Craig J Thomas

Craig J Thomas

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Craig J Thomas

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Targeting of Fumarate Hydratase from Using Allosteric Inhibitors with a Dimeric-Binding Mode.

J Med Chem 2019 Dec 27;62(23):10586-10604. Epub 2019 Sep 27.

Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01203DOI Listing
December 2019

JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis.

Front Immunol 2019 19;10:2972. Epub 2019 Dec 19.

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States.

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http://dx.doi.org/10.3389/fimmu.2019.02972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930870PMC
December 2019

()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions.

Proc Natl Acad Sci U S A 2019 03 13;116(13):6441-6450. Epub 2019 Mar 13.

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201;

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http://dx.doi.org/10.1073/pnas.1819540116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442605PMC
March 2019

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.

Cell Metab 2018 11 16;28(5):706-720.e6. Epub 2018 Aug 16.

Institute of Biochemistry, Graz University of Technology, Humboldtstrasse 46/III, 8010 Graz, Austria; BioTechMed-Graz, Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390946PMC
November 2018

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R)-hydroxynorketamine.

J Psychopharmacol 2018 Nov 29:269881118812095. Epub 2018 Nov 29.

1 Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/0269881118812095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541551PMC
November 2018

Plasma metabolomic profiling of a ketamine and placebo crossover trial of major depressive disorder and healthy control subjects.

Psychopharmacology (Berl) 2018 Oct 16;235(10):3017-3030. Epub 2018 Aug 16.

Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00213-018-4992-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193489PMC
October 2018

Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Pharmacol Rev 2018 07;70(3):621-660

Departments of Psychiatry (P.Z., L.M.R., J.N.H., P.G., T.D.G.), Pharmacology (E.F.R.P., E.X.A., T.D.G.), Anatomy and Neurobiology (T.D.G.), Epidemiology and Public Health, Division of Translational Toxicology (E.F.R.P., E.X.A.), Medicine (E.X.A.), and Program in Neuroscience (L.M.R.) and Toxicology (J.N.H.), University of Maryland School of Medicine, Baltimore, Maryland; Biomedical Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland (R.M.); Division of Preclinical Innovation, National Center for Advancing Translational Sciences, Intramural Research Program, National Institutes of Health, Rockville, Maryland (P.J.M., C.J.T.); and Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland (C.A.Z.)

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http://dx.doi.org/10.1124/pr.117.015198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020109PMC
July 2018

Synthesis and N-Methyl-d-aspartate (NMDA) Receptor Activity of Ketamine Metabolites.

Org Lett 2017 09 22;19(17):4572-4575. Epub 2017 Aug 22.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health , Rockville, Maryland 20850, United States.

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http://dx.doi.org/10.1021/acs.orglett.7b02177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641405PMC
September 2017

Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3'-Kinase.

Biochemistry 2017 08 8;56(33):4335-4345. Epub 2017 Aug 8.

Department of Chemistry and Department of Biochemistry & Cellular & Molecular Biology, Georgetown University , 37th and O Streets NW, Washington, D.C. 20057, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00416DOI Listing
August 2017

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins.

PLoS One 2016 24;11(8):e0161415. Epub 2016 Aug 24.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996465PMC
July 2017

Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.

Biol Psychiatry 2017 04 30;81(8):e69-e71. Epub 2016 Sep 30.

Department of Psychiatry, National Institute on Aging, National Institutes of Health, Baltimore; Department of Division of Translational Toxicology, Pharmacology, National Institute on Aging, National Institutes of Health, Baltimore; Department of Anatomy and Neurobiology, National Institute on Aging, National Institutes of Health, Baltimore. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.08.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359040PMC
April 2017

Large-scale pharmacological profiling of 3D tumor models of cancer cells.

Cell Death Dis 2016 12 1;7(12):e2492. Epub 2016 Dec 1.

National Center for Advancing Translational Sciences, Division of Pre-Clinical Innovation, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/cddis.2016.360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261027PMC
December 2016

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Cell Metab 2016 11 13;24(5):716-727. Epub 2016 Oct 13.

The Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102768PMC
November 2016

Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens.

J Biomol Screen 2016 Oct 25;21(9):942-55. Epub 2016 Apr 25.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA

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http://dx.doi.org/10.1177/1087057116644890DOI Listing
October 2016

Drug resistant integrase mutants cause aberrant HIV integrations.

