Conrad V Fernandez

Conrad V Fernandez

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Conrad V Fernandez

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Treatment of stage I anaplastic Wilms' tumour: a report from the Children's Oncology Group AREN0321 study.

Eur J Cancer 2019 Sep 17;118:58-66. Epub 2019 Jul 17.

Division of Oncology, Children's National Medical Center, Center for Cancer and Blood Disorders, George Washington University School of Medicine and Health Sciences, 111 Michigan Avenue NW, Washington, DC 20010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690766PMC
September 2019

Chemotherapy and Supportive Care Agents as Essential Medicines for Children With Cancer.

JAMA Pediatr 2019 May;173(5):477-484

Pediatric Hematology-Oncology, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://archpedi.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamapediatrics.2019.0070DOI Listing
May 2019

Reply to L. Xie et al.

J Clin Oncol 2019 May 15;37(14):1264-1265. Epub 2019 Mar 15.

Elizabeth A. Mullen, MD, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Geetika Khanna, MD, Washington University School of Medicine, St Louis, MO; James I. Geller, MD, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Conrad V. Fernandez, MD, Dalhousie University, Halifax, Nova Scotia, Canada; and Jeffrey S. Dome, MD, PhD, Children's National Health System, Washington, DC.

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http://dx.doi.org/10.1200/JCO.19.00012DOI Listing
May 2019

Genome-wide sequencing in acutely ill infants: genomic medicine's critical application?

Genet Med 2019 02 12;21(2):498-504. Epub 2018 Jun 12.

Centre of Genomics and Policy, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/s41436-018-0055-zDOI Listing
February 2019

Outcome of Wilms tumor patients with bone metastasis enrolled on National Wilms Tumor Studies 1-5: A report from the Children's Oncology Group.

Pediatr Blood Cancer 2019 Jan 30;66(1):e27430. Epub 2018 Aug 30.

Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Canada.

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http://dx.doi.org/10.1002/pbc.27430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249096PMC
January 2019

Impact of Surveillance Imaging Modality on Survival After Recurrence in Patients With Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group.

J Clin Oncol 2018 Oct 18:JCO1800076. Epub 2018 Oct 18.

Elizabeth A. Mullen, Dana-Farber Cancer Institute/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Yueh-Yun Chi and Emily Hibbitts, University of Florida, Gainesville, FL; James R. Anderson, Merck Research Laboratories, North Wales, PA; Katarina J. Steacy, University of Maryland Medical Center, Baltimore, MD; James I. Geller, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Daniel M. Green, St Jude Children's Research Hospital, Memphis, TN; Geetika Khanna, Washington University School of Medicine, St Louis, MO; Marcio H. Malogolowkin, University of California at Davis Comprehensive Cancer Center, Sacramento, CA; Paul E. Grundy, Stollery Children's Hospital, University of Alberta, Alberta; Conrad V. Fernandez, IWK Health Center, Dalhousie University Halifax, Nova Scotia, Canada; and Jeffrey S. Dome, Children's National Health System, George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://dx.doi.org/10.1200/JCO.18.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269130PMC
October 2018

Reply to D.M. Green.

J Clin Oncol 2018 Sep 13:JCO1800659. Epub 2018 Sep 13.

David B. Dix, British Columbia Children's Hospital, Vancouver, BC, Canada; Nita L. Seibel, National Cancer Institute, Bethesda, MD; Yueh-Yun Chi, University of Florida, Gainesville, FL; Geetika Khanna, Washington University School of Medicine, St Louis, MO; Elizabeth A. Mullen, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; James I. Geller, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; John A. Kalapurakal, Lurie Comprehensive Cancer Centre of Northwestern University, Chicago, IL; Peter F. Ehrlich, University of Michigan, Ann Arbor, MI; Marcio H. Malogolowkin, University of California at Davis Comprehensive Cancer Center, Sacramento, CA; Conrad V. Fernandez, IWK Health Center, Dalhousie University, Halifax, NS, Canada; and Jeffrey S. Dome, Children's National Health System, George Washington University School of Medicine and Health Sciences, Washington, DC.

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http://ascopubs.org/doi/10.1200/JCO.18.00659
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http://dx.doi.org/10.1200/JCO.18.00659DOI Listing
September 2018

Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children's Oncology Group AREN0533 Study.

J Clin Oncol 2018 06 16;36(16):1564-1570. Epub 2018 Apr 16.

