Craig R Lee

Craig R Lee

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Craig R Lee

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Frequency and clinical outcomes of CYP2C19 genotype-guided escalation and de-escalation of antiplatelet therapy in a real-world clinical setting.

Genet Med 2019 Jul 18. Epub 2019 Jul 18.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41436-019-0611-1DOI Listing
July 2019

A case for genotype-guided de-escalation of antiplatelet therapy after percutaneous coronary angioplasty.

Future Cardiol 2019 Jul 6;15(4):251-254. Epub 2019 Aug 6.

Division of Pharmacotherapy & Experimental Therapeutics, Eshelman School of Pharmacy & McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7569, USA.

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http://dx.doi.org/10.2217/fca-2019-0017DOI Listing
July 2019

Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model.

J Pharmacol Toxicol Methods 2019 Jul - Aug;98:106590. Epub 2019 May 31.

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.vascn.2019.106590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6701468PMC
May 2019

CYP2C19 Genotype-Guided Antiplatelet Therapy and 30-Day Outcomes After Percutaneous Coronary Intervention.

Circ Genom Precis Med 2019 Feb;12(2):e002441

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy (A.K.W., J.M., C.R.L.), School of Medicine, University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1161/CIRCGEN.119.002441DOI Listing
February 2019

Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome.

Prostaglandins Other Lipid Mediat 2018 09 7;138:15-22. Epub 2018 Aug 7.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2018.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162147PMC
September 2018

Clinical outcomes of CYP2C19 genotype-guided antiplatelet therapy: existing evidence and future directions.

Pharmacogenomics 2018 08 20;19(13):1039-1046. Epub 2018 Jul 20.

Division of Cardiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.2217/pgs-2018-0072DOI Listing
August 2018

Response by Lee and Stouffer to Letter Regarding Article, "Clinical Outcomes and Sustainability of Using Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention".

Circ Genom Precis Med 2018 07;11(7):e002258

Division of Cardiology, UNC School of Medicine (G.A.S.) University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1161/CIRCGEN.118.002258DOI Listing
July 2018

Projected impact of a multigene pharmacogenetic test to optimize medication prescribing in cardiovascular patients.

Pharmacogenomics 2018 06 25;19(9):771-782. Epub 2018 May 25.

Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2217/pgs-2018-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367721PMC
June 2018

Clinical Outcomes and Sustainability of Using Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.

Circ Genom Precis Med 2018 04;11(4):e002069

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy (C.R.L., A.C., K.H., M.J.P., J.A.L.), UNC Center for Pharmacogenomics and Individualized Therapy (C.R.L., K.E.W.), UNC McAllister Heart Institute (C.R.L., G.A.S.), Division of Cardiology, UNC School of Medicine (V.B.S., L.A.H., N.V., S.M., G.A.S.), Department of Pharmacy, UNC HealthCare Medical Center (M.C., J.D.C.), and Department of Pathology and Laboratory Medicine, UNC School of Medicine (K.E.W.), University of North Carolina at Chapel Hill.

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.117.002069
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http://dx.doi.org/10.1161/CIRCGEN.117.002069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889089PMC
April 2018

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention.

JACC Cardiovasc Interv 2018 01 1;11(2):181-191. Epub 2017 Nov 1.

Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida; Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jcin.2017.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775044PMC
January 2018

Urinary 11-dehydro-thromboxane B2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease.

Prostaglandins Other Lipid Mediat 2018 01 16;134:24-31. Epub 2017 Nov 16.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803431PMC
January 2018

Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.

Am J Pathol 2017 Dec 16;187(12):2895-2911. Epub 2017 Nov 16.

McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718092PMC
December 2017

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact.

Clin Transl Sci 2017 11 10;10(6):443-454. Epub 2017 Aug 10.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1111/cts.12490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698804PMC
November 2017

CYP2C19-guided antiplatelet therapy: a cost-effectiveness analysis of 30-day and 1-year outcomes following percutaneous coronary intervention.

Pharmacogenomics 2017 Aug 26;18(12):1155-1166. Epub 2017 Jul 26.

Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs-2017-0075
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http://dx.doi.org/10.2217/pgs-2017-0075DOI Listing
August 2017

Oral Anticoagulant Use After Bariatric Surgery: A Literature Review and Clinical Guidance.

Am J Med 2017 May 1;130(5):517-524. Epub 2017 Feb 1.

Division of Hematology/Oncology, University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1016/j.amjmed.2016.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401640PMC
May 2017

Implementation of inpatient models of pharmacogenetics programs.

Am J Health Syst Pharm 2016 Dec;73(23):1944-1954

Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL.

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http://dx.doi.org/10.2146/ajhp150946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359627PMC
December 2016

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.

Prostaglandins Other Lipid Mediat 2016 09 9;125:19-29. Epub 2016 Jul 9.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035202PMC
September 2016

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.

Exp Neurol 2016 May 20;279:75-85. Epub 2016 Feb 20.

