Consuelo Borras

Consuelo Borras

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Consuelo Borras

Publications by authors named "Consuelo Borras"

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SOX2 expression diminishes with ageing in several tissues in mice and humans.

Mech Ageing Dev 2019 01 21;177:30-36. Epub 2018 Mar 21.

Cellular Oncology Group, Biodonostia Health Research Institute, San Sebastian, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; CIBERfes, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2018.03.008DOI Listing
January 2019

A free radical theory of frailty.

Free Radic Biol Med 2018 Aug 26;124:358-363. Epub 2018 Jun 26.

Freshage Research Group. Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibañez, 15, Valencia, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.06.028DOI Listing
August 2018

Centenarians overexpress pluripotency-related genes.

J Gerontol A Biol Sci Med Sci 2018 Jul 19. Epub 2018 Jul 19.

Freshage Research Group-Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibañez nº, Valencia, Spain.

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http://dx.doi.org/10.1093/gerona/gly168DOI Listing
July 2018

[Identification of single nucleotide polymorphisms related to frailty].

Rev Esp Geriatr Gerontol 2018 Jul - Aug;53(4):202-207. Epub 2018 Apr 7.

Freshage Research Group-Departamento de Fisiología, Universidad de Valencia, CIBERFES, INCLIVA, Valencia, España.

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http://dx.doi.org/10.1016/j.regg.2017.11.003DOI Listing
April 2018

Ultrasonic Echo Intensity as a New Noninvasive In Vivo Biomarker of Frailty.

J Am Geriatr Soc 2017 Dec 7;65(12):2685-2690. Epub 2017 Sep 7.

Department of Physiology, Universidad de Valencia/INCLIVA, Valencia, Spain.

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http://dx.doi.org/10.1111/jgs.15002DOI Listing
December 2017

[Identification of single nucleotide polymorphisms in centenarians].

Rev Esp Geriatr Gerontol 2016 May-Jun;51(3):146-9. Epub 2015 Nov 2.

Departamento de Fisiología, Facultad de Medicina, Universitat de València/INCLIVA, Valencia, España. Electronic address:

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http://dx.doi.org/10.1016/j.regg.2015.09.006DOI Listing
October 2017

Role of p16 and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells.

Redox Biol 2017 08 7;12:690-698. Epub 2017 Apr 7.

Department of Physiology. Faculty of Medicine and Dentistry. University of Valencia, Av/ Blasco Ibáñez, 15, 46010 Valencia, Spain; INCLIVA Health Research Institute, Av/ de Menéndez y Pelayo, 4, 46010 Valencia, Spain; Center for Biomedical Network Research on Frailty and Healthy Aging (CIBERFES), CIBER-ISCIII, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317173017
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http://dx.doi.org/10.1016/j.redox.2017.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390672PMC
August 2017

Brain-Derived Neurotrophic Factor as a Marker of Cognitive Frailty.

J Gerontol A Biol Sci Med Sci 2017 03;72(3):450-451

Faculty of Medicine, Department of Physiology, University of Valencia, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Spain.

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http://dx.doi.org/10.1093/gerona/glw145DOI Listing
March 2017

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.

J Gerontol A Biol Sci Med Sci 2017 01 24;72(1):30-37. Epub 2016 Mar 24.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Spain.

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http://dx.doi.org/10.1093/gerona/glw048DOI Listing
January 2017

Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function.

Mol Aspects Med 2016 08 6;50:88-108. Epub 2016 May 6.

Department of Physiology, Investigación Hospital Clínico Universitario/INCLIVA, University of Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2016.04.005DOI Listing
August 2016

Role of NAD(+)/NADH redox ratio in cell metabolism: A tribute to Helmut Sies and Theodor Bücher and Hans A. Krebs.

Arch Biochem Biophys 2016 Apr;595:176-80

Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.11.027DOI Listing
April 2016

Response to Vidal and colleagues.

J Am Geriatr Soc 2015 Apr;63(4):838-9

Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.

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http://dx.doi.org/10.1111/jgs.13362DOI Listing
April 2015

Pharmacological properties of physical exercise in the elderly.

Curr Pharm Des 2014 ;20(18):3019-29

Department of Physiology. Faculty of Medicine. University of Valencia., Av. Blasco Ibanez, 15, Valencia, E46010 Spain.

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January 2015

PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations.

Biomed Res Int 2014 10;2014:580852. Epub 2014 Apr 10.

