Publications by authors named "Cong Liu"

954 Publications

A Meta-Analysis: Intervention Effect of Mind-Body Exercise on Relieving Cancer-Related Fatigue in Breast Cancer Patients.

Evid Based Complement Alternat Med 2021 3;2021:9980940. Epub 2021 Jul 3.

Donghua Universuty, Shanghai 201620, China.

Objective: This paper aims to systematically evaluate the intervention effect of mind-body exercise on cancer-related fatigue in breast cancer patients.

Methods: Databases including PubMed, the Cochrane Library, Embase, Web of Science, CNKI, Wanfang Data, and SINOMED were retrieved to collect randomized controlled trials on the effects of mind-body exercise on relieving cancer-related fatigue in breast cancer patients. The retrieval period started from the founding date of each database to January 6, 2021. Cochrane bias risk assessment tools were used to evaluate the methodological quality assessment of the included literature, and RevMan 5.3 software was used for meta-analyses.

Results: 17 pieces of researches in 16 papers were included with a total of 1133 patients. Compared with the control group, mind-body exercise can improve cancer-related fatigue in breast cancer patients. The combined effect size SMD = 0.59, 95% CI was [0.27, 0.92], < 0.00001. Doing Tai Chi for over 40 minutes each time with an exercise cycle of ≤6 weeks can improve cancer-related fatigue in breast cancer patients more significantly. Sensitivity analysis shows that the combined effect results of the meta-analysis were relatively stable.

Conclusion: Mind-body exercise can effectively improve cancer-related fatigue in breast cancer patients.
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http://dx.doi.org/10.1155/2021/9980940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275388PMC
July 2021

Associations of fine particulate matter and constituents with pediatric emergency room visits for respiratory diseases in Shanghai, China.

Int J Hyg Environ Health 2021 Jul 13;236:113805. Epub 2021 Jul 13.

School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China. Electronic address:

Background: Although ambient fine particulate matter (PM) has been associated with adverse respiratory outcomes in children, few studies have examined PM constituents with respiratory diseases in children in China.

Objectives: To investigate the associations of short-term exposure to PM and its constituents with pediatric emergency room visits (ERVs) for respiratory diseases in Shanghai, China.

Methods: We collected daily concentrations of PM and its constituents in urban Shanghai from January 1, 2016, to December 31, 2018. Daily pediatric ERVs for four major respiratory diseases, including upper respiratory tract infection, bronchitis, pneumonia, and asthma, were obtained from 66 hospitals in Shanghai during the same period. Associations of exposure to daily PM and constituents with respiratory ERVs were estimated using the over-dispersed generalized additive models.

Result: Short-term exposure to PM and its constituents were associated with increased pediatric ERVs for respiratory diseases. Specifically, an interquartile range increase in the 3-day average PM level (31 μg/m) was associated with 1.86% (95%CI: 0.52, 3.22), 1.53% (95%CI: 0.01, 3.08), 1.90% (95%CI: 0.30, 3.52), and 2.67% (95%CI: 0.70, 4.68) increase of upper respiratory tract infection, bronchitis, pneumonia, and asthma ERVs, respectively. As for PM constituents, we found organic carbon, ammonium, nitrate, selenium, and zinc were associated with higher risk of respiratory ERVs in the single constituent and the constituent-PM models.

Conclusion: Short-term exposure to PM was associated with increased pediatric ERVs for respiratory diseases. Constituents related to anthropogenic combustion and traffic might be the dominant contributors of the observed associations.
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http://dx.doi.org/10.1016/j.ijheh.2021.113805DOI Listing
July 2021

Tunable Doppler shift using a time-varying epsilon-near-zero thin film near 1550  nm.

Opt Lett 2021 Jul;46(14):3444-3447

We experimentally investigate the tunable Doppler shift in an 80 nm thick indium-tin-oxide (ITO) film at its epsilon-near-zero (ENZ) region. Under strong and pulsed excitation, ITO exhibits a time-varying change in the refractive index. A maximum frequency redshift of 1.8 THz is observed in the reflected light when the pump light has a peak intensity of ∼140/ and a pulse duration of ∼580, at an incident angle of 40°. The frequency shift increases with the increase in pump intensity and saturates at the intensity of ∼140/. When the pump pulse duration increases from ∼580 to ∼1380, the maximum attainable frequency shift decreases from 1.8 THz to 0.7 THz. In addition, the pump energy required to saturate the frequency shift decreases with the increase in pump pulse duration for ∼<1 and remains unchanged for ∼>1 durations. Tunability exists among the pump pulse energy, duration, and incident angle for the Doppler shift of the ITO-ENZ material, which can be employed to design efficient frequency shifters for telecom applications.
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http://dx.doi.org/10.1364/OL.430106DOI Listing
July 2021

Lipid droplet polarity decreases during the pathology of muscle injury as revealed by a polarity sensitive sensor.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 3;262:120149. Epub 2021 Jul 3.

Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, PR China; Guangxi Key Laboratory of Electrochemical Energy Materials, Institute of Optical Materials and Chemical Biology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, PR China. Electronic address:

Revealing the relationship between lipid droplets (LDs)polarity and disease is indispensable in clinicopathological diagnosis. So far, muscle injury is often ignored as it is not life-threatening as cardiovascular and cerebrovascular diseases, making the exploration of the internal relationship between muscle injury and LDs polarity a gray area. Herein, a fluorescent probe (CCB) with powerful polar-sensitive as well as precise LDs targeting was designed for visualizing the LDs polarity in the pathology of muscle injury. By means of the probe CCB, the identification of cancer cells and the monitoring of LDs polarity changes in dysfunctional cells were successfully realized. Furthermore, the penetration ability of CCB in tissues of mice was tested to verify the applicability of the probe in organisms. Importantly, by CCB, the relationship between muscle damage and LDs polarity was explored, revealing that muscle damage caused a significant decrease in LDs polarity accompanied by a significant increase in fluorescence. Most importantly, it is the first time to reveal the relationship between muscle damage and LDs polarity. Therefore, the probe CCB will be a powerful monitoring platform for diagnosing related diseases caused by abnormal LDs polarity.
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http://dx.doi.org/10.1016/j.saa.2021.120149DOI Listing
July 2021

Adiabatic Frequency Conversion Using a Time-Varying Epsilon-Near-Zero Metasurface.

Nano Lett 2021 Jul 12. Epub 2021 Jul 12.

Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, California 90089, United States.

A time-dependent change in the refractive index of a material leads to a change in the frequency of an optical beam passing through that medium. Here, we experimentally demonstrate that this effect-known as adiabatic frequency conversion (AFC)-can be significantly enhanced by a nonlinear epsilon-near-zero-based (ENZ-based) plasmonic metasurface. Specifically, by using a 63-nm-thick metasurface, we demonstrate a large, tunable, and broadband frequency shift of up to ∼11.2 THz with a pump intensity of 4 GW/cm. Our results represent a decrease of ∼10 times in device thickness and 120 times in pump peak intensity compared with the cases of bare, thicker ENZ materials for the similar amount of frequency shift. Our findings might potentially provide insights for designing efficient time-varying metasurfaces for the manipulation of ultrafast pulses.
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http://dx.doi.org/10.1021/acs.nanolett.1c00550DOI Listing
July 2021

Head-nodding: a driving force for the circulation of cerebrospinal fluid.

Sci Rep 2021 Jul 9;11(1):14233. Epub 2021 Jul 9.

Department of Anatomy, Dalian Medical University, Dalian, 116044, China.

The myodural bridge (MDB) is a dense connective tissue bridge connecting the suboccipital muscles to the spinal dura mater, and it has been proven to be a normal common existing structure in humans and mammals. Some scholars believe that the suboccipital muscles can serve as a dynamic cerebrospinal fluid (CSF) pump via the MDB, and they found head rotations promote the CSF flow in human body, which provided evidence for this hypothesis. Head movement is a complex motion, but the effects of other forms of head movement on CSF circulation are less known. The present study explored the effects of head-nodding on CSF circulation. The CSF flow of 60 healthy volunteers was analyzed via cine phase-contrast magnetic resonance imaging at the level of the occipitocervical junction before and after one-minute-head-nodding period. Furthermore, the CSF pressures of 100 volunteers were measured via lumbar puncture before and after 5 times head-nodding during their anesthetizing for surgical preparation. As a result, it was found that the maximum and average CSF flow rates at the level of the upper border of atlas during ventricular diastole were significantly decreased from 1.965 ± 0.531 to 1.839 ± 0.460 ml/s and from 0.702 ± 0.253 to 0.606 ± 0.228 ml/s respectively. In the meantime, the changes in the ratio of cranial and caudal orientation of the net flow volume were found differed significantly after the one-minute-head-nodding period (p = 0.017). And on the other hand, the CSF pressures at the L3-L4 level were markedly increased 116.03 ± 26.13 to 124.64 ± 26.18 mmHO. In conclusion, the head-nodding has obvious effects on CSF circulation and head movement is one of the important drivers of cerebrospinal fluid circulation. We propose that the suboccipital muscles, participating in various head movements, might pull the dura sac via the myodural bridge, and thus, head movement provides power for the CSF circulation.
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http://dx.doi.org/10.1038/s41598-021-93767-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8270937PMC
July 2021

Heat Killed Protects Intestine Against Radiation Injury Through Wnt Signaling Pathway.

J Oncol 2021 18;2021:5550956. Epub 2021 Jun 18.

Department of Radiation Medicine, Faculty of Naval Medicine, Naval Medical University, Shanghai, China.

Gastrointestinal (GI) toxicity caused by ionizing radiation (IR) is a dose limiting factor in radiotherapy and a great threat for individual nuclear-related military missions. However, there are currently no available strategies to effectively prevent the damage on the intestine induced by IR. In the present study, the protective activity of Heat Killed (HKST) on intestine against IR was investigated. Through mouse intestinal organoids and whole body irradiation of mice, we found that the pretreatment with HKST significantly preserved the structure of small intestine upon IR exposure and promoted the proliferation of intestinal cells post-IR. Further study revealed that the radioprotective effects of HKST were involved in DNA damage response (DDR) signaling. Moreover, the stimulation of DDR signaling by HKST upon radiation damage was mediated by Wnt signaling, in which the inhibition of Wnt signaling diminished the radioprotective effects of HKST. To sum up, our study suggested HKST as a potential radioprotectant used for prevention of IR-induced GI toxicity.
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http://dx.doi.org/10.1155/2021/5550956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233082PMC
June 2021

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation.

Cell Res 2021 Jul 8. Epub 2021 Jul 8.

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/s41422-021-00526-5DOI Listing
July 2021

3D printing of Cu-doped bioactive glass composite scaffolds promotes bone regeneration through activating the HIF-1α and TNF-α pathway of hUVECs.

Biomater Sci 2021 Jul 8. Epub 2021 Jul 8.

School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, P. R. China. and National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, P. R. China.

