Dr. Collet Dandara, PhD - University of Cape Town - Professor

Dr. Collet Dandara

PhD

University of Cape Town

Professor

Cape Town, Western Cape | South Africa

Additional Specialties: Genetics

ORCID logohttps://orcid.org/0000-0002-5925-4895

Dr. Collet Dandara, PhD - University of Cape Town - Professor

Dr. Collet Dandara

PhD

Introduction

I have spent my research life in the medical genetics and medical biochemistry fields. I have the expertise, leadership, training, expertise and motivation necessary to successfully carry out the proposed research project. My PhD project focused on pharmacogenetics of African populations. I have specific training and expertise in characterizing genetic variation in humans; drug metabolism, and differential responses to drug treatment. As part of my PhD training, I spent my PhD training in the Clinical Pharmacology Department, Huddinge Hospital, Sweden. My research includes characterization of genetic variation that affects how individuals respond to antiretroviral therapy, chemotherapy and antipsychotic drugs. My research also includes evaluating, in in-vitro systems, effects of new chemical entities on heterologous expressed recombinant human enzymes. I also have expertise in the use of human-derived cell lines for cell culture experiments that evaluate the effects of drug treatment on gene expression. I am also competent in the characterization of drug/herbal compounds for their inductive as well as inhibitory properties. As PI on several university of Cape Town, South African Medical Research Council (SAMRC) and National Research Foundation (NRF) of South Africa-funded grants, I laid the groundwork for the proposed research by publishing on the differences observed when populations with African-ancestry are compared to other world populations as documented in the publications listed below. I have assembled a research group and a collaboration network that is actively working on decoding the pharmacogenomics of diseases such HIV/AIDS, schizophrenia and cancer. The research group has created a biological biorepository rich with biological material and supplemented by relevant clinical history for participants. I have developed protocols of participant recruitment, genetic characterization and data analysis through strong ties with community health centers that makes it possible to recruit and track participants as required. I have successfully administered projects (e.g. staffing and budget), collaborated with other researchers, and produced several peer-reviewed publications from each project. This exposure has improved my awareness of the importance communication and decision-making among project team members.

Primary Affiliation: University of Cape Town - Cape Town, Western Cape , South Africa

Additional Specialties:

Research Interests:


View Dr. Collet Dandara’s Resume / CV

Education

Jan 2000 - Dec 2002
University of Zimbabwe
PhD
Biochemistry
Jan 2000 - Dec 2002
University of Zimbabwe
PhD
Biochemistry

Experience

Jan 2016
University of Cape
Professor
Div of Human Genetics, Dept of Pathology
Feb 2009 - Dec 2012
University of Cape Town
Senior lecturer
Clinical laboratory sciences
Feb 2009 - Dec 2012
University of Cape Town
Senior lecturer
Clinical laboratory sciences
Sep 2007 - Jan 2009
University of the Witwatersrand
Lecturer
Molecular and Cell Biology

Publications

101Publications

1270Reads

8Profile Views

Exploring new genetic variants within COL5A1 intron 4-exon 5 region and TGF-β family with risk of anterior cruciate ligament ruptures.

J Orthop Res 2020 Jan 10. Epub 2020 Jan 10.

Division of Exercise Science and Sports Medicine (ESSM), University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1002/jor.24585DOI Listing
January 2020
2.986 Impact Factor

Childhood Obesity Risk in Relationship to Perilipin 1 () Gene Regulation by Circulating microRNAs.

OMICS 2020 Jan 17;24(1):43-50. Epub 2019 Dec 17.

Division of Human Genetics, Department of Pathology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1089/omi.2019.0150DOI Listing
January 2020
2.362 Impact Factor

Interview with Prof. Collet Dandara: A Pioneer and Advocate of Multiomics Science and Health Innovation in Africa.

Authors:
Collet Dandara

OMICS 2019 12 22;23(12):603-606. Epub 2019 Nov 22.

