Costas A Lyssiotis

Costas A Lyssiotis

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Costas A Lyssiotis

Costas A Lyssiotis

Publications by authors named "Costas A Lyssiotis"

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Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells.

J Biol Chem 2019 Aug 18;294(32):12077-12090. Epub 2019 Jun 18.

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109

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http://dx.doi.org/10.1074/jbc.RA119.009442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690701PMC
August 2019

Metabolic Regulation of Redox Balance in Cancer.

Cancers (Basel) 2019 Jul 8;11(7). Epub 2019 Jul 8.

Departments of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.3390/cancers11070955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678865PMC
July 2019

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics.

Metabolomics 2019 Jul 9;15(7):103. Epub 2019 Jul 9.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1007/s11306-019-1564-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616221PMC
July 2019

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Cell Metab 2019 Jun 28;29(6):1390-1399.e6. Epub 2019 Feb 28.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602533PMC
June 2019

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.

Cancer Cell 2019 Jun;35(6):916-931.e9

Department of Medicine, Division of Hematology & Medical Oncology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.05.002DOI Listing
June 2019

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma.

Sci Rep 2019 Jun 25;9(1):9273. Epub 2019 Jun 25.

Kresge Hearing Research Institute and Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, 48109, Ann Arbor, USA.

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http://dx.doi.org/10.1038/s41598-019-45385-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592947PMC
June 2019

Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function.

Proc Natl Acad Sci U S A 2019 04 25;116(15):7439-7448. Epub 2019 Mar 25.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109;

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http://dx.doi.org/10.1073/pnas.1901376116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462103PMC
April 2019

New tricks for an old drug.

Nat Chem Biol 2018 11;14(11):990-991

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41589-018-0137-xDOI Listing
November 2018

Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.

Biochemistry 2018 11 12;57(47):6604-6614. Epub 2018 Nov 12.

Department of Molecular and Integrative Physiology, Department of Internal Medicine, Division of Gastroenterology, and Rogel Cancer Center , University of Michigan , Ann Arbor , Michigan 48109 , United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.8b00914
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http://dx.doi.org/10.1021/acs.biochem.8b00914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487875PMC
November 2018

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis.

Nat Commun 2018 11 23;9(1):4945. Epub 2018 Nov 23.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41467-018-07472-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251888PMC
November 2018

Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation.

Trends Endocrinol Metab 2018 09 23;29(9):599-602. Epub 2018 Apr 23.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA; http://lyssiotislab.com. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2018.04.002DOI Listing
September 2018

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.

Bioorg Med Chem Lett 2018 09 27;28(16):2675-2678. Epub 2018 Apr 27.

California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.04.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119644PMC
September 2018

Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer.

Am J Physiol Gastrointest Liver Physiol 2018 07 15;315(1):G27-G35. Epub 2018 Mar 15.

Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, Michigan.

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http://dx.doi.org/10.1152/ajpgi.00416.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109710PMC
July 2018

Emerging Roles for SIRT5 in Metabolism and Cancer.

Antioxid Redox Signal 2018 03 26;28(8):677-690. Epub 2017 Oct 26.

1 Department of Pathology, University of Michigan , Ann Arbor, Michigan.

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http://www.liebertpub.com/doi/10.1089/ars.2017.7264
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http://dx.doi.org/10.1089/ars.2017.7264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824490PMC
March 2018

When Cancer Cells Are Given Lemo[NH]s, They Make Lemo[NH]ade.

Cell Metab 2017 12;26(6):811-813

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131173067
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http://dx.doi.org/10.1016/j.cmet.2017.11.008DOI Listing
December 2017

Metabolic Interactions in the Tumor Microenvironment.

Trends Cell Biol 2017 11 19;27(11):863-875. Epub 2017 Jul 19.

Department of Radiation Oncology, Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814137PMC
November 2017

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

Proc Natl Acad Sci U S A 2017 11 30;114(46):E9903-E9912. Epub 2017 Oct 30.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;

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http://dx.doi.org/10.1073/pnas.1716009114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699095PMC
November 2017

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

Recent Results Cancer Res 2016;207:39-72

Department of Medicine, the Cancer Center, Weill Cornell Medical College, The Belfer Research Building, 413 East 69th Street, Floor 13 Room BB-1362, New York, NY, 10021, USA.

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http://dx.doi.org/10.1007/978-3-319-42118-6_3DOI Listing
March 2017

Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer.

Cancer Cell 2017 01;31(1):5-19

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.12.006DOI Listing
January 2017

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant KRAS-Driven Cancers.

Gastroenterology 2016 11 3;151(5):798-801. Epub 2016 Oct 3.

Department of Molecular and Integrative Physiology and Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.09.036DOI Listing
November 2016

Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer.

Biochem Biophys Rep 2016 Sep 7;7:144-149. Epub 2016 Jun 7.

Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery, Ann Arbor Veteran's Administration Hospital, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.bbrep.2016.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014359PMC
September 2016

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Proc Natl Acad Sci U S A 2016 07 8;113(30):E4338-47. Epub 2016 Jul 8.

Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1522223113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968752PMC
July 2016

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Mol Cell Oncol 2016 Jul 30;3(4):e1164280. Epub 2016 Mar 30.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1080/23723556.2016.1164280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972100PMC
July 2016

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Nat Cell Biol 2016 05 18;18(5):572-8. Epub 2016 Apr 18.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncb3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848114PMC
May 2016

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.

Anal Chem 2015 Nov 12;87(21):10995-1006. Epub 2015 Oct 12.

Division of Signal Transduction, Beth Israel Deaconess Medical Center , Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/acs.analchem.5b03040
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http://dx.doi.org/10.1021/acs.analchem.5b03040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585869PMC
November 2015

Acetate fuels the cancer engine.

Cell 2014 Dec;159(7):1492-4

Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.12.009DOI Listing
December 2014

Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.

J Pharmacol Exp Ther 2014 Nov 14;351(2):298-307. Epub 2014 Aug 14.

Lycera Corporation, Ann Arbor, Michigan (G.D.G., C.L., B.S., X.L., L.-Y.H., C.T., A.H., A.W.O.); Departments of Chemical Biology (G.D.G., D.W.), Chemistry (G.D.G.), Pediatrics and Communicable Disease (J.L.M.F., V.T., C.A.B.), and Obstetrics and Gynecology (A.W.O.), University of Michigan, Ann Arbor, Michigan; Université Victor Segalen, Bordeaux, France (R.R.); Department of Medicine, Weill Cornell Medical College, New York, New York (C.A.L.); and SIDMAP, Los Angeles, California (L.B.)

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.114.21809
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http://dx.doi.org/10.1124/jpet.114.218099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201277PMC
November 2014

Targeting metabolic scavenging in pancreatic cancer.

Clin Cancer Res 2014 Jan 28;20(1):6-8. Epub 2013 Oct 28.

Authors' Affiliation: Department of Medicine, Weill Cornell Medical College, New York City, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930347PMC
January 2014

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.

EMBO J 2013 Oct 6;32(19):2589-602. Epub 2013 Sep 6.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.

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http://dx.doi.org/10.1038/emboj.2013.186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791369PMC
October 2013

Metabolic syndrome: F stands for fructose and fat.

Nature 2013 Oct;502(7470):181-2

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http://dx.doi.org/10.1038/502181aDOI Listing
October 2013

Small molecule-based approaches to adult stem cell therapies.

Annu Rev Pharmacol Toxicol 2013 ;53:107-25

Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1146/annurev-pharmtox-011112-140300DOI Listing
July 2013

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.

Science 2013 Jan 1;339(6116):222-6. Epub 2012 Nov 1.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1226603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652341PMC
January 2013

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Nat Cell Biol 2012 Dec 25;14(12):1295-304. Epub 2012 Nov 25.

Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncb2629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511602PMC
December 2012

SIRT6 puts cancer metabolism in the driver's seat.

Cell 2012 Dec;151(6):1155-6

Department of Signal Transduction, Division of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757516PMC
http://dx.doi.org/10.1016/j.cell.2012.11.020DOI Listing
December 2012

A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling.

BMC Cancer 2011 Jul 20;11:304. Epub 2011 Jul 20.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA.

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http://dx.doi.org/10.1186/1471-2407-11-304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171728PMC
July 2011

Chemical control of stem cell fate and developmental potential.

Angew Chem Int Ed Engl 2011 Jan;50(1):200-42

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://doi.wiley.com/10.1002/anie.201004284
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http://dx.doi.org/10.1002/anie.201004284DOI Listing
January 2011

Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax.

Biochem Pharmacol 2009 Oct 27;78(8):966-73. Epub 2009 May 27.

Department of Pediatrics and Communicable Diseases, University of Michigan, F6865 Mott SPC 5297, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5297, United States.

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http://dx.doi.org/10.1016/j.bcp.2009.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759512PMC
October 2009

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

Proc Natl Acad Sci U S A 2009 Oct 23;106(40):17025-30. Epub 2009 Sep 23.

The Skaggs Institute of Chemical Biology and the Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0909292106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761329PMC
October 2009

A small molecule primes embryonic stem cells for differentiation.

Cell Stem Cell 2009 May;4(5):416-26

The Skaggs Institute of Chemical Biology and the Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.stem.2009.04.001DOI Listing
May 2009

Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax.

Free Radic Biol Med 2008 Nov 3;45(9):1232-42. Epub 2008 Aug 3.

Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.07.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837238PMC
November 2008

Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.

Proc Natl Acad Sci U S A 2007 Sep 12;104(38):14982-7. Epub 2007 Sep 12.

The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA.

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http://www.pnas.org/content/104/38/14982.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.0707044104
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http://dx.doi.org/10.1073/pnas.0707044104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986599PMC
September 2007

A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis.

J Biol Chem 2004 Jul 3;279(28):29615-21. Epub 2004 May 3.

Departments of Chemistry and Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1074/jbc.M403507200DOI Listing
July 2004