The increasing insight into the molecular and cellular processes within the angiogenic cascade assists in enhancing the survival and integration of engineered bone constructs. Copper-doped bioactive glass (Cu-BG) is now a potential structural component of the novel scaffolds and implants used in orthopedic and dental repairs. However, it is difficult for BG, especially micro-nano particles, to be printed into scaffolds and still retain its biological activity and ability to biodegrade. Additionally, the mechanisms of the copper-stimulating autocrine and paracrine effects of human umbilical vein endothelial cells (hUVECs) during repair and regeneration of bone are not yet clear. Therefore, in this study, we created monodispersed micro-nano spherical Cu-BG particles with varying copper content through a sol-gel process. Through in vitro tests, we found that Cu-BG enhanced angiogenesis by activating the pro-inflammatory environment and the HIF-1α pathway of hUVECs. Furthermore, 2Cu-BG diluted extracts directly promoted the osteogenic differentiation of mouse bone mesenchymal stem cells (BMSCs) in vitro. Then, a new 3D-printed tyramine-modified gelatin/silk fibroin/copper-doped bioactive glass (Gel/SF/Cu-BG) scaffold for rat bone defects was constructed, and the mechanism of the profound angiogenesis effect regulated by copper was explored in vivo. Finally, we found that hydrogel containing 1 wt% 2Cu-BG effectively regulated the spatiotemporal coupling of vascularization and osteogenesis. Therefore, Cu-BG-containing scaffolds have great potential for a wide range of bone defect repairs.
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http://dx.doi.org/10.1039/d1bm00870fDOI Listing
July 2021

Fine particulate matter constituents and infant mortality in Africa: A multicountry study.

Environ Int 2021 Jun 30;156:106739. Epub 2021 Jun 30.

School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Fudan University, Shanghai 200030, China. Electronic address:

Background: Few studies have investigated the association between exposure to fine particulate matter (PM) and infant mortality in developing countries, especially for the health effects of specific PM constituents.

Objective: We aimed to examine the association of long-term exposure to specific PM constituents with infant mortality in 15 African countries from 2005 to 2015.

Methods: Based on the Demographic and Health Surveys (DHS) dataset, we included birth history records from 15 countries in Africa and conducted a multicountry cross-sectional study to examine the associations between specific PM constituents and infant mortality. We estimated annual residential exposure using satellite-derived PM for mass and a chemical transport model (GEOS-Chem) for its six constituents, including organic matter (OM), black carbon (BC), sulfate (SO), nitrate (NO), ammonium (NH), and soil dust (DUST). Multivariable logistic regression analysis was employed by fitting single-constituent models, the constituent-PM models, and the constituent-residual models. We also conducted stratified analyses by potential effect modifiers and examined the specific associations for each country.

Results: We found positive and significant associations between PM total mass and most of its constituents with infant mortality. In the single-constituent model, for an IQR increase in pollutant concentrations, the odds ratio (OR) of infant mortality was 1.03 (95 %CI; 1.01, 1.06) for PM total mass, and was 1.04 (95 %CI: 1.02, 1.06), 1.04 (95 %CI: 1.02, 1.05), 1.02 (95 %CI: 1.00, 1.03), 1.04 (1.01, 1.06) for BC, OM, SO, and DUST, respectively. The associations of BC, OM, and SO remained significant in the other two models. We observed larger estimates in subgroups with older maternal age, living in urban areas, using unclean cooking energy, and with access to piped water. The associations varied among countries, and by different constituents.

Conclusions: The carbonaceous fractions and sulfate play a major important role among PM constituents on infant mortality. Our findings have certain policy implications for implementing effective measures for targeted reduction in specific sources (fossil fuel combustion and biomass burning) of PM constituents against the risk of infant mortality.
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http://dx.doi.org/10.1016/j.envint.2021.106739DOI Listing
June 2021

Mutation analysis of 28 autosomal short tandem repeats in the Chinese Han population.

Mol Biol Rep 2021 Jul 2. Epub 2021 Jul 2.

Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Short tandem repeats (STRs) have been extensively used in forensic genetics. However, according to previous studies, the mutation rates of STRs are relatively high and are affected by many factors. Therefore, it is important to analyze STR mutations and determine the influence of underlying factors on STR mutation rates. Mutation rates of 28 autosomal STRs were determined from 8708 paternity testing cases in the Chinese Han population, and the relationships between STR mutation rates and population, sex, age, allele length and heterozygosity were investigated. A total of 279 mutations were observed at 27 loci in a total of 233,530 meiosis cases, including 273 (97.8%) one-step, 5 (1.8%) two-step and 1 (0.4%) three-step mutations. The overall average mutation rate was 1.19 × 10 (95% CI 1.06 × 10 - 1.34 × 10) ranging from 0 (TPOX) to 2.79 × 10 (D13S325). Mutation rate comparisons revealed statistically significant differences at several STRs among populations. Paternal mutations occurred more frequently than maternal mutations, at a ratio of 6.04:1, and the mutation rate tended to increase with paternal age. Moreover, our study revealed a bias towards contraction mutations for long alleles and expansion mutations for short alleles. No obvious bias was observed in the overall mutation direction. In addition, STR loci with higher expected heterozygosity (H) tended to have higher mutation rates. This work revealed the relationships between STR mutation rates and several influencing factors, providing useful data and information for further research on STR mutations in forensic genetics.
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http://dx.doi.org/10.1007/s11033-021-06522-7DOI Listing
July 2021

Analysis of In Vivo Transcriptome of Intracellular Bacterial Pathogen Isolated from Mouse Spleen.

Pathogens 2021 Jun 30;10(7). Epub 2021 Jun 30.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Taian 271018, China.