Pharmacogenomics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology & Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1089/omi.2019.0174DOI Listing
December 2019
2.362 Impact Factor

Implementing Artificial Intelligence and Digital Health in Resource-Limited Settings? Top 10 Lessons We Learned in Congenital Heart Defects and Cardiology.

OMICS 2019 Oct 8. Epub 2019 Oct 8.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1089/omi.2019.0142DOI Listing
October 2019
1 Read
2.362 Impact Factor

MicroRNA Mediated Changes in Drug Metabolism and Target Gene Expression by Efavirenz and Rifampicin : Clinical Implications.

OMICS 2019 10 16;23(10):496-507. Epub 2019 Sep 16.

Division of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.

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https://www.liebertpub.com/doi/10.1089/omi.2019.0122
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http://dx.doi.org/10.1089/omi.2019.0122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806364PMC
October 2019
2 Reads
2.362 Impact Factor

Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe.

Viral Immunol 2019 Sep 26;32(7):289-295. Epub 2019 Jul 26.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1089/vim.2019.0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751388PMC
September 2019
3 Reads
1.636 Impact Factor

Herbal Remedies: Throwing Off Phenotype Prediction-A Culprit for Pharmacogenomic-Guided Drug Therapy and Drug Safety.

Clin Pharmacol Ther 2019 Aug 27;106(2):302-304. Epub 2019 Jun 27.

Oncology IMED Biotech Unit, AstraZeneca, Cambridge, UK.

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http://dx.doi.org/10.1002/cpt.1509DOI Listing
August 2019
3 Reads
7.903 Impact Factor

An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C.

Pharmacogenomics J 2019 06 13;19(3):240-248. Epub 2018 Aug 13.

Division of Human Genetic, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1038/s41397-018-0035-3DOI Listing
June 2019
26 Reads
4.230 Impact Factor

Post genome-wide association analysis: dissecting computational pathway/network-based approaches.

Brief Bioinform 2019 03;20(2):690-700

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Private Bag, Rondebosch, 7700, Cape Town, South Africa; African Institute for Mathematical Sciences, 7945 Muizenberg, Cape Town, South Africa and Computational Biology Division, Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925, Cape Town, South Africa.

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http://dx.doi.org/10.1093/bib/bby035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556901PMC
March 2019
15 Reads
9.620 Impact Factor

The Genetics of Warfarin Dose-Response Variability in Africans: An Expert Perspective on Past, Present, and Future.

OMICS 2019 03;23(3):152-166

1 Pharmacogenomics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1089/omi.2019.0018DOI Listing
March 2019
8 Reads
2.362 Impact Factor

Warfarin Dose and CYP2C Gene Cluster: An African Ancestral-Specific Variant Is a Strong Predictor of Dose in Black South African Patients.

OMICS 2019 01 19;23(1):36-44. Epub 2018 Dec 19.

1 Pharmacogenomics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology & Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0174DOI Listing
January 2019
10 Reads
2.362 Impact Factor

Rosuvastatin pharmacogenetics in African populations.

Pharmacogenomics 2018 12 6;19(18):1373-1375. Epub 2018 Nov 6.

Department of Pathology, Division of Human Genetic, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.2217/pgs-2018-0168DOI Listing
December 2018
4 Reads
3.220 Impact Factor

Pharmacogenetics of Antiretroviral Drug Response and Pharmacokinetic Variations in Indigenous South African Populations.

OMICS 2018 09;22(9):589-597

1 Systems Genetics Working Group, Department of Genetics, Stellenbosch University , Stellenbosch, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0117DOI Listing
September 2018
6 Reads
2.362 Impact Factor

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices.

Int J Mol Sci 2018 Sep 20;19(10). Epub 2018 Sep 20.

Division of Medical Biochemistry and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.3390/ijms19102861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213202PMC
September 2018
9 Reads
2.862 Impact Factor

Genetic Susceptibility for Cervical Cancer in African Populations: What Are the Host Genetic Drivers?

