Colin Watts

Colin Watts

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Colin Watts

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Longitudinal molecular trajectories of diffuse glioma in adults.

Nature 2019 12 20;576(7785):112-120. Epub 2019 Nov 20.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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http://dx.doi.org/10.1038/s41586-019-1775-1DOI Listing
December 2019

Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.

Eur Radiol 2019 Oct 19;29(10):5559-5566. Epub 2019 Mar 19.

Department of Radiology, School of Clinical Medicine, University of Cambridge, Box 218, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1007/s00330-019-6011-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719328PMC
October 2019

Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation.

Front Immunol 2018 24;9:2449. Epub 2018 Oct 24.

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung and Blood Institute, Bethesda, MD, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02449
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http://dx.doi.org/10.3389/fimmu.2018.02449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207624PMC
September 2019

Diabetes insipidus-an extremely rare complication from replacement of an external ventricular drain.

Acta Neurochir (Wien) 2019 07 9;161(7):1377-1380. Epub 2019 May 9.

Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2TH, UK.

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http://dx.doi.org/10.1007/s00701-019-03937-xDOI Listing
July 2019

Missed opportunities for diagnosing brain tumours in primary care: a qualitative study of patient experiences.

Br J Gen Pract 2019 Apr 11;69(681):e224-e235. Epub 2019 Mar 11.

Centre for Oral, Clinical and Translational Science, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London.

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http://dx.doi.org/10.3399/bjgp19X701861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428480PMC
April 2019

Designing Next-Generation Local Drug Delivery Vehicles for Glioblastoma Adjuvant Chemotherapy: Lessons from the Clinic.

Adv Healthc Mater 2019 02 11;8(3):e1801391. Epub 2019 Jan 11.

Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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http://doi.wiley.com/10.1002/adhm.201801391
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http://dx.doi.org/10.1002/adhm.201801391DOI Listing
February 2019

An adherent tissue-inspired hydrogel delivery vehicle utilised in primary human glioma models.

Biomaterials 2018 10 4;179:199-208. Epub 2018 Jun 4.

Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.05.054DOI Listing
October 2018

WINDOW consortium: A path towards increased therapy efficacy against glioblastoma.

Drug Resist Updat 2018 09 30;40:17-24. Epub 2018 Oct 30.

Department of Neurosurgery, Brain Tumor Center Amsterdam, Amsterdam University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HZ, Amsterdam, Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13687646183004
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http://dx.doi.org/10.1016/j.drup.2018.10.001DOI Listing
September 2018

Residual enhancing disease after surgery for glioblastoma: evaluation of practice in the United Kingdom.

Neurooncol Pract 2018 May 27;5(2):74-81. Epub 2017 Sep 27.

Department of Neurosurgery, Addenbrookes Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.

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http://dx.doi.org/10.1093/nop/npx023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6655490PMC
May 2018

Intraoperative imaging technology to maximise extent of resection for glioma.

Cochrane Database Syst Rev 2018 Jan 22;1:CD012788. Epub 2018 Jan 22.

Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Lower Lane, Liverpool, Merseyside, UK, L9 7LJ.

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http://dx.doi.org/10.1002/14651858.CD012788.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491323PMC
January 2018

Evidence-based management of adult patients with diffuse glioma - Authors' reply.

Lancet Oncol 2017 08 26;18(8):e430-e431. Epub 2017 Jul 26.

Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany; German Consortium of Translational Cancer Research, Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(17)30515-6DOI Listing
August 2017

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas.

Lancet Oncol 2017 06 5;18(6):e315-e329. Epub 2017 May 5.

Neurology Clinic and National Centre for Tumour Diseases, University Hospital Heidelberg, Heidelberg, Germany; German Consortium of Translational Cancer Research (DKTK), Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1016/S1470-2045(17)30194-8DOI Listing
June 2017

Surgical approaches for the gliomas.

Handb Clin Neurol 2016 ;134:51-69

Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ, USA.

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http://dx.doi.org/10.1016/B978-0-12-802997-8.00004-9DOI Listing
December 2016

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.

Neuro Oncol 2016 12 10;18(12):1644-1655. Epub 2016 Jun 10.

