Concepción Pérez

Concepción Pérez

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Concepción Pérez

Concepción Pérez

Publications by authors named "Concepción Pérez"

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1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation.

Bioorg Med Chem Lett 2019 Jul 29;29(13):1597-1600. Epub 2019 Apr 29.

Department of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch 7602, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.04.049DOI Listing
July 2019

Indazolylketones as new multitarget cannabinoid drugs.

Eur J Med Chem 2019 Mar 17;166:90-107. Epub 2019 Jan 17.

Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.030DOI Listing
March 2019

Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.

Bioorg Med Chem 2019 Mar 23;27(6):931-943. Epub 2018 Dec 23.

School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. Café s/n, 14040-930 Ribeirão Preto, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.12.030DOI Listing
March 2019

Physio-metabolic response of rainbow trout during prolonged food deprivation before slaughter.

Fish Physiol Biochem 2019 Feb 23;45(1):253-265. Epub 2018 Aug 23.

Department of Animal Science, College of Agricultural Engineering, Technical University of Madrid, Avenida Puerta de Hierro 2, 28040, Madrid, Spain.

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http://link.springer.com/10.1007/s10695-018-0559-0
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http://dx.doi.org/10.1007/s10695-018-0559-0DOI Listing
February 2019

Use of Red Wine Polyphenols as a Natural Preservative in Health-Promoting Omega-3 Fatty Acids-Enriched Lamb Patties.

Molecules 2018 Nov 25;23(12). Epub 2018 Nov 25.

Departamento de Tecnología de Alimentos. Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Carretera de La Coruña, km. 7, Madrid 28040, Spain.

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http://dx.doi.org/10.3390/molecules23123080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321312PMC
November 2018

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.

Eur J Med Chem 2018 Oct 11;158:781-800. Epub 2018 Sep 11.

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.07.056DOI Listing
October 2018

A survey of perceptions, attitudes, knowledge and practices of medical oncologists about cancer pain management in Spain.

Clin Transl Oncol 2018 Aug 2;20(8):1061-1071. Epub 2018 May 2.

Hospital Universitario de Salamanca-Universidad de Salamanca (USAL), Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.

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http://dx.doi.org/10.1007/s12094-017-1826-8DOI Listing
August 2018

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.

Eur J Med Chem 2018 Aug 11;156:534-553. Epub 2018 Jul 11.

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), C/ Juan de la Cierva 3, 28006, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.07.026DOI Listing
August 2018

Chronic Pain Features Relate to Quality of Life More than Physiopathology: A Cross-Sectional Evaluation in Pain Clinics.

Pain Pract 2017 09 25;17(7):866-878. Epub 2017 Feb 25.

Department of Statistical Design and Biometrics, Medicxact SL, Alpedrete, Spain.

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http://dx.doi.org/10.1111/papr.12533DOI Listing
September 2017

3-(Benzyloxy)-1-(5-[F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain.

Future Med Chem 2017 06 20;9(10):983-994. Epub 2017 Jun 20.

Grupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.

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http://dx.doi.org/10.4155/fmc-2017-0023DOI Listing
June 2017

Does Duration of Neuropathic Pain Impact the Effectiveness of Pregabalin?

Pain Pract 2017 04 2;17(4):470-479. Epub 2016 Sep 2.

Pfizer Ltd, Tadworth, Surrey, U.K.

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http://dx.doi.org/10.1111/papr.12469DOI Listing
April 2017

Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.

Eur J Med Chem 2017 Apr 22;130:60-72. Epub 2017 Feb 22.

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), C/ Juan de la Cierva 3, 28006, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.02.034DOI Listing
April 2017

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.

Eur J Med Chem 2016 Oct 25;121:376-386. Epub 2016 May 25.

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), C/Juan de la Cierva 3, 28006, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.05.055DOI Listing
October 2016

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

Future Med Chem 2016 07 12;8(11):1191-207. Epub 2016 Jul 12.

Instituto de Química Médica (IQM-CSIC), C/Juan de la Cierva 3, 28006-Madrid, Spain.

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http://dx.doi.org/10.4155/fmc-2016-0036DOI Listing
July 2016

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets.

Fitoterapia 2016 Mar 11;109:241-7. Epub 2016 Jan 11.

Department for Life Quality Studies, Alma Mater Studiorum - University of Bologna, Corso d'Augusto 237, 47 921 Rimini, Italy.

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http://dx.doi.org/10.1016/j.fitote.2016.01.008DOI Listing
March 2016

Supercritical fluid extraction of grape seeds: extract chemical composition, antioxidant activity and inhibition of nitrite production in LPS-stimulated Raw 264.7 cells.