OMICS 2018 07;22(7):468-483

3 Pharmacogenetics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0075DOI Listing
July 2018
6 Reads
2.362 Impact Factor

Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine.

Stem Cells Int 2018 30;2018:2495848. Epub 2018 Jul 30.

Department of Biomedical Sciences, Faculty of Science, Tshwane University of Technology, Pretoria 0001, South Africa.

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http://dx.doi.org/10.1155/2018/2495848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091336PMC
July 2018
340 Reads
2.810 Impact Factor

Personalized Herbal Medicine? A Roadmap for Convergence of Herbal and Precision Medicine Biomarker Innovations.

OMICS 2018 06;22(6):375-391

1 Pharmacogenomics and Drug Metabolism Research Group, Division of Human Genetics, Department of Pathology and Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0074DOI Listing
June 2018
18 Reads
2.362 Impact Factor

A cost effective RFLP method to genotype Solute carrier organic anion 1B1 (SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics.

BMC Res Notes 2018 Jun 14;11(1):384. Epub 2018 Jun 14.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Anzio Road, Observatory, Cape Town, South Africa.

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http://dx.doi.org/10.1186/s13104-018-3469-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000981PMC
June 2018
56 Reads

Genomics and Epigenomics of Congenital Heart Defects: Expert Review and Lessons Learned in Africa.

OMICS 2018 05;22(5):301-321

1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, Institute for Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2018.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016577PMC
May 2018
32 Reads
2.362 Impact Factor

Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?

Molecules 2018 04 17;23(4). Epub 2018 Apr 17.

Pharmacogenomics and Drug Metabolism Group, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.3390/molecules23040930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017867PMC
April 2018
20 Reads
2.420 Impact Factor

A Genomic and Protein-Protein Interaction Analyses of Nonsyndromic Hearing Impairment in Cameroon Using Targeted Genomic Enrichment and Massively Parallel Sequencing.

OMICS 2017 02 11;21(2):90-99. Epub 2017 Jan 11.

1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences - University of Cape Town , Cap Town, South Africa .

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http://dx.doi.org/10.1089/omi.2016.0171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913793PMC
February 2017
19 Reads
2.362 Impact Factor

Cancer Stem Cell Hypothesis for Therapeutic Innovation in Clinical Oncology? Taking the Root Out, Not Chopping the Leaf.

OMICS 2016 12;20(12):681-691

1 International Centre for Genetic Engineering and Biotechnology (ICGEB) , Cape Town Component, Wernher and Beit Building (South), UCT Medical Campus, Anzio Road, Observatory 7925, Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2016.0152DOI Listing
December 2016
24 Reads
2.362 Impact Factor

Harnessing Knowledge on Very Important Pharmacogenes CYP2C9 and CYP2C19 Variation for Precision Medicine in Resource-Limited Global Conflict Zones.

OMICS 2016 10;20(10):604-609

5 Pharmacogenetics and Drug Safety Unit, Department of Toxicology, Faculty of Pharmacy, Marmara University , Istanbul, Turkey .

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http://dx.doi.org/10.1089/omi.2016.0133DOI Listing
October 2016
19 Reads
2.362 Impact Factor

Rolling out Efavirenz for HIV Precision Medicine in Africa: Are We Ready for Pharmacovigilance and Tackling Neuropsychiatric Adverse Effects?

OMICS 2016 10 14;20(10):575-580. Epub 2016 Sep 14.

4 Centre of Clinical Research, Regional Hospital North Denmark, Clinical Institute Aalborg University , Aalborg, Denmark .

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http://dx.doi.org/10.1089/omi.2016.0120DOI Listing
October 2016
22 Reads
2.362 Impact Factor

An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine.

OMICS 2016 10 16;20(10):565-574. Epub 2016 Sep 16.

1 Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town , Cape Town, Republic of South Africa.

