Craig Sykes

Craig Sykes

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Craig Sykes

Craig Sykes

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Differential extracellular, but similar intracellular, disposition of two tenofovir formulations in the male genital tract.

Antivir Ther 2019 ;24(1):45-50

UNC School of Medicine, Department of Internal Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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https://www.intmedpress.com/journals/avt/abstract.cfm?id=327
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http://dx.doi.org/10.3851/IMP3277DOI Listing
March 2020

Translational Approach to Predicting the Efficacy of Maraviroc-Based Regimens as HIV Preexposure Prophylaxis.

Antimicrob Agents Chemother 2020 01 27;64(2). Epub 2020 Jan 27.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/AAC.01729-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985753PMC
January 2020

Population Modeling Highlights Drug Disposition Differences Between Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in the Blood and Semen.

Clin Pharmacol Ther 2019 Oct 31;106(4):821-830. Epub 2019 May 31.

University of North Carolina (UNC), UNC Eshelman School of Pharmacy, Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/cpt.1464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079728PMC
October 2019

Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

J Pharmacol Exp Ther 2019 09 24;370(3):360-368. Epub 2019 Jun 24.

Eshelman School of Pharmacy (E.B., J.K.F., N.W., A.P.S., C.S., P.C.S., A.D.M.K.) and School of Medicine (M.K., J.V.G., A.D.M.K.), University of North Carolina, Chapel Hill, North Carolina; School of Medicine, Colorado State University, Fort Collins, Colorado (L.R.-M., R.A.); and School of Medicine, University of California, Davis, California (L.A., P.L.)

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http://dx.doi.org/10.1124/jpet.119.259150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695867PMC
September 2019

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery.

Nat Commun 2019 09 20;10(1):4324. Epub 2019 Sep 20.

International Center for the Advancement of Translational Science, Division of Infectious Diseases, Center for Aids Research, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41467-019-12141-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754500PMC
September 2019

The Effect of Blood Loss on Cefazolin Levels in Women Undergoing Cesarean Delivery.

Am J Perinatol 2019 06 18;36(7):688-694. Epub 2018 Oct 18.

Division of Maternal-Fetal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673654
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http://dx.doi.org/10.1055/s-0038-1673654DOI Listing
June 2019

A Pharmacokinetic/Pharmacodynamic Model to Predict Effective HIV Prophylaxis Dosing Strategies for People Who Inject Drugs.

J Pharmacol Exp Ther 2018 11 27;367(2):245-251. Epub 2018 Aug 27.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (K.L.G., J.C., B.M.M., M.L.C., C.S., A.P.S., J.B.D.), and School of Medicine (H.A.P., N.W.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.251009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170970PMC
November 2018

Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair.

Anal Bioanal Chem 2018 Nov 2;410(29):7773-7781. Epub 2018 Oct 2.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 1099C Genetic Medicine Building, CB# 7361, 120 Mason Farm Road, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s00216-018-1394-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501839PMC
November 2018

Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Nat Commun 2018 10 8;9(1):4156. Epub 2018 Oct 8.

Division of Infectious Diseases, Center for AIDS Research, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, 120 Mason Farm Rd. CB 7042, Chapel Hill, NC 27599, USA.

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http://www.nature.com/articles/s41467-018-06490-w
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http://dx.doi.org/10.1038/s41467-018-06490-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175887PMC
October 2018

Validation of an LC-MS/MS assay to simultaneously monitor the intracellular active metabolites of tenofovir, emtricitabine, and lamivudine in dried blood spots.

J Pharm Biomed Anal 2018 Feb 31;149:40-45. Epub 2017 Oct 31.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC 27599, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085173217
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http://dx.doi.org/10.1016/j.jpba.2017.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741486PMC
February 2018

The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue.

AIDS 2018 Jan;32(1):11-15

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://Insights.ovid.com/crossref?an=00002030-201801020-0000
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http://dx.doi.org/10.1097/QAD.0000000000001678DOI Listing
January 2018

Multimodal analysis of drug transporter expression in gastrointestinal tissue.

AIDS 2017 07;31(12):1669-1678

aEshelman School of Pharmacy bSchool of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina cSchool of Medicine, Colorado State University, Fort Collins, Colorado dSchool of Medicine, University of California, Davis, California, USA.

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http://dx.doi.org/10.1097/QAD.0000000000001554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546623PMC
July 2017

Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues.

J Antimicrob Chemother 2017 06;72(6):1731-1740

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/jac/dkx064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536328PMC
June 2017

Cervicovaginal and Rectal Fluid as a Surrogate Marker of Antiretroviral Tissue Concentration: Implications for Clinical Trial Design.

