Colin Watts

Institute of Cancer and Genomic Sciences, University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom of Great Britain and Northern Ireland.

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January 2021

Machine learning-based radiomic, clinical and semantic feature analysis for predicting overall survival and MGMT promoter methylation status in patients with glioblastoma.

Authors:

Yiping Lu Markand Patel Kal Natarajan Ismail Ughratdar Paul Sanghera Raj Jena Colin Watts Vijay Sawlani

Magn Reson Imaging 2020 12 25;74:161-170. Epub 2020 Sep 25.

Neuroradiology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Edgbaston, Birmingham B15 2TH, UK; University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address:

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December 2020

Impact of COVID-19 pandemic on surgical neuro-oncology multi-disciplinary team decision making: a national survey (COVID-CNSMDT Study).

BMJ Open 2020 08 16;10(8):e040898. Epub 2020 Aug 16.

Department of Neurosurgery, The Walton Centre National Health Service Foundation Trust, Liverpool, UK.

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August 2020

Correction to: PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas.

Genome Biol 2020 Aug 17;21(1):206. Epub 2020 Aug 17.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.

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August 2020

Spatial heterogeneity of cell-matrix adhesive forces predicts human glioblastoma migration.

Authors:

Rasha Rezk Bill Zong Jia Astrid Wendler Ivan Dimov Colin Watts Athina E Markaki Kristian Franze Alexandre J Kabla

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa081. Epub 2020 Jul 3.

Department of Engineering, University of Cambridge, Cambridge, UK.

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July 2020

PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas.

Genome Biol 2020 07 30;21(1):181. Epub 2020 Jul 30.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.

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July 2020

Multiparametric MRI: practical approach and pictorial review of a useful tool in the evaluation of brain tumours and tumour-like lesions.

Authors:

Vijay Sawlani Markand Dipankumar Patel Nigel Davies Robert Flintham Roman Wesolowski Ismail Ughratdar Ute Pohl Santhosh Nagaraju Vladimir Petrik Andrew Kay Saiju Jacob Paul Sanghera Victoria Wykes Colin Watts Harish Poptani

Insights Imaging 2020 Jul 17;11(1):84. Epub 2020 Jul 17.

Centre for Pre-Clinical Imaging, Department of Cellular and Molecular Physiology, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK.

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July 2020

Dynamic changes in glioma macrophage populations after radiotherapy reveal CSF-1R inhibition as a strategy to overcome resistance.

Authors:

Leila Akkari Robert L Bowman Jeremy Tessier Florian Klemm Shanna M Handgraaf Marnix de Groot Daniela F Quail Lucie Tillard Jules Gadiot Jason T Huse Dieta Brandsma Johan Westerga Colin Watts Johanna A Joyce

Sci Transl Med 2020 07;12(552)

Department of Oncology, University of Lausanne, 1011 Lausanne, Switzerland.

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July 2020

Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial.

Authors:

Lucy Brazil Angela L Swampillai Ka Man Mak Darren Edwards Pavlina Mesiri Laura Clifton-Hadley Richard Shaffer Joanne Lewis Colin Watts Sarah Jeffries Pinelopi Gkogkou Anthony J Chalmers Naomi L Fersht Allan Hackshaw Susan C Short

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa046. Epub 2020 Apr 27.

St James's University Hospital, Leeds, UK.

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April 2020

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities.

Nat Commun 2020 06 10;11(1):2935. Epub 2020 Jun 10.

Department of Neurosurgery, Amsterdam UMC, location VUMC, Cancer Center, Amsterdam, the Netherlands.

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June 2020

Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial.

Authors:

Catherine Hanna Kathreena M Kurian Karin Williams Colin Watts Alan Jackson Ross Carruthers Karen Strathdee Garth Cruickshank Laurence Dunn Sara Erridge Lisa Godfrey Sarah Jefferies Catherine McBain Rebecca Sleigh Alex McCormick Marc Pittman Sarah Halford Anthony J Chalmers

Neuro Oncol 2020 12;22(12):1840-1850

Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

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December 2020

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase.