David B. Dix, British Columbia Children's Hospital, Vancouver, British Columbia; Paul E. Grundy, University of Alberta, Edmonton, Alberta; Conrad V. Fernandez, Dalhousie University, Halifax, Nova Scotia, Canada; Nita L. Seibel, National Cancer Institute, Bethesda, MD; Yueh-Yun Chi, University of Florida, Gainesville, FL; Geetika Khanna, Washington University School of Medicine, St Louis, MO; Eric Gratias, University of Tennessee College of Medicine Chattanooga, Chattanooga, TN; James R. Anderson, Merck Research Laboratories, North Wales, PA; Elizabeth A. Mullen, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; James I. Geller, Cincinnati Children's Hospital Medical Center, Cincinnati; Julie M. Gastier-Foster and Elizabeth Wagner, Nationwide Children's Hospital; Julie M. Gastier-Foster, The Ohio State University College of Medicine, Columbus, OH; John A. Kalapurakal, Lurie Comprehensive Cancer Centre of Northwestern University; Elizabeth J. Perlman, Ann and Robert H. Lurie Children's Hospital, Chicago, IL; Arnold C. Paulino, MD Anderson Cancer Center, Houston, TX; Peter F. Ehrlich, University of Michigan, Ann Arbor, MI; Marcio Malogolowkin, University of California at Davis Comprehensive Cancer Center, Sacramento, CA; Jeffrey S. Dome, George Washington University School of Medicine and Health Sciences, Washington, DC; on behalf of the AREN0533 Study Committee.

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http://dx.doi.org/10.1200/JCO.2017.77.1931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075846PMC
June 2018

Key Implications of Data Sharing in Pediatric Genomics.

JAMA Pediatr 2018 05;172(5):476-481

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1001/jamapediatrics.2017.5500DOI Listing
May 2018

Reply to B. Zhang et al.

J Clin Oncol 2018 05 3;36(14):1454-1455. Epub 2018 Apr 3.

Conrad V. Fernandez, Dalhousie University, Halifax, Nova Scotia, Canada; Elizabeth J. Perlman, Ann and Robert H. Lurie Children's Hospital, Chicago, IL; Julie Gastier-Foster, Nationwide Children's Hospital, Columbus, OH; James I. Geller, Cincinnati Children's Hospital Medical Centre, Cincinnati, OH; Elizabeth A. Mullen, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Peter F. Ehrlich, University of Michigan, Ann Arbor, MI; and Jeffrey S. Dome, Children's National Medical Center, Washington, DC.

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http://dx.doi.org/10.1200/JCO.2018.78.0445DOI Listing
May 2018

Pragmatic Tools for Sharing Genomic Research Results with the Relatives of Living and Deceased Research Participants.

J Law Med Ethics 2018 03 27;46(1):87-109. Epub 2018 Mar 27.

