Connor A Emdin

Connor A Emdin

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Connor A Emdin

Publications by authors named "Connor A Emdin"

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Genetic Association of Albuminuria with Cardiometabolic Disease and Blood Pressure.

Am J Hum Genet 2018 10 13;103(4):461-473. Epub 2018 Sep 13.

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183027
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http://dx.doi.org/10.1016/j.ajhg.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174360PMC
October 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

Mendelian Randomization.

JAMA 2017 Nov;318(19):1925-1926

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.

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http://dx.doi.org/10.1001/jama.2017.17219DOI Listing
November 2017

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease.

Diabetes 2017 08 14;66(8):2310-2315. Epub 2017 Apr 14.

Center for Genomic Medicine, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db17-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521864PMC
August 2017

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression.

Cell 2017 Jul;170(3):522-533.e15

Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785707PMC
July 2017

Genetic Predisposition to Abdominal Obesity and Cardiometabolic Risk-Reply.

JAMA 2017 06;317(22):2334-2335

Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jama.2017.5044DOI Listing
June 2017

Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor.

Circ Cardiovasc Genet 2017 Apr;10(2)

From the Center for Genomic Medicine (D.K., C.A.E., P.N., S.K.), Department of Surgery (D.K.), and Division of Vascular and Endovascular Surgery (M.E.C.), Massachusetts General Hospital, Harvard Medical School, Boston; and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (D.K., C.A.E., P.N., S.K.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395047PMC
April 2017

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

J Am Coll Cardiol 2017 Apr 3;69(16):2054-2063. Epub 2017 Apr 3.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404817PMC
April 2017

Proportion and Characteristics of US Adults Who May Be Eligible From Additional Blood Pressure Lowering Based on Absolute Risk.

Am J Hypertens 2017 03;30(3):232-235

St John's College, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1093/ajh/hpw130DOI Listing
March 2017

Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort.

Am J Cardiol 2017 Mar 18;119(6):881-885. Epub 2016 Dec 18.

Center for Human Genetic Research and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2016.11.042DOI Listing
March 2017

Genetic Risk, Lifestyle, and Coronary Artery Disease.

N Engl J Med 2017 03;376(12):1194-5

Massachusetts General Hospital, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1700362DOI Listing
March 2017

Referral for Specialist Follow-up and Its Association With Post-discharge Mortality Among Patients With Systolic Heart Failure (from the National Heart Failure Audit for England and Wales).

Am J Cardiol 2017 Feb 1;119(3):440-444. Epub 2016 Nov 1.

Department of Obstetrics and Gynecology, The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2016.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282396PMC
February 2017

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease.

JAMA 2017 02;317(6):626-634

Center for Genomic Medicine and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston2Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1001/jama.2016.21042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571980PMC
February 2017

AKI and Long-Term Risk for Cardiovascular Events and Mortality.

J Am Soc Nephrol 2017 Jan 13;28(1):377-387. Epub 2016 Jun 13.

School of Medicine, University of Tasmania, Hobart, Australia.

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http://dx.doi.org/10.1681/ASN.2016010105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198285PMC
January 2017

Associations of Epicardial, Abdominal, and Overall Adiposity With Atrial Fibrillation.

Circ Arrhythm Electrophysiol 2016 Dec;9(12)

From the Clinical Trial Service Unit and Epidemiological Studies Unit (C.X.W., R.C.), George Institute for Global Health (C.A.E.), Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (A.O.), University of Oxford, United Kingdom; Churchill Hospital, Oxford University Hospitals NHS Trust, United Kingdom (M.T.S.); Faculty of Medicine, University of Toronto, Ontario, Canada (A.O.); Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Australia, Australia (R.M., D.H.L., R.K.P., P.S.); Monash Cardiovascular Research Centre, Department of Medicine, Monash Medical Centre, Monash University and Monash Health, Melbourne, Victoria, Australia (D.T.W.); and Department of Cardiology, Flinders Medical Centre, Adelaide, South Australia, Australia (J.B.S.).

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http://dx.doi.org/10.1161/CIRCEP.116.004378DOI Listing
December 2016

Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease.