Department of Physiology, Faculty of Medicine, University of Valencia, Blasco Ibañez Avenue 15, 46010 Valencia, Spain.

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http://dx.doi.org/10.1155/2014/580852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000926PMC
December 2014

Activation of p38, p21, and NRF-2 mediates decreased proliferation of human dental pulp stem cells cultured under 21% O2.

Stem Cell Reports 2014 Oct 18;3(4):566-73. Epub 2014 Sep 18.

Department of Physiology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223702PMC
October 2014

Oxidative stress is related to frailty, not to age or sex, in a geriatric population: lipid and protein oxidation as biomarkers of frailty.

J Am Geriatr Soc 2014 Jul 24;62(7):1324-8. Epub 2014 Jun 24.

Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, Valencia, Spain.

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http://dx.doi.org/10.1111/jgs.12876DOI Listing
July 2014

[Resveratrol: distribution, properties and perspectives].

Rev Esp Geriatr Gerontol 2013 Mar-Apr;48(2):79-88. Epub 2013 Jan 15.

Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, INCLIVA, Valencia, Spain.

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http://dx.doi.org/10.1016/j.regg.2012.04.007DOI Listing
March 2014

Application of mesenchymal stem cells in bone regenerative procedures in oral implantology. A literature review.

J Clin Exp Dent 2014 Feb 1;6(1):e60-5. Epub 2014 Feb 1.

Assistant professor of Oral Surgery. University Medical and Dental School. Professor of Master of Oral Surgery and Implantology. Valencia University Medical and Dental School. Valencia, Spain.

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http://dx.doi.org/10.4317/jced.51186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935907PMC
February 2014

Early, but not late onset estrogen replacement therapy prevents oxidative stress and metabolic alterations caused by ovariectomy.

Antioxid Redox Signal 2014 Jan 20;20(2):236-46. Epub 2013 Jul 20.

1 Department of Physiology, School of Medicine, University of Valencia/INCLIVA , Valencia, Spain .

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http://dx.doi.org/10.1089/ars.2012.5112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887441PMC
January 2014

The free radical theory of aging revisited: the cell signaling disruption theory of aging.

Antioxid Redox Signal 2013 Sep;19(8):779-87

Department of Physiology, University of Valencia and Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia 46010, Spain.

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http://dx.doi.org/10.1089/ars.2012.5111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749699PMC
September 2013

Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase.

Mech Ageing Dev 2012 Jun 10;133(6):401-13. Epub 2012 May 10.

Southern Methodist University, Airline Dr, Dallas, TX 75275, USA.

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http://dx.doi.org/10.1016/j.mad.2012.04.006DOI Listing
June 2012

Mitochondria as sources and targets of damage in cellular aging.

Clin Chem Lab Med 2012 Feb 1;50(8):1287-95. Epub 2012 Feb 1.

Department of Physiology, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario/INCLIVA, Valencia, Spain.

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https://www.degruyter.com/view/j/cclm.2012.50.issue-8/cclm-2
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http://dx.doi.org/10.1515/cclm-2011-0795DOI Listing
February 2012

Females live longer than males: role of oxidative stress.

Curr Pharm Des 2011 Dec;17(36):3959-65

Department of Physiology, Valencia, Spain.

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December 2011

Free [NADH]/[NAD(+)] regulates sirtuin expression.

Arch Biochem Biophys 2011 Aug 7;512(1):24-9. Epub 2011 May 7.

Department of Physiology, Faculty of Medicine, University of Valencia, Fundacion Investigacion Hospital Clinico Universitario INCLIVA, Spain.

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http://dx.doi.org/10.1016/j.abb.2011.04.020DOI Listing
August 2011

The dual role of p53: DNA protection and antioxidant.

Free Radic Res 2011 Jun 31;45(6):643-52. Epub 2011 Mar 31.

Department of Physiology, Faculty of Medicine, University of Valencia, Av. Blasco Ibáñez, 15 46010 Valencia, Spain.

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http://dx.doi.org/10.3109/10715762.2011.571685DOI Listing
June 2011

Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients.

Free Radic Biol Med 2011 May 22;50(10):1215-21. Epub 2011 Jan 22.

Endocrinology Service, University Hospital Dr. Peset, and Department of Medicine, University of Valencia, Valencia, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.01.019DOI Listing
May 2011

RasGrf1 deficiency delays aging in mice.

