Constantin Tamvakopoulos

Constantin Tamvakopoulos

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Constantin Tamvakopoulos

Constantin Tamvakopoulos

Publications by authors named "Constantin Tamvakopoulos"

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49Publications

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Design, synthesis and biological evaluation of novel substituted purine isosters as EGFR kinase inhibitors, with promising pharmacokinetic profile and in vivo efficacy.

Eur J Med Chem 2019 Aug 8;176:393-409. Epub 2019 May 8.

Division of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.05.029DOI Listing
August 2019

Development of bioactive gemcitabine-D-Lys-GnRH prodrugs with linker-controllable drug release rate and enhanced biopharmaceutical profile.

Eur J Med Chem 2019 Mar 18;166:256-266. Epub 2019 Jan 18.

Department of Chemistry, Section of Organic Chemistry and Biochemistry, Laboratory of Chemical Biology, University of Ioannina, Ioannina, GR-45110, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.041DOI Listing
March 2019

Dexamethasone induces ω3-derived immunoresolvents driving resolution of allergic airway inflammation.

J Allergy Clin Immunol 2018 08 24;142(2):691-695.e4. Epub 2018 Apr 24.

Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183061
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http://dx.doi.org/10.1016/j.jaci.2018.04.004DOI Listing
August 2018

Versatile quarto stimuli nanostructure based on Trojan Horse approach for cancer therapy: Synthesis, characterization, in vitro and in vivo studies.

Mater Sci Eng C Mater Biol Appl 2017 Oct 13;79:605-612. Epub 2017 May 13.

Institute for Nanoscience and Nanotechnology, NCSR "Demokritos", 15310 Aghia Paraskevi, Attikis, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2017.05.082DOI Listing
October 2017

Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease.

Proc Natl Acad Sci U S A 2017 04 27;114(15):3999-4004. Epub 2017 Mar 27.

Center for Clinical Research, Experimental Surgery, and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens 11527, Greece;

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http://dx.doi.org/10.1073/pnas.1616874114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393203PMC
April 2017

Gemcitabine Based Peptide Conjugate with Improved Metabolic Properties and Dual Mode of Efficacy.

Mol Pharm 2017 03 1;14(3):674-685. Epub 2017 Feb 1.

Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens , 4 Soranou Ephessiou Street, 11527 Athens, Greece.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00961DOI Listing
March 2017

Design and synthesis of novel 7-aminosubstituted pyrido[2,3-b]pyrazines exhibiting anti-breast cancer activity.

Eur J Med Chem 2017 Jan 12;126:954-968. Epub 2016 Dec 12.

Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation Academy of Athens (BRFAA), Athens, 11527, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.12.025DOI Listing
January 2017

Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.

Cancer Res 2016 Mar 8;76(5):1181-92. Epub 2015 Dec 8.

Division of Pharmacology-Pharmacotechnology, Clinical, Experimental Surgery & Translational Research Center, Biomedical Research Foundation Academy of Athens (BRFAA), Athens, Greece.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2138DOI Listing
March 2016

Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer.

J Natl Cancer Inst 2014 Dec 11;106(12). Epub 2014 Oct 11.

Biomedical Research Foundation, Academy of Athens, Athens, Greece (DS, AP, CA, ZC, CT, AK, AE); Department of Pathology and Cell Biology (MS) and Division of Hematology/Oncology (SK), Columbia University Medical Center, New York, NY; Regeneron Research Laboratories, Tarrytown, NY (ZL).

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http://jnci.oxfordjournals.org/content/106/12/dju320.full.pd
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/dju320
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http://dx.doi.org/10.1093/jnci/dju320DOI Listing
December 2014

GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.

Bioconjug Chem 2014 Apr 3;25(4):813-23. Epub 2014 Apr 3.

Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou Street 4, Athens GR-11527, Greece.

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http://dx.doi.org/10.1021/bc500081gDOI Listing
April 2014

Peptide and protein drugs: the study of their metabolism and catabolism by mass spectrometry.

Mass Spectrom Rev 2012 Jan-Feb;31(1):110-33. Epub 2011 Jun 22.

Biomedical Research Foundation, Academy of Athens, Division of Pharmacology-Pharmacotechnology, Soranou Efesiou Street 4, Athens GR-11527, Greece.

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http://dx.doi.org/10.1002/mas.20340DOI Listing
April 2012

Oral administration of chios mastic gum or extracts in mice: quantification of triterpenic acids by liquid chromatography-tandem mass spectrometry.

Planta Med 2011 Nov 25;77(17):1916-23. Epub 2011 Aug 25.

Laboratory of Pharmacology-Pharmacotechnology, Biomedical Research Foundation Academy of Athens, Athens, Greece.

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http://dx.doi.org/10.1055/s-0031-1279996DOI Listing
November 2011

Evaluation of a stable gonadotropin-releasing hormone analog in mice for the treatment of endocrine disorders and prostate cancer.

J Pharmacol Exp Ther 2011 Mar 24;336(3):613-23. Epub 2010 Nov 24.

Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, Athens, Greece.

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http://dx.doi.org/10.1124/jpet.110.174375DOI Listing
March 2011

Simultaneous absolute quantification of the glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 in mouse plasma by LC/ESI-MS/MS: preclinical evaluation of DP-IV inhibitors.

J Proteome Res 2009 Jul;8(7):3487-96

Division of Pharmacology-Pharmacotechnology and Centre of Experimental Surgery, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Efesiou Street, Athens 11527, Greece.

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http://dx.doi.org/10.1021/pr900155hDOI Listing
July 2009

In vivo evaluation and in vitro metabolism of leuprolide in mice--mass spectrometry-based biomarker measurement for efficacy and toxicity.

J Mass Spectrom 2008 Oct;43(10):1381-92

Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece.

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http://dx.doi.org/10.1002/jms.1416DOI Listing
October 2008

A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice.

Rapid Commun Mass Spectrom 2007 ;21(15):2431-8

Department of Pharmacology-Pharmacotechnology, Foundation of Biomedical Research of the Academy of Athens, Soranou Efesiou Street 4, Athens 11527, Greece.

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http://dx.doi.org/10.1002/rcm.3106DOI Listing
October 2007

Mass spectrometry for the quantification of bioactive peptides in biological fluids.

Mass Spectrom Rev 2007 May-Jun;26(3):389-402

Foundation for Biomedical Research of the Academy of Athens (IIBEAA), Laboratory of Pharmacology-Pharmacotechnology, Athens, Greece 11527.

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http://doi.wiley.com/10.1002/mas.20120
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http://dx.doi.org/10.1002/mas.20120DOI Listing
June 2007

Analysis of the in vitro metabolites of diferuloylmethane (curcumin) by liquid chromatography--tandem mass spectrometry on a hybrid quadrupole linear ion trap system: newly identified metabolites.

Eur J Drug Metab Pharmacokinet 2007 Jan-Mar;32(1):51-7

Department of Pharmacology-Pharmacotechnology, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece.

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http://dx.doi.org/10.1007/BF03190990DOI Listing
June 2007

Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats.

Brain Res 2003 Jul;977(2):221-30

Department of Obesity and Metabolic Research, Merck Research Laboratories, P.O. Box 2000, R80M-213, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0006-8993(03)02683-0DOI Listing
July 2003

Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method.

J Chromatogr B Analyt Technol Biomed Life Sci 2002 May;772(1):89-98

Department of Basic Chemistry, Merck Research Laboratories, RY800B-206, P.O. Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s1570-0232(02)00061-2DOI Listing
May 2002