N Engl J Med 2016 12 13;375(24):2349-2358. Epub 2016 Nov 13.

From the Center for Human Genetic Research and Cardiology Division, Massachusetts General Hospital (A.V.K., P.N., S.K.), and the Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital (N.R.C., D.I.C., P.M.R.), Boston, and the Program in Medical and Population Genetics, Broad Institute, Cambridge (A.V.K., C.A.E., A.G.B., S.K.) - all in Massachusetts; the Department of Clinical Sciences, Lund University, Malmö, Sweden (I.D., O.M., M.O.-M.); the Cardiovascular Institute, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, New York (U.B., R.M., V.F.); Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (D.J.R.); and the University of Texas Health Science Center School of Public Health, Houston (E.B.).

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http://dx.doi.org/10.1056/NEJMoa1605086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338864PMC
December 2016

Meta-Analysis of Anxiety as a Risk Factor for Cardiovascular Disease.

Am J Cardiol 2016 Aug 28;118(4):511-9. Epub 2016 May 28.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; Department of Medicine, University of Tasmania, Hobart, Australia.

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http://dx.doi.org/10.1016/j.amjcard.2016.05.041DOI Listing
August 2016

Blood pressure lowering for cardiovascular disease - Authors' reply.

Lancet 2016 Jul;388(10040):126-7

The George Institute for Global Health, University of Oxford, Oxford OX1 3BD, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)30669-9DOI Listing
July 2016

Blood Pressure and Risk of Vascular Dementia: Evidence From a Primary Care Registry and a Cohort Study of Transient Ischemic Attack and Stroke.

Stroke 2016 06 10;47(6):1429-35. Epub 2016 May 10.

From the George Institute for Global Health (C.A.E., G.S.-K., A.K., N.C., T.C., S.G.A., H.M., M.W., K.R.), Stroke Prevention Research Unit, Nuffield Department of Clinical Neurosciences (P.M.R., Z.M., S.T.P.), and Division of Cardiovascular Medicine, Radcliffe Department of Medicine (K.R.), University of Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Australia (M.W.); and Department of Epidemiology, Johns Hopkins University, Baltimore, MD (M.W.).

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http://dx.doi.org/10.1161/STROKEAHA.116.012658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341765PMC
June 2016

Meta-Analysis of Anticoagulation Use, Stroke, Thromboembolism, Bleeding, and Mortality in Patients With Atrial Fibrillation on Dialysis.

Am J Cardiol 2016 Jun 13;117(12):1934-41. Epub 2016 Apr 13.

Churchill Hospital, Oxford University Hospitals National Health Service Trust, Oxford, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S00029149163042
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http://dx.doi.org/10.1016/j.amjcard.2016.03.042DOI Listing
June 2016

Prevalence of Albuminuria in a General Population Cohort of Patients With Established Chronic Heart Failure.

J Card Fail 2016 Jan 23;22(1):33-7. Epub 2015 Oct 23.

St John's College, St Giles', University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.cardfail.2015.10.009DOI Listing
January 2016

Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies.

BMJ 2016 Jan 19;532:h7013. Epub 2016 Jan 19.

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482349PMC
http://dx.doi.org/10.1136/bmj.h7013DOI Listing
January 2016

Mortality from heart failure, acute myocardial infarction and other ischaemic heart disease in England and Oxford: a trend study of multiple-cause-coded death certification.

J Epidemiol Community Health 2015 Oct 1;69(10):1000-5. Epub 2015 Jul 1.

Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1136/jech-2015-205689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602272PMC
October 2015

Reporting of a Publicly Accessible Protocol and Its Association With Positive Study Findings in Cardiovascular Trials (from the Epidemiological Study of Randomized Trials [ESORT]).

Am J Cardiol 2015 Oct 29;116(8):1280-3. Epub 2015 Jul 29.

The George Institute for Global Health, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2015.07.046DOI Listing
October 2015

Usual Blood Pressure and Risk of New-Onset Diabetes: Evidence From 4.1 Million Adults and a Meta-Analysis of Prospective Studies.