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http://dx.doi.org/10.1089/omi.2016.0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067801PMC
October 2016
55 Reads
2.362 Impact Factor

Targeted genomic enrichment and massively parallel sequencing identifies novel nonsyndromic hearing impairment pathogenic variants in Cameroonian families.

Clin Genet 2016 09 1;90(3):288-90. Epub 2016 Jun 1.

Division of Human Genetics, Department of Pathology, Faculty of Health Sciences University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/cge.12799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324826PMC
September 2016
26 Reads
3.931 Impact Factor

Precision Medicine 2.0: The Rise of Glocal Innovation, Superconnectors, and Design Thinking.

OMICS 2016 09;20(9):493-5

12 Faculty of Communications, Gaziantep University , Gaziantep, Turkey .

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http://dx.doi.org/10.1089/omi.2016.0129DOI Listing
September 2016
27 Reads
2.362 Impact Factor

Conference Report: First Pharmacogenetics and Precision Medicine Conference in Africa (April 7-9, 2016, Cape Town, South Africa).

OMICS 2016 09;20(9):496-7

3 Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet , Stockholm, Sweden .

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http://dx.doi.org/10.1089/omi.2016.0128DOI Listing
September 2016
10 Reads
2.362 Impact Factor

Pharmacogenomics of Rosuvastatin: A Glocal (Global+Local) African Perspective and Expert Review on a Statin Drug.

OMICS 2016 09;20(9):498-509

1 Pharmacogenetics Research Group, Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, and University of Cape Town , Cape Town, South Africa .

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http://dx.doi.org/10.1089/omi.2016.0114DOI Listing
September 2016
16 Reads
2.362 Impact Factor

African Lettuce (Launaea taraxacifolia) Displays Possible Anticancer Effects and Herb-Drug Interaction Potential by CYP1A2, CYP2C9, and CYP2C19 Inhibition.

OMICS 2016 09;20(9):528-37

1 Pharmacogenetics Research Group, Division of Human Genetics, Department of Pathology and Institute of Infectious Diseases and Molecular medicine, Faculty of Health Sciences, University of Cape Town , Cape Town, South Africa .

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http://www.liebertpub.com/doi/10.1089/omi.2016.0117
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http://dx.doi.org/10.1089/omi.2016.0117DOI Listing
September 2016
48 Reads
2.362 Impact Factor

Fibroblast-Derived Extracellular Matrix Induces Chondrogenic Differentiation in Human Adipose-Derived Mesenchymal Stromal/Stem Cells in Vitro.

Int J Mol Sci 2016 Aug 3;17(8). Epub 2016 Aug 3.

International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Anzio Road, Observatory, Cape Town 7925, South Africa.

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http://dx.doi.org/10.3390/ijms17081259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000657PMC
August 2016
31 Reads
2.862 Impact Factor

In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions.

Molecules 2016 Jul 7;21(7). Epub 2016 Jul 7.

Division of Human Genetics, Department of Pathology & Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.

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http://dx.doi.org/10.3390/molecules21070891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274561PMC
July 2016
39 Reads
2.420 Impact Factor

Evaluating the contribution of APOBEC3G haplotypes, on influencing HIV infection in a Zimbabwean paediatric population.

S Afr Med J 2016 May 25;106(6 Suppl 1):S119-23. Epub 2016 May 25.

Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town; Department of Chemical Pathology, University of Zimbabwe, Harare; and Letten Foundation Research House, Harare, Zimbabwe.

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http://dx.doi.org/10.7196/SAMJ.2016.v106i6.11013DOI Listing
May 2016
15 Reads
1.712 Impact Factor

Implementation of POCT in the diabetic clinic in a large hospital.

Afr Health Sci 2015 Sep;15(3):902-7

Chris Hani Baragwanath Academic Hospital, National Health Laboratory Services (NHLS), Chemical Pathology Department, Chris Hani Road, Bertham, 2000 Johannesburg. South Africa.