  () is an important intracellular pathogen that poses a health threat to humans. This study tries to clarify the mechanism of survival and reproduction in the host. In this study, high-throughput sequencing analysis was performed on RNA extracted from the strains isolated from infected mouse spleens and an reference strain (ATCC 14028) based on the BGISEQ-500 platform. A total of 1340 significant differentially expressed genes (DEGs) were screened. Functional annotation revealed DEGs associated with regulation, metabolism, transport and binding, pathogenesis, and motility. Through data mining and literature retrieval, 26 of the 58 upregulated DEGs (FPKM > 10) were not reported to be related to the adaptation to intracellular survival and were classified as candidate key genes (CKGs) for survival and proliferation in vivo. Our data contribute to our understanding of the mechanisms used by to regulate virulence gene expression whilst replicating inside mammalian cells.
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http://dx.doi.org/10.3390/pathogens10070823DOI Listing
June 2021

Effects of Case Management on Risky Sexual Behaviors and Syphilis among HIV-infected Men Who Have Sex with Men in China: A Randomized Controlled Study.

Sex Transm Dis 2021 Jun 23. Epub 2021 Jun 23.

From the Department of HIV/AIDS Prevention and Control, Wuhan Center for Disease Control and Prevention, Wuhan, Hubei, China Department of Infectious Diseases, Wuhan Jin Yin-tan Hospital, Wuhan, Hubei, China.

Background: The prevalence of syphilis is very high in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), and effective interventions are needed to educate HIV-positive individuals about the behavioral and biological risk factors. Therefore, we developed a standard case management process and conducted a randomized controlled study to investigate the impact on risky sexual behaviors and syphilis in HIV-positive MSM.

Methods: MSM (n = 220) were enrolled and randomized to the case management intervention group and the control group between May 2016 and January 2017. The control group received routine HIV related care. In addition to routine HIV related care, those in the intervention group regularly received extended services from a well-trained case manager. Epidemiological information was collected during the baseline face-to-face interviews by a trained investigator. Serological tests for syphilis and assessments of risky sexual behaviors were performed at baseline and 6 and 12 months after the initiation of treatment.

Results: The syphilis incidence rates in the intervention and control groups were 11.3 per 100 person-years and 20.6 per 100 person-years respectively. The multivariable-adjusted hazard ratio (95% CI) for syphilis in case management group was 0.34 (0.14-0.87). The percentages of participants who resumed risky sexual behaviors in both groups were significantly reduced (p < 0.05), but did not significantly differ between two groups.

Conclusions: A case management intervention reduced the incidence of syphilis in HIV-positive MSM. We should further increase the content of case management on the basis of providing routine HIV related care to those people.
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http://dx.doi.org/10.1097/OLQ.0000000000001502DOI Listing
June 2021

Facile synthesis of chitosan-derived maillard reaction productions coated CuFeO with abundant oxygen vacancies for higher Fenton-like catalytic performance.

Chemosphere 2021 Jun 14;283:131191. Epub 2021 Jun 14.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210046, China. Electronic address:

The two shortcomings of the Fenton-like catalyst delafossite-type oxide (CuFeO) lie in its spontaneous agglomeration and deactivation under neutral working pH. To remedy these drawbacks, novel Fenton-like catalyst chitosan-derived maillard reaction productions coated CuFeO with abundant oxygen vacancies ([email protected]) was synthesized by hydrothermal method with no extra chemical reducing agent. The systemic characterization illustrated that richer oxygen vacancies and higher particles dispersion of [email protected] contributed to better Rhodamine B (RhB) degradation under neutral pH compared to pure CuFeO. Cooper antisite defects in [email protected] were evidenced by X-ray powder diffraction (XRD), fourier transform infrared spectrometer (FTIR), Raman spectra and energy dispersive X-ray spectrometer (EDX) linescan. To keep the charge balance, [email protected] should form rich oxygen vacancies, which was confirmed by X-ray photoelectron spectroscopy (XPS) and solid-state electron paramagnetic resonance spectrometer (solid-state EPR). Furthermore, the electrochemical impedance spectroscopy (EIS) analysis revealed that oxygen vacancies could improve the electron transfer. Scavenging experiments and electron spin resonance spectroscopy (ESR) analysis demonstrated that OH was main active radical during Fenton-like reaction, and the density functional theory (DFT) calculation verified that the oxygen vacancy could effectively adsorb HO and elongate O-O bond of HO, thus promoting the activation of HO into OH.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131191DOI Listing
June 2021

Ambient fine particulate matter air pollution and the risk of preterm birth: A multicenter birth cohort study in China.

Environ Pollut 2021 Jun 22;287:117629. Epub 2021 Jun 22.

Heart Center, Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China. Electronic address:

Preterm birth (PTB), defined as live birth before the 37th week of gestation, is believed to have profound impacts on the infant's health in later life. Air pollution has been suggested to be a potential risk factor of PTB, but the evidence was inconsistent. In this multicenter birth cohort study, we aimed to examine the association between fine particulate matter (PM) exposure during pregnancy and PTB in China. A total of 5976 live births were identified between Jan. 2009 and Feb. 2011 from 8 provinces in China. Residential exposures to PM were assigned based on satellite remote sensing estimates. Cox proportional hazards regressions were employed to explore the correlation for each trimester as well as the entire pregnancy. A total of 443 (7.4%) preterm births were observed. The average PM during pregnancy was 57.2 ± 8.8 μg/m. We found exposure to PM during the whole pregnancy (hazard ratio, HR = 1.262; 95% CI: 1.087-1.465) and in the first trimester (HR = 1.114; 95% CI: 1.007-1.232) was associated with higher risk of PTB. The associations of PM were stronger for subjects with older maternal or paternal age, lower maternal pre-pregnancy BMI, and lower family income. This study adds supports to the cumulating evidence linking PM exposure and elevated PTB risk. Measures of air pollution reduction are needed during pregnancy, especially at early stage of pregnancy to prevent adverse birth outcomes.
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http://dx.doi.org/10.1016/j.envpol.2021.117629DOI Listing
June 2021

The switching between newly learned languages impacts executive control.