Department of Biomedicine, University of Bergen, Norway (E.E., G.V.R., K.M.T., O.K., T.T., K.V., J.A.H., J.V.J., R.J., H.S.S., L.L., T.D., P.Ø.E., R.B., H.M.); KG Jebsen Brain Tumor Research Center, University of Bergen, Norway (E.E., G.V.R., K.M.T., O.K., K.V., J.A.H., J.V.J., T.D., P. Ø.E., S.P.N., R.B., H.M.); Department of Clinical Science, University of Bergen, Norway (S.K.); Department of Oncology, Haukeland University Hospital, Bergen, Norway (S.K.); Norlux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg (O.K., S.F., S.P.N., R.B.); Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK (A.S.); Department of Clinical Pharmacy, Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany (S.F., C.A.R.); Department of Neurooncology, University Hospital Heidelberg, Germany (G.S., F.W.); Institute of Scientific Instruments, ASCR, Brno, Czech Republic (R.J.); Edinger-Intsitute, Goethe-University Medical School, Frankfurt am Main, Germany (P.N.H.); Department of Pathology, Haukeland University Hospital, Bergen, Norway (J.A.H., H.M.); Department of Clinical Neurosciences, University of Cambridge, UK (S.G.P., C.W.); Statistics and Computational Biology Laboratory, University of Cambridge, UK (I.S.); Neuro Clinic, Haukeland University Hospital, Bergen, Norway; Department of Experimental Neurology, Charité - Universitätsmedizin Berlin, Germany (P.E.); Department of Systems Medicine, University of Rome «Tor Vergata», Rome, Italy (G.G.); INSERM U1029 - University of Bordeaux, Allée Geoffroy St. Hilaire, Pessac, France (T.D.); Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway (M.L.-J., P. Ø.E.).

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http://dx.doi.org/10.1093/neuonc/now113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791772PMC
December 2016

Selective 5-aminolevulinic acid-induced protoporphyrin IX fluorescence in Gliomas.

Acta Neurochir (Wien) 2016 10 6;158(10):1935-41. Epub 2016 Aug 6.

Department of Neurosurgery, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1007/s00701-016-2897-yDOI Listing
October 2016

PET imaging in glioma: is it time for mainstream practice?

Neuro Oncol 2016 09;18(9):1193-4

Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (C.W.); Institute of Neuroscience and Medicine, Research Center Jülich and Department of Nuclear Medicine, RWTH Aachen University Clinic, Aachen, Germany (K.-J. L.).

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http://dx.doi.org/10.1093/neuonc/now134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999004PMC
September 2016

Assessing and monitoring intratumor heterogeneity in glioblastoma: how far has multimodal imaging come?

CNS Oncol 2015 26;4(6):399-410. Epub 2015 Oct 26.

Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.2217/cns.15.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083939PMC
August 2016

Neuro-oncology: Amino acid PET for brain tumours - ready for the clinic?

Nat Rev Neurol 2016 07 10;12(7):375-6. Epub 2016 Jun 10.

University of Cambridge, Department of Clinical Neurosciences, Division of Neurosurgery, Cambridge BOX 167 Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1038/nrneurol.2016.80DOI Listing
July 2016

Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis.

Immunity 2016 Apr 5;44(4):795-806. Epub 2016 Apr 5.

Division of Cell Signaling & Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK. Electronic address:

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http://www.cell.com/immunity/pdf/S1074-7613(16)30069-3.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S107476131630069
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http://dx.doi.org/10.1016/j.immuni.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846977PMC
April 2016

Clonal diversity in glioblastoma: is it clinically relevant?

Future Oncol 2015 ;11(12):1703-6

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http://dx.doi.org/10.2217/fon.15.73DOI Listing
March 2016

Kinetics of tumor size and peritumoral brain edema before, during, and after systemic therapy in recurrent WHO grade II or III meningioma.

