Colin Semple

Colin Semple

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Colin Semple

Publications by authors named "Colin Semple"

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Clinical and molecular characterization of ovarian carcinoma displaying isolated lymph node relapse.

Am J Obstet Gynecol 2019 Sep 2;221(3):245.e1-245.e15. Epub 2019 May 2.

Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.ajog.2019.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857430PMC
September 2019

Breaking point: the genesis and impact of structural variation in tumours.

F1000Res 2018 19;7. Epub 2018 Nov 19.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH42XU, UK.

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http://dx.doi.org/10.12688/f1000research.16079.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248261PMC
March 2019

Modeling double strand break susceptibility to interrogate structural variation in cancer.

Genome Biol 2019 02 8;20(1):28. Epub 2019 Feb 8.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/s13059-019-1635-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368699PMC
February 2019

Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline.

Genome Biol 2018 07 30;19(1):101. Epub 2018 Jul 30.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/s13059-018-1483-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066925PMC
July 2018

Enhanced response rate to pegylated liposomal doxorubicin in high grade serous ovarian carcinomas harbouring BRCA1 and BRCA2 aberrations.

BMC Cancer 2018 01 3;18(1):16. Epub 2018 Jan 3.

Nicola Murray Centre for Ovarian Cancer Research, Edinburgh Cancer Research UK Centre, MRC IGMM, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-017-3981-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753521PMC
January 2018

The circadian dynamics of small nucleolar RNA in the mouse liver.

J R Soc Interface 2017 05;14(130)

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1098/rsif.2017.0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454292PMC
May 2017

When TADs go bad: chromatin structure and nuclear organisation in human disease.

F1000Res 2017 24;6. Epub 2017 Mar 24.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.12688/f1000research.10792.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373421PMC
March 2017

Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types.

PLoS Genet 2016 08 4;12(8):e1006207. Epub 2016 Aug 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1006207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973979PMC
August 2016

Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization.

Genome Biol 2015 May 27;16:110. Epub 2015 May 27.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/s13059-015-0661-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443654PMC
May 2015

Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid.

Hum Mol Genet 2014 Oct 12;23(19):5061-8. Epub 2014 May 12.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/hmg/ddu227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159153PMC
October 2014

Sequence-level mechanisms of human epigenome evolution.

Genome Biol Evol 2014 Jun 24;6(7):1758-71. Epub 2014 Jun 24.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, United Kingdom.

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http://dx.doi.org/10.1093/gbe/evu142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122940PMC
June 2014

Properties of local interactions and their potential value in complementing genome-wide association studies.

PLoS One 2013 5;8(8):e71203. Epub 2013 Aug 5.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071203PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733963PMC
April 2014

A promoter-level mammalian expression atlas.