Susan M. Wolf, J.D., is McKnight Presidential Professor of Law, Medicine & Public Policy; Faegre Baker Daniels Professor of Law; Professor of Medicine; and Chair of the Consortium on Law and Values in Health, Environment & the Life Sciences, University of Minnesota. She was one of three Principal Investigators on NIH/NCI/NHGRI grant 1R01CA154517 on return of genomic results to family members, including after the death of the proband. Emily Scholtes, J.D., is a graduate of the University of Minnesota Law School, where she served as a Research Assistant on the project on return of genomic results to family members. She then clerked for the U.S. Court of Appeals for the Eighth Circuit before going into private practice. The views expressed in this article are exclusively those of the authors. This article has been prepared for informational purposes only and does not constitute legal advice. Barbara A. Koenig, Ph.D., is Director of Bioethics and Professor of Bioethics and Medical Anthropology based at the Institute for Health & Aging, University of California, San Francisco. She was one of three Principal Investigators on NIH/NCI/NHGRI grant 1R01CA154517 on return of genomic results to family members, including after the death of the proband. Gloria M. Petersen, Ph.D., is Professor of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine. She is a Founding Fellow of the American College of Medical Genetics and Genomics. She was one of three Principal Investigators on NIH/NCI/NHGRI grant 1R01CA154517 on return of genomic results to family members, including after the death of the proband. Susan A. Berry, M.D., is Professor of Pediatrics & Genetics and Division Director for Genetics and Metabolism in the Department of Pediatrics, University of Minnesota. She is a Fellow of the American Academy of Pediatrics and the American College of Medical Genetics. Laura M. Beskow, M.P.H., Ph.D., is Professor of Health Policy and Director of Research Ethics, Center for Biomedical Ethics & Society, Vanderbilt University. She received her M.P.H. with a concentration in health law from Boston University and her Ph.D. in Health Policy and Administration, with a minor in Epidemiology, at the University of North Carolina at Chapel Hill. Mary B. Daly, M.D., Ph.D., is a medical oncologist and epidemiologist who chairs the Department of Clinical Genetics at Fox Chase Cancer Center. Her research focuses on defining the best methods of communicating hereditary cancer risk information and on providing risk management strategies and coping skills to family members dealing with an increased risk for cancer. Conrad V. Fernandez, B.Sc., M.D., is Professor and Head of the Division of Pediatric Hematology/Oncology in the Department of Pediatrics, IWK Health Centre, Dalhousie University and is cross-appointed in Bioethics, Medicine, and Postgraduate Studies. He obtained his medical degree at McMaster University, specialist certification in Pediatrics as a Fellow of the Royal College of Physicians and Surgeons of Canada at Dalhousie University, and completed specialty training in Pediatric Hematology/Oncology at the University of British Columbia. Robert C. Green, M.D., M.P.H., is a medical geneticist and physician-scientist who directs the G2P Research Program in translational genomics and health outcomes in the Division of Genetics, Brigham and Women's Hospital and Harvard Medical School. He is also Associate Director for Research at Partners Personalized Medicine. Dr. Green leads and co-leads the MedSeq Project and the BabySeq Project respectively, two NIH-funded randomized trials designed to explore the medical, behavioral, and economic implications of integrating genome sequencing into the medical care of adults and newborns. Bonnie S. LeRoy, M.S., C.G.C., is Professor and Director of the Graduate Program in Genetic Counseling, University of Minnesota. Her work focuses on preparing graduate students to enter the profession of genetic counseling. Her research examines the ethical and social challenges associated with the genetic counseling profession. She served as the President of the American Board of Genetic Counseling from 2001-03. Noralane M. Lindor, M.D., is Professor of Medical Genetics in the Department of Health Sciences Research at Mayo Clinic in Scottsdale, Arizona. She received her medical degree from Mayo Medical School, and did her residencies at Bowman Gray School of Medicine in Winston-Salem, North Carolina, and at Mayo Clinic in Rochester. P. Pearl O'Rourke, M.D., is Director of Human Research Affairs at Partners HealthCare in Boston, and Associate Professor of Pediatrics at Harvard Medical School. She completed medical school at Dartmouth Medical School and the University of Minnesota Medical School. Carmen Radecki Breitkopf, Ph.D., is Professor of Health Services Research in the Department of Health Sciences Research at Mayo Clinic College of Medicine and Science in Rochester, Minnesota. She earned her Master's and Doctoral degrees in Psychology from the State University of New York at Albany. Mark A. Rothstein, J.D., is Herbert F. Boehl Chair of Law & Medicine and Director of the Institute for Bioethics, Health Policy & Law at the University of Louisville School of Medicine. He is past-President of the American Society of Law, Medicine & Ethics and serves as Public Health Ethics editor for the American Journal of Public Health. Brian Van Ness, Ph.D., is Professor of Genetics, Cell Biology and Development at the University of Minnesota. He earned his doctorate in Biochemistry from the University of Minnesota, completed a postdoctoral fellowship at Fox Chase Cancer Center, and has served as the Department Head and Director of the Institute of Human Genetics at the University of Minnesota. Benjamin S. Wilfond, M.D., is Director of the Treuman Katz Center for Pediatric Bioethics, Seattle Children's Hospital; Professor and Chief of the Division of Bioethics; Professor, Pulmonary and Sleep Medicine, Department of Pediatrics; and Adjunct Professor, Department of Bioethics and Humanities, University of Washington School of Medicine. He is past-President of the Association of Bioethics Program Directors, Chair for the Clinical Research Ethics Consultation Working Group for the Clinical and Translational Science Awards program, and a member of the Bioethics and Legal Working Group of the Newborn Screening Translational Research Network.

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http://dx.doi.org/10.1177/1073110518766024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040667PMC
March 2018

Peripherally Inserted Central Catheters in Pediatric Oncology Patients: A 15-Year Population-based Review From Maritimes, Canada.

J Pediatr Hematol Oncol 2018 01;40(1):e55-e60

Department of Pediatrics, IWK Health Centre, Division of Hematology Oncology, Halifax, NS, Canada.

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http://Insights.ovid.com/crossref?an=00043426-900000000-9818
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http://dx.doi.org/10.1097/MPH.0000000000000882DOI Listing
January 2018

Outcome and Prognostic Factors in Stage III Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group Study AREN0532.

J Clin Oncol 2018 01 6;36(3):254-261. Epub 2017 Dec 6.

