biomediques August Pi i Sunyer-IDIBAPS, Rossello 149-153, 08036- Barcelona, Spain.

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http://dx.doi.org/10.2174/1381612820666140826152420DOI Listing
June 2015

Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells.

Oncotarget 2015 Mar;6(8):6179-90

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467430PMC
http://dx.doi.org/10.18632/oncotarget.3350DOI Listing
March 2015

A genetic fiber modification to achieve matrix-metalloprotease-activated infectivity of oncolytic adenovirus.

J Control Release 2014 Oct 15;192:148-56. Epub 2014 Jul 15.

Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.07.008DOI Listing
October 2014

miR-148a- and miR-216a-regulated oncolytic adenoviruses targeting pancreatic tumors attenuate tissue damage without perturbation of miRNA activity.

Mol Ther 2014 Sep 4;22(9):1665-77. Epub 2014 Jun 4.

1] Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain [2] Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.

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http://dx.doi.org/10.1038/mt.2014.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435498PMC
September 2014

uPAR-controlled oncolytic adenoviruses eliminate cancer stem cells in human pancreatic tumors.

Stem Cell Res 2014 Jan 27;12(1):1-10. Epub 2013 Sep 27.

Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2013.09.008DOI Listing
January 2014

Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.

Exp Neurol 2013 Jan 1;239:229-34. Epub 2012 Nov 1.

Instituto de Neurociencias de Castilla y León (INCYL), Universidad de Salamanca, (IBSAL), Spain.

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http://dx.doi.org/10.1016/j.expneurol.2012.10.016DOI Listing
January 2013

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.

Proc Natl Acad Sci U S A 2012 Nov 10;109(45):E3136-45. Epub 2012 Oct 10.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain.

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http://dx.doi.org/10.1073/pnas.1206506109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494930PMC
November 2012

Gene therapy for Down syndrome.

Prog Brain Res 2012 ;197:237-47

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1016/B978-0-444-54299-1.00012-1DOI Listing
September 2012

Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models.

Cancer Lett 2012 Apr 10;317(1):16-23. Epub 2011 Nov 10.

Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.canlet.2011.11.004DOI Listing
April 2012

Irreversible electroporation shows efficacy against pancreatic carcinoma without systemic toxicity in mouse models.

Cancer Lett 2012 Apr 10;317(1):16-23. Epub 2011 Nov 10.

Institut d'Investigacions Biomèdiques August Pi i Sunyer-IDIBAPS, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.canlet.2011.11.004DOI Listing
April 2012

Connexin-26 is a key factor mediating gemcitabine bystander effect.

Mol Cancer Ther 2011 Mar;10(3):505-17

Programa Gens i Malaltia, Centre de Regulació Genòmica. Dr. Aiguader, 88. 08003-Barcelona, Spain.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0693DOI Listing
March 2011

Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.

PLoS One 2011 Feb 25;6(2):e17010. Epub 2011 Feb 25.

Centre for Genomic Regulation, Barcelona Biomedical Research Park, and CIBER de Enfermedades Raras, Barcelona, Catalonia, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017010PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045383PMC
February 2011

Pancreatic cancer gene therapy: from molecular targets to delivery systems.

Cancers (Basel) 2011 Jan 18;3(1):368-95. Epub 2011 Jan 18.

Programa Gens i Malaltia, Centre de Regulació Genòmica-CRG, UPF, Parc de Recerca Biomèdica de Barcelona-PRBB and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain.

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http://dx.doi.org/10.3390/cancers3010368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756366PMC
January 2011

Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.

Cell Stem Cell 2010 Sep;7(3):367-79

Departamento de Biología Celular and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universidad de Valencia, 46100 Burjassot, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091000345
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http://dx.doi.org/10.1016/j.stem.2010.06.021DOI Listing
September 2010

Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.

Cell Stem Cell 2010 Sep;7(3):367-79

Departamento de Biología Celular and Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Universidad de Valencia, 46100 Burjassot, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091000345
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http://dx.doi.org/10.1016/j.stem.2010.06.021DOI Listing
September 2010

Insights from mouse models to understand neurodegeneration in Down syndrome.

CNS Neurol Disord Drug Targets 2010 Aug;9(4):429-38

Centre de Regulació Genòmica, UPF, Parc de Recerca Biomèdica de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Raras, Spain.

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August 2010

Antitumor therapy based on cellular competition.

Hum Gene Ther 2009 Jul;20(7):728-38

Gene and Viral Therapy Group, IDIBELL-Catalan Institute of Oncology (ICO) , L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

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http://www.liebertpub.com/doi/10.1089/hum.2008.144
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http://dx.doi.org/10.1089/hum.2008.144DOI Listing
July 2009

Urokinase-type plasminogen activator receptor transcriptionally controlled adenoviruses eradicate pancreatic tumors and liver metastasis in mouse models.

Neoplasia 2009 Jun;11(6):518-28, 4 p following 528

Programa Gens i Malaltia, Centre de Regulació Genòmica-CRG, UPF, Parc de Recerca Biomèdica de Barcelona-PRBB, Barcelona, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685441PMC
http://dx.doi.org/10.1593/neo.81674DOI Listing
June 2009

Keratin 7 promoter selectively targets transgene expression to normal and neoplastic pancreatic ductal cells in vitro and in vivo.

FASEB J 2009 May 5;23(5):1366-75. Epub 2009 Jan 5.

