Conor R Caffrey

Conor R Caffrey

UNVERIFIED PROFILE

Are you Conor R Caffrey?   Register this Author

Register author
Conor R Caffrey

Conor R Caffrey

Publications by authors named "Conor R Caffrey"

Are you Conor R Caffrey?   Register this Author

100Publications

1809Reads

5Profile Views

Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty.

Pharmaceuticals (Basel) 2020 02 3;13(2). Epub 2020 Feb 3.

Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College, University of Delhi, Delhi 110007, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ph13020025DOI Listing
February 2020

Bioactivity of Farnesyltransferase Inhibitors Against and .

Front Cell Infect Microbiol 2019 29;9:180. Epub 2019 May 29.

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2019.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548881PMC
January 2020

20S Proteasome as a Drug Target in Trichomonas vaginalis.

Antimicrob Agents Chemother 2019 11 22;63(11). Epub 2019 Oct 22.

Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, La Jolla, California, USA

View Article

Download full-text PDF

Source
http://aac.asm.org/lookup/doi/10.1128/AAC.00448-19
Publisher Site
http://dx.doi.org/10.1128/AAC.00448-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811414PMC
November 2019

Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.

Eur J Med Chem 2019 Oct 22;179:765-778. Epub 2019 Jun 22.

Laboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Avenida Antonio Carlos 6627, Belo Horizonte, MG, 31270-901, Brazil. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.06.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718330PMC
October 2019

The Proteasome as a Drug Target in the Metazoan Pathogen, .

ACS Infect Dis 2019 10 12;5(10):1802-1812. Epub 2019 Aug 12.

Center for Discovery and Innovation in Parasitic Diseases , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsinfecdis.9b00237DOI Listing
October 2019

Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery.

Parasit Vectors 2019 Oct 22;12(1):493. Epub 2019 Oct 22.

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13071-019-3747-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805474PMC
October 2019

Benzimidazole inhibitors of the major cysteine protease of .

Future Med Chem 2019 Jul;11(13):1537-1551

Laboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc-2018-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722484PMC
July 2019

A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response.

PLoS Negl Trop Dis 2019 01 17;13(1):e0007070. Epub 2019 Jan 17.

Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pntd.0007070
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0007070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353221PMC
January 2019

Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment.

J R Soc Interface 2019 01;16(150):20180675

1 Department of Mechanical and Aerospace Engineering, University of California San Diego , San Diego, CA , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsif.2018.0675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364656PMC
January 2019

TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.

Int J Parasitol Drugs Drug Resist 2018 12 20;8(3):571-586. Epub 2018 Nov 20.

Center for Discovery and Innovation in Parasitic Diseases, University of California, 1700 4th St, San Francisco, CA, 94158, USA; Department of Pathology, University of California, 1700 4th St, San Francisco, CA, 94158, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpddr.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287543PMC
December 2018

High Throughput and Computational Repurposing for Neglected Diseases.

Pharm Res 2018 Dec 17;36(2):27. Epub 2018 Dec 17.

Collaborations Pharmaceuticals Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina, 27606, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-018-2558-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792295PMC
December 2018

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis.

ChemMedChem 2018 09 7;13(17):1751-1754. Epub 2018 Aug 7.

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201800404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286711PMC
September 2018

Cysteine proteases as digestive enzymes in parasitic helminths.

PLoS Negl Trop Dis 2018 08 23;12(8):e0005840. Epub 2018 Aug 23.

School of Biological Sciences, Medical Biology Centre, Queen´s University Belfast, Belfast, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0005840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107103PMC
August 2018

Cysteine proteases during larval migration and development of helminths in their final host.

PLoS Negl Trop Dis 2018 08 23;12(8):e0005919. Epub 2018 Aug 23.

Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0005919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107106PMC
August 2018

Octopamine signaling in the metazoan pathogen : localization, small-molecule screening and opportunities for drug development.

Dis Model Mech 2018 07 30;11(7). Epub 2018 Jul 30.

Institute of Parasitology, McGill University, Macdonald Campus, 21, 111 Lakeshore Road, Ste Anne de Bellevue, Quebec, Canada H9X-3V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.033563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078403PMC
July 2018

Effect of Phenotypic Screening of Extracts and Fractions of Leaf and Stem Bark on Immature and Adult Stages of .