Conrad V. Fernandez, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia; Paul E. Grundy, University of Alberta, Edmonton, Alberta, Canada; Elizabeth A. Mullen, Dana-Farber/Boston Children's Cancer and Blood Disorders Centre, Boston; Thomas E. Hamilton and Robert C. Shamberger, Boston Children's Hospital, Boston, MA; Yueh-Yun Chi and Yeonil Kim, University of Florida, Gainesville, FL; Peter F. Ehrlich, University of Michigan, Ann Arbor, MI; Elizabeth J. Perlman, Ann and Robert H. Lurie Children's Hospital, Chicago; John A. Kalapurakal, Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL; Geetika Khanna, Washington University School of Medicine in St Louis, St Louis, MO; Arnold C. Paulino, MD Anderson Cancer Center, Houston, TX; Kenneth W. Gow, Seattle Children's Hospital, Seattle, WA; Zelig Tochner, University of Pennsylvania, Philadelphia; James R. Anderson, Merck Research Laboratories-Oncology, North Wales, PA; Fredric A. Hoffer, Imaging & Radiation Oncology Core Group in Rhode Island, Lincoln, RI; Janice S. Withycombe, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; James I. Geller, Cincinnati Children's Hospital Medical Centre, Cincinnati, OH; and Jeffrey S. Dome, Children's National Medical Center, Washington, DC, for the Children's Oncology Group AREN0532 Committee.

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http://dx.doi.org/10.1200/JCO.2017.73.7999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773840PMC
January 2018

Imaging of renal medullary carcinoma in children and young adults: a report from the Children's Oncology Group.

Pediatr Radiol 2017 Nov 8;47(12):1615-1621. Epub 2017 Jul 8.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway, Campus Box 8131, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s00247-017-3926-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768308PMC
November 2017

Results of the First Prospective Multi-institutional Treatment Study in Children With Bilateral Wilms Tumor (AREN0534): A Report From the Children's Oncology Group.

Ann Surg 2017 09;266(3):470-478

*Section of Pediatric Surgery CS Mott Children's Hospital, University of Michigan, Ann Arbor MI †COG Data Center, University of Florida, Gainesville, FL ‡Texas Children's Cancer Center at Baylor College of Medicine, Houston, TX §Fred Hutchison Cancer Center, University of Washington, Seattle, WA ¶Ann and Robert H Lurie Children's Hospital, Chicago, IL ||Northwestern University, Chicago, IL **Walter Reed National Military Medical Center, Washington DC ††Boston Children's Hospital and Dana Farber Cancer Center, Boston, MA ‡‡Washington University of St Louis, St Louis, MO §§University of Washington, Seattle, WA ¶¶MD Anderson Cancer Center, Houston, TX ||||Children's Oncology Group, Philadelphia, PA ***Cincinnati Children's Hospital, Cincinnati, OH †††University of Alberta Children's Hospital, Edmonton, Alberta, Canada ‡‡‡IWK Children's Hospital, Halifax, Nova Scotia, Canada §§§Phoenix Children's Hospital, Phoenix, AZ ¶¶¶Children National Medical Center, Washington, DC.

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http://dx.doi.org/10.1097/SLA.0000000000002356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629006PMC
September 2017

Clinical Outcome and Biological Predictors of Relapse After Nephrectomy Only for Very Low-risk Wilms Tumor: A Report From Children's Oncology Group AREN0532.

Ann Surg 2017 04;265(4):835-840

*IWK Health Center, Dalhousie University, Halifax, Nova Scotia, Canada †Ann and Robert H. Lurie Children's Hospital, Chicago, IL ‡Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA §Department of Biostatistics, University of Florida, Gainesville, FL ¶Boston Children's Hospital, Boston, MA ||Division of General and Thoracic Surgery, Seattle Children's Hospital, Seattle, WA **Connecticut Children's Medical Center, Hartford, CT ††Primary Children's Hospital, Salt Lake City, UT ‡‡University of Michigan, Ann Arbor, MI §§Washington University School of Medicine in St. Louis, St. Louis, MO ¶¶Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL ||||Anderson Cancer Center, Houston, TX ***Children's Oncology Group Data Center, University of Florida, Gainesville, FL †††Cincinnati Children's Hospital Medical Center, Cincinnati, OH ‡‡‡Alberta Health Services, Edmonton, Alberta, Canada §§§Merck Research Laboratories - Oncology, North Wales, PA ¶¶¶Children's National Medical Center, District of Columbia, WA.

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http://dx.doi.org/10.1097/SLA.0000000000001716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145762PMC
April 2017

Returning a Research Participant's Genomic Results to Relatives: Analysis and Recommendations.

J Law Med Ethics 2015 ;43(3):440-63

Director of the Treuman Katz Center for Pediatric Bioethics, Seattle Children's Hospital; Professor and Chief of the Division of Bioethics; Professor, Pulmonary and Sleep Medicine, Department of Pediatrics; and Adjunct Professor, Department of Bioethics and Humanities, University of Washington School of Medicine. He is President of the Association of Bioethics Program Directors, Chair for the Clinical Research Ethics Consultation Working Group for the Clinical and Translational Science Awards program, and a member of the Bioethics and Legal Working Group of the Newborn Screening Translational Research Network.