Neuro Oncol 2016 Mar 9;18(3):401-7. Epub 2015 Sep 9.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (J.F., V.S.); Department of Psychology, University of Graz, Graz, Austria (V.S.); BioTechMed, Graz, Austria (V.S.); Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland (K.S., M.W.); Department of Neuro-oncology, University Hospital, Lille, France (E.L.R.); Breast Cancer Department, Oscar Lambret Center, Lille, France (E.L.R.); PRISM Inserm U1191, Villeneuve D'Ascq, France (E.L.R.); Department of Neuro-Oncology, University of Torino, Torino, Italy (R.R., R.S.); Department of Neurology and Brain Tumor Center, Cantonal Hospital Aarau, Aarau, Switzerland (U.R.); Department of Neurology, University of Essen, Essen, Germany (S.K.); Department of Medicine I, Medical University of Vienna, Vienna, Austria (A.S.B., C.M., M.P.); Department of Oncology, KU Leuven, Leuven, Belgium (P.C.); Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy (M.F.); Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge, England (C.W.); Neurology Clinic and National Center for Tumor Disease, University of Heidelberg, Heidelberg, Germany (W.W.); Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany (W.W.).

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http://dx.doi.org/10.1093/neuonc/nov183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767240PMC
March 2016

Corrigendum.

Future Oncol 2015 11;11(20):2851. Epub 2015 Sep 11.

John van Geest Centre for Brain Repair, Department of Clinical, Neurosciences, University of Cambridge, Cambridge, CB2 0PY, UK.

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http://dx.doi.org/10.2217/fon.15.234DOI Listing
January 2016

Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer.

Mol Cancer Res 2015 Dec 13;13(12):1523-32. Epub 2015 Oct 13.

Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, Australia. School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0383DOI Listing
December 2015

The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.

J Immunol 2015 Nov 23;195(9):4264-72. Epub 2015 Sep 23.

Division of Cell Signaling and Immunology, College of Life Science, University of Dundee, Dundee DD1 5EH, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1501520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640173PMC
November 2015

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells.

Cancer Res 2015 Oct 17;75(20):4416-28. Epub 2015 Aug 17.

Translational Radiation Biology, Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.

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http://cancerres.aacrjournals.org/content/early/2015/10/01/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-14-3790DOI Listing
October 2015

The role of sub-ventricular zone in gliomagenesis.

Aging (Albany NY) 2015 Oct;7(10):738-9

University of Cambridge, Clinical Neurosciences, Cambridge, U.K.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637196PMC
http://dx.doi.org/10.18632/aging.100823DOI Listing
October 2015

Novel Surgical Approaches to High-Grade Gliomas.

Curr Treat Options Neurol 2015 Sep;17(9):369

Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK,

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http://dx.doi.org/10.1007/s11940-015-0369-yDOI Listing
September 2015

CD15 Expression Does Not Identify a Phenotypically or Genetically Distinct Glioblastoma Population.

Stem Cells Transl Med 2015 Jul 27;4(7):822-31. Epub 2015 May 27.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, Cambridge University, Cambridge, United Kingdom; MRC Cancer Unit, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, United Kingdom; The Institute of Cancer Research, London, United Kingdom

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http://dx.doi.org/10.5966/sctm.2014-0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479614PMC
July 2015

Cystatin F regulates proteinase activity in IL-2-activated natural killer cells.

Protein Pept Lett 2014 ;21(9):957-65

Department of Biochemistry Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.2174/0929866521666140403124146DOI Listing
March 2015

Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells.

Mol Cell Biol 2015 Jan 20;35(1):132-40. Epub 2014 Oct 20.

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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http://dx.doi.org/10.1128/MCB.00773-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295372PMC
January 2015

Genetic and functional diversity of propagating cells in glioblastoma.

Stem Cell Reports 2015 Jan 18;4(1):7-15. Epub 2014 Dec 18.

Centre for Evolution and Cancer, Division of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297869PMC
January 2015

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.

Nat Commun 2014 Oct 28;5:5359. Epub 2014 Oct 28.

1] Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK [2] Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland.

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http://dx.doi.org/10.1038/ncomms6359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258606PMC
October 2014

Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma.

Nanoscale 2014 Sep 13;6(18):10865-73. Epub 2014 Aug 13.

Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge CB3 0FF, UK.

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http://dx.doi.org/10.1039/c4nr03693jDOI Listing
September 2014

Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3).

Bioorg Med Chem 2014 Feb 30;22(3):1029-39. Epub 2013 Dec 30.

Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.12.041DOI Listing
February 2014

A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.

Biosci Rep 2014 02 1;34(1). Epub 2014 Feb 1.

Division of Cell Signalling and Immunology, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BSR20130094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908613PMC
February 2014

Huntington's disease and cell therapies: past, present, and future.

