Collen M Masimirembwa

Collen M Masimirembwa

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Collen M Masimirembwa

Collen M Masimirembwa

Publications by authors named "Collen M Masimirembwa"

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Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies.

Bioorg Med Chem 2015 Sep 30;23(17):5419-32. Epub 2015 Jul 30.

Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch 7701, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.051DOI Listing
September 2015

Inhibition of major drug metabolizing CYPs by common herbal medicines used by HIV/AIDS patients in Africa-- implications for herb-drug interactions.

Drug Metab Lett 2014 Jul;7(2):83-95

Division of Clinical Pharmacology, Department of Medicine, University of Stellenbosch, PO Box 19063, Tygerberg, Cape Town, 7505, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354708PMC
http://dx.doi.org/10.2174/1872312808666140129123210DOI Listing
July 2014

Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.

Xenobiotica 2012 Oct 25;42(10):989-1000. Epub 2012 Apr 25.

Department of DMPK/PD-BAC, African Institute of Biomedical Science & Technology (AIBST), Harare, Zimbabwe.

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http://www.tandfonline.com/doi/full/10.3109/00498254.2012.68
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http://dx.doi.org/10.3109/00498254.2012.681077DOI Listing
October 2012

Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.

Bioorg Med Chem Lett 2012 Aug 9;22(15):5046-50. Epub 2012 Jun 9.

Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.

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http://dx.doi.org/10.1016/j.bmcl.2012.06.010DOI Listing
August 2012

Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan.

Drug Metab Dispos 2010 Jan;38(1):187-99

Department of Chemistry, Medicinal Chemistry, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1124/dmd.109.028670DOI Listing
January 2010

In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions.

Drug Metab Dispos 2009 Jun 19;37(6):1286-94. Epub 2009 Mar 19.

Department of Drug Metabolism and Pharmacokinetics/PD and Toxicology, African Institute of Biomedical Science and Technology, Harare, Zimbabwe.

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http://dx.doi.org/10.1124/dmd.108.024604DOI Listing
June 2009

The molecular basis of CYP2D6-mediated N-dealkylation: balance between metabolic clearance routes and enzyme inhibition.

Drug Metab Dispos 2008 Nov 25;36(11):2199-210. Epub 2008 Aug 25.

Discovery DMPK & Bioanalytical Chemistry, AstraZeneca R&D Mölndal, SE-431 81 Mölndal, Sweden.

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http://dx.doi.org/10.1124/dmd.108.022376DOI Listing
November 2008

Exploration of enzyme-ligand interactions in CYP2D6 & 3A4 homology models and crystal structures using a novel computational approach.

J Chem Inf Model 2007 May-Jun;47(3):1234-47. Epub 2007 Mar 24.

Discovery DMPK & Bioanalytical Chemisty Department, AstraZeneca R&D Mölndal, SE-431 81, Sweden.

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http://dx.doi.org/10.1021/ci600561vDOI Listing
September 2007

Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans.

Eur J Clin Pharmacol 2005 Nov 29;61(10):755-61. Epub 2005 Oct 29.

African Institute of Biomedical Science & Technology (AIBST), P.O. Box 2294, Harare, Zimbabwe.

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http://dx.doi.org/10.1007/s00228-005-0037-3DOI Listing
November 2005

Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.

Drug Metab Dispos 2004 Nov;32(11):1218-29

Department of Drug Metabolism and Pharmacokinetics and Bioanalytical Chemistry, AstraZeneca R&D, Mölndal, Sweden.

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http://dx.doi.org/10.1124/dmd.32.11.DOI Listing
November 2004

Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges.

Clin Pharmacokinet 2003 ;42(6):515-28

Department of Drug Metabolism and Pharmacokinetics & Bioanalytical Chemistry, AstraZeneca R &D Mölndal, Mölndal, Sweden.

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http://dx.doi.org/10.2165/00003088-200342060-00002DOI Listing
June 2004

Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data.

Eur J Clin Pharmacol 2003 Sep 12;59(5-6):429-42. Epub 2003 Aug 12.

Department of Drug Metabolism and Pharmacokinetics and Bioanalytical Chemistry, AstraZeneca R and D Mölndal, 431 83 Mölndal, Sweden.

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http://dx.doi.org/10.1007/s00228-003-0636-9DOI Listing
September 2003

Combining pharmacophore and protein modeling to predict CYP450 inhibitors and substrates.

Methods Enzymol 2002 ;357:133-44

AstraZeneca R&D Mäolndal, S-431 83 Mölndal, Sweden.

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http://dx.doi.org/10.1016/s0076-6879(02)57673-4DOI Listing
January 2003

Discriminant and quantitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors.

J Comput Aided Mol Des 2002 Jul;16(7):443-58

Department of Organic Pharmaceutical Chemistry, Biomedical Center, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1023/a:1021281008423DOI Listing
July 2002

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate.

J Pharmacol Exp Ther 2002 Feb;300(2):399-407

Drug Metabolism and Pharmacokinetics and Bioanalytical Chemistry, AstraZeneca Research and Development, Mölndal, Sweden.

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http://dx.doi.org/10.1124/jpet.300.2.399DOI Listing
February 2002