Publications by authors named "Craig J Thomas"

96Publications

Increased demand for NAD relative to ATP drives aerobic glycolysis.

Mol Cell 2020 Dec 22. Epub 2020 Dec 22.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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December 2020

Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway.

Cell Metab 2020 Nov;32(5):736-750.e5

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. Electronic address:

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November 2020

Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia.

Transl Oncol 2021 Jan 22;14(1):100913. Epub 2020 Oct 22.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC 1374, Bethesda, MD 20892, USA. Electronic address:

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January 2021

JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis.

Front Immunol 2019 19;10:2972. Epub 2019 Dec 19.

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States.

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November 2020

Targeting of Fumarate Hydratase from Using Allosteric Inhibitors with a Dimeric-Binding Mode.

J Med Chem 2019 12 27;62(23):10586-10604. Epub 2019 Sep 27.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.

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December 2019

()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions.

Proc Natl Acad Sci U S A 2019 03 13;116(13):6441-6450. Epub 2019 Mar 13.

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201;

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March 2019

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ()-hydroxynorketamine.

J Psychopharmacol 2019 01 29;33(1):12-24. Epub 2018 Nov 29.

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.

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January 2019

Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.

J Am Chem Soc 2018 10 4;140(42):13542-13545. Epub 2018 Oct 4.

Department of Microbiology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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October 2018

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.

Cell Metab 2018 11 16;28(5):706-720.e6. Epub 2018 Aug 16.

Institute of Biochemistry, Graz University of Technology, Humboldtstrasse 46/III, 8010 Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

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November 2018

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.

Psychopharmacology (Berl) 2018 Oct 16;235(10):3017-3030. Epub 2018 Aug 16.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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October 2018

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Pharmacol Rev 2018 07;70(3):621-660

Departments of Psychiatry (P.Z., L.M.R., J.N.H., P.G., T.D.G.), Pharmacology (E.F.R.P., E.X.A., T.D.G.), Anatomy and Neurobiology (T.D.G.), Epidemiology and Public Health, Division of Translational Toxicology (E.F.R.P., E.X.A.), Medicine (E.X.A.), and Program in Neuroscience (L.M.R.) and Toxicology (J.N.H.), University of Maryland School of Medicine, Baltimore, Maryland; Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland (R.M.); Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Rockville, Maryland (P.J.M., C.J.T.); and Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)

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July 2018

Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites.

Org Lett 2017 09 22;19(17):4572-4575. Epub 2017 Aug 22.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health , Rockville, Maryland 20850, United States.

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September 2017

Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3'-Kinase.

Biochemistry 2017 08 8;56(33):4335-4345. Epub 2017 Aug 8.

Department of Chemistry and Department of Biochemistry & Cellular & Molecular Biology, Georgetown University , 37th and O Streets NW, Washington, D.C. 20057, United States.

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August 2017

Large-scale pharmacological profiling of 3D tumor models of cancer cells.

Cell Death Dis 2016 12 1;7(12):e2492. Epub 2016 Dec 1.

National Center for Advancing Translational Sciences, Division of Pre-Clinical Innovation, National Institutes of Health, Bethesda, MD, USA.

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December 2016

Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.

Biol Psychiatry 2017 04 30;81(8):e69-e71. Epub 2016 Sep 30.

Department of Psychiatry, National Institute on Aging, National Institutes of Health, Baltimore; Department of Division of Translational Toxicology, Pharmacology, National Institute on Aging, National Institutes of Health, Baltimore; Department of Anatomy and Neurobiology, National Institute on Aging, National Institutes of Health, Baltimore. Electronic address:

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April 2017

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Cell Metab 2016 11 13;24(5):716-727. Epub 2016 Oct 13.

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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November 2016

Drug resistant integrase mutants cause aberrant HIV integrations.

Retrovirology 2016 Sep 29;13(1):71. Epub 2016 Sep 29.

HIV Dynamics and Replication Program, Vector Design and Replication Section, National Cancer Institute-Frederick, 1050 Boyles Street, Bldg. 539, Room 130A, Frederick, MD, 21702, USA.

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September 2016

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins.

PLoS One 2016 24;11(8):e0161415. Epub 2016 Aug 24.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America.

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July 2017

Cancer network activity associated with therapeutic response and synergism.

Genome Med 2016 08 24;8(1):88. Epub 2016 Aug 24.

Breast Cancer and Systems Biology Lab, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), Gran via 199, L'Hospitalet del Llobregat, Barcelona, 08908, Catalonia, Spain.