J Am Coll Cardiol 2015 Oct;66(14):1552-1562

The George Institute for Global Health, University of Oxford, Oxford, United Kingdom; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.07.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595710PMC
October 2015

Usual blood pressure, peripheral arterial disease, and vascular risk: cohort study of 4.2 million adults.

BMJ 2015 Sep 29;351:h4865. Epub 2015 Sep 29.

The George Institute for Global Health, Oxford Martin School, University of Oxford, Oxford OX1 3DB, UK Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586462PMC
http://dx.doi.org/10.1136/bmj.h4865DOI Listing
September 2015

Blood pressure targets and absolute cardiovascular risk.

Hypertension 2015 Aug 8;66(2):280-5. Epub 2015 Jun 8.

From the Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (A.O.); and Nuffield Department of Population Health, George Institute for Global Health (K.R., C.A.E.) and Department of Economics (A.J.H.), University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04997DOI Listing
August 2015

Meta-Analysis of Large-Scale Randomized Trials to Determine the Effectiveness of Inhibition of the Renin-Angiotensin Aldosterone System in Heart Failure.

Am J Cardiol 2015 Jul 9;116(1):155-61. Epub 2015 Apr 9.

Nuffield Department of Population Health, George Institute for Global Health, University of Oxford, Oxford, United Kingdom; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2015.03.052DOI Listing
July 2015

Outcomes of Percutaneous Coronary Intervention Performed at Offsite Versus Onsite Surgical Centers in the United Kingdom.

J Am Coll Cardiol 2015 Jul;66(4):363-72

The George Institute for Global Health, Nuffield Department of Population Health, Oxford Martin School, University of Oxford, Oxford, United Kingdom; The George Institute for Global Health, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1016/j.jacc.2015.05.052DOI Listing
July 2015

Lowering blood pressure in patients with diabetes--reply.

JAMA 2015 Jun;313(21):2183-4

George Institute for Global Health, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1001/jama.2015.4265DOI Listing
June 2015

Effect of antihypertensive agents on risk of atrial fibrillation: a meta-analysis of large-scale randomized trials.

Europace 2015 May 7;17(5):701-10. Epub 2015 Apr 7.

George Institute for Global Health, Oxford Martin School, University of Oxford, 34 Broad Street, Oxford, UK

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http://dx.doi.org/10.1093/europace/euv021DOI Listing
May 2015

The association between development assistance for health and malaria, HIV and tuberculosis mortality: a cross-national analysis.

J Epidemiol Glob Health 2015 Mar 10;5(1):41-8. Epub 2014 Nov 10.

The George Institute for Global Health, Department of Population Health, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jegh.2014.10.001DOI Listing
March 2015

The epidemiology of blood pressure and its worldwide management.

Circ Res 2015 Mar;116(6):925-36

From the Division of Cardiovascular Medicine (K.R.), Nuffield Department of Population Health (C.A.E., S.M.), The George Institute for Global Health, and Oxford Martin School (K.R., C.A.E., S.M.), University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304723DOI Listing
March 2015

Association between randomised trial evidence and global burden of disease: cross sectional study (Epidemiological Study of Randomized Trials--ESORT).

BMJ 2015 Jan 28;350:h117. Epub 2015 Jan 28.

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UKJ.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309646PMC
http://dx.doi.org/10.1136/bmj.h117DOI Listing
January 2015

Non-physician clinician provided HIV treatment results in equivalent outcomes as physician-provided care: a meta-analysis.

J Int AIDS Soc 2013 Jul 3;16:18445. Epub 2013 Jul 3.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702014PMC
http://dx.doi.org/10.7448/IAS.16.1.18445DOI Listing
July 2013

Chlamydia Pneumoniae CdsL Regulates CdsN ATPase Activity, and Disruption with a Peptide Mimetic Prevents Bacterial Invasion.

Front Microbiol 2011 14;2:21. Epub 2011 Feb 14.

Michael G. DeGroote Institute for Infectious Disease Research, Faculty of Health Sciences, Department of Pathology and Molecular Medicine, McMaster University, Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare Hamilton, ON, Canada.

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http://dx.doi.org/10.3389/fmicb.2011.00021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109343PMC
July 2011