Aging (Albany NY) 2011 Mar;3(3):262-76

Department of Physiology, School of Medicine, University of Valencia, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091520PMC
http://dx.doi.org/10.18632/aging.100279DOI Listing
March 2011

Biogerontology in Spain: the most significant studies.

Biogerontology 2011 Feb 14;12(1):77-81. Epub 2010 Dec 14.

Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain.

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http://dx.doi.org/10.1007/s10522-010-9314-3DOI Listing
February 2011

[Aging and ovariectomy cause a decrease in brain glucose consumption in vivo in Wistar rats].

Rev Esp Geriatr Gerontol 2010 May-Jun;45(3):136-40. Epub 2010 Mar 4.

Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, España.

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http://dx.doi.org/10.1016/j.regg.2009.12.005DOI Listing
September 2010

Women live longer than men: understanding molecular mechanisms offers opportunities to intervene by using estrogenic compounds.

Antioxid Redox Signal 2010 Aug;13(3):269-78

Department of Physiology, University of Valencia, Spain.

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http://dx.doi.org/10.1089/ars.2009.2952DOI Listing
August 2010

Mitochondrial DNA sequences are present inside nuclear DNA in rat tissues and increase with age.

Mitochondrion 2010 Aug 28;10(5):479-86. Epub 2010 May 28.

Department of Animal Physiology-II, Complutense University of Madrid, Spain.

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http://dx.doi.org/10.1016/j.mito.2010.05.004DOI Listing
August 2010

Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes.

Brain Res 2010 Feb 27;1312:138-44. Epub 2009 Nov 27.

Department of Physiology, Faculty of Medicine, University of Valencia, Blasco Ibañez 15, 46010-Valencia, Spain.

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http://dx.doi.org/10.1016/j.brainres.2009.11.044DOI Listing
February 2010

Direct antioxidant and protective effect of estradiol on isolated mitochondria.

Biochim Biophys Acta 2010 Jan 12;1802(1):205-11. Epub 2009 Sep 12.

Department of Physiology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibáñez 17, 46010 Valencia, Spain.

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http://dx.doi.org/10.1016/j.bbadis.2009.09.007DOI Listing
January 2010

Mitochondrial biogenesis in exercise and in ageing.

Adv Drug Deliv Rev 2009 Nov 27;61(14):1369-74. Epub 2009 Aug 27.

Department of Physiology, University of Valencia, Spain.

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http://dx.doi.org/10.1016/j.addr.2009.06.006DOI Listing
November 2009

Adverse cutaneous reactions induced by TNF-alpha antagonist therapy.

South Med J 2009 Nov;102(11):1133-40

Pharmacy Department, Hospital de Sagunto, Sagunto, Spain.

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http://sma.org/southern-medical-journal/article/adverse-cuta
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http://dx.doi.org/10.1097/SMJ.0b013e3181bb554cDOI Listing
November 2009

Low in vivo brain glucose consumption and high oxidative stress in accelerated aging.

FEBS Lett 2009 Jul 13;583(13):2287-93. Epub 2009 Jun 13.

Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain.

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http://dx.doi.org/10.1016/j.febslet.2009.06.019DOI Listing
July 2009

Anti-aging activity of the Ink4/Arf locus.

Aging Cell 2009 Apr;8(2):152-61

Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1111/j.1474-9726.2009.00458.xDOI Listing
April 2009

Telomerase reverse transcriptase delays aging in cancer-resistant mice.

Cell 2008 Nov;135(4):609-22

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, Madrid, Spain.

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http://dx.doi.org/10.1016/j.cell.2008.09.034DOI Listing
November 2008

Modulation of longevity-associated genes by estrogens or phytoestrogens.

Biol Chem 2008 Mar;389(3):273-7

Departamento de Fisiología, Universidad de Valencia, E-46010 Valencia, Spain.

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http://dx.doi.org/10.1515/BC.2008.027DOI Listing
March 2008

Molecular mechanisms involved in the hormonal prevention of aging in the rat.

J Steroid Biochem Mol Biol 2008 Feb 7;108(3-5):318-26. Epub 2007 Sep 7.

Department of Physiology, Faculty of Medicine, Complutense University, Avenida Complutense s/n, Madrid, Spain.

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http://dx.doi.org/10.1016/j.jsbmb.2007.09.010DOI Listing
February 2008

Oestradiol or genistein rescues neurons from amyloid beta-induced cell death by inhibiting activation of p38.

Aging Cell 2008 Jan 21;7(1):112-8. Epub 2007 Nov 21.

Department of Physiology, University of Valencia, School of Medicine, Valencia, Spain.

