Cristian Boboila, PhD - Columbia University - Associate research scientist

Cristian Boboila

PhD

Columbia University

Associate research scientist

New York, NY | United States

Main Specialties: Neurology

Additional Specialties: Neuroscience research

ORCID logohttps://orcid.org/0000-0003-4633-0366


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Cristian Boboila, PhD - Columbia University - Associate research scientist

Cristian Boboila

PhD

Introduction

As a biologist, I feel that some of the most exciting discoveries in our lifetimes will be made in understanding the brain. With the realization that the mind stems from the brain and the brain uses the same molecular principles as simple bacteria, it became apparent to me that my molecular training can be a foundation upon which to build in becoming a neuroscientist. My graduate training in immunology gave me the analytical ability and the drive to excel in a rigorous scientific environment. Studying the mysteries of the brain was the next challenge and I am fortunate to do that with a mentor who has a truly remarkable passion for science. In Richard Axel’s lab I developed expertise in cutting edge techniques such as 2-photon calcium imaging, behavior and optogenetic manipulations. I uncovered a circuit for associative learning, one of the most fundamental functions of the brain. Looking towards the future, I am confident that I am prepared to transition successfully to the next step of my career, that of an independent investigator.
My interest in neuroscience has been focused on the biological basis of learning. My research elucidated an interesting transformation of information from odor identity in piriform cortex to odor value in orbitofrontal and medial prefrontal cortex during learning. Moreover, I showed that prefrontal cortex, which has conventionally been implicated in complex learning, is also required for the formation of simple odor-reward associations, a novel and unexpected function. A unique property of olfactory sensory perception is that only three synapses separate the sensory organ from higher order brain regions in the prefrontal cortex. This allows one to grasp the nature of the circuits that transform the identity of a sensory stimulus into a representation that leads to appropriate behavior. As a consequence, my studies contribute to the understanding of sensation, cognition and action, central elements that underlie much of the research in neuroscience today and which are perturbed in both neurological and psychiatric disease

Primary Affiliation: Columbia University - New York, NY , United States

Specialties:

Additional Specialties:

Research Interests:


View Cristian Boboila’s Resume / CV

Education

Jul 2011
Harvard University
PhD
Molecular biology/ Immunology
May 2004
Yale University
BS
MCDB/ Econ

Experience

Sep 2011
Postdoctoral fellow

Richard Axel lab, Columbia University

Publications

16Publications

300Reads

-Profile Views

Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks.

Adv Immunol 2012 ;116:1-49

Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-394300-2.00001-6DOI Listing
January 2013
5 Reads
5.962 Impact Factor

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2473-8. Epub 2012 Jan 30.

Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Children's Hospital Boston and Department of Genetics, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1121470109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289296PMC
February 2012
17 Reads
9.809 Impact Factor

Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination.

J Exp Med 2011 Dec 5;208(13):2733-46. Epub 2011 Dec 5.

Program in Cellular and Molecular Medicine and Immune Disease Institute, Children's Hospital Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20111155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244039PMC
December 2011
25 Reads
12.515 Impact Factor

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.

Nature 2011 Jan 15;469(7329):250-4. Epub 2010 Dec 15.

Howard Hughes Medical Institute, The Children's Hospital, the Immune Disease Institute and the Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature09604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058373PMC
January 2011
14 Reads
42.351 Impact Factor

Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.

Proc Natl Acad Sci U S A 2010 Feb 1;107(7):3040-5. Epub 2010 Feb 1.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0915072107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840363PMC
February 2010
36 Reads
9.809 Impact Factor

Mre11: roles in DNA repair beyond homologous recombination.

Nat Struct Mol Biol 2009 Aug;16(8):798-800

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http://dx.doi.org/10.1038/nsmb0809-798DOI Listing
August 2009
31 Reads

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination.

J Exp Med 2008 Mar 3;205(3):557-64. Epub 2008 Mar 3.

Howard Hughes Medical Institute, the Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20080044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275379PMC
March 2008
1 Read
12.515 Impact Factor

IgH class switching and translocations use a robust non-classical end-joining pathway.

Nature 2007 Sep 22;449(7161):478-82. Epub 2007 Aug 22.

Howard Hughes Medical Institute, of Genetics, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature06020
Publisher Site
http://dx.doi.org/10.1038/nature06020DOI Listing
September 2007
14 Reads
42.351 Impact Factor

The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations.

J Immunol 2007 Aug;179(4):2270-81

Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.179.4.2270DOI Listing
August 2007
3 Reads
4.922 Impact Factor

Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes.

J Immunol 2007 Jul;179(1):195-200

Cancer Center, Massachusetts General Hospital, Harvard Medical Scool, 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.4049/jimmunol.179.1.195DOI Listing
July 2007
3 Reads
4.922 Impact Factor

Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations.

Mol Immunol 2006 Apr 26;43(10):1694-9. Epub 2005 Oct 26.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.

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http://www.jimmunol.org/content/171/4/1875.full.pdf
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S016158900500341
Publisher Site
http://dx.doi.org/10.1016/j.molimm.2005.09.009DOI Listing
April 2006
5 Reads
2.973 Impact Factor

Mutational analysis of terminal deoxynucleotidyltransferase-mediated N-nucleotide addition in V(D)J recombination.

J Immunol 2004 May;172(9):5478-88

Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.4049/jimmunol.172.9.5478DOI Listing
May 2004
1 Read
4.922 Impact Factor