Craig Behnke

Craig Behnke

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Craig Behnke

Craig Behnke

Publications by authors named "Craig Behnke"

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Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.

Bioorg Med Chem 2018 07 27;26(12):3261-3286. Epub 2018 Apr 27.

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173208
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http://dx.doi.org/10.1016/j.bmc.2018.04.051DOI Listing
July 2018

Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.

Bioorg Med Chem 2016 11 13;24(22):5771-5780. Epub 2016 Sep 13.

Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraoka-Higashi, 2-Chome, Fujisawa, Kanagawa 251-8555, Japan.

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http://dx.doi.org/10.1016/j.bmc.2016.09.030DOI Listing
November 2016

Novel approach of fragment-based lead discovery applied to renin inhibitors.

Bioorg Med Chem 2016 11 28;24(22):6066-6074. Epub 2016 Sep 28.

Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, 2-26-1, Muraoka-higashi, Fujisawa, Kanagawa 251-8555, Japan.

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http://dx.doi.org/10.1016/j.bmc.2016.09.065DOI Listing
November 2016

Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor.

ACS Med Chem Lett 2016 Oct 12;7(10):933-938. Epub 2016 Sep 12.

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited , 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066151PMC
October 2016

The structure of rice weevil pectin methylesterase.

Acta Crystallogr F Struct Biol Commun 2014 Nov 25;70(Pt 11):1480-4. Epub 2014 Oct 25.

Department of Biochemistry, University of Washington, Box 357430, Seattle, WA 98195-7430, USA.

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http://dx.doi.org/10.1107/S2053230X14020433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231848PMC
November 2014

Host cell pigmentation in Scenedesmus dimorphus as a beacon for nascent parasite infection.

Biotechnol Bioeng 2014 Sep 13;111(9):1748-57. Epub 2014 Jun 13.

Bioenergy and Defense Technologies Department, Sandia National Laboratories, Albuquerque, New Mexico, 87185.

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http://dx.doi.org/10.1002/bit.25235DOI Listing
September 2014

Evolution of acyl-ACP-thioesterases and β-ketoacyl-ACP-synthases revealed by protein-protein interactions.

J Appl Phycol 2014 Aug;26(4):1619-1629

Department of Chemistry and Biochemistry, University of California-San Diego, La Jolla, CA 92093-0358, USA.

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http://dx.doi.org/10.1007/s10811-013-0203-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125210PMC
August 2014

Manipulating fatty acid biosynthesis in microalgae for biofuel through protein-protein interactions.

PLoS One 2012 13;7(9):e42949. Epub 2012 Sep 13.

Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042949PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441505PMC
March 2013

Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.

Bioorg Med Chem 2013 Jan 15;21(1):28-41. Epub 2012 Nov 15.

Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

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http://dx.doi.org/10.1016/j.bmc.2012.11.006DOI Listing
January 2013

Engineering highly thermostable xylanase variants using an enhanced combinatorial library method.

Protein Eng Des Sel 2011 Aug 26;24(8):597-605. Epub 2011 Jun 26.

Protelica 26136 Research Road, Hayward, CA 94545, USA.

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http://dx.doi.org/10.1093/protein/gzr028DOI Listing
August 2011

Atomic resolution studies of carbonic anhydrase II.

Acta Crystallogr D Biol Crystallogr 2010 May 21;66(Pt 5):616-27. Epub 2010 Apr 21.

Department of Biochemistry, University of Washington, Box 357430, Seattle, WA 98195-7430, USA.

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http://dx.doi.org/10.1107/S0907444910006554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865367PMC
May 2010

The mechanism of topoisomerase I poisoning by a camptothecin analog.

Proc Natl Acad Sci U S A 2002 Nov 8;99(24):15387-92. Epub 2002 Nov 8.

deCODE genetics, Incorporated, BioStructures Group, 7869 Northeast Day Road West, Bainbridge Island, WA 98110, USA.

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http://dx.doi.org/10.1073/pnas.242259599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137726PMC
November 2002

High-throughput crystallization and structure determination in drug discovery.

Drug Discov Today 2002 Feb;7(3):187-96

Emerald BioStructures, MediChem Life Sciences, 7869 N.E. Day Rd W., Bainbridge Island, WA 98110, USA.

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February 2002