Colin J Ross

Colin J Ross

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Colin J Ross

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Vincristine-induced peripheral neurotoxicity: A prospective cohort.

Pediatr Hematol Oncol 2019 Nov 4:1-14. Epub 2019 Nov 4.

Department of Pediatrics, BC Children's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1080/08880018.2019.1677832DOI Listing
November 2019

Genome-Wide Association Studies of Drug-Induced Liver Injury Make Progress Beyond the HLA Region.

Gastroenterology 2019 10 23;157(4):1167-1168. Epub 2019 Jul 23.

Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1053/j.gastro.2019.03.076DOI Listing
October 2019

Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings, and Future Avenues of Research.

Clin Pharmacol Ther 2019 Aug 12;106(2):350-359. Epub 2019 Jun 12.

BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/cpt.1483DOI Listing
August 2019

Deficiency of perforin and hCNT1, a novel inborn error of pyrimidine metabolism, associated with a rapidly developing lethal phenotype due to multi-organ failure.

Biochim Biophys Acta Mol Basis Dis 2019 Jun 15;1865(6):1182-1191. Epub 2019 Jan 15.

Departments of Clinical Chemistry, Pediatrics and Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology & Metabolism, 1105 AZ Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.01.013DOI Listing
June 2019

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in .

N Engl J Med 2019 04;380(15):1433-1441

From Amsterdam University Medical Centers, University of Amsterdam, Departments of Clinical Chemistry, Pediatrics, and Clinical Genetics, Emma Children's Hospital, Amsterdam Gastroenterology and Metabolism (A.B.P.K., R.L., J.K., J. Meijer, L.A.T., M.T., M.W., R.J.A.W., H.R.W., C.D.M.K.), and United for Metabolic Diseases (A.B.P.K., R.J.A.W., H.R.W., C.D.M.K.), Amsterdam, and the Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht (J.J.F.A.V., J.H.V.), and the Project MinE ALS Sequencing Consortium (J.J.F.A.V., J.H.V.), Utrecht - all in the Netherlands; the Departments of Biochemistry and Molecular Biology and Medical Genetics, Cumming School of Medicine, and Alberta Children's Hospital Research Institute, University of Calgary, Calgary (M.T.-G.), Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute (P.A.R., M.J.J., M.S.K., J. MacIsaac, W.W.W., C.D.M.K.), the Faculty of Pharmaceutical Sciences (B.I.D., G.E.B.W., C.J.R.), and the Departments of Medical Genetics (C.M., I.-S.R.-B., W.W.W.) and Pediatrics (C.D.M.K.), University of British Columbia, Vancouver, the Zebrafish Centre for Advanced Drug Discovery, St. Michael's Hospital and University of Toronto (K.B.-A., F.K., M.L., Y.W., X.-Y.W.), the Centre for Applied Genomics, Genetics and Genome Biology, the Hospital for Sick Children (C.N., S.W.S., B.T., R.K.C.Y.), and the Department of Molecular Genetics (C.N., S.W.S., R.K.C.Y.), the McLaughlin Centre (S.W.S.), and the Departments of Medicine, Physiology, and Laboratory Medicine and Pathobiology, Institute of Medical Science (X.-Y.W.), University of Toronto, Toronto, and the Division of Medical Genetics, Department of Pediatrics, Children's Hospital Eastern Ontario, University of Ottawa, Ottawa (J.S.W., M.T.G.) - all in Canada; the Departments of Medicine and Physiology, National University of Singapore (M.A.P.), and the Translational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research (M.A.P., B.S., X.X., J.Z.) - both in Singapore; Uppsala University, Department of Chemistry-Biomedical Center, Uppsala, Sweden (D.D.); Illumina, San Diego, CA (E.D., M.A.E.); Gene Structure and Disease Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (B.H., D.K., K.U.); and the Department of Clinical Inherited Metabolic Disorders, Birmingham Children's Hospital, Birmingham, United Kingdom (S.S.).

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http://dx.doi.org/10.1056/NEJMoa1806627DOI Listing
April 2019

Analyses of Adverse Drug Reactions-Nationwide Active Surveillance Network: Canadian Pharmacogenomics Network for Drug Safety Database.

J Clin Pharmacol 2019 Mar 19;59(3):356-363. Epub 2018 Nov 19.

Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://doi.wiley.com/10.1002/jcph.1336
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http://dx.doi.org/10.1002/jcph.1336DOI Listing
March 2019

Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18 months.

EBioMedicine 2019 Feb 30;40:655-662. Epub 2019 Jan 30.

BC Children's Hospital Research Institute, Vancouver, Canada; Pediatrics, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.01.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413679PMC
February 2019

HUME: large-scale detection of causal genetic factors of adverse drug reactions.

Bioinformatics 2018 12;34(24):4274-4283

Department of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada.

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http://dx.doi.org/10.1093/bioinformatics/bty475DOI Listing
December 2018

Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype.

Neuroscience 2018 08 29;384:152-164. Epub 2018 May 29.

Division of Biochemical Diseases, Department of Pediatrics, B.C. Children's Hospital, University of British Columbia, Vancouver, Canada; BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada; Department of Pediatrics and Clinical Genetics, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S03064522183038
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http://dx.doi.org/10.1016/j.neuroscience.2018.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679957PMC
August 2018

Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G>A and a large intragenic inversion in DPYD spanning intron 8 to intron 12.

Hum Mutat 2018 07 10;39(7):947-953. Epub 2018 May 10.

Departments of Clinical Chemistry, Laboratory Genetic Metabolic Diseases, Pediatrics and Clinical Genetics, Academic Medical Center, University of Amsterdam, Emma Children's Hospital, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/humu.23538DOI Listing
July 2018

A systematic review of the effects of CYP2D6 phenotypes on risperidone treatment in children and adolescents.

Child Adolesc Psychiatry Ment Health 2018 16;12:37. Epub 2018 Jul 16.

1Department of Pharmacology, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC V6T 1Z3 Canada.

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http://dx.doi.org/10.1186/s13034-018-0243-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048722PMC
July 2018

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

PM R 2018 03 1;10(3):235-243. Epub 2017 Sep 1.

Division of Rehabilitation Medicine, Children's Mercy-Kansas City, 2401 Gillham Road, Kansas City, MO 64108; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

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http://dx.doi.org/10.1016/j.pmrj.2017.08.441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880219PMC
March 2018

The genotypic and phenotypic spectrum of MTO1 deficiency.

Mol Genet Metab 2018 01 15;123(1):28-42. Epub 2017 Nov 15.

Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada; Centre for Molecular Medicine and Therapeutics, Vancouver, BC, Canada; BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada; Departments of Pediatrics and Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780301PMC
January 2018

Exploring genetic influences underlying acute aerobic exercise effects on motor learning.

Sci Rep 2017 09 21;7(1):12123. Epub 2017 Sep 21.

Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1038/s41598-017-12422-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608967PMC
September 2017

A case of splenomegaly in CBL syndrome.

Eur J Med Genet 2017 Jul 13;60(7):374-379. Epub 2017 Apr 13.

British Columbia Children's Hospital Research Institute, Vancouver, Canada; Centre for Molecular Medicine & Therapeutics, University of British Columbia, Vancouver, Canada; Treatable Intellectual Disability Endeavour in British Columbia (TIDE-BC), Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada; Department of Pediatrics, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2017.04.009DOI Listing
July 2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer.

Br J Clin Pharmacol 2017 05 19;83(5):1143-1145. Epub 2017 Mar 19.

BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/bcp.13218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401971PMC
May 2017

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.

PLoS One 2017 13;12(4):e0175711. Epub 2017 Apr 13.

Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175711PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391095PMC
April 2017

A girl with developmental delay, ataxia, cranial nerve palsies, severe respiratory problems in infancy-Expanding NDST1 syndrome.

Am J Med Genet A 2017 Mar;173(3):712-715

BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1002/ajmg.a.37621DOI Listing
March 2017

The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America.

Eur J Hum Genet 2017 02 21;25(3):332-340. Epub 2016 Dec 21.

Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, V5Z 4H4 Canada.

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http://dx.doi.org/10.1038/ejhg.2016.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315506PMC
February 2017

Identification of a large intronic transposal insertion in SLC17A5 causing sialic acid storage disease.

Orphanet J Rare Dis 2017 02 10;12(1):28. Epub 2017 Feb 10.

Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s13023-017-0584-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303239PMC
February 2017

Case-Control Studies Are Not Familial Studies.

Neuron 2016 Oct;92(2):339-341

Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.09.053DOI Listing
October 2016

Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.