Retrovirology 2016 Sep 29;13(1):71. Epub 2016 Sep 29.

HIV Dynamics and Replication Program, Vector Design and Replication Section, National Cancer Institute-Frederick, 1050 Boyles Street, Bldg. 539, Room 130A, Frederick, MD, 21702, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041404PMC
http://dx.doi.org/10.1186/s12977-016-0305-6DOI Listing
September 2016

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.

Proc Natl Acad Sci U S A 2016 08 1;113(34):9587-92. Epub 2016 Aug 1.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202

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http://dx.doi.org/10.1073/pnas.1610099113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003239PMC
August 2016

Cancer network activity associated with therapeutic response and synergism.

Genome Med 2016 08 24;8(1):88. Epub 2016 Aug 24.

Breast Cancer and Systems Biology Lab, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), Gran via 199, L'Hospitalet del Llobregat, Barcelona, 08908, Catalonia, Spain.

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http://dx.doi.org/10.1186/s13073-016-0340-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995628PMC
August 2016

Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.

Proc Natl Acad Sci U S A 2016 07 20;113(27):7503-8. Epub 2016 Jun 20.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20850;

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http://dx.doi.org/10.1073/pnas.1600630113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941444PMC
July 2016

PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers.

Sci Rep 2016 05 5;6:25379. Epub 2016 May 5.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/srep25379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857081PMC
May 2016

Structure Property Relationships of Carboxylic Acid Isosteres.

J Med Chem 2016 Apr 30;59(7):3183-203. Epub 2016 Mar 30.

Department of Chemistry, School of Arts and Sciences, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833640PMC
April 2016

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model.

J Neurosci 2016 04;36(17):4859-75

Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045, University of Colorado, School of Medicine, Department of Cell and Developmental Biology, Aurora, Colorado 80045

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.4632-15.2
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http://dx.doi.org/10.1523/JNEUROSCI.4632-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846677PMC
April 2016

Augmented efficacy of brentuximab vedotin combined with ruxolitinib and/or Navitoclax in a murine model of human Hodgkin's lymphoma.

Proc Natl Acad Sci U S A 2016 Feb 25;113(6):1624-9. Epub 2016 Jan 25.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1524668113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760778PMC
February 2016

Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.

Retrovirology 2016 Feb 16;13:11. Epub 2016 Feb 16.

HIV Drug Resistance Program, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD, USA.

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http://dx.doi.org/10.1186/s12977-016-0244-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754833PMC
February 2016

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia.

Proc Natl Acad Sci U S A 2015 Oct 22;112(40):12480-5. Epub 2015 Sep 22.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1516208112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603455PMC
October 2015

A small molecule that inhibits OGT activity in cells.

ACS Chem Biol 2015 Jun 18;10(6):1392-7. Epub 2015 Mar 18.

†Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1021/acschembio.5b00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475500PMC
June 2015

Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway.

Arterioscler Thromb Vasc Biol 2015 Apr 19;35(4):804-16. Epub 2015 Feb 19.

From the Centers for Metabolic Disease Research, Cardiovascular Research, Thrombosis Research (Y.Y., X.L., X.S., H.X., Y.-F.L., Y.S., J.M., A.V., J.L.-P., S.M., M.A.M., E.T.C., X.J., H.W., X.-F.Y.), Center for Translational Medicine (D.G.T.), Department of Pharmacology (Y.Y., X.L., X.S., H.X., Y.-F.L, Y.S., J.M., A.V., J.L.-P., S.M., D.G.T., X.J., H.W., X.-F.Y.), and Department of Surgery (M.A.M., E.T.C.), Temple University School of Medicine, Philadelphia, PA; and NIH Chemical Genomics Center, Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD (C.J.T.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376583PMC
April 2015

Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.

Antimicrob Agents Chemother 2015 Feb 1;59(2):1070-9. Epub 2014 Dec 1.

Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, USA

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http://aac.asm.org/content/59/2/1070.full.pdf
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http://aac.asm.org/content/early/2014/11/25/AAC.04617-14.ful
Web Search
http://aac.asm.org/lookup/doi/10.1128/AAC.04617-14
Publisher Site
http://dx.doi.org/10.1128/AAC.04617-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335860PMC
February 2015

Playing well with others! Initiating and sustaining successful collaborations between industry, academia and government.

