Dr Courage Dele Famusiwa, B. Tech, M. Tech, Ph. D in view - Skyline University Nigeria Kano - Lecturer

Dr Courage Dele Famusiwa

B. Tech, M. Tech, Ph. D in view

Skyline University Nigeria Kano

Lecturer

kano, kano | Nigeria

Main Specialties: Biochemical Genetics, Chemical Pathology, Molecular Genetic Pathology, Neurology

Additional Specialties: BIOCHEMISTRY

ORCID logohttps://orcid.org/0000-0002-2981-3553


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Dr Courage Dele Famusiwa, B. Tech, M. Tech, Ph. D in view - Skyline University Nigeria Kano - Lecturer

Dr Courage Dele Famusiwa

B. Tech, M. Tech, Ph. D in view

Introduction

Mr Courage Dele Famusiwa, (IUBMB, NAT)
Lecturer II (Biochemistry)
Biography
Mr. Courage F. has M. Tech in Applied Biochemistry and Toxicology, B. Tech in Applied Biochemistry from Federal University of Technology, Akure. He is currently undergoing his Ph.D in Biochemistry, Toxicology and medicinal chemistry in the Federal University of Technology, Akure. He has an A-level certificate in Science Laboratory technology. He has a Certificate of Intensive Computer Training and a Diploma in Data and Information Technology. He manages and heads the Skyline University chemistry and biochemistry laboratory and teaches physical chemistry, general science, chemistry I and II practical, organic chemistry, inorganic chemistry and analytical chemistry practicals.
He is a certified member of the international union of biochemist and molecular biologist (IUBMB), Nigeria chapter. He is equally member of Nigeria association of toxicologist (NAT).
Experience
Mr. Courage F. has over 8 years’ work experience of in teaching and extensive research in the area of chemistry and biochemistry both theoretically and practically from institutions such as Federal University of Technology, Akure. He has consulted for a number of Universities and Schools in Nigeria. He has received a number of trainings on handling chemistry, biochemistry and molecular biology instrument and heavy equipment and attained the rank of a certified handler.


Research Interest
His research interest spans through the areas of chemistry and biochemistry, with specific interest in toxicology, industrial chemistry and biochemistry, molecular biology, medicinal chemistry and Phytomedicine. His key area of research and interest is the alleviation of diseases with phytochemicals such as flavonoids, phenolics and saponins.
Journals & Publications
Mr. Courage F. is widely published in reputable journals both nationally and internationally. He has over ten (10) publications to his credit in reputable journals. He has presented papers in International/Local Conferences, contributed and published papers in peer-reviewed Journals which includes Elsevier, pathophysiology, journal of ethnopharmacology and Refereed indexed journals etc. His recent papers “Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity?” and “Improvement of mitochondrial function by Tapinanthus globifer (A. Rich.) Tiegh. Against hepatotoxic agent in isolated rat's liver mitochondria” were published in Journal of Pathophysiology in November, 2018 and Journal of ethnopharmacology in June, 2019 respectively. Currently, He is working on the effect aqueous extract of Momordica charantia on alloxan-induced Diabetes; in vivo and molecular studies.


Publications and Citations:
Google https://scholar.google.com/citations?user=iDOGAkQAAAAJ&hl=en
Research Gate: ? https://www.researchgate.net/profile/Courage_Famusiwa
ORCID ID: https://orcid.org/0000-0002-2981-3553

Primary Affiliation: Skyline University Nigeria Kano - kano, kano , Nigeria

Specialties:

Additional Specialties:

Research Interests:


View Dr Courage Dele Famusiwa’s Resume / CV

Education

Jul 2018
federal university of technology akure
Biochemical instrumentation
certified handler

Experience

Dec 2019
BEST RESEARCHER, SUN.
HOLDER
honors.

Publications

7Publications

42Reads

2Profile Views

13PubMed Central Citations

Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annonaceae: in silico and in vivo studies.

J Diabetes Metab Disord 2020 Mar 12:1-8. Epub 2020 Mar 12.

1Bioinformatics and Molecular Biology Unit, Department of Biochemistry, Federal University of Technology Akure, P.M.B 704, Akure, Ondo State Nigeria.