Department of Anesthesiology & Perioperative Medicine, The Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834246PMC
May 2016

Implementation and evaluation of a CYP2C19 genotype-guided antiplatelet therapy algorithm in high-risk coronary artery disease patients.

Pharmacogenomics 2015 ;16(4):303-13

Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.2217/pgs.14.180DOI Listing
January 2016

Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study.

J Lipid Res 2016 Jan 10;57(1):109-19. Epub 2015 Nov 10.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

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http://dx.doi.org/10.1194/jlr.M061697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689337PMC
January 2016

Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer.

Nanomedicine 2015 Oct 17;11(7):1797-807. Epub 2015 Jun 17.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2015.05.007DOI Listing
October 2015

Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis.

Prostaglandins Other Lipid Mediat 2015 Jul 20;120:139-47. Epub 2015 Apr 20.

Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA; Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575626PMC
July 2015

Epoxyeicosatrienoic acids and cardioprotection: the road to translation.

J Mol Cell Cardiol 2014 Sep 2;74:199-208. Epub 2014 Jun 2.

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115045PMC
September 2014

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

FASEB J 2014 Jul 25;28(7):2915-31. Epub 2014 Mar 25.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA;

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http://dx.doi.org/10.1096/fj.13-241927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062824PMC
July 2014

A renaissance in pharmacy education at the University of North Carolina at Chapel Hill.

N C Med J 2014 Jan-Feb;75(1):48-52

UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://classic.ncmedicaljournal.com/wp-content/uploads/2014/
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April 2014

Highlights from recent advances in antiplatelet pharmacogenomics.

Per Med 2014 Mar;11(2):135-138

Division of Pharmacotherapy & Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.2217/pme.13.112DOI Listing
March 2014

Dual modulation of cyclooxygenase and CYP epoxygenase metabolism and acute vascular inflammation in mice.

Prostaglandins Other Lipid Mediat 2013 Jul-Aug;104-105:67-73. Epub 2012 Sep 19.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.prostaglandins.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549041PMC
January 2014

Role of endothelial soluble epoxide hydrolase in cerebrovascular function and ischemic injury.

PLoS One 2013 9;8(4):e61244. Epub 2013 Apr 9.

Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061244PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621731PMC
October 2013

Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.

Prostaglandins Other Lipid Mediat 2012 Dec 2;99(3-4):68-78. Epub 2012 Oct 2.

Department of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

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http://linkinghub.elsevier.com/retrieve/pii/S109888231200121
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http://dx.doi.org/10.1016/j.prostaglandins.2012.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520445PMC
December 2012

Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans.

Pharmacogenet Genomics 2012 Aug;22(8):620-8

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32835516e5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599320PMC
August 2012

Research Highlights: Highlights from the latest articles in personalized cardiovascular medicine.

Per Med 2012 Jun;9(4):363-366

Institute for Pharmacogenomics & Individualized Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.2217/pme.12.45DOI Listing
June 2012

Relation between digital peripheral arterial tonometry and brachial artery ultrasound measures of vascular function in patients with coronary artery disease and in healthy volunteers.

Am J Cardiol 2012 Mar 6;109(5):651-7. Epub 2011 Dec 6.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.

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http://dx.doi.org/10.1016/j.amjcard.2011.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288302PMC
March 2012

Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism.

Am J Physiol Endocrinol Metab 2012 Mar 20;302(5):E500-9. Epub 2011 Dec 20.

Div. of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, Univ. of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1152/ajpendo.00370.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311291PMC
March 2012

Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.

FASEB J 2011 Oct 22;25(10):3436-47. Epub 2011 Jun 22.

Division of Intramural Research, National Institute for Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1096/fj.11-188300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177568PMC
October 2011

Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism.

Drug Metab Dispos 2011 Jan 14;39(1):22-9. Epub 2010 Oct 14.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1124/dmd.110.035287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014271PMC
January 2011

Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with forearm vasodilator responses in humans.

Hypertension 2011 Jan 22;57(1):116-22. Epub 2010 Nov 22.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599-7569, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.161695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020911PMC
January 2011

Cytochrome P450 epoxygenases, soluble epoxide hydrolase, and the regulation of cardiovascular inflammation.

J Mol Cell Cardiol 2010 Feb 3;48(2):331-41. Epub 2009 Nov 3.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599-7569, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2009.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813356PMC
February 2010

The impact of ezetimibe on endothelial function and other markers of cardiovascular risk.

Ann Pharmacother 2009 Dec 17;43(12):2021-30. Epub 2009 Nov 17.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1345/aph.1M302DOI Listing
December 2009

Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendations.

Pharmacogenomics 2009 Nov;10(11):1799-817

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, CB# 7569, Kerr Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-27569, USA.

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http://dx.doi.org/10.2217/pgs.09.143DOI Listing
November 2009

High-impact articles related to the management of heart failure: 2008 update.