Curr Top Med Chem 2014 ;14(3):291-3

Division of Preclinical Innovation NCATS National Institutes of Health Bethesda, MD 20892 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337773PMC
http://dx.doi.org/10.2174/1568026613666131127125351DOI Listing
October 2014

RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction.

Arterioscler Thromb Vasc Biol 2014 Oct 21;34(10):2321-9. Epub 2014 Aug 21.

From the Allen and Frances Adler Laboratory of Blood and Vascular Biology, Rockefeller University, New York, NY (J.L., S.V., B.S.C.); Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY (Y.S., A.N., M.F.); NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD (J.-k.J., C.J.T.); Ekam Imaging, Boston, MA (M.N.); and Departments of Pediatrics and Pathology, Columbia University Medical Center, New York, NY (T.G.D.).

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http://dx.doi.org/10.1161/ATVBAHA.114.303724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180209PMC
October 2014

A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.

Bioorg Med Chem Lett 2014 Feb 8;24(4):1148-53. Epub 2014 Jan 8.

NIH Chemical Genomics Center, Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.12.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951875PMC
February 2014

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2349-54. Epub 2014 Jan 27.

Division of Preclinical Innovation, National Institutes of Health Chemical Genomics Center, National Center for Advancing Translational Sciences, Metabolism Branch, Center for Cancer Research, and Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1311846111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926026PMC
February 2014

Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.

Bioorg Med Chem Lett 2014 Jan 4;24(2):630-5. Epub 2013 Dec 4.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X130137
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http://dx.doi.org/10.1016/j.bmcl.2013.11.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970110PMC
January 2014

CD28 and ITK signals regulate autoreactive T cell trafficking.

Nat Med 2013 Dec 24;19(12):1632-7. Epub 2013 Nov 24.

Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://www.nature.com/articles/nm.3393
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http://dx.doi.org/10.1038/nm.3393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005518PMC
December 2013

Identification of potent Yes1 kinase inhibitors using a library screening approach.

Bioorg Med Chem Lett 2013 Aug 29;23(15):4398-403. Epub 2013 May 29.

Basic Science Program, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, United States.

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http://dx.doi.org/10.1016/j.bmcl.2013.05.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769177PMC
August 2013

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Bioorg Med Chem Lett 2013 Feb 10;23(3):682-6. Epub 2012 Dec 10.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547291PMC
February 2013

A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().

Medchemcomm 2012 Dec;3(12):1505-1511

Department of Chemistry, Zanvyl Krieger School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland, 21218, USA ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, 20892, USA.

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http://dx.doi.org/10.1039/C2MD20238GDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509744PMC
December 2012

A 1536-well quantitative high-throughput screen to identify compounds targeting cancer stem cells.

J Biomol Screen 2012 Oct 27;17(9):1231-42. Epub 2012 Aug 27.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1177/1087057112458152DOI Listing
October 2012

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.

Proc Natl Acad Sci U S A 2012 Oct 24;109(41):E2794-802. Epub 2012 Sep 24.

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1073/pnas.1205742109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478592PMC
October 2012

Selecting, Acquiring, and Using Small Molecule Libraries for High-Throughput Screening.

Curr Protoc Chem Biol 2012;4:177-191. Epub 2012 Sep 1.

NIH Chemical Genomics Center, National Human Genome Research Institute, 9800 Medical Center Drive, MSC 3370 Bethesda, MD 20892-3370 USA.

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http://dx.doi.org/10.1002/9780470559277.ch110252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687755PMC
September 2012

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Bioorg Med Chem Lett 2011 Nov 14;21(21):6322-7. Epub 2011 Sep 14.

NIH Chemical Genomics Center, NIH Center for Translational Therapeutics, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.08.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224553PMC
November 2011

Exploratory analysis of kinetic solubility measurements of a small molecule library.

Bioorg Med Chem 2011 Jul 13;19(13):4127-34. Epub 2011 May 13.

NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, Bethesda, MD 20892-3370, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896110035
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http://dx.doi.org/10.1016/j.bmc.2011.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236531PMC
July 2011

Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction.

Tetrahedron Lett 2010 Dec;51(52):6852-6855

NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00404039100189
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http://dx.doi.org/10.1016/j.tetlet.2010.10.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079232PMC
December 2010