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http://dx.doi.org/10.1111/jlme.12288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617203PMC
January 2017

Canadian Research Ethics Board Leadership Attitudes to the Return of Genetic Research Results to Individuals and Their Families.

J Law Med Ethics 2015 ;43(3):514-22

Associate Professor at the Duke University School of Medicine and Duke Clinical Research Institute, where her work focuses on ethics and policy issues in biomedical research-particularly human subjects issues in large-scale genomic and translational research. She holds a B.S. in nutrition from Iowa State University, an M.P.H. with a concentration in health law from Boston University, and a Ph.D. in health policy and administration from the University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1111/jlme.12293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617195PMC
January 2017

Disclosing Secondary Findings from Pediatric Sequencing to Families: Considering the "Benefit to Families".

J Law Med Ethics 2015 ;43(3):552-8

Directs the Genomes-2People Research Program and Translational Genomics and Health Outcomes within the Division of Genetics, Department of Medicine, Brigham and Women's Hospital, with appointments at the Broad Institute and Harvard Medical School. He is also Associate Director for Research, Partners HealthCare Personalized Medicine.

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http://dx.doi.org/10.1111/jlme.12298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617182PMC
January 2017

A Multi-Informant Multi-Method Investigation of Family Functioning and Parent-Child Coping During Children's Acute Pain.

J Pediatr Psychol 2017 01;42(1):28-39

IWK Health Centre and Science, Pediatrics, Psychiatry, and Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1093/jpepsy/jsw045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939884PMC
January 2017

Severe, persistent, and fatal T-cell immunodeficiency following therapy for infantile leukemia.

Pediatr Blood Cancer 2016 11 29;63(11):2046-9. Epub 2016 Jun 29.

Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1002/pbc.26108DOI Listing
November 2016

Association of Chromosome 1q Gain With Inferior Survival in Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group.

J Clin Oncol 2016 09 11;34(26):3189-94. Epub 2016 Jul 11.

Eric J. Gratias, University of Tennessee College of Medicine-Chattanooga, Chattanooga, TN; Jeffrey S. Dome, Children's National Health System, Washington, DC; Lawrence J. Jennings and Elizabeth J. Perlman, Northwestern University, Chicago, IL; Yueh-Yun Chi and Jing Tian, University of Florida, Gainesville, FL; James Anderson, University of Nebraska Medical Center, Omaha, NE; Paul Grundy, University of Alberta, Edmonton, Alberta; Conrad V. Fernandez, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada; Elizabeth A. Mullen, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA; and James I. Geller, University of Cincinnati, Cincinnati, OH.

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http://dx.doi.org/10.1200/JCO.2015.66.1140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012705PMC
September 2016

Allergic Reactions With Intravenous Compared With Intramuscular Pegaspargase in Children With High-risk Acute Lymphoblastic Leukemia: A Population-based Study From the Maritimes, Canada.

J Pediatr Hematol Oncol 2016 07;38(5):341-4

*Department of Pharmacy ‡Division of Pediatric Hematology/Oncology, IWK Health Centre †Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1097/MPH.0000000000000520DOI Listing
July 2016

Stability of Attitudes to the Ethical Issues Raised by the Return of Incidental Genomic Research Findings in Children: A Follow-Up Study.

Public Health Genomics 2015 10;18(5):299-308. Epub 2015 Sep 10.

Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, N.S., Canada.

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http://dx.doi.org/10.1159/000439244DOI Listing
June 2016

An Ethical Framework for Allocating Scarce Life-Saving Chemotherapy and Supportive Care Drugs for Childhood Cancer.

J Natl Cancer Inst 2016 Jun 29;108(6):djv392. Epub 2016 Jan 29.

Division of Pediatric Hematology/Oncology, The Herman and Walter Samuelson Children's Hospital at Sinai, Baltimore, MD (YU); Johns Hopkins University, Berman Institute of Bioethics, Baltimore, MD (YU); IWK Health Centre, Departments of Pediatrics and Bioethics, Dalhousie University, Halifax, Nova Scotia, Canada (CVF); Texas Children's Hospital, Houston, TX (BB); Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX (SB); Division of Pediatric Hematology/Oncology/Stem Cell Transplant, Lucile Packard Children's Hospital, Stanford Palo Alto, CA (KPG); University of Iowa, Iowa City, IA (CW); Department of Medical Ethics & Health Policy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (SJ).

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http://dx.doi.org/10.1093/jnci/djv392DOI Listing
June 2016

Dyadic analysis of child and parent trait and state pain catastrophizing in the process of children's pain communication.