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http://dx.doi.org/10.4314/ahs.v15i3.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765443PMC
September 2015
25 Reads
0.662 Impact Factor

Population Diversity and Pharmacogenomics in Africa

Handbook of Pharmacogenomics and Stratified Medicine

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2014
18 Reads

Investigation of glucocorticoid receptor polymorphisms in relation to metabolic parameters in Addison's disease.

Eur J Endocrinol 2013 Mar 15;168(3):403-12. Epub 2013 Feb 15.

Division of Endocrinology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, J47 Old Main Building, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1530/EJE-12-0808DOI Listing
March 2013
22 Reads
4.070 Impact Factor

Association of transforming growth factor β-1 (TGFB1) regulatory region polymorphisms with myasthenia gravis-related ophthalmoparesis.

J Neuroimmunol 2012 May 27;246(1-2):96-9. Epub 2012 Mar 27.

Neurology Research Group, Department of Medicine, Groote Schuur Hospital & University of Cape Town, Cape Town 7925, South Africa.

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http://dx.doi.org/10.1016/j.jneuroim.2012.03.002DOI Listing
May 2012
7 Reads
2.470 Impact Factor

Influence of CYP2B6 516G>T polymorphism and interoccasion variability (IOV) on the population pharmacokinetics of efavirenz in HIV-infected South African children.

Eur J Clin Pharmacol 2012 Apr 6;68(4):339-47. Epub 2011 Nov 6.

Unit for Drug Research and Development, Division of Pharmacology, School of Pharmacy, North-West University, Potchefstroom, South Africa.

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http://link.springer.com/10.1007/s00228-011-1148-7
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http://dx.doi.org/10.1007/s00228-011-1148-7DOI Listing
April 2012
11 Reads
2.970 Impact Factor

CYP1A2, CYP2A6, CYP2B6, CYP3A4 and CYP3A5 Polymorphisms in Two Bantu-Speaking Populations from Cameroon and South Africa:Implications for Global Pharmacogenetics

Current Pharmacogenomics and Personalized Medicine

Abstract: The health burden resulting from parasitic and infectious diseases such as HIV/AIDS, tuberculosis and malaria, requires that available medication and limited healthcare resources be used optimally. However, due to co-morbidities, patients are often exposed to many drugs concurrently. Most of these drugs are metabolised by similar enzymes which are polymorphic, thus, drug-drug interactions are a constant problem. Quantitative and qualitative differences in drug metabolizing enzyme variants in different populations result in differential drug response. This study investigated the baseline frequencies of genetic variants in key drug metabolizing cytochrome P450 enzymes, CYP1A2, CYP2A6, CYP2B6, CYP3A4 and CYP3A5 in two previously understudied Bantu-speaking populations from Cameroon (N=72) and South Africa (N=163) using PCR-RFLP. Genotype frequencies for CYP1A2 C-163A and CYP3A4 A-392G single nucleotide polymorphisms (SNPs) were significantly different between these two populations (P=0.0004 and 0.0079, respectively). Significant differences were also observed when the two Bantu-speaking populations were each compared to other African populations as well as Caucasian and Asian populations. Importantly, correspondence analysis showed that the two Bantu-speaking African populations were separated from each other and from other African populations based on CYP1A2 C-163A and CYP2A6 G1093A SNPs. The data show that drugs that are substrates for these polymorphic enzymes are likely to have different response profiles among the Bantu-speaking populations and populations of either Caucasian or Asian origin, further emphasizing the need to genetically characterise as many African populations in order to realize personalised medicine. These data further emphasize that linguistically related Bantu-speaking populations are not necessarily genetically homogenous. Finally, we note that our observations also inform future pharmacogenetics guided rational therapeutic drug monitoring to prevent or minimize the risk for adverse drug-drug interactions mediated by these genetically polymorphic pathways.

