Costas A Lyssiotis

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Costas A Lyssiotis

Publications by authors named "Costas A Lyssiotis"

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60Publications

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Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation.

Trends Endocrinol Metab 2018 Apr 22. Epub 2018 Apr 22.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA; http://lyssiotislab.com. Electronic address:

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April 2018

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.

Bioorg Med Chem Lett 2018 Apr 27. Epub 2018 Apr 27.

California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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April 2018

Emerging Roles for SIRT5 in Metabolism and Cancer.

Antioxid Redox Signal 2018 03 26;28(8):677-690. Epub 2017 Oct 26.

1 Department of Pathology, University of Michigan , Ann Arbor, Michigan.

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March 2018

TUMOR CROSSTALK NETWORKS PROMOTE GROWTH AND SUPPORT IMMUNE EVASION IN PANCREATIC CANCER.

Am J Physiol Gastrointest Liver Physiol 2018 Mar 15. Epub 2018 Mar 15.

Molecular and Integrative Physiology, University of Michigan, United States.

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March 2018

When Cancer Cells Are Given Lemo[NH]s, They Make Lemo[NH]ade.

Cell Metab 2017 Dec;26(6):811-813

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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December 2017

Metabolic Interactions in the Tumor Microenvironment.

Trends Cell Biol 2017 11 19;27(11):863-875. Epub 2017 Jul 19.

Department of Radiation Oncology, Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address:

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November 2017

A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

Proc Natl Acad Sci U S A 2017 11 30;114(46):E9903-E9912. Epub 2017 Oct 30.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;

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November 2017

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

Recent Results Cancer Res 2016;207:39-72

Department of Medicine, the Cancer Center, Weill Cornell Medical College, The Belfer Research Building, 413 East 69th Street, Floor 13 Room BB-1362, New York, NY, 10021, USA.

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March 2017

Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer.

Cancer Cell 2017 01;31(1):5-19

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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January 2017

Mitochondrial Amino Acid Metabolism Provides Vulnerabilities in Mutant KRAS-Driven Cancers.

Gastroenterology 2016 11 3;151(5):798-801. Epub 2016 Oct 3.

Department of Molecular and Integrative Physiology and Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan. Electronic address:

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November 2016

Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer.

Biochem Biophys Rep 2016 Sep 7;7:144-149. Epub 2016 Jun 7.

Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery, Ann Arbor Veteran's Administration Hospital, Ann Arbor, MI, USA.

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September 2016

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Proc Natl Acad Sci U S A 2016 07 8;113(30):E4338-47. Epub 2016 Jul 8.

Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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July 2016

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Mol Cell Oncol 2016 Jul 30;3(4):e1164280. Epub 2016 Mar 30.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.

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July 2016

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Nat Cell Biol 2016 05 18;18(5):572-8. Epub 2016 Apr 18.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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May 2016

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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December 2015

Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.

Anal Chem 2015 Nov 12;87(21):10995-1006. Epub 2015 Oct 12.

Division of Signal Transduction, Beth Israel Deaconess Medical Center , Boston, Massachusetts 02115, United States.

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November 2015

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.

Cancer Metab 2015 12;3:12. Epub 2015 Oct 12.

Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Drive, Dallas, 75390-8807 TX USA ; Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX USA.

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October 2015

Acetate fuels the cancer engine.

Cell 2014 Dec;159(7):1492-4

Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address:

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December 2014

Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.

J Pharmacol Exp Ther 2014 Nov 14;351(2):298-307. Epub 2014 Aug 14.

Lycera Corporation, Ann Arbor, Michigan (G.D.G., C.L., B.S., X.L., L.-Y.H., C.T., A.H., A.W.O.); Departments of Chemical Biology (G.D.G., D.W.), Chemistry (G.D.G.), Pediatrics and Communicable Disease (J.L.M.F., V.T., C.A.B.), and Obstetrics and Gynecology (A.W.O.), University of Michigan, Ann Arbor, Michigan; Université Victor Segalen, Bordeaux, France (R.R.); Department of Medicine, Weill Cornell Medical College, New York, New York (C.A.L.); and SIDMAP, Los Angeles, California (L.B.)

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November 2014

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Nature 2014 Oct 10;514(7524):628-32. Epub 2014 Aug 10.

1] Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA [2] Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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October 2014

Targeting metabolic scavenging in pancreatic cancer.

Clin Cancer Res 2014 Jan 28;20(1):6-8. Epub 2013 Oct 28.

Authors' Affiliation: Department of Medicine, Weill Cornell Medical College, New York City, New York.

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January 2014

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.

EMBO J 2013 Oct 6;32(19):2589-602. Epub 2013 Sep 6.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.

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October 2013

A regenerative approach to the treatment of multiple sclerosis.

Nature 2013 Oct 9;502(7471):327-332. Epub 2013 Oct 9.

Department of Chemistry, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA.

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October 2013

Small molecule-based approaches to adult stem cell therapies.

Annu Rev Pharmacol Toxicol 2013 ;53:107-25

Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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July 2013

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Nature 2013 Apr 27;496(7443):101-5. Epub 2013 Mar 27.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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April 2013

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.

Science 2013 Jan 1;339(6116):222-6. Epub 2012 Nov 1.

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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January 2013

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Nat Cell Biol 2012 Dec 25;14(12):1295-304. Epub 2012 Nov 25.

Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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December 2012

SIRT6 puts cancer metabolism in the driver's seat.

Cell 2012 Dec;151(6):1155-6

Department of Signal Transduction, Division of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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December 2012

A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling.

BMC Cancer 2011 Jul 20;11:304. Epub 2011 Jul 20.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA.

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July 2011

Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.

Angew Chem Int Ed Engl 2011 Jun 5;50(25):5734-6. Epub 2011 May 5.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.

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June 2011

Chemical control of stem cell fate and developmental potential.

Angew Chem Int Ed Engl 2011 Jan;50(1):200-42

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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January 2011

Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax.

Biochem Pharmacol 2009 Oct 27;78(8):966-73. Epub 2009 May 27.

Department of Pediatrics and Communicable Diseases, University of Michigan, F6865 Mott SPC 5297, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5297, United States.

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October 2009

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.

Proc Natl Acad Sci U S A 2009 Oct 23;106(40):17025-30. Epub 2009 Sep 23.

The Skaggs Institute of Chemical Biology and the Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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October 2009

A small molecule primes embryonic stem cells for differentiation.

Cell Stem Cell 2009 May;4(5):416-26

The Skaggs Institute of Chemical Biology and the Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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May 2009

Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax.

Free Radic Biol Med 2008 Nov 3;45(9):1232-42. Epub 2008 Aug 3.

Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.

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November 2008

Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells.

Proc Natl Acad Sci U S A 2007 Sep 12;104(38):14982-7. Epub 2007 Sep 12.

The Skaggs Institute of Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA.

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September 2007

A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis.

J Biol Chem 2004 Jul 3;279(28):29615-21. Epub 2004 May 3.

Departments of Chemistry and Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA.

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July 2004