J Parasitol Res 2018 7;2018:9431467. Epub 2018 Jun 7.

Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/9431467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011076PMC
June 2018

Targeting proteasomes in infectious organisms to combat disease.

FEBS J 2017 05 16;284(10):1503-1517. Epub 2017 Feb 16.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/febs.14029DOI Listing
May 2017

Anthelmintics: From discovery to resistance II (San Diego, 2016).

Int J Parasitol Drugs Drug Resist 2016 12 29;6(3):297-298. Epub 2016 Sep 29.

Center for Discovery and Innovation in Parasitic Diseases Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpddr.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197440PMC
December 2016

Odanacatib, a Cathepsin K Cysteine Protease Inhibitor, Kills Hookworm In Vivo.

Pharmaceuticals (Basel) 2016 Jul 4;9(3). Epub 2016 Jul 4.

Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039492PMC
http://dx.doi.org/10.3390/ph9030039DOI Listing
July 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Schistosomiasis and its treatment.

Authors:
Conor R Caffrey

Future Med Chem 2015 ;7(6):675-6

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4155/fmc.15.27DOI Listing
February 2016

Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni.

PLoS Negl Trop Dis 2016 Jan 11;10(1):e0004356. Epub 2016 Jan 11.

Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0004356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709140PMC
January 2016

Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil.

PLoS Negl Trop Dis 2016 Jan 11;10(1):e0004357. Epub 2016 Jan 11.

Center for Discovery and Innovation in Parasitic Diseases and the Department of Pathology, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0004357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709075PMC
January 2016

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni.

Molecules 2015 Jun 12;20(6):10873-83. Epub 2015 Jun 12.

Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules200610873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272620PMC
June 2015

The QDREC web server: determining dose-response characteristics of complex macroparasites in phenotypic drug screens.

Bioinformatics 2015 May 24;31(9):1515-8. Epub 2014 Dec 24.

Department of Computer Science, San Francisco State University, San Francisco, CA, USA, Department of Pathology and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, San Francisco, CA, USA Department of Computer Science, San Francisco State University, San Francisco, CA, USA, Department of Pathology and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btu831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410654PMC
May 2015

Anthelmintic drug discovery: into the future.

J Parasitol 2015 Apr 13;101(2):125-33. Epub 2015 Jan 13.

Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1645/14-703.1DOI Listing
April 2015

Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch.

Structure 2014 Dec 13;22(12):1786-1798. Epub 2014 Nov 13.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.str.2014.09.015DOI Listing
December 2014

Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib.

Int J Parasitol Drugs Drug Resist 2014 Dec 7;4(3):287-95. Epub 2014 Aug 7.

BFS, Institute for Parasitology, Justus-Liebig-University, Giessen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpddr.2014.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266805PMC
December 2014

Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.

PLoS One 2014 29;9(1):e87594. Epub 2014 Jan 29.

Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087594PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906178PMC
October 2014

Regulation of Schistosoma mansoni development and reproduction by the mitogen-activated protein kinase signaling pathway.

PLoS Negl Trop Dis 2014 Jun 19;8(6):e2949. Epub 2014 Jun 19.

Grupo de Genômica e Biologia Computacional, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais and Centro de Excelência em Bioinformática- CEBio, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz - FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil.

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pntd.0002949
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0002949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063740PMC
June 2014

Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'.

PLoS Negl Trop Dis 2014 Mar 27;8(3):e2766. Epub 2014 Mar 27.

Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Ceske Budejovice, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0002766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967958PMC
March 2014

A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection.

Antimicrob Agents Chemother 2013 Dec 23;57(12):6063-73. Epub 2013 Sep 23.

National Reference Centre for Parasitology, Research Institute of the McGill University Health Center, Montreal, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00734-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837922PMC
December 2013

New insights into the machinery of blood digestion by ticks.

Trends Parasitol 2013 Jun 7;29(6):276-85. Epub 2013 May 7.

Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, České Budějovice, CZ 370 05, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pt.2013.04.002DOI Listing
June 2013

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.

PLoS Negl Trop Dis 2012 6;6(12):e1942. Epub 2012 Dec 6.

Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biomedical Research (QB3), University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0001942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516576PMC
May 2013

Cure of hookworm infection with a cysteine protease inhibitor.

PLoS Negl Trop Dis 2012 3;6(7):e1680. Epub 2012 Jul 3.