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March 2012
14 Reads

An Idea Whose Time Has Come? An African Foresight Observatory on Genomics Medicine and Data-Intensive Global Science

Current Pharmacogenomics and Personalized Medicine

“Africa is the Center of the World.” Fela Anikulapo Kuti (Musician and Pioneer of Afrobeat, Nigeria; 1938–1997) [1] “Today most discoveries are made by scientist-clinicians who are funded to generate data, build a model or hypothesis, provide a validation of their idea, and then share the results as a paper in a peer-reviewed journal. But as the scale of the data needed to make insights grows (…) the power of coordinated team approaches will grow. By analogy to physics, astronomy, and the writing of the software, the benefits of dynamic teams sharing data and ideas in real time will multiply. The logical extension is to start considering a “commons” where omics data, projects, and models can be evolved in a shared manner.” Stephen Friend [2]

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March 2012
19 Reads

Pharmacogenetics Research Developments in Africa: A Focus on Malawi

Elizabeth Kampira, Johnstone Kumwenda, Joep J. van Oosterhout, Mas Chaponda, Collet Dandara, 2012, 'Pharmacogenetics Research Developments in Africa: A Focus on Malawi', Current Pharmacogenomics and Personalized Medicine, vol. 10, no. 1

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March 2012
14 Reads

Editorial (An Idea Whose Time Has Come? An African Foresight Observatory on Genomics Medicine and Data-Intensive Global Science)

Collet Dandara, 2012, 'Editorial (An Idea Whose Time Has Come? An African Foresight Observatory on Genomics Medicine and Data-Intensive Global Science)', Current Pharmacogenomics and Personalized Medicine, vol. 10, no. 1

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March 2012
11 Reads

Absence Seizures Associated With Efavirenz Initiation

Renate Strehlau, Leigh Martens, Ashraf Coovadia, Collet Dandara, Jennifer Norman, Julia Maisel, Louise Kuhn, Elaine J. Abrams, 2011, 'Absence Seizures Associated With Efavirenz Initiation', The Pediatric Infectious Disease Journal, vol. 30, no. 11, pp. 1001-1003

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2011
12 Reads

Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer

Dong-Ping Li, Collet Dandara, Gabi Walther, M. Iqbal Parker, 2008, 'Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer', Clinical Chemical Laboratory Medicine, vol. 46, no. 3

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January 2008
11 Reads

Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus.

Clin Chem Lab Med 2005 ;43(4):370-5

MRC/UCT Oesophageal Cancer Research Group, Institute of Infectious Disease and Molecular Medicine, Division of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, South Africa.

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https://www.degruyter.com/view/j/cclm.2005.43.issue-4/cclm.2
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http://dx.doi.org/10.1515/CCLM.2005.067DOI Listing
September 2005
13 Reads
2.960 Impact Factor

Genetic polymorphism of CYP2D6 and CYP2C19 in east- and southern African populations including psychiatric patients.

Eur J Clin Pharmacol 2001 Apr;57(1):11-7

Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe.

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http://dx.doi.org/10.1007/s002280100282DOI Listing
April 2001
8 Reads
2.970 Impact Factor

Genetic polymorphism of cytochrome P4501A1, microsomal epoxide hydrolase, and glutathione S-transferases M1 and T1 in Zimbabweans and Venda of southern Africa.

Pharmacogenetics 1998 Feb;8(1):83-5

Department of Biochemistry, University of Zimbabwe, Mount Pleasant, Harare, Zimbabwe.

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http://dx.doi.org/10.1097/00008571-199802000-00011DOI Listing
February 1998
9 Reads

Geology of the Dandara Area

Authors:
BAHAY ISSAWI

Prehistory of the Nile Valley

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1976
11 Reads

The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

DongPing Li, Collet Dandara, M IQBAL Parker, 2010, 'The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer', BMC Genetics, vol. 11, no. 1, p. 47

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1969
10 Reads

Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana

Suvi Torniainen, M Iqbal Parker, Ville Holmberg, Elisa Lahtela, Collet Dandara, Irma Jarvela, 2009, 'Screening of variants for lactase persistence/non-persistence in populations from South Africa and Ghana', BMC Genetics, vol. 10, no. 1, p. 31