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http://dx.doi.org/10.1007/s40200-020-00491-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223953PMC
March 2020

Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies

Journal of Diabetes & Metabolic Disorders, 2020, 1-8.

Journal of Diabetes & Metabolic Disorders

AbstractBackground Annona muricata (Annonaceae) known as soursop is a common tropical plant species known for its numerousmedicinal properties including obesity. The underlying mechanism of anti-obesity effect of A. muricata was investigated. The fatmass and obesity associated protein (FTO) is a validated potential target for anti-obesity drugs.Methods The interaction of compounds previously characterized from A. muricata was investigated against FTO usingAutodock Vina. Also, modulation of FTO and STAT-3 mRNA expression by A. muricata was investigated in high fat dietinduced obese rats (HFDR) using RT-PCR.Results A significant up-regulation of FTO gene was observed in HFDR when compared to control rats, while administration ofA. muricata (200 mg/kg) significantly (p < 0.05) down-regulated FTO gene expression when compared to HFDR group. Theeffect of obesity on STAT-3 gene expression was also reversed by A. muricata (200 mg/kg). In silico study revealed annonaineand annonioside (−9.2 kcal/mol) exhibited the highest binding affinity with FTO, followed by anonaine and isolaureline(−8.6 kcal/mol). Arg-96 is a critical amino acid enhancing anonaine, isolaureline-FTO binding.Conclusion This study suggests the possible anti-obesity mechanism of A. muricata is via down-regulation of FTO with concomitantup-regulation of STAT-3 genes. This study confirmed the use of this plant in the management of obesity and theprobable compounds responsible for its antiobesity effect are annonaine and annonioside.Keywords Annona muricata . Molecular docking . FTO and STAT-3 genes . Obesity

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March 2020

Impact Factor 1.180

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Ameliorative effect of quercetin, catechin, and taxifolin on rotenone-induced testicular and splenic weight gain and oxidative stress in rats.

J Basic Clin Physiol Pharmacol 2020 Jan 15;31(3). Epub 2020 Jan 15.

Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria.

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http://dx.doi.org/10.1515/jbcpp-2018-0230DOI Listing
January 2020

In silico antimicrobial properties of saponins against food pathogens and spoilage microorganism.

Nig. J. Pure & Appl. Sci. Vol. 32 (Issue 2, 2019)

Nigerian Journal of Pure and Applied Sciences

ABSTRACT Most recent outbreaks of foodborne diseases and illnesses have been linked to microbial contamination of food products, which can most definitely cause food loss due to food spoilage and eventual wastage and hence play a key role in global food security. Prevention of food spoilage is commonly done with the use of chemical preservatives, most of which possess negative impacts on human health such as carcinogenicity, gastrointestinal upset and cardiovascular diseases. This necessitate a healthier and natural alternative preservative. Saponins are natural plants compounds with many health benefits. This current study evaluates the antimicrobial potential of saponins on some food pathogens and spoilage microorganisms such as Staphylococcus aureus (Gram positive bacterium), Escherichia coli (Gram negative bacterium) and Aspergillus niger (fungus). Molecular docking of different saponins were carried out with drug targets peptide deformylase (Staphylococcus aureus), DNA gyrase (E. coli) and DNA topoisomerase (Aspergillus niger) using Autodock Vina. Cucurbitacin and diosgenin exhibited better interaction (-7.9 kcal/mol) with peptide deformylase when compared with actinonin (-7.6 kcal/mol), while momordin 1C showed more binding affinity with DNA gyrase (-8.6 kcal/mol) and DNA topoisomerase (-9.5 kcal/mol) respectively. Glu 155 (peptide deformylase), Asn-46, Glu-50, Gly-77, Thr-165, Val-171 (DNA gyrase) and Glu-382, Arg-390, Asn-517, Thr-526, Asp-553 are important amino acid residues enhancing protein-saponin interaction. Saponins may help to improve global food security and shelf life by preventing food spoilage and wastage due to their excellent antimicrobial activity occasioned by their inhibitory action on key proteins essential for survival of microbes investigated in this study.