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August 2016

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Proc Natl Acad Sci U S A 2016 08 1;113(34):9587-92. Epub 2016 Aug 1.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202

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August 2016

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.

Proc Natl Acad Sci U S A 2016 07 20;113(27):7503-8. Epub 2016 Jun 20.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20850;

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July 2016

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers.

Sci Rep 2016 05 5;6:25379. Epub 2016 May 5.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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May 2016

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model.

J Neurosci 2016 04;36(17):4859-75

Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045, University of Colorado, School of Medicine, Department of Cell and Developmental Biology, Aurora, Colorado 80045

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April 2016

Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens.

J Biomol Screen 2016 Oct 25;21(9):942-55. Epub 2016 Apr 25.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA

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October 2016

Structure Property Relationships of Carboxylic Acid Isosteres.

J Med Chem 2016 Apr 30;59(7):3183-203. Epub 2016 Mar 30.

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

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April 2016

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.

Retrovirology 2016 Feb 16;13:11. Epub 2016 Feb 16.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD, USA.

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February 2016

Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin's lymphoma.

Proc Natl Acad Sci U S A 2016 Feb 25;113(6):1624-9. Epub 2016 Jan 25.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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February 2016

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.

Proc Natl Acad Sci U S A 2015 Oct 22;112(40):12480-5. Epub 2015 Sep 22.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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October 2015

A small molecule that inhibits OGT activity in cells.

ACS Chem Biol 2015 Jun 18;10(6):1392-7. Epub 2015 Mar 18.

†Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States.

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June 2015

Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway.

Arterioscler Thromb Vasc Biol 2015 Apr 19;35(4):804-16. Epub 2015 Feb 19.

From the Centers for Metabolic Disease Research, Cardiovascular Research, Thrombosis Research (Y.Y., X.L., X.S., H.X., Y.-F.L., Y.S., J.M., A.V., J.L.-P., S.M., M.A.M., E.T.C., X.J., H.W., X.-F.Y.), Center for Translational Medicine (D.G.T.), Department of Pharmacology (Y.Y., X.L., X.S., H.X., Y.-F.L, Y.S., J.M., A.V., J.L.-P., S.M., D.G.T., X.J., H.W., X.-F.Y.), and Department of Surgery (M.A.M., E.T.C.), Temple University School of Medicine, Philadelphia, PA; and NIH Chemical Genomics Center, Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD (C.J.T.).

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April 2015

Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.

Antimicrob Agents Chemother 2015 Feb 1;59(2):1070-9. Epub 2014 Dec 1.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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February 2015

RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction.

Arterioscler Thromb Vasc Biol 2014 Oct 21;34(10):2321-9. Epub 2014 Aug 21.

From the Allen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY (J.L., S.V., B.S.C.); Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY (Y.S., A.N., M.F.); NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD (J.-k.J., C.J.T.); Ekam Imaging, Boston, MA (M.N.); and Departments of Pediatrics and Pathology, Columbia University Medical Center, New York, NY (T.G.D.).

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October 2014

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2349-54. Epub 2014 Jan 27.

Division of Preclinical Innovation, National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Metabolism Branch, Center for Cancer Research, and Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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February 2014

A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.

Bioorg Med Chem Lett 2014 Feb 8;24(4):1148-53. Epub 2014 Jan 8.

NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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February 2014

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.

Bioorg Med Chem Lett 2014 Jan 4;24(2):630-5. Epub 2013 Dec 4.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States. Electronic address:

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January 2014

Playing well with others! Initiating and sustaining successful collaborations between industry, academia and government.

Curr Top Med Chem 2014 ;14(3):291-3

Division of Preclinical Innovation NCATS National Institutes of Health Bethesda, MD 20892 USA.

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October 2014

CD28 and ITK signals regulate autoreactive T cell trafficking.

Nat Med 2013 Dec 24;19(12):1632-7. Epub 2013 Nov 24.

Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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December 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.

Bioorg Med Chem Lett 2013 Aug 29;23(15):4398-403. Epub 2013 May 29.

Basic Science Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States.

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August 2013

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Bioorg Med Chem Lett 2013 Feb 10;23(3):682-6. Epub 2012 Dec 10.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

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February 2013

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Medchemcomm 2012 Dec;3(12):1505-1511

Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, 21218, USA ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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December 2012

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.

Proc Natl Acad Sci U S A 2012 Oct 24;109(41):E2794-802. Epub 2012 Sep 24.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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October 2012

A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.

J Biomol Screen 2012 Oct 27;17(9):1231-42. Epub 2012 Aug 27.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD 20850, USA.

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October 2012