Psychophysiology 2021 Jun 27:e13888. Epub 2021 Jun 27.

Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China.

Previous research has explored the relationship between language control and executive control based on performance in bilinguals' skilled languages. However, this relationship between bilingualism and executive control has not been examined at the very initial stage of language learning. In the present study, we trained Chinese speakers to learn words in German and Japanese, two languages with which they had no prior experience. In pre- and post-training, we measured participants' electrophysiological data to investigate how switching between these two newly learned languages affected executive control. We observed that, while lacking the language switching effect in the behavioral data, a flanker task elicited larger N2 and P3 amplitudes in the post-training session when participants were required to switch between German and Japanese compared to when they responded to only German or Japanese. These results provided evidence of language control of newly learned languages on domain-general executive control, specifically at the (very) initial period of language learning. Our findings support the adaptive nature of the relationship between bilingual language control and executive control.
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http://dx.doi.org/10.1111/psyp.13888DOI Listing
June 2021

Preoperative Prediction of G1 and G2/3 Grades in Patients With Nonfunctional Pancreatic Neuroendocrine Tumors Using Multimodality Imaging.

Acad Radiol 2021 Jun 23. Epub 2021 Jun 23.

Department of Radiology, Changhai Hospital, Naval Medical University, Changhai road 168, Shanghai 200434, China. Electronic address:

Objectives: We aimed to develop and validate a multimodality radiomics model for the preoperative prediction of nonfunctional pancreatic neuroendocrine tumor (NF-pNET) grade (G).

Methods: This retrospective study assessed 123 patients with surgically resected, pathologically confirmed NF-pNETs who underwent multidetector computed tomography and MRI scans between December 2012 and May 2020. Radiomic features were extracted from multidetector computed tomography and MRI. Wilcoxon rank-sum test and Max-Relevance and Min-Redundancy tests were used to select the features. The linear discriminative analysis (LDA) was used to construct the four models including a clinical model, MRI radiomics model, computed tomography radiomics model, and mixed radiomics model. The performance of the models was assessed using a training cohort (82 patients) and a validation cohort (41 patients), and decision curve analysis was applied for clinical use.

Results: We successfully constructed 4 models to predict the tumor grade of NF- pNETs. Model 4 combined 6 features of T2-weighted imaging radiomics features and 1 arterial-phase computed tomography radiomics feature, and showed better discrimination in the training cohort (AUC = 0.92) and validation cohort (AUC = 0.85) relative to the other models. In the decision curves, if the threshold probability was 0.07-0.87, the use of the radiomics score to distinguish NF-pNET G1 and G2/3 offered more benefit than did the use of a "treat all patients" or a "treat none" scheme in the training cohort of the MRI radiomics model.

Conclusion: The LDA classifier combining multimodality images may be a valuable noninvasive tool for distinguishing NF-pNET grades and avoid unnecessary surgery.
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http://dx.doi.org/10.1016/j.acra.2021.05.017DOI Listing
June 2021

Corrigendum to "Perturbation of the lipid metabolism and intestinal inflammation in growing pigs with low birth weight is associated with the alterations of gut microbiota" [Sci. Total Environ. 719 (2020) 1 - 2/137382].

Sci Total Environ 2021 Oct 24;789:148588. Epub 2021 Jun 24.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2021.148588DOI Listing
October 2021

Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease.

Proc Natl Acad Sci U S A 2021 Jun;118(26)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China;

The spread of pathological α-synuclein (α-syn) is a crucial event in the progression of Parkinson's disease (PD). Cell surface receptors such as lymphocyte activation gene 3 (LAG3) and amyloid precursor-like protein 1 (APLP1) can preferentially bind α-syn in the amyloid over monomeric state to initiate cell-to-cell transmission. However, the molecular mechanism underlying this selective binding is unknown. Here, we perform an array of biophysical experiments and reveal that LAG3 D1 and APLP1 E1 domains commonly use an alkaline surface to bind the acidic C terminus, especially residues 118 to 140, of α-syn. The formation of amyloid fibrils not only can disrupt the intramolecular interactions between the C terminus and the amyloid-forming core of α-syn but can also condense the C terminus on fibril surface, which remarkably increase the binding affinity of α-syn to the receptors. Based on this mechanism, we find that phosphorylation at serine 129 (pS129), a hallmark modification of pathological α-syn, can further enhance the interaction between α-syn fibrils and the receptors. This finding is further confirmed by the higher efficiency of pS129 fibrils in cellular internalization, seeding, and inducing PD-like α-syn pathology in transgenic mice. Our work illuminates the mechanistic understanding on the spread of pathological α-syn and provides structural information for therapeutic targeting on the interaction of α-syn fibrils and receptors as a potential treatment for PD.
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http://dx.doi.org/10.1073/pnas.2011196118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256039PMC
June 2021

Horizontal Motion of a Superhydrophobic Substrate Affects the Drop Bouncing Dynamics.

Phys Rev Lett 2021 Jun;126(23):234503

Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116024, China.