J Acquir Immune Defic Syndr 2016 08;72(5):498-506

*Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC; †University of North Carolina at Chapel Hill School of Medicine, Division of Infectious Diseases, Chapel Hill, NC; and ‡University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Biostatistics, Chapel Hill, NC.

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http://dx.doi.org/10.1097/QAI.0000000000000996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942408PMC
August 2016

Saquinavir Loaded Acetalated Dextran Microconfetti - a Long Acting Protease Inhibitor Injectable.

Pharm Res 2016 08 6;33(8):1998-2009. Epub 2016 May 6.

Division of Molecular Pharmaceutics, Eshelman College of Pharmacy, University of North Carolina, 4211 Marsico Hall, 125 Mason Farm Road, Chapel Hill, North Carolina, 27599, USA.

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http://dx.doi.org/10.1007/s11095-016-1936-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776024PMC
August 2016

Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis.

Virology 2016 Feb 6;489:173-8. Epub 2016 Jan 6.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2015.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906038PMC
February 2016

Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation.

AIDS 2015 Aug;29(13):1597-606

aClinical Research Division, Fred Hutchinson Cancer Research Center bWashington National Primate Research Center, Seattle cVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington dDivision of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, North Carolina eDepartment of Microbiology fDepartment of Pediatrics gDepartment of Laboratory Medicine hDepartment of Medicine iDepartment of Pharmaceutics jDepartment of Pathology, University of Washington, Seattle, Washington, USA. *Christopher W. Peterson and Kevin G. Haworth contributed equally to the writing of this article.

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http://pdfs.journals.lww.com/aidsonline/2015/08240/Lack_of_v
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/QAD.0000000000000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572605PMC
August 2015

Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs.

Antimicrob Agents Chemother 2015 May 2;59(5):2944-8. Epub 2015 Mar 2.

W. M. Keck FTMS Laboratory for Human Health Research, Department of Chemistry, North Carolina State University, Raleigh, North Carolina, USA

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http://dx.doi.org/10.1128/AAC.04952-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394831PMC
May 2015

Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.

J Acquir Immune Defic Syndr 2015 Apr;68(4):420-4

*Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC; †Center for AIDS Research, University of North Carolina, Chapel Hill, NC; ‡Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC; §Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC; and ‖Health Sciences Center, University of Tennessee Health, Memphis, TN.

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http://dx.doi.org/10.1097/QAI.0000000000000480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334681PMC
April 2015

Models for predicting effective HIV chemoprevention in women.

J Acquir Immune Defic Syndr 2015 Apr;68(4):369-76

*Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC; †Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC; and ‡Departments of Medicine and §Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC (Melanie R. Nicol is now with the Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN).

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http://dx.doi.org/10.1097/QAI.0000000000000472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334725PMC
April 2015

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.

Anal Bioanal Chem 2015 Mar 16;407(8):2073-84. Epub 2014 Oct 16.

W.M. Keck Fourier Transform Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.

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http://dx.doi.org/10.1007/s00216-014-8220-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495968PMC
March 2015

Quantitative analysis of microbicide concentrations in fluids, gels and tissues using confocal Raman spectroscopy.

PLoS One 2013 30;8(12):e85124. Epub 2013 Dec 30.

Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America ; Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085124PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875564PMC
February 2015

Mapping antiretroviral drugs in tissue by IR-MALDESI MSI coupled to the Q Exactive and comparison with LC-MS/MS SRM assay.

J Am Soc Mass Spectrom 2014 Dec 18;25(12):2038-47. Epub 2014 Apr 18.

W. M. Keck FT Mass Spectrometry Laboratory, Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA.

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http://dx.doi.org/10.1007/s13361-014-0884-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201889PMC
December 2014

Single and multiple dose pharmacokinetics of dolutegravir in the genital tract of HIV-negative women.

Antivir Ther 2013 31;18(8):1005-13. Epub 2013 Jul 31.

University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, NC, USA.

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http://dx.doi.org/10.3851/IMP2665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038682PMC
October 2014

Targeted cytotoxic therapy kills persisting HIV infected cells during ART.

PLoS Pathog 2014 Jan 9;10(1):e1003872. Epub 2014 Jan 9.

Division of Infectious Diseases, Department of Medicine, UNC Center for AIDS Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887103PMC
January 2014

Thermal vaporization-vacuum ultraviolet laser ionization time-of-flight mass spectrometry of single aerosol particles.

Anal Chem 2002 May;74(9):2048-52

Department of Chemistry, University of North Carolina, Chapel Hill 27599-3290, USA.

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http://dx.doi.org/10.1021/ac011225aDOI Listing
May 2002