Pain 2016 Apr;157(4):938-48

aDepartment of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada bCentre for Pediatric Pain Research, IWK Health Centre, Halifax, NS, Canada cDepartment of Pediatrics, Dalhousie University & IWK Health Centre, Halifax, NS, Canada dDepartment of Anesthesia, Pain, and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada eIWK Health Centre and Department of Science, Pediatrics, Psychiatry and Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada fDepartments of Science, Pediatrics, Psychiatry, and Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1097/j.pain.0000000000000461DOI Listing
April 2016

Acceptability by parents and children of deception in pediatric research.

J Dev Behav Pediatr 2015 Feb-Mar;36(2):75-85

*Centre for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA; †Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada; ‡Centre for Pediatric Pain Research, IWK Health Center, Halifax, NS, Canada; §Department of Pediatrics, Dalhousie University, Halifax, NS, Canada; ‖Department of Applied Psychology and Human Development, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/DBP.0000000000000122DOI Listing
March 2016

Statement of principles on the return of research results and incidental findings in paediatric research: a multi-site consultative process.

Genome 2015 Dec 10;58(12):541-8. Epub 2015 Nov 10.

e Sainte-Justine University Health Center, Research Center, Department of Pediatrics, University of Montreal, 3175 Chemin de la Côte Sainte-Catherine, Montreal, QC H3T 1C5, Canada.

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http://www.nrcresearchpress.com/doi/10.1139/gen-2015-0092
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http://dx.doi.org/10.1139/gen-2015-0092DOI Listing
December 2015

Improving diagnostic precision, care and syndrome definitions using comprehensive next-generation sequencing for the inherited bone marrow failure syndromes.

J Med Genet 2015 Sep 1;52(9):575-84. Epub 2015 Jul 1.

Program in Genetics and Genome Biology, Research Institute, Toronto, Ontario, Canada Marrow Failure and Myelodysplasia Program, Division of Hematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada Faculty of Medicine, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jmedgenet-2015-103270DOI Listing
September 2015

Incident Vertebral Fractures in Children With Leukemia During the Four Years Following Diagnosis.

J Clin Endocrinol Metab 2015 Sep 14;100(9):3408-17. Epub 2015 Jul 14.

Dalhousie University (E.A.C., C.V.F., B.La.), Halifax, Nova Scotia B3H 4R2, Canada; University of Ottawa (H.M., J.Ha., N.S., M.A.M., L.M.W.), Ottawa, Ontario K1N 6N5, Canada; Université de Montréal (N.A.), Montreal, Quebec H3T 1J4, Canada; University of Calgary (P.M.M., J.Ho., D.S.), Calgary, Alberta T2N 1N4, Canada; University of Alberta (J.L.J., R.C., K.S.), Edmonton, Alberta T6G 2R3, Canada; University of British Columbia (B.Le.), Vancouver, British Columbia V6T 1Z4, Canada; University of Western Ontario (R.S.), London, Ontario N6A 3K7, Canada; McGill University (A.M.S., F.R.), Montréal, Quebec H3A 0G4, Canada; University of Manitoba (C.R., S.I.), Winnipeg, Manitoba R3T 2N2, Canada; University of Toronto (R.M.G.), Toronto, Ontario M5S 2J7, Canada; McMaster University (R.B.), Hamilton, Ontario L8S 4L8, Canada; and Brock University (J.H.), St. Catharines, Ontario L2S 3A1, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909472PMC
September 2015

Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2999-3007. Epub 2015 Aug 24.

Jeffrey S. Dome, Children's National Health System, Washington, DC; James I. Geller, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Elizabeth A. Mullen, Dana-Farber Cancer Institute, Boston, MA; Norbert Graf, Saarland University, Homburg, Germany; Conrad V. Fernandez, IWK Health Centre, Halifax, Nova Scotia, Canada; Filippo Spreafico, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Marry Van den Heuvel-Eibrink, Princess Màxima Center for Pediatric Oncology, Utrecht, the Netherlands; and Kathy Pritchard-Jones, University College London Institute of Child Health, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2015.62.1888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567702PMC
September 2015

Are hybrid umbilical cord blood banks really the best of both worlds?

J Med Ethics 2015 Mar 13;41(3):272-5. Epub 2014 May 13.

Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1136/medethics-2013-101673DOI Listing
March 2015

The choice of normative pediatric reference database changes spine bone mineral density Z-scores but not the relationship between bone mineral density and prevalent vertebral fractures.

J Clin Endocrinol Metab 2015 Mar 11;100(3):1018-27. Epub 2014 Dec 11.