Authors:

Anita N Kremer Judith Bausenwein Ellie Lurvink Andreas E Kremer Caroline E Rutten Cornelis A M van Bergen Sascha Kretschmann Edith van der Meijden Maria W Honders Daniela Mazzeo Colin Watts Andreas Mackensen J H Frederik Falkenburg Marieke Griffioen

Front Immunol 2020 11;11:381. Epub 2020 Mar 11.

Department of Hematology, Leiden University Medical Center, Leiden, Netherlands.

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March 2020

Longitudinal molecular trajectories of diffuse glioma in adults.

Authors:

Floris P Barthel Kevin C Johnson Frederick S Varn Anzhela D Moskalik Georgette Tanner Emre Kocakavuk Kevin J Anderson Olajide Abiola Kenneth Aldape Kristin D Alfaro Donat Alpar Samirkumar B Amin David M Ashley Pratiti Bandopadhayay Jill S Barnholtz-Sloan Rameen Beroukhim Christoph Bock Priscilla K Brastianos Daniel J Brat Andrew R Brodbelt Alexander F Bruns Ketan R Bulsara Aruna Chakrabarty Arnab Chakravarti Jeffrey H Chuang Elizabeth B Claus Elizabeth J Cochran Jennifer Connelly Joseph F Costello Gaetano Finocchiaro Michael N Fletcher Pim J French Hui K Gan Mark R Gilbert Peter V Gould Matthew R Grimmer Antonio Iavarone Azzam Ismail Michael D Jenkinson Mustafa Khasraw Hoon Kim Mathilde C M Kouwenhoven Peter S LaViolette Meihong Li Peter Lichter Keith L Ligon Allison K Lowman Tathiane M Malta Tali Mazor Kerrie L McDonald Annette M Molinaro Do-Hyun Nam Naema Nayyar Ho Keung Ng Chew Yee Ngan Simone P Niclou Johanna M Niers Houtan Noushmehr Javad Noorbakhsh D Ryan Ormond Chul-Kee Park Laila M Poisson Raul Rabadan Bernhard Radlwimmer Ganesh Rao Guido Reifenberger Jason K Sa Michael Schuster Brian L Shaw Susan C Short Peter A Sillevis Smitt Andrew E Sloan Marion Smits Hiromichi Suzuki Ghazaleh Tabatabai Erwin G Van Meir Colin Watts Michael Weller Pieter Wesseling Bart A Westerman Georg Widhalm Adelheid Woehrer W K Alfred Yung Gelareh Zadeh Jason T Huse John F De Groot Lucy F Stead Roel G W Verhaak

Nature 2019 12 20;576(7785):112-120. Epub 2019 Nov 20.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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December 2019

Molecular Evolution of Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study.

J Clin Oncol 2020 01 19;38(1):81-99. Epub 2019 Nov 19.

Erasmus University Medical Center, Rotterdam, the Netherlands.

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January 2020

Quality improvement of neuro-oncology services: integrating the routine collection of patient-reported, health-related quality-of-life measures.

Authors:

Rocío Fernández-Méndez Rebecca J Rastall William A Sage Ingela Oberg Gemma Bullen Amy Louise Charge Anna Crofton Thomas Santarius Colin Watts Stephen J Price Andrew Brodbelt Alexis J Joannides

Neurooncol Pract 2019 May 17;6(3):226-236. Epub 2018 Oct 17.

Neurosurgery Department, Cambridge University Hospitals NHS Trust, Addenbrookes Hospital, UK.

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May 2019

SDHC epi-mutation testing in gastrointestinal stromal tumours and related tumours in clinical practice.

Sci Rep 2019 07 15;9(1):10244. Epub 2019 Jul 15.

Department of Medical Genetics, University of Cambridge and NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge, CB2 OQQ, United Kingdom.

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July 2019

Diabetes insipidus-an extremely rare complication from replacement of an external ventricular drain.

Authors:

Khandkar Ali Kawsar Masna Bin Inam Colin Watts

Acta Neurochir (Wien) 2019 07 9;161(7):1377-1380. Epub 2019 May 9.

Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2TH, UK.

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July 2019

'It was nothing that you would think was anything': Qualitative analysis of appraisal and help seeking preceding brain cancer diagnosis.

Authors:

Suzanne E Scott Clarissa Penfold Smiji Saji Sarah Curtis Colin Watts Willie Hamilton Alexis J Joannides Fiona M Walter

PLoS One 2019 22;14(3):e0213599. Epub 2019 Mar 22.

The Primary Care Unit, Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom.

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December 2019

Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.

Authors:

Fulvio Zaccagna Frank Riemer Andrew N Priest Mary A McLean Kieren Allinson James T Grist Carmen Dragos Tomasz Matys Jonathan H Gillard Colin Watts Stephen J Price Martin J Graves Ferdia A Gallagher

Eur Radiol 2019 Oct 19;29(10):5559-5566. Epub 2019 Mar 19.

Department of Radiology, School of Clinical Medicine, University of Cambridge, Box 218, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

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October 2019

Missed opportunities for diagnosing brain tumours in primary care: a qualitative study of patient experiences.

Authors:

Fiona M Walter Clarissa Penfold Alexis Joannides Smiji Saji Margaret Johnson Colin Watts Andrew Brodbelt Michael D Jenkinson Stephen J Price Willie Hamilton Suzanne E Scott

Br J Gen Pract 2019 Apr 11;69(681):e224-e235. Epub 2019 Mar 11.

Centre for Oral, Clinical and Translational Science, Faculty of Dentistry, Oral and Craniofacial Sciences, King's College London, London.

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April 2019

Designing Next-Generation Local Drug Delivery Vehicles for Glioblastoma Adjuvant Chemotherapy: Lessons from the Clinic.

Authors:

Anthony Tabet Melanie P Jensen Christopher C Parkins Parag G Patil Colin Watts Oren A Scherman

Adv Healthc Mater 2019 02 11;8(3):e1801391. Epub 2019 Jan 11.

Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

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February 2019

A non-hierarchical organization of tumorigenic NG2 cells in glioblastoma promoted by EGFR.

Authors:

Talal F Al-Mayhani Richard M Heywood Vamsidhara Vemireddy Justin D Lathia Sara G M Piccirillo Colin Watts

Neuro Oncol 2019 06;21(6):719-729

Brain Repair Centre, University of Cambridge, Cambridge, UK.

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June 2019

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.

Authors:

Jonathan Martínez-Fábregas Alan Prescott Sander van Kasteren Deena Leslie Pedrioli Irwin McLean Anna Moles Thomas Reinheckel Valeria Poli Colin Watts

Nat Commun 2018 12 17;9(1):5343. Epub 2018 Dec 17.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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December 2018

The molecular landscape of glioma in patients with Neurofibromatosis 1.

Nat Med 2019 01 10;25(1):176-187. Epub 2018 Dec 10.

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA.

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January 2019

WINDOW consortium: A path towards increased therapy efficacy against glioblastoma.

Authors:

Kulsoom U Abdul Megan Houweling Fredrik Svensson Ravi S Narayan Fleur M G Cornelissen Asli Küçükosmanoglu Emmanouil Metzakopian Colin Watts David Bailey Tom Wurdinger Bart A Westerman

Drug Resist Updat 2018 09 30;40:17-24. Epub 2018 Oct 30.

Department of Neurosurgery, Brain Tumor Center Amsterdam, Amsterdam University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HZ, Amsterdam, Netherlands. Electronic address:

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September 2018

Asparaginyl Endopeptidase (Legumain) Supports Human Th1 Induction via Cathepsin L-Mediated Intracellular C3 Activation.

Authors:

Simon Freeley John Cardone Sira C Günther Erin E West Thomas Reinheckel Colin Watts Claudia Kemper Martin V Kolev

Front Immunol 2018 24;9:2449. Epub 2018 Oct 24.

Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung and Blood Institute, Bethesda, MD, United States.

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September 2019

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