Authors:
Alistair R R Forrest Hideya Kawaji Michael Rehli J Kenneth Baillie Michiel J L de Hoon Vanja Haberle Timo Lassmann Ivan V Kulakovskiy Marina Lizio Masayoshi Itoh Robin Andersson Christopher J Mungall Terrence F Meehan Sebastian Schmeier Nicolas Bertin Mette Jørgensen Emmanuel Dimont Erik Arner Christian Schmidl Ulf Schaefer Yulia A Medvedeva Charles Plessy Morana Vitezic Jessica Severin Colin A Semple Yuri Ishizu Robert S Young Margherita Francescatto Intikhab Alam Davide Albanese Gabriel M Altschuler Takahiro Arakawa John A C Archer Peter Arner Magda Babina Sarah Rennie Piotr J Balwierz Anthony G Beckhouse Swati Pradhan-Bhatt Judith A Blake Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher A Maxwell Burroughs Andrea Califano Carlo V Cannistraci Daniel Carbajo Yun Chen Marco Chierici Yari Ciani Hans C Clevers Emiliano Dalla Carrie A Davis Michael Detmar Alexander D Diehl Taeko Dohi Finn Drabløs Albert S B Edge Matthias Edinger Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Michela Fagiolini Lynsey Fairbairn Hai Fang Mary C Farach-Carson Geoffrey J Faulkner Alexander V Favorov Malcolm E Fisher Martin C Frith Rie Fujita Shiro Fukuda Cesare Furlanello Masaaki Furino Jun-ichi Furusawa Teunis B Geijtenbeek Andrew P Gibson Thomas Gingeras Daniel Goldowitz Julian Gough Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Matthias Harbers Jayson Harshbarger Akira Hasegawa Yuki Hasegawa Takehiro Hashimoto Meenhard Herlyn Kelly J Hitchens Shannan J Ho Sui Oliver M Hofmann Ilka Hoof Furni Hori Lukasz Huminiecki Kei Iida Tomokatsu Ikawa Boris R Jankovic Hui Jia Anagha Joshi Giuseppe Jurman Bogumil Kaczkowski Chieko Kai Kaoru Kaida Ai Kaiho Kazuhiro Kajiyama Mutsumi Kanamori-Katayama Artem S Kasianov Takeya Kasukawa Shintaro Katayama Sachi Kato Shuji Kawaguchi Hiroshi Kawamoto Yuki I Kawamura Tsugumi Kawashima Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura S Peter Klinken Alan J Knox Miki Kojima Soichi Kojima Naoto Kondo Haruhiko Koseki Shigeo Koyasu Sarah Krampitz Atsutaka Kubosaki Andrew T Kwon Jeroen F J Laros Weonju Lee Andreas Lennartsson Kang Li Berit Lilje Leonard Lipovich Alan Mackay-Sim Ri-ichiroh Manabe Jessica C Mar Benoit Marchand Anthony Mathelier Niklas Mejhert Alison Meynert Yosuke Mizuno David A de Lima Morais Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Efthymios Motakis Hozumi Motohashi Christine L Mummery Mitsuyoshi Murata Sayaka Nagao-Sato Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Kenichi Nakazato Erik van Nimwegen Noriko Ninomiya Hiromi Nishiyori Shohei Noma Shohei Noma Tadasuke Noazaki Soichi Ogishima Naganari Ohkura Hiroko Ohimiya Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Arnab Pain Robert Passier Margaret Patrikakis Helena Persson Silvano Piazza James G D Prendergast Owen J L Rackham Jordan A Ramilowski Mamoon Rashid Timothy Ravasi Patrizia Rizzu Marco Roncador Sugata Roy Morten B Rye Eri Saijyo Antti Sajantila Akiko Saka Shimon Sakaguchi Mizuho Sakai Hiroki Sato Suzana Savvi Alka Saxena Claudio Schneider Erik A Schultes Gundula G Schulze-Tanzil Anita Schwegmann Thierry Sengstag Guojun Sheng Hisashi Shimoji Yishai Shimoni Jay W Shin Christophe Simon Daisuke Sugiyama Takaai Sugiyama Masanori Suzuki Naoko Suzuki Rolf K Swoboda Peter A C 't Hoen Michihira Tagami Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Zuotian Tatum Mark Thompson Hiroo Toyodo Tetsuro Toyoda Elvind Valen Marc van de Wetering Linda M van den Berg Roberto Verado Dipti Vijayan Ilya E Vorontsov Wyeth W Wasserman Shoko Watanabe Christine A Wells Louise N Winteringham Ernst Wolvetang Emily J Wood Yoko Yamaguchi Masayuki Yamamoto Misako Yoneda Yohei Yonekura Shigehiro Yoshida Susan E Zabierowski Peter G Zhang Xiaobei Zhao Silvia Zucchelli Kim M Summers Harukazu Suzuki Carsten O Daub Jun Kawai Peter Heutink Winston Hide Tom C Freeman Boris Lenhard Vladimir B Bajic Martin S Taylor Vsevolod J Makeev Albin Sandelin David A Hume Piero Carninci Yoshihide Hayashizaki

Nature 2014 Mar;507(7493):462-70

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http://dx.doi.org/10.1038/nature13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529748PMC
March 2014

Postgraduate education in internal medicine in Europe.

Eur J Intern Med 2013 Oct 10;24(7):633-8. Epub 2013 Sep 10.

West Suffolk Hospital, Bury St Edmunds, United Kingdom.

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http://dx.doi.org/10.1016/j.ejim.2013.08.006DOI Listing
October 2013

The practice of internal medicine in Europe: organisation, clinical conditions and procedures.

Eur J Intern Med 2013 Oct 10;24(7):627-32. Epub 2013 Sep 10.

West Suffolk Hospital, Bury St Edmunds, United Kingdom.