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http://dx.doi.org/10.1111/j.1474-9726.2007.00356.xDOI Listing
January 2008

Theories of ageing.

IUBMB Life 2007 Apr-May;59(4-5):249-54

Department of Physiology, School of Medicine, University of Valencia.

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http://dx.doi.org/10.1080/15216540601178067DOI Listing
December 2007

Effect of gender on mitochondrial toxicity of Alzheimer's Abeta peptide.

Antioxid Redox Signal 2007 Oct;9(10):1677-90

Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1089/ars.2007.1773DOI Listing
October 2007

Fostering antioxidant defences: up-regulation of antioxidant genes or antioxidant supplementation?

Br J Nutr 2007 Oct;98 Suppl 1:S36-40

Department of Physiology, Faculty of Medicine, University of Valencia, Spain.

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http://dx.doi.org/10.1017/S0007114507839596DOI Listing
October 2007

Glutathione is recruited into the nucleus in early phases of cell proliferation.

J Biol Chem 2007 Jul 23;282(28):20416-24. Epub 2007 Apr 23.

Department of Physiology, Faculty of Medicine, University of Valencia, Avenida Blasco Ibáñez 17, 46010 Valencia, Spain.

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http://dx.doi.org/10.1074/jbc.M609582200DOI Listing
July 2007

Delayed ageing through damage protection by the Arf/p53 pathway.

Nature 2007 Jul;448(7151):375-9

Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

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http://dx.doi.org/10.1038/nature05949DOI Listing
July 2007

Mitochondrial oxidant signalling in Alzheimer's disease.

J Alzheimers Dis 2007 May;11(2):175-81

Departamento de Fisiología, Facultad de Medicina, Valencia, Spain.

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May 2007

Mitochondrial oxidant generation is involved in determining why females live longer than males.

Front Biosci 2007 Jan 1;12:1008-13. Epub 2007 Jan 1.

Catholic University of Valencia, Spain.

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January 2007

Why females live longer than males: control of longevity by sex hormones.

Sci Aging Knowledge Environ 2005 Jun 8;2005(23):pe17. Epub 2005 Jun 8.

Departamento de Fisiología, Facultad de Medicina, Avenida Blasco Ibáñez 17, 46010 Valencia, Spain.

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http://dx.doi.org/10.1126/sageke.2005.23.pe17DOI Listing
June 2005

Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds.

FEBS Lett 2005 May 14;579(12):2541-5. Epub 2005 Apr 14.

Departamento de Fisiología, Facultad de Medicina, Valencia, Spain.

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http://dx.doi.org/10.1016/j.febslet.2005.03.090DOI Listing
May 2005

Age-associated oxidative damage leads to absence of gamma-cystathionase in over 50% of rat lenses: relevance in cataractogenesis.

Free Radic Biol Med 2005 Mar;38(5):575-82

Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibañez 17, 46010 Valencia, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.11.029DOI Listing
March 2005

Glutathione regulates telomerase activity in 3T3 fibroblasts.

J Biol Chem 2004 Aug 7;279(33):34332-5. Epub 2004 Jun 7.

Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez 17, 46010 Valencia, Spain.

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http://dx.doi.org/10.1074/jbc.M402425200DOI Listing
August 2004

Mitochondrial theory of aging: importance to explain why females live longer than males.

Antioxid Redox Signal 2003 Oct;5(5):549-56

Departamento de Fisiología, Facultad de Medicina, Valencia, Spain.

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http://dx.doi.org/10.1089/152308603770310194DOI Listing
October 2003

Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males.

Free Radic Biol Med 2003 Mar;34(5):546-52

Department of Physiology, School of Medicine, University of Valencia, Valencia, Spain.

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March 2003

Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver.

Cell Mol Biol (Noisy-le-grand) 2002 Sep;48(6):685-92

Departamento de Fisiologia, Facultad de Medicina, Universitat de València, Spain.

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September 2002

Phosphatidylglycerol potently protects human retinal pigment epithelial cells against apoptosis induced by A2E, a compound suspected to cause age-related macula degeneration.

Exp Eye Res 2002 Jul;75(1):99-108

Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), Universitätstr, 16, CH-8092, Zurich, Switzerland.

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July 2002

Mitochondrial damage in aging and apoptosis.

Ann N Y Acad Sci 2002 Apr;959:448-51

Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Avda. Blasco Ibañez 17, 46010 Valencia, Spain.

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April 2002