While the drop impact dynamics on stationary surfaces has been widely studied, the way a drop impacts a moving solid is by far less known. Here, we report the physical mechanisms of water drops impacting on superhydrophobic surfaces with horizontal motions. We find that a viscous force is created due to the entrainment of a thin air layer between the liquid and solid interfaces, which competes with the capillary and inertia forces, leading to an asymmetric elongation of the drop and an unexpected contact time reduction. Our experimental and theoretical results uncover consolidated scaling relations: the maximum spreading diameter is controlled by both the Weber and capillary numbers D_{max}/D_{0}∼We^{1/4}Ca^{1/6}, while the dimensionless contact time depends on the capillary number τ/τ_{0}∼Ca^{-1/6}. These findings strengthen our fundamental understandings of interactions between drops and moving solids and open up new opportunities for controlling the preferred water repellency through largely unexplored active approaches.
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http://dx.doi.org/10.1103/PhysRevLett.126.234503DOI Listing
June 2021

Downstream of GA, PbCYP78A6 participates in regulating cell cycle-related genes and parthenogenesis in pear (Pyrus bretshneideri Rehd.).

BMC Plant Biol 2021 Jun 24;21(1):292. Epub 2021 Jun 24.

State Key Laboratory of Crop Stress Biology for Arid Areas, College of Horticulture, Northwest A&F University, Shaanxi Province, Taicheng Road No.3, Yangling, 712100, China.

Background: Parthenocarpy results in traits attractive to both consumers and breeders, and it overcomes the obstacle of self-incompatibility in the fruit set of horticultural crops, including pear (Pyrus bretshneider). However, there is limited knowledge regarding the genetic and molecular mechanisms that regulate parthenogenesis.

Results: Here, in a transcriptional comparison between pollination-dependent fruit and GA-induced parthenocarpy, PbCYP78A6 was identified and proposed as a candidate gene involved in parthenocarpy. PbCYP78A6 is similar to Arabidopsis thaliana CYP78A6 and highly expressed in pear hypanthia. The increased PbCYP78A6 expression, as assessed by RT-qPCR, was induced by pollination and GA exposure. The ectopic overexpression of PbCYP78A6 contributed to parthenocarpic fruit production in tomato. The PbCYP78A6 expression coincided with fertilized and parthenocarpic fruitlets development and the expression of fruit development-related genes as assessed by cytological observations and RT-qPCR, respectively. PbCYP78A6 RNA interference and overexpression in pear calli revealed that the gene is an upstream regulator of specific fruit development-related genes in pear.

Conclusions: Our findings indicate that PbCYP78A6 plays a critical role in fruit formation and provide insights into controlling parthenocarpy.
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http://dx.doi.org/10.1186/s12870-021-03098-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223387PMC
June 2021

The prospective effects of long-term exposure to ambient PM and constituents on mortality in rural East China.

Chemosphere 2021 Oct 4;280:130740. Epub 2021 May 4.

School of Public Health, Key Laboratory of Public Health Safety, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China. Electronic address:

Few cohort studies explored the associations of long-term exposure to ambient fine particulate matter with an aerodynamic diameter of 2.5 μm or less (PM) and its chemical constituents with mortality risk in rural China. We conducted a 12-year prospective study of 28,793 adults in rural Deqing, China from 2006 to 2018. Annual mean PM and its constituents, including black carbon (BC), organic carbon (OC), ammonium (NH), nitrate (NO), sulfate (SO), and soil dust were measured at participants' addresses at enrollment from a satellite-based exposure predicting model. Cox proportional hazard model was used to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs) of long-term exposure to PM for mortality. A total of 1960 deaths were identified during the follow-up. We found PM, BC, OC, NH, NO, and SO were significantly associated with an increased risk of non-accidental mortality. The HR for non-accidental mortality was 1.17 (95%CI: 1.07, 1.28) for each 10 μg/m increase in PM. As for constituents, the strongest association was found for BC (HR = 1.21, 95%CI: 1.11, 1.33), followed by NO, NH, SO, and OC (HR = 1.14-1.17 per interquartile range). A non-linear relationship was found between PM and non-accidental mortality. Similar associations were found for cardio-cerebrovascular and cancer mortality. Associations were stronger among men and ever smokers. Conclusively, we found long-term exposure to ambient PM and its chemical constituents (especially BC and NO) increased mortality risk. Our results suggested the importance of adopting effective targeted emission control to improve air quality for health protection in rural East China.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130740DOI Listing
October 2021

Comparative effectiveness of medical concept embedding for feature engineering in phenotyping.

JAMIA Open 2021 Apr 16;4(2):ooab028. Epub 2021 Jun 16.

Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York 10032, USA.

Objective: Feature engineering is a major bottleneck in phenotyping. Properly learned medical concept embeddings (MCEs) capture the semantics of medical concepts, thus are useful for retrieving relevant medical features in phenotyping tasks. We compared the effectiveness of MCEs learned from knowledge graphs and electronic healthcare records (EHR) data in retrieving relevant medical features for phenotyping tasks.

Materials And Methods: We implemented 5 embedding methods including node2vec, singular value decomposition (SVD), LINE, skip-gram, and GloVe with 2 data sources: (1) knowledge graphs obtained from the observational medical outcomes partnership (OMOP) common data model; and (2) patient-level data obtained from the OMOP compatible electronic health records (EHR) from Columbia University Irving Medical Center (CUIMC). We used phenotypes with their relevant concepts developed and validated by the electronic medical records and genomics (eMERGE) network to evaluate the performance of learned MCEs in retrieving phenotype-relevant concepts. in retrieving phenotype-relevant concepts based on a single and multiple seed concept(s) was used to evaluate MCEs.