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http://dx.doi.org/10.1016/j.ejim.2013.08.005DOI Listing
October 2013

Side effects: substantial non-neutral evolution flanking regulatory sites.

PLoS Genet 2013 May 30;9(5):e1003528. Epub 2013 May 30.

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1003528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667769PMC
May 2013

Divergence of mammalian higher order chromatin structure is associated with developmental loci.

PLoS Comput Biol 2013 Apr 4;9(4):e1003017. Epub 2013 Apr 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1003017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617018PMC
April 2013

The genomic signature of trait-associated variants.

BMC Genomics 2013 Feb 18;14:108. Epub 2013 Feb 18.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK.

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http://dx.doi.org/10.1186/1471-2164-14-108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600003PMC
February 2013

High-throughput analysis of epistasis in genome-wide association studies with BiForce.

Bioinformatics 2012 Aug 21;28(15):1957-64. Epub 2012 May 21.

Finnish Microarray and Sequencing Centre, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20520, Turku, Finland.

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http://dx.doi.org/10.1093/bioinformatics/bts304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400955PMC
August 2012

BiForce Toolbox: powerful high-throughput computational analysis of gene-gene interactions in genome-wide association studies.

Nucleic Acids Res 2012 Jul 11;40(Web Server issue):W628-32. Epub 2012 Jun 11.

Finnish Microarray and Sequencing Centre, Turku Centre for Biotechnology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1093/nar/gks550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394281PMC
July 2012

Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway.

Inflamm Bowel Dis 2012 May 21;18(5):889-99. Epub 2011 Oct 21.

Gastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1002/ibd.21912DOI Listing
May 2012

A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci.

Epigenetics Chromatin 2012 May 19;5(1). Epub 2012 May 19.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, , Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/1756-8935-5-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438052PMC
May 2012

Opening sequence: computational genomics in the era of high-throughput sequencing.

Genome Biol 2011 Dec 28;12(12):310. Epub 2011 Dec 28.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2011-12-12-310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334611PMC
December 2011

Widespread signatures of recent selection linked to nucleosome positioning in the human lineage.

Genome Res 2011 Nov 8;21(11):1777-87. Epub 2011 Sep 8.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

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http://dx.doi.org/10.1101/gr.122275.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205563PMC
November 2011

The retroviral proteinase active site and the N-terminus of Ddi1 are required for repression of protein secretion.

FEBS Lett 2011 Jan 19;585(1):139-42. Epub 2010 Nov 19.

Cardiff School of Biosciences, Cardiff University, Park Place, Cardiff, UK.

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http://dx.doi.org/10.1016/j.febslet.2010.11.026DOI Listing
January 2011

A high-resolution anatomical atlas of the transcriptome in the mouse embryo.

PLoS Biol 2011 Jan 18;9(1):e1000582. Epub 2011 Jan 18.

Telethon Institute of Genetics and Medicine, Naples, Italy.

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http://digital.csic.es/bitstream/10261/52826/1/A%20High-Reso
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http://dx.plos.org/10.1371/journal.pbio.1000582
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http://dx.doi.org/10.1371/journal.pbio.1000582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022534PMC
January 2011

European examinations in internal medicine.

Eur J Intern Med 2010 Feb 17;21(1). Epub 2009 Nov 17.

Section of Internal medicine, Southern General Hospital, Glasgow, Scotland, UK.

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http://dx.doi.org/10.1016/j.ejim.2009.10.006DOI Listing
February 2010

New ATPase regulators--p97 goes to the PUB.

Int J Biochem Cell Biol 2009 Dec 2;41(12):2380-8. Epub 2009 Jun 2.

Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1016/j.biocel.2009.05.017DOI Listing
December 2009

Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome.

J Biol Chem 2009 May 6;284(22):15246-54. Epub 2009 Apr 6.

Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685705PMC
http://dx.doi.org/10.1074/jbc.M900016200DOI Listing
May 2009

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

Authors:
Harukazu Suzuki Alistair R R Forrest Erik van Nimwegen Carsten O Daub Piotr J Balwierz Katharine M Irvine Timo Lassmann Timothy Ravasi Yuki Hasegawa Michiel J L de Hoon Shintaro Katayama Kate Schroder Piero Carninci Yasuhiro Tomaru Mutsumi Kanamori-Katayama Atsutaka Kubosaki Altuna Akalin Yoshinari Ando Erik Arner Maki Asada Hiroshi Asahara Timothy Bailey Vladimir B Bajic Denis Bauer Anthony G Beckhouse Nicolas Bertin Johan Björkegren Frank Brombacher Erika Bulger Alistair M Chalk Joe Chiba Nicole Cloonan Adam Dawe Josee Dostie Pär G Engström Magbubah Essack Geoffrey J Faulkner J Lynn Fink David Fredman Ko Fujimori Masaaki Furuno Takashi Gojobori Julian Gough Sean M Grimmond Mika Gustafsson Megumi Hashimoto Takehiro Hashimoto Mariko Hatakeyama Susanne Heinzel Winston Hide Oliver Hofmann Michael Hörnquist Lukasz Huminiecki Kazuho Ikeo Naoko Imamoto Satoshi Inoue Yusuke Inoue Ryoko Ishihara Takao Iwayanagi Anders Jacobsen Mandeep Kaur Hideya Kawaji Markus C Kerr Ryuichiro Kimura Syuhei Kimura Yasumasa Kimura Hiroaki Kitano Hisashi Koga Toshio Kojima Shinji Kondo Takeshi Konno Anders Krogh Adele Kruger Ajit Kumar Boris Lenhard Andreas Lennartsson Morten Lindow Marina Lizio Cameron Macpherson Norihiro Maeda Christopher A Maher Monique Maqungo Jessica Mar Nicholas A Matigian Hideo Matsuda John S Mattick Stuart Meier Sei Miyamoto Etsuko Miyamoto-Sato Kazuhiko Nakabayashi Yutaka Nakachi Mika Nakano Sanne Nygaard Toshitsugu Okayama Yasushi Okazaki Haruka Okuda-Yabukami Valerio Orlando Jun Otomo Mikhail Pachkov Nikolai Petrovsky Charles Plessy John Quackenbush Aleksandar Radovanovic Michael Rehli Rintaro Saito Albin Sandelin Sebastian Schmeier Christian Schönbach Ariel S Schwartz Colin A Semple Miho Sera Jessica Severin Katsuhiko Shirahige Cas Simons George St Laurent Masanori Suzuki Takahiro Suzuki Matthew J Sweet Ryan J Taft Shizu Takeda Yoichi Takenaka Kai Tan Martin S Taylor Rohan D Teasdale Jesper Tegnér Sarah Teichmann Eivind Valen Claes Wahlestedt Kazunori Waki Andrew Waterhouse Christine A Wells Ole Winther Linda Wu Kazumi Yamaguchi Hiroshi Yanagawa Jun Yasuda Mihaela Zavolan David A Hume Takahiro Arakawa Shiro Fukuda Kengo Imamura Chikatoshi Kai Ai Kaiho Tsugumi Kawashima Chika Kawazu Yayoi Kitazume Miki Kojima Hisashi Miura Kayoko Murakami Mitsuyoshi Murata Noriko Ninomiya Hiromi Nishiyori Shohei Noma Chihiro Ogawa Takuma Sano Christophe Simon Michihira Tagami Yukari Takahashi Jun Kawai Yoshihide Hayashizaki

Nat Genet 2009 May 19;41(5):553-62. Epub 2009 Apr 19.

RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa, Japan.

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http://dx.doi.org/10.1038/ng.375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711855PMC
May 2009

Molecular biology. The structure of change.

Science 2009 Jan;323(5912):347-8

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1169408
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http://dx.doi.org/10.1126/science.1169408DOI Listing
January 2009

Ubxd1 is a novel co-factor of the human p97 ATPase.

Int J Biochem Cell Biol 2008 5;40(12):2927-42. Epub 2008 Jul 5.

Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1016/j.biocel.2008.06.008DOI Listing
December 2008

Rapidly evolving human promoter regions.

Nat Genet 2008 Nov;40(11):1262-3; author reply 1263-4

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http://dx.doi.org/10.1038/ng1108-1262DOI Listing
November 2008

Posttranscriptional regulation of miRNAs harboring conserved terminal loops.

Mol Cell 2008 Nov;32(3):383-93

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1016/j.molcel.2008.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631628PMC
November 2008

Characterisation of the nascent polypeptide-associated complex in fission yeast.

Mol Biol Rep 2007 Dec 9;34(4):275-81. Epub 2007 Jan 9.