Unitat de Biologia Cellular i Molecular, Institut Municipal d'Investigació Mèdica, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1096/fj.08-115576DOI Listing
May 2009

Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

Am J Hum Genet 2008 Oct;83(4):479-88

Programa Gens i Malaltia. Centre de Regulació Genòmica-CRG, UPF, Parc de Recerca Biomèdica de Barcelona-PRBB, Barcelona 08003, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297080050
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2008.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561933PMC
October 2008

Novel membrane cell projection defects in Wiskott-Aldrich syndrome B cells.

Int J Mol Med 2007 Oct;20(4):445-50

Programa Gens i Malaltia, Centre de Regulació Genòmica-CRG-UPF, Parc de Recerca Biomèdica (PRBB), 08003 Barcelona, Spain.

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October 2007

Two novel mutations identified in the Wiskott-Aldrich syndrome protein gene cause Wiskott-Aldrich syndrome and thrombocytopenia.

Int J Mol Med 2007 May;19(5):777-82

Programa Gens i Malaltia, Centre de Regulació Genòmica CRG-UPF, Barcelona, Spain.

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May 2007

Two novel mutations identified in the Wiskott-Aldrich syndrome protein gene cause Wiskott-Aldrich syndrome and thrombocytopenia.

Int J Mol Med 2007 May;19(5):777-82

Programa Gens i Malaltia, Centre de Regulació Genòmica CRG-UPF, Barcelona, Spain.

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May 2007

Role of the putative heparan sulfate glycosaminoglycan-binding site of the adenovirus type 5 fiber shaft on liver detargeting and knob-mediated retargeting.

J Gen Virol 2006 Sep;87(Pt 9):2487-95

Translational Research Laboratory, IDIBELL-Institut Catala d'Oncologia, Av. Gran Via s/n Km 2.7, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

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http://jgv.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/vir.0.81889-0DOI Listing
September 2006

Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments.

Behav Genet 2006 May 7;36(3):454-68. Epub 2006 Mar 7.

Genes and Disease Program, Genomic Regulation Center, (CRG-UPF), Barcelona Biomedical Research Park, Spain.

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http://dx.doi.org/10.1007/s10519-006-9050-2DOI Listing
May 2006

Non-invasive bioluminescence imaging for monitoring herpes simplex virus type 1 hematogenous infection.

Microbes Infect 2006 Apr 24;8(5):1330-8. Epub 2006 Mar 24.

Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Spain.

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http://dx.doi.org/10.1016/j.micinf.2005.12.021DOI Listing
April 2006

Pitfalls and hopes in Down syndrome therapeutic approaches: in the search for evidence-based treatments.

Behav Genet 2006 May 7;36(3):454-68. Epub 2006 Mar 7.

Genes and Disease Program, Genomic Regulation Center, (CRG-UPF), Barcelona Biomedical Research Park, Spain.

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http://dx.doi.org/10.1007/s10519-006-9050-2DOI Listing
May 2006

Enhancement of gemcitabine-induced apoptosis by restoration of p53 function in human pancreatic tumors.

Oncology 2005 4;68(2-3):179-89. Epub 2005 Jul 4.

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

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https://www.karger.com/Article/FullText/86772
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http://dx.doi.org/10.1159/000086772DOI Listing
August 2005

Identification and characterization of a novel splice-site mutation in a patient with Wiskott-Aldrich syndrome.

J Hum Genet 2003 18;48(11):590-3. Epub 2003 Oct 18.

Programa Gens i Malaltia, Centre de Regulació Genòmica, 37-49 Passeig Marítim, 08003, Barcelona, Spain.

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http://dx.doi.org/10.1007/s10038-003-0083-6DOI Listing
October 2004

Wiskott-Aldrich syndrome in a female with skewed X-chromosome inactivation.

Blood Cells Mol Dis 2003 Nov-Dec;31(3):332-7

Programa Gens i malaltia, Centre de Regulació Genòmica, Passeig Marítim 37-49, Barcelona 08003, Spain.

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July 2004

Regression of advanced diabetic nephropathy by hepatocyte growth factor gene therapy in rats.

Diabetes 2004 Apr;53(4):1119-27

Nephrology Service, Medicine Department, Hospital Universitari Bellvitge, University of Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.2337/diabetes.53.4.1119DOI Listing
April 2004

Adenovirus-mediated retinoblastoma 94 gene transfer induces human pancreatic tumor regression in a mouse xenograft model.

Clin Cancer Res 2004 Feb;10(4):1454-62

Department of Biochemistry and Molecular Biology, University of Barcelona, Barcelona, Spain.

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February 2004

Intramuscular SP1017-formulated DNA electrotransfer enhances transgene expression and distributes hHGF to different rat tissues.

J Gene Med 2004 Jan;6(1):111-8

Medical and Molecular Genetic Center, Institut de Recerca Oncològica (IRO), Bellaterra, Spain.

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http://doi.wiley.com/10.1002/jgm.463
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http://dx.doi.org/10.1002/jgm.463DOI Listing
January 2004

Autoimmune thyroiditis after bone marrow transplantation in a boy with Wiskott-Aldrich syndrome.

J Pediatr Hematol Oncol 2002 Dec;24(9):772-6

Departamento de Pediatría, Facultad de Medicina, Universidad de Zaragoza c/Domingo Miral s/n 50009 Zaragoza, Spain.

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http://dx.doi.org/10.1097/00043426-200212000-00020DOI Listing
December 2002

Autoimmune thyroiditis after bone marrow transplantation in a boy with Wiskott-Aldrich syndrome.

J Pediatr Hematol Oncol 2002 Dec;24(9):772-6

Departamento de Pediatría, Facultad de Medicina, Universidad de Zaragoza c/Domingo Miral s/n 50009 Zaragoza, Spain.

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http://dx.doi.org/10.1097/00043426-200212000-00020DOI Listing
December 2002