Colleen Fearns

Colleen Fearns

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Colleen Fearns

Colleen Fearns

Publications by authors named "Colleen Fearns"

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20Publications

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Targeting protein aggregation for the treatment of degenerative diseases.

Nat Rev Drug Discov 2015 Nov 4;14(11):759-80. Epub 2015 Sep 4.

Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nrd4593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628595PMC
November 2015

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

J Mol Biol 2012 Aug 5;421(2-3):185-203. Epub 2012 Jan 5.

Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.12.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350832PMC
August 2012

Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment.

Mol Ther 2012 Apr 24;20(4):849-59. Epub 2012 Jan 24.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/mt.2011.310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321595PMC
April 2012

Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.

Cancer Cell 2010 Sep;18(3):258-67

Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939729PMC
September 2010

Kinome siRNA screen identifies SMG-1 as a negative regulator of hypoxia-inducible factor-1alpha in hypoxia.

J Biol Chem 2009 Jun 30;284(25):16752-8. Epub 2009 Apr 30.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M109.014316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719310PMC
June 2009

CDC25B mediates rapamycin-induced oncogenic responses in cancer cells.

Cancer Res 2009 Mar 10;69(6):2663-8. Epub 2009 Mar 10.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697620PMC
March 2009

Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.

J Biol Chem 2006 Nov 12;281(45):34592-600. Epub 2006 Sep 12.

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M604019200
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http://dx.doi.org/10.1074/jbc.M604019200DOI Listing
November 2006

A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy.

Nat Med 2006 Jan 4;12(1):128-32. Epub 2005 Dec 4.

Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037-1000, USA.

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http://dx.doi.org/10.1038/nm1327DOI Listing
January 2006

Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis.

Cancer Res 2005 Sep;65(17):7699-706

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4540DOI Listing
September 2005

Tid1 is required for T cell transition from double-negative 3 to double-positive stages.

J Immunol 2005 May;174(10):6105-12

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.4049/jimmunol.174.10.6105DOI Listing
May 2005