Children's Hospital of Eastern Ontario Research Institute (J.M., M.S.), Ottawa, ON; University of Alberta (K.S., R.C.), Edmonton, AB; Université de Montréal (N.A.), Montréal, QC; University of Ottawa (J.H., M.M., N.S., L.M.W.), Ottawa, ON; University of Calgary (J.H.), Calgary, AB; University of British Columbia (B.L., D.A.C.), Vancouver, BC; McMaster University (S.A., R.B.), Hamilton, ON; Dalhousie University (E.A.C., C.V.F.), Halifax, NS; University of Toronto (R.M.G.), Toronto, ON; University of Manitoba (C.R.), Winnipeg, MB; McGill University (A.M.S., F.R.), Montréal, QC.

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http://dx.doi.org/10.1210/jc.2014-3096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519277PMC
March 2015

Understanding the translation of scientific knowledge about arsenic risk exposure among private well water users in Nova Scotia.

Sci Total Environ 2015 Feb 18;505:1259-73. Epub 2014 Jan 18.

Dalhousie University, Population Cancer Research Program, Department of Pediatrics, 1494 Carlton Street, P.O. Box 15000, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address:

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February 2015

Management of familial cancer: sequencing, surveillance and society.

Nat Rev Clin Oncol 2014 12 14;11(12):723-31. Epub 2014 Oct 14.

1] Department of Medical Biophysics, University of Toronto, Division of Hematology/Oncology and Genetics &Genome Biology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. [2] Department of Pediatrics and Institute of Medical Science, University of Toronto, Division of Hematology/Oncology and Genetics &Genome Biology Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nrclinonc.2014.169DOI Listing
December 2014

Development of the Pediatric Advanced Care Quality of Life Scale (PAC-QoL): evaluating comprehension of items and response options.

Pediatr Blood Cancer 2014 Oct 19;61(10):1835-9. Epub 2014 Jun 19.

Department of Psychology, University of Western Ontario, London, Ontario, Canada.

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October 2014

Development of a quality of life instrument for children with advanced cancer: the pediatric advanced care quality of life scale (PAC-QoL).

Pediatr Blood Cancer 2014 Oct 19;61(10):1840-5. Epub 2014 Jun 19.

Department of Psychology, Children's Hospital, London Health Sciences Centre, London, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.25115DOI Listing
October 2014

Arsenic in private drinking water wells: an assessment of jurisdictional regulations and guidelines for risk remediation in North America.

J Water Health 2014 Sep;12(3):372-92

Department of Pediatrics, Dalhousie University, Population Cancer Research Program, 1494 Carlton Street, PO Box 15000, Halifax, Nova Scotia, B3H 4R2, Canada E-mail:

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http://jwh.iwaponline.com/cgi/doi/10.2166/wh.2014.054
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September 2014

Chemotherapy drug shortages in pediatric oncology: a consensus statement.

Pediatrics 2014 Mar 2;133(3):e716-24. Epub 2014 Feb 2.

Johns Hopkins Berman Institute of Bioethics, Baltimore, Maryland;

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http://dx.doi.org/10.1542/peds.2013-2946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934344PMC
March 2014

Children's Oncology Group's 2013 blueprint for research: renal tumors.

Pediatr Blood Cancer 2013 Jun 19;60(6):994-1000. Epub 2012 Dec 19.

Division of Oncology, Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC 20010, USA.

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http://dx.doi.org/10.1002/pbc.24419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127041PMC
June 2013

Ethical issues for control-arm patients after revelation of benefits of experimental therapy: a framework modeled in neuroblastoma.

J Clin Oncol 2013 Feb 7;31(5):641-6. Epub 2013 Jan 7.

Division of Pediatric Hematology/Oncology, The Herman and Walter Samuelson Children's Hospital at Sinai, 2401 West Belvedere Ave, Baltimore, MD 21215-5271, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565183PMC
February 2013

Using MS-MLPA as an efficient screening tool for detecting 9p21 abnormalities in pediatric acute lymphoblastic leukemia.

Pediatr Blood Cancer 2012 Jun 27;58(6):852-9. Epub 2011 Jul 27.

Department of Microbiology and Immunology, IWK Health Centre/Dalhousie University, Halifax, NS, Canada.

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http://dx.doi.org/10.1002/pbc.23285DOI Listing
June 2012

The publication of ethically uncertain research: attitudes and practices of journal editors.

BMC Med Ethics 2012 Apr 11;13. Epub 2012 Apr 11.

Division of Pediatric Emergency Medicine, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1186/1472-6939-13-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378458PMC
April 2012

The cold pressor task: is it an ethically acceptable pain research method in children?

J Pediatr Psychol 2011 Nov-Dec;36(10):1071-81. Epub 2010 Oct 5.