Pharmacotherapy 2009 Jan;29(1):82-120

Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.

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http://dx.doi.org/10.1592/phco.29.1.82DOI Listing
January 2009

Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk.

Pharmacogenomics 2007 Oct;8(10):1369-83

University of North Carolina at Chapel Hill, Division of Pharmacotherapy and Experimental Therapeutics, CB# 7360, Kerr Hall, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.2217/14622416.8.10.1369DOI Listing
October 2007

Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways.

Am J Physiol Heart Circ Physiol 2007 Jul 23;293(1):H142-51. Epub 2007 Feb 23.

Institite of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, #1095 Jie Fang Da Dao Avenue, Wuhan 430030, People's Republic of China.

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http://dx.doi.org/10.1152/ajpheart.00783.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100428PMC
July 2007

CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study.

Pharmacogenet Genomics 2007 May;17(5):349-58

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32809913eaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1947003PMC
May 2007

Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).

Pharmacogenet Genomics 2007 Feb;17(2):145-60

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1097/01.fpc.0000236340.87540.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2041861PMC
February 2007

Warfarin dosing and the promise of pharmacogenomics.

Curr Clin Pharmacol 2007 Jan;2(1):11-21

Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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January 2007

NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities study.

Pharmacogenet Genomics 2006 Dec;16(12):891-9

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27709, USA.

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http://dx.doi.org/10.1097/01.fpc.0000236324.96056.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978174PMC
December 2006

Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study.

Hum Mol Genet 2006 May 4;15(10):1640-9. Epub 2006 Apr 4.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health Research, Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/hmg/ddl085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040335PMC
May 2006

The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.

Hum Mol Genet 2005 Oct 22;14(19):2829-37. Epub 2005 Aug 22.

Institute of Molecular Medicne for the prevention of Human Diseases, University of Texas Health Science Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/hmg/ddi315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1343524PMC
October 2005

Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis.

J Am Coll Cardiol 2005 Aug;46(3):497-504

Department of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27517, USA.

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http://dx.doi.org/10.1016/j.jacc.2005.02.091DOI Listing
August 2005

Twenty-four hour tolbutamide plasma concentration as a phenotypic measure of CYP2C9 activity.

Eur J Clin Pharmacol 2005 Jun 4;61(4):315-6. Epub 2005 May 4.

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http://dx.doi.org/10.1007/s00228-005-0922-9DOI Listing
June 2005

Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy.

Pharmacogenet Genomics 2005 Apr;15(4):227-34

Department of Pharmacy Practice, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.

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April 2005

High-impact articles related to the pharmacotherapeutic management of systolic heart failure.

Pharmacotherapy 2004 Nov;24(11):1594-633

School of Pharmacy, University of Southern California, Los Angeles, California, 90033, USA.

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http://dx.doi.org/10.1592/phco.24.16.1594.50942DOI Listing
November 2004

Vasopressin: a new target for the treatment of heart failure.

Am Heart J 2003 Jul;146(1):9-18

School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7075, USA.

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http://dx.doi.org/10.1016/S0002-8703(02)94708-3DOI Listing
July 2003

Losartan and E3174 pharmacokinetics in cytochrome P450 2C9*1/*1, *1/*2, and *1/*3 individuals.

Pharmacotherapy 2003 Jun;23(6):720-5

Division of Pharmacotherapy, University of North Carolina at Chapel Hill, 27599-7360, USA.

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http://dx.doi.org/10.1592/phco.23.6.720.32187DOI Listing
June 2003

Differences in flurbiprofen pharmacokinetics between CYP2C9*1/*1, *1/*2, and *1/*3 genotypes.

Eur J Clin Pharmacol 2003 Apr 26;58(12):791-4. Epub 2003 Feb 26.

Division of Pharmacotherapy, University of North Carolina at Chapel Hill, NC 27599-7360, Chapel Hill, USA.

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http://dx.doi.org/10.1007/s00228-003-0574-6DOI Listing
April 2003

Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans.

J Clin Pharmacol 2003 Jan;43(1):84-91

Divisions of Pharmacotherapy, CB# 7360, Beard Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.

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http://dx.doi.org/10.1177/0091270002239710DOI Listing
January 2003

Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes.

Clin Pharmacol Ther 2002 Nov;72(5):562-71

Divisions of Pharmacotherapy and Cardiology, University of North Carolina at Chapel Hill, USA.

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http://dx.doi.org/10.1067/mcp.2002.127913DOI Listing
November 2002

Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.

Pharmacogenetics 2002 Apr;12(3):251-63

Division of Pharmacotherapy, University of North Carolina at Chapel Hill, 27599-7360, USA.

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April 2002

Surrogate end points in heart failure.

Ann Pharmacother 2002 Mar;36(3):479-88

School of Pharmacy, Division of Pharmacotherapy, University of North Carolina at Chapel Hill, 27599-7360, USA.

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http://dx.doi.org/10.1345/aph.1A177DOI Listing
March 2002