Results: Among all MCEs, MCEs learned by using node2vec with knowledge graphs showed the best performance. Of MCEs based on knowledge graphs and EHR data, MCEs learned by using node2vec with knowledge graphs and MCEs learned by using GloVe with EHR data outperforms other MCEs, respectively.

Conclusion: MCE enables scalable feature engineering tasks, thereby facilitating phenotyping. Based on current phenotyping practices, MCEs learned by using knowledge graphs constructed by hierarchical relationships among medical concepts outperformed MCEs learned by using EHR data.
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http://dx.doi.org/10.1093/jamiaopen/ooab028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206403PMC
April 2021

Associations of residential greenness with peripheral and central obesity in China.

Sci Total Environ 2021 May 28;791:148084. Epub 2021 May 28.

China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.

Background: Obesity is a well-known risk factor for public health. Recent studies found that greenness exposure may protect against obesity. However, the accumulated evidence on associations of greenness-obesity is inconsistent and most of them are from developed countries.

Objectives: This study aimed to evaluate the associations of greenness exposure with indicators of peripheral and central obesity.

Methods: This cross-sectional study was based on a Chinese national Sub-Clinical Outcomes of Polluted Air (SCOPA) prospective cohort across 15 provinces, and 5849 participants with average age of 64.7 were included. Surrounding greenness was estimated with the Enhanced Vegetation Index (EVI), which was calculated at each participant's residential addresses within a 250 m buffer. Weight, height and waist circumference (WC) were measured, and body mass index (BMI) and the waist-to-height ratio% (WHtR%) were calculated based on those measurements. The relationships between EVI and obese outcomes were explored using multiple linear regression and logistic regression models.

Results: Non-linear associations were observed between EVI and obese indicators. Participants living in Quartile 3 benefited more than in Quartile 4 compared to the lowest quartile (Quartile 1) of greenness. For peripheral obesity, participants living in Quartile 3 of EVI had 0.86 kg/m (β -0.86, 95% CI: -1.10, -0.61) lower BMI, and 46% (OR 0.54, 95% CI: 0.44-0.66) lower odds of peripheral obesity than in Quartile 1. For central obesity, participants living in Quartile 3 of EVI had 1.85 cm (β -1.85, 95% CI: -2.54, -1.15) lower waist circumference, 1.12% (β -1.12, 95% CI: -1.56, -0.67) lower waist-to-height ratio% (WHtR%), and 33% (OR 0.67, 95% CI: 0.57-0.78) lower odds of central obesity than in Quartile 1 of EVI.

Conclusions: Higher levels of greenness were statistically significant associated with lower obesity risk.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148084DOI Listing
May 2021

Comparison of indoor and outdoor oxidative potential of PM: pollution levels, temporal patterns, and key constituents.

Environ Int 2021 Oct 9;155:106684. Epub 2021 Jun 9.

School of Energy and Environment, Southeast University, Nanjing, China; Engineering Research Center of Building Equipment, Energy, and Environment, Ministry of Education, Nanjing, China.

Oxidative potential (OP) of PM is an emerging health indicator representing its ability to induce oxidative stress and cause adverse health effects. We examined pollution levels, temporal variations, and key constituents of PM OP by DTT assay in both indoor and outdoor environments in Nanjing, China, for over one year. Outdoor OP (mass-normalized OP characterizes toxicity) and OP (volume-based OP characterizes overall oxidative burden) in Nanjing were at a medium level compared to results reported for twenty-seven cities. Although PM mass concentration consistently decreased during outdoor-to-indoor transport, OP varied by a factor of up to 2 in either direction, indicating a change of PM's ability to disrupt oxidative-reductive balance. Temporally, both outdoor and indoor OP exhibited a significant seasonality pattern (P < 0.01) as autumn > summer > spring > winter. Outdoor and indoor daytime-nighttime OP and OP are fluctuating within two-fold range. In addition, the change in water-soluble Fe had the highest correlation coefficient (P < 0.05) with ΔOP (ΔOP = OP-OP) among constituents measured here. Our results suggest that development of mitigation strategies take indoor PM's OP into account, instead of outdoors only, since they differ.
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http://dx.doi.org/10.1016/j.envint.2021.106684DOI Listing
October 2021

Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study.

Cell Res 2021 Jun 9. Epub 2021 Jun 9.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu, China.

Emerging evidence suggests that children conceived through assisted reproductive technology (ART) have a higher risk of congenital heart defects (CHDs) even when there is no family history. De novo mutation (DNM) is a well-known cause of sporadic congenital diseases; however, whether ART procedures increase the number of germline DNM (gDNM) has not yet been well studied. Here, we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously. Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously, including 3.32 paternal and 1.26 maternal DNMs, after correcting for parental age at conception, cigarette smoking, alcohol drinking, and exercise behaviors. Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites, which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD. In addition, the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father. Among ART offspring, infertility of the father was associated with elevated paternal DNMs; usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs. In sum, the increased gDNMs in offspring conceived by ART were primarily originated from fathers, indicating that ART itself may not be a major reason for the accumulation of gDNMs. Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART.
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http://dx.doi.org/10.1038/s41422-021-00521-wDOI Listing
June 2021

A systematic review of myasthenia gravis complicated with myocarditis.

Brain Behav 2021 Jun 9. Epub 2021 Jun 9.