Department of Psychology, Dalhousie University, Canada.

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http://dx.doi.org/10.1093/jpepsy/jsq092DOI Listing
March 2012

Parental views on tissue banking in pediatric oncology patients.

Pediatr Blood Cancer 2011 Dec 19;57(7):1217-21. Epub 2011 Jan 19.

Department of Kinesiology, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada.

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December 2011

Fever and purpuric lesions in a preschool child.

Can J Infect Dis Med Microbiol 2009 ;20(3):e110-1

Faculty of Medicine;

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http://dx.doi.org/10.1155/2009/916893DOI Listing
July 2011

Allogeneic hematopoietic stem cell transplantation of patients with FA and high risk features using fludarabine without radiation.

Pediatr Blood Cancer 2009 May;52(5):683-5

Division of Hematology-Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.21921DOI Listing
May 2009

JAK2 V617F positive polycythemia Vera in a child with neurofibromatosis type I.

Pediatr Blood Cancer 2008 Nov;51(5):689-91

Dalhousie Cancer Genetics Research Group, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1002/pbc.21659DOI Listing
November 2008

Clinical and genetic analysis of unclassifiable inherited bone marrow failure syndromes.

Pediatrics 2008 Jul;122(1):e139-48

Marrow Failure and Myelodysplasia Program, Division of Haematology, Research Institute, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada.

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July 2008

Routine bone marrow examination in the initial evaluation of paediatric Hodgkin lymphoma: the Canadian perspective.

Br J Haematol 2008 Jun 18;141(6):820-6. Epub 2008 Apr 18.

Department of Paediatrics, Dalhousie University, and IWK Health Centre, Halifax, NS, Canada.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07094.xDOI Listing
June 2008

Offering results to research subjects: U.S. Institutional Review Board policy.

Account Res 2007 Oct-Dec;14(4):255-67

School of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1080/08989620701670179DOI Listing
March 2008

Successful neurological outcome of a child with classical phenylketonuria and acute lymphoblastic leukemia: a 7-year follow-up.

Am J Med Genet A 2007 Dec;143A(24):3324-7

Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

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http://doi.wiley.com/10.1002/ajmg.a.31726
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December 2007

Validity and consequence of informed consent in pediatric bone marrow transplantation: The parental experience.

Pediatr Blood Cancer 2007 Nov;49(6):846-51

Department of Family Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1002/pbc.21073DOI Listing
November 2007

Attitudes of research ethics board chairs towards disclosure of research results to participants: results of a national survey.

J Med Ethics 2007 Sep;33(9):549-53

Department of Surgery, Division of Otolaryngology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1136/jme.2006.017129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598188PMC
September 2007

Obligations in offering to disclose genetic research results.

Am J Bioeth 2006 Nov-Dec;6(6):44-6; author reply W10-2

Dalhousie University, Canada.

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http://dx.doi.org/10.1080/15265160600938575DOI Listing
January 2007

Involving children with cancer in decision-making about research participation.

J Pediatr 2006 Dec;149(6):862-868

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.jpeds.2006.08.027DOI Listing
December 2006

Hyperphagia following childhood acute lymphoblastic leukemia: a symptom worth heeding.

Clin Pediatr (Phila) 2006 Apr;45(3):271-3

Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, Canada.

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http://dx.doi.org/10.1177/000992280604500311DOI Listing
April 2006

Adolescents and young adults with cancer: An orphaned population.

Paediatr Child Health 2006 Feb;11(2):103-6

Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia.

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http://dx.doi.org/10.1093/pch/11.2.103DOI Listing
February 2006

C-Kit-positive metastatic malignant pigmented clear-cell epithelioid tumor arising from the kidney in a child without tuberous sclerosis.

Ann Diagn Pathol 2005 Dec;9(6):330-4

Department of Pathology and Laboratory Medicine, Alberta Children's Hospital, (Calgary Laboratory Services), Calgary, Alberta, Canada T2T 5C7.

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December 2005

Publication of ethically suspect research: should it occur?

Int J Qual Health Care 2005 Oct 12;17(5):377-8. Epub 2005 Aug 12.

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http://dx.doi.org/10.1093/intqhc/mzi068DOI Listing
October 2005

The crucial role of tumour specimen handling in childhood cancer outcomes.

Paediatr Child Health 2005 Oct;10(8):471-2

Departments of Pediatrics and.

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October 2005

Mixed donor chimerism and low level iduronidase expression may be adequate for neurodevelopmental protection in Hurler Syndrome.

J Pediatr 2005 Jul;147(1):106-8

Department of Pediatrics, Division of Genetics, IWK Health Centre, Halifax, Nova Scotia, Canada.

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July 2005