Methods Mol Biol 2013 ;1010:19-32

Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1007/978-1-62703-411-1_2DOI Listing
January 2014

Professor Robert Sutherland FAA, AO (1947-2012).

Horm Mol Biol Clin Investig 2013 Dec;16(3):113-4

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http://dx.doi.org/10.1515/hmbci-2013-0046DOI Listing
December 2013

Strategies to accelerate diagnosis of primary brain tumors at the primary-secondary care interface in children and adults.

CNS Oncol 2013 Sep;2(5):447-62

Children's Brain Tumor Research Centre, Queen's Medical Centre, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.2217/cns.13.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136128PMC
September 2013

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.

Proc Natl Acad Sci U S A 2013 Mar 14;110(10):4009-14. Epub 2013 Feb 14.

Department of Oncology, University of Cambridge, Cambridge CB2 2XZ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1219747110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593922PMC
March 2013

Establishing the efficacy of Gliadel wafers: progress towards a Phase III trial.

Acta Neurochir (Wien) 2013 Jan 30;155(1):61-2. Epub 2012 Oct 30.

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http://dx.doi.org/10.1007/s00701-012-1533-8DOI Listing
January 2013

Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome.

Brain 2013 Jan;136(Pt 1):245-58

Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience–an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/brain/aws321DOI Listing
January 2013

Surgical management of high-grade glioma: a standard of care.

Authors:
Colin Watts

CNS Oncol 2012 Nov;1(2):181-92

University of Cambridge Department of Clinical Neurosciences, Division of Neurosurgery, Box 167 Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.2217/cns.12.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178118PMC
November 2012

Enhanced stability and activity of temozolomide in primary glioblastoma multiforme cells with cucurbit[n]uril.

Chem Commun (Camb) 2012 Oct 30;48(79):9843-5. Epub 2012 Aug 30.

Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK.

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http://xlink.rsc.org/?DOI=c2cc35131e
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http://dx.doi.org/10.1039/c2cc35131eDOI Listing
October 2012

Umbilical cord stem cells: the hidden swan in a family of ugly ducklings.

Authors:
Colin Watts

Acta Neurochir (Wien) 2012 Sep 4;154(9):1727. Epub 2012 Jul 4.

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http://dx.doi.org/10.1007/s00701-012-1430-1DOI Listing
September 2012

A review of the role of stem cells in the development and treatment of glioma.

Acta Neurochir (Wien) 2012 Jun 20;154(6):951-69; discussion 969. Epub 2012 Apr 20.

Centre for Brain Repair, Department Clinical Neurosciences, Cambridge University, UK.

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http://link.springer.com/content/pdf/10.1007/s00701-012-1338
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http://link.springer.com/10.1007/s00701-012-1338-9
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http://dx.doi.org/10.1007/s00701-012-1338-9DOI Listing
June 2012

Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells.

Eur J Cell Biol 2012 May 23;91(5):391-401. Epub 2012 Feb 23.

Jožef Stefan Institute, Department of Biotechnology, Ljubljana, Slovenia.

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https://linkinghub.elsevier.com/retrieve/pii/S01719335120000
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http://dx.doi.org/10.1016/j.ejcb.2012.01.001DOI Listing
May 2012

Application of a novel highly sensitive activity-based probe for detection of cathepsin G.

Anal Biochem 2012 Feb 23;421(2):667-72. Epub 2011 Nov 23.

Division of Endocrinology and Diabetes, Center for Internal Medicine, University Medical Center Ulm, 89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.ab.2011.11.016DOI Listing
February 2012

The endosome-lysosome pathway and information generation in the immune system.

Authors:
Colin Watts

Biochim Biophys Acta 2012 Jan 18;1824(1):14-21. Epub 2011 Jul 18.

Division of Cell Signaling & Immunology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1016/j.bbapap.2011.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476823PMC
January 2012

Internalization of exogenous cystatin F supresses cysteine proteases and induces the accumulation of single-chain cathepsin L by multiple mechanisms.

J Biol Chem 2011 Dec 28;286(49):42082-90. Epub 2011 Sep 28.

Division of Cell Signaling and Immunology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.253914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234946PMC
December 2011

A multifunctional protease inhibitor to regulate endolysosomal function.

ACS Chem Biol 2011 Nov 19;6(11):1198-204. Epub 2011 Sep 19.

Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, U.K.

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http://dx.doi.org/10.1021/cb200292cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220280PMC
November 2011

Serum albumin and survival in glioblastoma multiforme.

J Neurooncol 2011 Oct 16;105(1):77-81. Epub 2011 Mar 16.

Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.

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http://link.springer.com/10.1007/s11060-011-0562-0
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http://dx.doi.org/10.1007/s11060-011-0562-0DOI Listing
October 2011

Glioblastoma cell lines derived under serum-free conditions can be used as an in vitro model system to evaluate therapeutic response.

Cancer Lett 2011 Jun 12;305(1):50-7. Epub 2011 Mar 12.

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.canlet.2011.02.025DOI Listing
June 2011

Asparagine endopeptidase is required for normal kidney physiology and homeostasis.

FASEB J 2011 May 3;25(5):1606-17. Epub 2011 Feb 3.

Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1096/fj.10-172312DOI Listing
May 2011

Human stem cell-derived neurons: a system to study human tau function and dysfunction.

PLoS One 2010 Nov 11;5(11):e13947. Epub 2010 Nov 11.

Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013947PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978712PMC
November 2010

Brain-machine interface: the challenge of neuroethics.

Surgeon 2010 Oct 13;8(5):267-9. Epub 2010 Jul 13.

Department of Neurosurgery, King's College Hospital, London SE5 9RS, UK.

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http://dx.doi.org/10.1016/j.surge.2010.05.006DOI Listing
October 2010

Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14.

J Cell Sci 2010 May 31;123(Pt 9):1427-37. Epub 2010 Mar 31.

Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.056515
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http://dx.doi.org/10.1242/jcs.056515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858019PMC
May 2010

Distinct protease requirements for antigen presentation in vitro and in vivo.

J Immunol 2010 Mar;184(5):2423-31

Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.0901486DOI Listing
March 2010

TLR signalling regulated antigen presentation in dendritic cells.

Curr Opin Immunol 2010 Feb 18;22(1):124-30. Epub 2010 Jan 18.

Division of Cell Biology & Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.coi.2009.12.005DOI Listing
February 2010

Diverse regulatory roles for lysosomal proteases in the immune response.

Eur J Immunol 2009 Nov;39(11):2955-65

Division of Cell biology & Immunology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://doi.wiley.com/10.1002/eji.200939650
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http://dx.doi.org/10.1002/eji.200939650DOI Listing
November 2009

Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice.

Eur J Neurosci 2009 May 28;29(9):1853-69. Epub 2009 Apr 28.

Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2009.06736.xDOI Listing
May 2009

Glycosylation directs targeting and activation of cystatin f from intracellular and extracellular sources.

Traffic 2009 Apr 24;10(4):425-37. Epub 2009 Jan 24.

Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/j.1600-0854.2009.00881.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691902PMC
April 2009

An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours.

J Neurosci Methods 2009 Jan;176(2):192-9

Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0PY, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S016502700800450
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http://dx.doi.org/10.1016/j.jneumeth.2008.07.022DOI Listing
January 2009

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.

J Cell Biol 2008 Sep 1;182(5):993-1005. Epub 2008 Sep 1.

Division of Cell Biology and Immunology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1083/jcb.200801022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528573PMC
September 2008

Cell therapy in Huntington disease.

Neurosurg Focus 2008 ;24(3-4):E9

Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom.

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http://dx.doi.org/10.3171/FOC/2008/24/3-4/E8DOI Listing
April 2008

Location, location, location: identifying the neighborhoods of LPS signaling.

Authors:
Colin Watts

Nat Immunol 2008 Apr;9(4):343-5

Division of Cell Biology and Immunology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1038/ni0408-343DOI Listing
April 2008

A role for ARF6 in dendritic cell podosome formation and migration.

Eur J Immunol 2008 Mar;38(3):818-28

Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/eji.200737331DOI Listing
March 2008

Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis.

EMBO J 2008 Feb;27(3):499-508

Division of Cell Biology & Immunology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241651PMC
February 2008

Putative tumor suppressor EDD interacts with and up-regulates APC.

Genes Cells 2007 Dec;12(12):1339-45

Division of Gastroenterological Surgery, Department of Surgery, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2007.01138.xDOI Listing
December 2007