Department of Respiratory and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Among many of the autoimmune diseases observed in patients with myasthenia gravis (MG), myocarditis is one of the most critical. The goal of this review is to systematically describe and investigate the characteristics of MG complicated with myocarditis. We identified 183 records in PubMed (MEDLINE), Web of Science, and EMBASE from 1948 to September 10, 2020. Studies were included if they presented clinical data on MG complicated with myocarditis. Of the 35 patients from 28 studies in this review, 57.14% (20/35) were males, with a mean age of 59.11 ± 15.87. Dyspnea was the most common cardiac symptom accounting for over 60% in the study. Among the 35 patients, 13 cases of myocarditis occurred concomitantly with MG and the longest interval between MG and myocarditis was 7 years. Forty percent of patients developed myocarditis caused by immune checkpoint inhibitors (ICI). Among the patients with myocarditis, over half of the patients were diagnosed by myocardial biopsy. After active immune regulation and symptomatic treatment, only 15 of 35 patients with MG complicated with myocarditis improved, 18 patients died during hospitalization, one patient died due to tumor progression and 1patient died 5 years later. The prognosis of patients with MG complicated with myocarditis is poor, and myocardial enzymes and other indexes need to be monitored for patients taking ICI drugs. Patients with dyspnea who are still not ideally treated by mechanical ventilation should be vigilant against the occurrence of MG complicated with myocarditis.
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http://dx.doi.org/10.1002/brb3.2242DOI Listing
June 2021

The Calcium-Sensing Receptor Is Involved in Follicle-Stimulating Hormone-Induced Cumulus Expansion in Cultured Porcine Cumulus-Oocyte Complexes.

Front Cell Dev Biol 2021 20;9:625036. Epub 2021 May 20.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.

The Calcium-Sensing Receptor (CASR) is a G protein-coupled receptor of the C family that reportedly promotes maturation of porcine oocytes. However, its role in cumulus expansion of cumulus-oocyte complexes (COCs) is not well known. This study was conducted to determine the role of CASR and potential mechanisms involved during maturation (IVM) of porcine COCs. After culture of COCs in follicle-stimulating hormone (FSH)-supplement maturation medium for 24 h, the time of breakdown of the germinal vesicle (GVBD), indicative of initiation of meiotic maturation, resulted in an increased ( < 0.05) mRNA expression level in cumulus cells. Moreover, IVM of COCs in 10 μM of the CASR agonist NPS R-568 promoted ( < 0.05) cumulus expansion but only in FSH-containing medium. Conversely, 20 μM of the CASR inhibitor NPS2390 precluded cumulus expansion. We next tested the effect of the CASR agonist/inhibitor on the expression of cumulus expansion-related genes. The CASR agonist significantly upregulated the expression of hyaluronan acid synthase 2 (), whereas the CASR inhibitor downregulated the expression of all , prostaglandin-endoperoxide synthase 2 (), and tumor necrosis factor a-induced protein 6 (). Altogether, these results suggest that CASR activity is involved in FSH-stimulated porcine cumulus expansion.
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http://dx.doi.org/10.3389/fcell.2021.625036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173154PMC
May 2021

A bi-layered membrane with micro-nano bioactive glass for guided bone regeneration.

Colloids Surf B Biointerfaces 2021 Sep 30;205:111886. Epub 2021 May 30.

Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510000, PR China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510000, PR China. Electronic address:

Guided bone regeneration (GBR) is widely used to treat oral bone defects. However, the osteogenic effects are limited by the deficiency of the available barrier membranes. In this study, a novel bi-layer membrane was prepared by solvent casting and electrospinning. The barrier layer made of poly (lactic-co-glycolic acid) (PLGA) was smooth and compact, whereas the osteogenic layer consisting of micro-nano bioactive glass (MNBG) and PLGA was rough and porous. The mineralization evaluation confirmed that apatite formed on the membranes in simulated body fluid. Immersion in phosphate-buffered saline led to the degradation of the membranes with proper pH changes. Mechanical tests showed that the bi-layered membranes have stable mechanical properties under dry and wet conditions. The bi-layered membranes have good histocompatibility, and the MNBG/PLGA layer can enhance bone regeneration activity. This was confirmed by cell culture results, expression of osteogenic genes, and immunofluorescence staining of RUNX-related transcription factor 2 and osteopontin. Therefore, the bi-layered membranes could be a promising clinical strategy for GBR surgery.
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http://dx.doi.org/10.1016/j.colsurfb.2021.111886DOI Listing
September 2021

The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease.

Food Funct 2021 Jul 28;12(13):6091-6101. Epub 2021 May 28.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.

Parkinson's disease is the second most common neurodegenerative disease. Researchers have shown that oxidative stress and apoptosis play an important role in the Parkinson's disease process. Isoquercitrin (quercetin-3-O-β-d-glucopyranoside) is a natural flavonol compound and one of the main active ingredients of agricultural waste apple pomace. Increasing evidence indicates that this compound possesses anti-oxidation, anti-aging, and anti-inflammation properties. In this study, isoquercitrin was purified from apple pomace by high-speed countercurrent chromatography and its neuroprotective effect on Parkinson's disease was investigated in MPTP-induced acute mouse models. It was found that isoquercitrin ameliorated the animal behaviors against MPTP-induced neurotoxicity, mitigated the loss of dopamine neurons induced by MPTP, increased tyrosine hydroxylase and dopamine transporter expression, reduced the pro-apoptotic signaling molecule bax expression and inhibited MPTP-triggered oxidative stress. Our results demonstrated that isoquercitrin has protective effects on the MPTP subacute model mouse, which might be partially mediated through the actions of anti-oxidation and anti-apoptosis. Isoquercitrin might be a new promising protective drug for the improvement of Parkinson's disease.
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http://dx.doi.org/10.1039/d1fo00843aDOI Listing
July 2021