Publications by authors named "Craig Mickanin"

20Publications

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Cell 2017 Jul;170(3):577-592.e10

Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002, Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.

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http://dx.doi.org/10.1016/j.cell.2017.07.005DOI Listing
July 2017

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.

Genes Dev 2017 05 25;31(9):904-915. Epub 2017 May 25.

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.300053.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458757PMC
May 2017

TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasis.

Mol Cell 2013 Sep 22;51(5):559-72. Epub 2013 Aug 22.

Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands; Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.

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http://dx.doi.org/10.1016/j.molcel.2013.07.014DOI Listing
September 2013

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.

Nat Cell Biol 2012 Jun 17;14(7):717-26. Epub 2012 Jun 17.

Department of Molecular Cell Biology, Leiden University Medical Center, Postbus 9600 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ncb2522DOI Listing
June 2012

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.

Nature 2012 Apr 29;485(7397):195-200. Epub 2012 Apr 29.

Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature11019DOI Listing
April 2012

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.

Nat Cell Biol 2011 May 10;13(5):623-9. Epub 2011 Apr 10.

Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncb2222DOI Listing
May 2011

Design of a genome-wide siRNA library using an artificial neural network.

Nat Biotechnol 2005 Aug 17;23(8):995-1001. Epub 2005 Jul 17.

Novartis Institutes for BioMedical Research, Genome and Proteome Sciences, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1038/nbt1118DOI Listing
August 2005