Department of Pediatrics, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0001680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389033PMC
November 2012

Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1).

J Biol Chem 2012 Jun 26;287(25):21152-63. Epub 2012 Apr 26.

From the Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, České Budějovice, CZ 370 05, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.347922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375538PMC
June 2012

Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target.

Int J Parasitol 2012 May 24;42(5):481-8. Epub 2012 Apr 24.

Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpara.2012.03.009DOI Listing
May 2012

Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery.

Trends Parasitol 2011 Dec 23;27(12):555-64. Epub 2011 Oct 23.

Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pt.2011.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223292PMC
December 2011

Schistosomiasis: from drug deployment to drug development.

Curr Opin Infect Dis 2011 Oct;24(5):410-7

Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QCO.0b013e328349156fDOI Listing
October 2011

IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.

Int J Parasitol 2011 Oct 23;41(12):1253-62. Epub 2011 Jul 23.

Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Ceske Budejovice, CZ 37005, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpara.2011.06.006DOI Listing
October 2011

Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs.

PLoS Negl Trop Dis 2011 Oct 25;5(10):e1368. Epub 2011 Oct 25.

The Colorectal Research Center, Department of Surgery, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0001368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201919PMC
October 2011

From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis.

Acta Trop 2011 Sep 8;120 Suppl 1:S121-37. Epub 2010 Sep 8.

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, PO Box, CH-4002 Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.actatropica.2010.08.020DOI Listing
September 2011

Cysteine peptidases of kinetoplastid parasites.

Adv Exp Med Biol 2011 ;712:84-99

Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences, Byers Hall, University of California San Francisco, San Francisco, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4419-8414-2_6
Publisher Site
http://dx.doi.org/10.1007/978-1-4419-8414-2_6DOI Listing
September 2011

Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors.

ACS Chem Biol 2011 Jun 17;6(6):609-17. Epub 2011 Mar 17.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cb100411vDOI Listing
June 2011

Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection.

BMC Immunol 2010 Nov 15;11:56. Epub 2010 Nov 15.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2172-11-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993659PMC
November 2010

RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening.

PLoS Negl Trop Dis 2010 Oct 19;4(10):e850. Epub 2010 Oct 19.

Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0000850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957409PMC
October 2010

Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes.

Mol Biochem Parasitol 2010 Mar 13;170(1):37-40. Epub 2009 Nov 13.

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), 1700 4th St., University of California, San Francisco, CA 94158-2550, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2009.11.001DOI Listing
March 2010

Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases).

J Med Chem 2009 Nov;52(22):7192-210

School of Chemistry and Biochemistry, Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm900849h
Publisher Site
http://dx.doi.org/10.1021/jm900849hDOI Listing
November 2009

Structure-guided development of selective TbcatB inhibitors.

J Med Chem 2009 Oct;52(20):6489-93

Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, California 94143-2280, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm900908p
Publisher Site
http://dx.doi.org/10.1021/jm900908pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762491PMC
October 2009

Kinetoplastid papain-like cysteine peptidases.

Mol Biochem Parasitol 2009 Sep 3;167(1):12-9. Epub 2009 May 3.

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences, Byers Hall, University of California San Francisco, 1700 4th Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2009.04.009DOI Listing
September 2009

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

J Biol Chem 2009 Sep 20;284(38):25697-703. Epub 2009 Jul 20.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158-2550, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.014340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757971PMC
September 2009

Chapter 4. Peptidases of trematodes.

Adv Parasitol 2009 ;69:205-97

Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0065-308X(09)69004-7DOI Listing
September 2009

Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.

PLoS Negl Trop Dis 2009 Jul 14;3(7):e478. Epub 2009 Jul 14.

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0000478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702839PMC
July 2009

SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni.

PLoS Negl Trop Dis 2009 Jun 2;3(6):e449. Epub 2009 Jun 2.

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0000449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685030PMC
June 2009

A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni.

PLoS One 2009 9;4(2):e4413. Epub 2009 Feb 9.

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635471PMC
April 2009

A parasite cysteine protease is key to host protein degradation and iron acquisition.

J Biol Chem 2008 Oct 13;283(43):28934-43. Epub 2008 Aug 13.

Department of Pathology and Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California 94158-2550, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M805824200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570886PMC
October 2008

Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens.