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December 2019

Impact Factor 0.200

3 Reads

Improvement of mitochondrial function by Tapinanthus globifer (A.Rich.) Tiegh. Against hepatotoxic agent in isolated rat's liver mitochondria.

J Ethnopharmacol 2019 Oct 28;242:112026. Epub 2019 Jun 28.

Biochemical Toxicology Unit, Department of Chemistry, CCNE, Federal University of Santa. Maria, Santa Maria, RS, Brazil.

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http://dx.doi.org/10.1016/j.jep.2019.112026DOI Listing
October 2019
8 Reads
2.998 Impact Factor

Effects of Catechin, Quercetin and Taxifolin on Redox Parameters and Metabolites Linked with Renal Health in Rotenone-toxified Rats.

Niger J Physiol Sci 2019 Jun 30;34(1):1-10. Epub 2019 Jun 30.

The Federal University of Technology Akure.

Nephrotoxicity, with the attendant risk of progression to kidney failure, is a growing problem in many parts of the world. Current orthodox treatment options for nephrotoxicity and kidney failure are limited and there is need for alternative or complementary approaches. This study aimed at evaluating the effect of three structurally related flavonoids, catechin, quercetin and taxifolin on renal redox and metabolite biochemical disturbances in rotenone intoxicated animals. Male Wistar rats were administered 1.5 mg/kg rotenone (s.c.) for ten days followed by post-treatment with catechin (5, 10 or 20 mg/kg), quercetin (5, 10, or 20 mg/kg) and taxifolin (0.25, 0.5 or 1.0 mg/kg) (s.c.), for 3 days. Renal redox indices and levels of renal-related metabolites (creatinine, urea and uric acid) were assessed after sacrifice of animals. Catechin, quercetin and taxifolin significantly attenuated rotenone-induced effects on oxidative stress markers and metabolites linked to renal health.  Quercetin was clearly more effective than catechin. The activity demonstrated by taxifolin, despite being administered at the lowest doses, was compelling. The results highlight the potential of these phytochemicals in the management of renal dysfunction. The findings additionally suggest a correlation between the structure of the flavonoids and their activity but also indicate that additional structural considerations beyond conventionally acknowledged ones may be involved.

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June 2019
1 Citation

Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity?

Pathophysiology 2018 Dec 9;25(4):365-371. Epub 2018 Jul 9.

Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria.

Hepatotoxicity occurs as a result of adverse effects of some xenobiotics on the liver, which is often the target tissue of toxicity for environmental chemicals. Rotenone, used as a natural pesticide, is an environmental poison reported to cause organ toxicity. This study investigated the protective effect of three flavonoids, catechin, quercetin and taxifolin (2,3-Dihydroquercetin) in rotenone-induced hepatotoxicity. Male Wistar rats were administered rotenone for 10 days followed by post treatment with catechin (5, 10 and 20?mg/kg), quercetin (5, 10 and 20?mg/kg) or taxifolin (0.25, 0.5 and 1?mg/kg), respectively, for 3 days. Bioindices of oxidative stress and hepatocellular injury were measured in serum and tissue homogenate of animals. Rotenone intoxication produced liver damage in rats as reflected in alterations to activities/levels of enzymic and non-enzymic oxidative stress markers and enzymes linked with inflammation, as well as the transaminases, gamma glutamyl transpeptidase, bilirubin, and lactate dehydrogenase. Catechin, quercetin and taxifolin post treatment significantly attenuated these (p?

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http://dx.doi.org/10.1016/j.pathophys.2018.07.002DOI Listing
December 2018
34 Reads
12 Citations

Top co-authors

Afolabi C Akinmoladun
Afolabi C Akinmoladun

The Federal University of Technology

2
Olusola Olalekan Elekofehinti
Olusola Olalekan Elekofehinti

Adekunle Ajasin University

2
Jean Paul Kamdem
Jean Paul Kamdem

Adekunle Ajasin University

1
Olubukola Benedicta Ojo
Olubukola Benedicta Ojo

Biochemical Pharmacology and Toxicology Laboratories

1
AlineAugusti Boligon
AlineAugusti Boligon

Federal University of Santa Maria

1
Olorunfemi Raphael Molehin
Olorunfemi Raphael Molehin

Ekiti State University

1