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1969
8 Reads

Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation

Louise Warnich, Britt I. Drogemoller, Michael S. Pepper, Collet Dandara, Galen E.B. Wright, 2011, 'Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation', Current Pharmacogenomics and Personalized Medicine, vol. 9, no. 3

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1969
10 Reads

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

Marelize Swart, Heather Whitehorn, Yuan Ren, Peter Smith, Rajkumar S Ramesar, Collet Dandara, 2012, 'PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients', BMC Medical Genetics, vol. 13, no. 1

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1969
10 Reads

Genetic variants inCYP(-1A2,-2C9,-2C19,-3A4and-3A5),VKORC1andABCB1genes in a black South African population: a window into diversity

Collet Dandara, Zané Lombard, Ingrid Du Plooy, Tracy McLellan, Shane A Norris, Michèle Ramsay, 2011, 'Genetic variants inCYP(-1A2,-2C9,-2C19,-3A4and-3A5),VKORC1andABCB1genes in a black South African population: a window into diversity', Pharmacogenomics, vol. 12, no. 12

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1969
10 Reads

Fibrodysplasia Ossificans Progressiva in South Africa

Chris Scott, Mike Urban, Regan Arendse, Collet Dandara, Peter Beighton, 2011, 'Fibrodysplasia Ossificans Progressiva in South Africa', Journal of Clinical Rheumatology, vol. 17, no. 1

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1969
11 Reads

CYP3A5 genotypes and risk of oesophageal cancer in two South African populations

Collet Dandara, Robea Ballo, M. Iqbal Parker, 2005, 'CYP3A5 genotypes and risk of oesophageal cancer in two South African populations', Cancer Letters, vol. 225, no. 2, pp. 275-282

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1969
16 Reads

CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

Koushik Chatterjee, Collet Dandara, Margaret Hoffman, Anna-Lise Williamson, 2010, 'CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women', BMC Cancer, vol. 10, no. 1, p. 278

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1969
11 Reads

CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer

Koushik Chatterjee, Anna-Lise Williamson, Margaret Hoffman, Collet Dandara, 2011, 'CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer', Journal of Medical Virology, vol. 83, no. 4, pp. 630-636

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1969
9 Reads

Arylamine N-acetyltransferase (NAT2) genotypes in Africans

Collet Dandara, Collen M Masimirembwa, Ayoub Magimba, Sylvia Kaaya, Jane Sayi, De K Sommers, J R Snyman, Julia A Hasler, 2003, 'Arylamine N-acetyltransferase (NAT2) genotypes in Africans', Pharmacogenetics, vol. 13, no. 1, pp. 55-58

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1969
9 Reads

ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients

Marelize Swart, Yuan Ren, Peter Smith, Collet Dandara, 2012, 'ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients', Frontiers in Genetics, vol. 3

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1969
10 Reads

Top co-authors

Ambroise Wonkam
Ambroise Wonkam

University of Cape Town

13
Nicholas Ekow Thomford
Nicholas Ekow Thomford

University of Cape Town

11
Kevin Dzobo
Kevin Dzobo

University of Cape Town

10
Arielle Rowe
Arielle Rowe

3 International Centre for Genetic Engineering and Biotechnology (ICGEB)

6
Emile Chimusa
Emile Chimusa

Institute of Infectious Disease and Molecular Medicine

6
Collen Masimirembwa
Collen Masimirembwa

University of Zimbabwe

5
Dimakatso Alice Senthebane
Dimakatso Alice Senthebane

University of Cape Town

4
Nicholas E Thomford
Nicholas E Thomford

University of Cape Town

3
Arinao Ndadza
Arinao Ndadza

Institute of Infectious Disease and Molecular Medicine (IDM)

3
Kerina Duri
Kerina Duri

University of Zimbabwe

3