Food Funct 2015 Aug 1;6(8):2607-13. Epub 2015 Jul 1.

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), c/Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1039/c5fo00325cDOI Listing
August 2015

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

ACS Chem Neurosci 2015 May 9;6(5):800-10. Epub 2015 Apr 9.

†Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), C/Juan de la Cierva 3, 28006-Madrid, Spain.

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http://dx.doi.org/10.1021/acschemneuro.5b00041DOI Listing
May 2015

Modeling the predictive value of pain intensity on costs and resources utilization in patients with peripheral neuropathic pain.

Clin J Pain 2015 Mar;31(3):273-9

*Pain Clinic, Hospital Universitario La Princesa †Primary Care Health Centre Puerta del Ángel ∥Health Economics and Outcomes Research Department, Pfizer, S.L.U., Alcobendas, Madrid ‡Primary Care Health Centre Raíces, Castrillón, Asturias, Spain §Health Economic & Outcomes Research Europe, Pfizer Inc., Walton Oaks, United Kingdom.

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https://insights.ovid.com/crossref?an=00002508-201503000-000
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http://dx.doi.org/10.1097/AJP.0000000000000110DOI Listing
March 2015

Effect of dietary supplementation with red wine extract or vitamin E, in combination with linseed and fish oil, on lamb meat quality.

Meat Sci 2014 Oct 22;98(2):116-23. Epub 2014 May 22.

Departamento de Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda Puerta de Hierro, s/n, Madrid 28040, Spain.

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http://dx.doi.org/10.1016/j.meatsci.2014.05.009DOI Listing
October 2014

Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.

Eur J Med Chem 2014 Jun 12;81:350-8. Epub 2014 May 12.

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.075DOI Listing
June 2014

Guanidinium-based derivatives: searching for new kinase inhibitors.

Eur J Med Chem 2014 Jun 9;81:427-41. Epub 2014 May 9.

School of Chemistry, Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, 154-160 Pearse St., Dublin 2, Ireland. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.05.025DOI Listing
June 2014

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.

Curr Alzheimer Res 2013 Oct;10(8):797-808

Departament de Bioquímica i Biología Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

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October 2013

Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.

Eur J Med Chem 2013 Sep 25;67:64-74. Epub 2013 Jun 25.

Laboratorio de Química Médica, Instituto de Química Orgánica General (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2013.06.021DOI Listing
September 2013

Survey of European patients assessing their own noncancer chronic pain: results from Spain.

Curr Med Res Opin 2013 Jun 9;29(6):643-51. Epub 2013 Apr 9.

Hospital de la Princesa, Madrid, Spain.

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http://dx.doi.org/10.1185/03007995.2013.787978DOI Listing
June 2013

Multitarget cannabinoids as novel strategy for Alzheimer disease.

Curr Alzheimer Res 2013 Mar;10(3):229-39

Instituto de Quimica Medica (CSIC), Juan de Cierva, 3, 28006-Madrid-Spain.

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March 2013

Effect of dietary supplementation with either red wine extract or vitamin E on the volatile profile of lamb meat fed with omega-3 sources.

Meat Sci 2013 Feb 29;93(2):178-86. Epub 2012 Aug 29.

Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Carretera de La Coruña, km 7, Madrid 28040, Spain.

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http://dx.doi.org/10.1016/j.meatsci.2012.08.017DOI Listing
February 2013

Simvastatin prevents the induction of interleukin-6 gene expression by titanium particles in human osteoblastic cells.

Acta Biomater 2013 Jan 23;9(1):4916-25. Epub 2012 Aug 23.

Unidad de Investigación, Hospital Universitario La Paz-IdiPAZ, Madrid, Spain.

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http://dx.doi.org/10.1016/j.actbio.2012.08.027DOI Listing
January 2013

Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.

Eur J Med Chem 2012 Dec 5;58:44-9. Epub 2012 Oct 5.

Grupo de Química Medicinal, Laboratorio de Química Orgánica, Facultad de Ciencias-Facultad de Química, Universidad de República, Iguá 4225, 11400 Montevideo, Uruguay.

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http://dx.doi.org/10.1016/j.ejmech.2012.09.044DOI Listing
December 2012

Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.

Eur J Med Chem 2012 Nov 29;57:296-301. Epub 2012 Sep 29.

Laboratorio de Química Médica, Instituto de Química Orgánica General (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2012.09.030DOI Listing
November 2012

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

ACS Chem Neurosci 2012 Jul 26;3(7):519-29. Epub 2012 Mar 26.

