Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer.
Biochem Biophys Rep 2016 Sep 7;7:144-149. Epub 2016 Jun 7.
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery, Ann Arbor Veteran's Administration Hospital, Ann Arbor, MI, USA.

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.
Cell 2016 Jan;164(3):433-46
Division of Hematology and Oncology, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS), Boston, MA 02215, USA. Electronic address:

Designing a broad-spectrum integrative approach for cancer prevention and treatment.
Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304
Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.
J Pharmacol Exp Ther 2014 Nov 14;351(2):298-307. Epub 2014 Aug 14.
Lycera Corporation, Ann Arbor, Michigan (G.D.G., C.L., B.S., X.L., L.-Y.H., C.T., A.H., A.W.O.); Departments of Chemical Biology (G.D.G., D.W.), Chemistry (G.D.G.), Pediatrics and Communicable Disease (J.L.M.F., V.T., C.A.B.), and Obstetrics and Gynecology (A.W.O.), University of Michigan, Ann Arbor, Michigan; Université Victor Segalen, Bordeaux, France (R.R.); Department of Medicine, Weill Cornell Medical College, New York, New York (C.A.L.); and SIDMAP, Los Angeles, California (L.B.)

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Nature 2014 Oct 10;514(7524):628-32. Epub 2014 Aug 10.
1] Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA [2] Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

A regenerative approach to the treatment of multiple sclerosis.
Nature 2013 Oct 9;502(7471):327-332. Epub 2013 Oct 9.
Department of Chemistry, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA.

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
Nature 2013 Apr 27;496(7443):101-5. Epub 2013 Mar 27.
Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
Science 2013 Jan 1;339(6116):222-6. Epub 2012 Nov 1.
Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.
Angew Chem Int Ed Engl 2011 Jun 5;50(25):5734-6. Epub 2011 May 5.
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA.

A genomic screen identifies TYRO3 as a MITF regulator in melanoma.
Proc Natl Acad Sci U S A 2009 Oct 23;106(40):17025-30. Epub 2009 Sep 23.
The Skaggs Institute of Chemical Biology and the Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.
Cancer Metab 2015 12;3:12. Epub 2015 Oct 12.
Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Drive, Dallas, 75390-8807 TX USA ; Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX USA.

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
Proc Natl Acad Sci U S A 2016 07 8;113(30):E4338-47. Epub 2016 Jul 8.
Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;