Institute for Molecular Biology and Physiology, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark.

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http://dx.doi.org/10.1007/s11033-006-9043-5DOI Listing
December 2007

Chromatin structure and evolution in the human genome.

BMC Evol Biol 2007 May 9;7:72. Epub 2007 May 9.

Colon Cancer Genetics Group, Division of Oncology, University of Edinburgh, Western General Hospital, Edinburgh, UK.

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http://link.springer.com/content/pdf/10.1186/1471-2148-7-72.
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http://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2
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http://dx.doi.org/10.1186/1471-2148-7-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876461PMC
May 2007

Core competencies of the European internist: A discussion paper.

Eur J Intern Med 2007 Mar;18(2):104-8

Division of Nephrology, Department of Medicine, Landspitali University Hospital, Hringbraut, 101 Reykjavik, Iceland.

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http://linkinghub.elsevier.com/retrieve/pii/S095362050600301
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http://dx.doi.org/10.1016/j.ejim.2006.10.002DOI Listing
March 2007

The changing of the guard: Molecular diversity and rapid evolution of beta-defensins.

Mol Divers 2006 Nov;10(4):575-84

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK.

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http://dx.doi.org/10.1007/s11030-006-9031-7DOI Listing
November 2006

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

Hum Mol Genet 2006 Aug 20;15(15):2324-34. Epub 2006 Jun 20.

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/hmg/ddl158DOI Listing
August 2006

Heterotachy in mammalian promoter evolution.

PLoS Genet 2006 Apr 28;2(4):e30. Epub 2006 Apr 28.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.0020030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1449885PMC
April 2006

Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.

Hum Mol Genet 2005 Dec 8;14(24):3899-909. Epub 2005 Nov 8.

MRC Human Genetics Unit, Western General Hospital, University of Edinburgh, UK.

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http://academic.oup.com/hmg/article/14/24/3899/2355858/Dazl-
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http://dx.doi.org/10.1093/hmg/ddi414DOI Listing
December 2005

The complexity of selection at the major primate beta-defensin locus.

BMC Evol Biol 2005 May 18;5:32. Epub 2005 May 18.

MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1186/1471-2148-5-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1156880PMC
May 2005

Deep genomics in shallow times: the finished sequence of human chromosomes 13 and 19.

Authors:
Colin A M Semple

Eur J Hum Genet 2004 Nov;12(11):875-6

MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU.

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http://dx.doi.org/10.1038/sj.ejhg.5201254DOI Listing
November 2004

POCUS: mining genomic sequence annotation to predict disease genes.

Genome Biol 2003 10;4(11):R75. Epub 2003 Oct 10.

MRC Human Genetics Unit, Crewe Road, Western General Hospital, Edinburgh EH4 2XU, UK.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2003-4-11-r75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC329128PMC
March 2004

Duplication and selection in the evolution of primate beta-defensin genes.

Genome Biol 2003 17;4(5):R31. Epub 2003 Apr 17.

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156587PMC
http://dx.doi.org/10.1186/gb-2003-4-5-r31DOI Listing
July 2003

The comparative proteomics of ubiquitination in mouse.

Genome Res 2003 Jun;13(6B):1389-94

MRC Human Genetics Unit, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1101/gr.980303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC403670PMC
June 2003

UBA domain containing proteins in fission yeast.

Int J Biochem Cell Biol 2003 May;35(5):629-36

August Krogh Institute, University of Copenhagen, Universitetsparken 13, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/s1357-2725(02)00393-xDOI Listing
May 2003

Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family.

Mol Biol Evol 2003 Mar;20(3):460-70

MRC Human Genetics Unit, Western General Hospital, Edinburgh, Scotland.

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http://dx.doi.org/10.1093/molbev/msg060DOI Listing
March 2003

Sushi gets serious: the draft genome sequence of the pufferfish Fugu rubripes.

Genome Biol 2002 Aug 28;3(9):reviews1025. Epub 2002 Aug 28.

MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139409PMC
http://dx.doi.org/10.1186/gb-2002-3-9-reviews1025DOI Listing
August 2002

Computational comparison of human genomic sequence assemblies for a region of chromosome 4.

Genome Res 2002 Mar;12(3):424-9

Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom.

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http://dx.doi.org/10.1101/gr.207902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155292PMC
March 2002