Instituto de Investigación Sanitaria, Servicio de Farmacología Clínica, Hospital Universitario de la Princesa, C/Diego de León, 62, 28006 Madrid, Spain; Instituto Teófilo Hernando and Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Autónoma de Madrid, C/Arzobispro Morcillo, 4, 28029, Madrid, Spain.

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http://dx.doi.org/10.1021/cn300009eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399582PMC
July 2012

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

J Med Chem 2012 Feb 27;55(3):1303-17. Epub 2012 Jan 27.

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (IQM-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jm201460yDOI Listing
February 2012

Is morphine still the best reference opioid?

Pain Manag 2012 Jan;2(1):33-45

Pain Unit, Hospital de la Princesa, Madrid, Spain.

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http://dx.doi.org/10.2217/pmt.11.78DOI Listing
January 2012

Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

J Med Chem 2011 Dec 16;54(24):8461-70. Epub 2011 Nov 16.

Instituto de Quimica Medica-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1021/jm200996gDOI Listing
December 2011

Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

J Med Chem 2011 Jun 17;54(12):4042-56. Epub 2011 May 17.

Instituto de Química Medica-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://pubs.acs.org/doi/abs/10.1021/jm1016279
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http://dx.doi.org/10.1021/jm1016279DOI Listing
June 2011

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.

PLoS One 2011 Feb 24;6(2):e17240. Epub 2011 Feb 24.

Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas CSIC-UAM, Arturo Duperier, 4 and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017240PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044733PMC
February 2011

Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.

Eur J Med Chem 2010 Dec;45(12):6152-8

Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2010.09.039DOI Listing
December 2010

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools.

Bioorg Med Chem 2009 Oct 22;17(19):6914-25. Epub 2009 Aug 22.

Instituto de Química Médica-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.bmc.2009.08.042DOI Listing
October 2009

Prevalence and characterization of neuropathic pain in a primary-care setting in Spain: a cross-sectional, multicentre, observational study.

Clin Drug Investig 2009 ;29(7):441-450

Health Outcomes Research Department, Medical Unit, Pfizer España, Alcobendas, Spain.

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http://dx.doi.org/10.2165/00044011-200929070-00002DOI Listing
August 2009

Trigeminal neuralgia treated with pregabalin in family medicine settings: its effect on pain alleviation and cost reduction.

J Clin Pharmacol 2009 May 19;49(5):582-90. Epub 2009 Mar 19.

Unidad del Dolor, Hospital de La Princesa, C/Diego de León, Madrid, Spain.

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http://dx.doi.org/10.1177/0091270009333017DOI Listing
May 2009

Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.

Bioorg Med Chem 2008 Jun 18;16(11):6193-206. Epub 2008 Apr 18.

Instituto de Química Médica, (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.bmc.2008.04.036DOI Listing
June 2008

Non-ATP competitive glycogen synthase kinase 3beta (GSK-3beta) inhibitors: study of structural requirements for thiadiazolidinone derivatives.

Bioorg Med Chem 2008 Jan 14;16(1):495-510. Epub 2007 Sep 14.

Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.bmc.2007.09.016DOI Listing
January 2008

Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase.

Bioorg Med Chem 2005 Dec 23;13(24):6795-802. Epub 2005 Sep 23.

Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, 28006 Madrid, Spain.

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http://dx.doi.org/10.1016/j.bmc.2005.07.019DOI Listing
December 2005

Benzothiadiazine dioxides (BTD) derivatives as non-nucleoside human cytomegalovirus (HCMV) inhibitors. study of structural requirements for biological activity.

Bioorg Med Chem 2003 May;11(11):2395-402

Instituto de Qui;mica Médica (CSIC), Juan de la Cierva 3, 28006, Madrid, Spain.

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May 2003

First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.

J Med Chem 2002 Mar;45(6):1292-9

Instituto de Química Médica (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.

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March 2002

[Metronidazole as aversion treatment in chronic alcoholism].

Arch Neurobiol (Madr) 1970 Apr-Jun;33(2):171-83

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September 1970

[An observation of audiovisual synesthesia].

Acta Otorinolaryngol Iber Am 1969 ;20(1):8-13

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August 1969

[Clinical experiences with CHBS-3, a new derivative of benzodiazepam].

Rev Esp Otoneurooftalmol Neurocir 1967 Mar-Apr;24(150):138-44

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February 1969

[Treatment of chronic schizophrenics using high doses of reserpine].

Actas Luso Esp Neurol Psiquiatr 1968 Nov;27(4):556-92

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November 1968