J Med Chem 2008 May 17;51(9):2816-32. Epub 2008 Apr 17.

School of Chemistry and Biochemistry and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm701311r
Publisher Site
http://dx.doi.org/10.1021/jm701311rDOI Listing
May 2008

Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.

Bioorg Med Chem Lett 2008 May 8;18(9):2883-5. Epub 2008 Apr 8.

Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94143-2280, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.03.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2435229PMC
May 2008

Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases.

Parasit Vectors 2008 Mar 18;1(1). Epub 2008 Mar 18.

Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Ceské Budejovice, CZ-370 05, The Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-3305-1-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2289814PMC
March 2008

Differential use of protease families for invasion by schistosome cercariae.

Biochimie 2008 Feb 8;90(2):345-58. Epub 2007 Sep 8.

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biomedical Research (QB3), 1700 4th Street, University of California, San Francisco, CA 94158-2550, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biochi.2007.08.013DOI Listing
February 2008

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

J Med Chem 2008 Feb 4;51(3):545-52. Epub 2008 Jan 4.

Graduate Program in Chemistry and Chemical Biology and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-2280, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm070760lDOI Listing
February 2008

Recent initiatives and strategies to developing new drugs for tropical parasitic diseases.

Expert Opin Drug Discov 2008 Feb;3(2):173-86

University of California San Francisco, Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences, Byers Hall 501E, 1700 4th Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.1517/17460441.3.2.173
Publisher Site
http://dx.doi.org/10.1517/17460441.3.2.173DOI Listing
February 2008

Chemotherapy of schistosomiasis: present and future.

Authors:
Conor R Caffrey

Curr Opin Chem Biol 2007 Aug 24;11(4):433-9. Epub 2007 Jul 24.

Sandler Center for Basic Research in Parasitic Diseases, Byers Hall N508, University of California San Francisco, 1700 4th Street, San Francisco, CA 94158-2330, United States.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S136759310700075
Publisher Site
http://dx.doi.org/10.1016/j.cbpa.2007.05.031DOI Listing
August 2007

Proteomic analysis of adult S. mansoni gut contents.

Mol Biochem Parasitol 2007 Jul 20;154(1):95-7. Epub 2007 Mar 20.

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biomedical Research (QB3), 1700 4th St., University of California, San Francisco, CA 94158-2330, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2007.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732360PMC
July 2007

IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.

Int J Parasitol 2007 Jun 30;37(7):713-24. Epub 2007 Jan 30.

Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Ceské Budejovice, Czech Republic.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpara.2006.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587490PMC
June 2007

The cysteine proteinase inhibitor Z-Phe-Ala-CHN2 alters cell morphology and cell division activity of Trypanosoma brucei bloodstream forms in vivo.

Kinetoplastid Biol Dis 2007 Feb 28;6. Epub 2007 Feb 28.

Abteilung Parasitologie, Hygiene-Institut der Ruprecht Karls-Universität, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://kinetoplastids.biomedcentral.com/articles/10.1186/147
Publisher Site
http://dx.doi.org/10.1186/1475-9292-6-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810305PMC
February 2007

Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor.

PLoS Med 2007 Jan;4(1):e14

Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biomedical Research, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pmed.0040014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764436PMC
January 2007

A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.

J Biol Chem 2006 Dec 6;281(51):39316-29. Epub 2006 Oct 6.

Department of Pathology, Tropical Disease Research Unit and Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://www.jbc.org/content/281/51/39316.full.pdf
Web Search
http://www.jbc.org/cgi/doi/10.1074/jbc.M607128200
Publisher Site
http://dx.doi.org/10.1074/jbc.M607128200DOI Listing
December 2006

Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design.

Mini Rev Med Chem 2006 Sep;6(9):1025-32

Biomedical Research Centre, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/138955706778195207DOI Listing
September 2006

Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents.

Bioorg Med Chem Lett 2006 May 3;16(10):2753-7. Epub 2006 Mar 3.

Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2006.02.026DOI Listing
May 2006

Genomic and proteomic approaches for Chagas' disease: critical analysis of diagnostic methods.

Expert Rev Mol Diagn 2005 Jul;5(4):521-30

Sandler Center for Basic Research in Parasitic Diseases, University of California, QB3 Building, Box 2550, 1700 4 Street, San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/14737159.5.4.521DOI Listing
July 2005