Ther Drug Monit 2016 08;38(4):423-31

*Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada; †Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; ‡Child and Family Research Institute, Vancouver, British Columbia, Canada; §Department of Pediatrics, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; ¶Department of Medical Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, Alberta, Canada; ‖Department of Medical Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada; **Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada; ††Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; and ‡‡Institute of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1097/FTD.0000000000000298DOI Listing
August 2016

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.

Pharmacogenomics 2015 31;16(10):1065-76. Epub 2015 Jul 31.

Centre for Molecular Medicine & Therapeutics, Child & Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.2217/pgs.15.61DOI Listing
June 2016

Exome Sequencing and the Management of Neurometabolic Disorders.

N Engl J Med 2016 Jun 25;374(23):2246-55. Epub 2016 May 25.

From the Centre for Molecular Medicine and Therapeutics (M.T.-G., C. Shyr, X.C.Y., L.-H.Z., J.J.Y.L., B.I.D., I.G., W.W.W., C.D.K.), the Departments of Medical Genetics (M.T.-G., C. Shyr, C.J.R., X.C.Y., J.J.Y.L., L.A., J.M.F., S.L., M.M., M.I.V.A., A.M.L., W.W.W.), Pediatrics (C.J.R., G.A.H., R.S., L.-H.Z., A.P.B., B.I.D., M.B.C., M.D., T.D., J.D., A. Michoulas, D.M., J.R., K.R.S., K.S., S.E.T., John Wu, S.S.-I., C.D.K.), and Pathology and Laboratory Medicine (B.R., P.E., H.V., G.S.), the Child and Family Research Institute (M.T.-G., C. Shyr, C.J.R., G.A.H., X.C.Y., A.P.B., J.J.Y.L., B.I.D., L.A., M.B.C., M.D., J.D., J.M.F., I.G., S.L., M.M., D.M., J.R., K.R.S., K.S., S.E.T., M.I.V.A., John Wu, P.E., A.M.L., H.V., S.S.-I., G.S., W.W.W., C.D.K.), and the Division of Endocrinology, Adult Metabolic Diseases Clinic (A. Mattman, S. Sirrs), University of British Columbia, and the Divisions of Biochemical Diseases (G.A.H., R.S., B.S., S.S.-I., C.D.K.), Pediatric Neurology (M.B.C., M.D., A. Michoulas, K.S.), Pediatric Nephrology (J.D.), Pediatric Endocrinology (D.M.), and Immunology (S.E.T.) and the Division of Hematology, Oncology and Transplantation, Michael Cuccione Childhood Cancer Research Program (J.R., K.R.S., John Wu), BC Children's Hospital, Vancouver, the Department of Pathology and Laboratory Medicine, Hospital for Sick Children, University of Toronto, Toronto (J.C.), the Department of Biological and Computing Sciences, University of Alberta (R.M., D.W.), and the National Institute for Nanotechnology (D.W.), Edmonton, AB, and the Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC (M. Abdelsayed, P.R.) - all in Canada; the Division of Genetics, Department of Pediatrics, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia (M. Alfadhel); the Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich (M.R.B., P.B.), and the Departmen

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http://dx.doi.org/10.1056/NEJMoa1515792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983272PMC
June 2016

Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.

Mol Genet Metab 2016 May 4;118(1):21-7. Epub 2016 Mar 4.

Centre for Molecular Medicine, Child & Family Research Institute, Vancouver, Canada; Department of Pediatrics, University of British Columbia, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192163002
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http://dx.doi.org/10.1016/j.ymgme.2016.03.001DOI Listing
May 2016

Forensic Investigation of Methadone Concentrations in Deceased Breastfed Infants.

J Forensic Sci 2016 Mar 29;61(2):576-580. Epub 2015 Oct 29.

Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, and Ivey Chair in Molecular Toxicology, Western University, London, ON, Canada.

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http://dx.doi.org/10.1111/1556-4029.12972DOI Listing
March 2016

Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics.

Pharmacogenet Genomics 2016 Jan;26(1):28-39

aTranslational Laboratory in Genetic Medicine, Agency for Science, Technology, and Research bSaw Swee Hock School of Public Health cNUS Graduate School for Integrative Sciences and Engineering dLife Sciences Institute Departments of eStatistics and Applied Probability fMedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Departments of gParasitology hAnatomy, University of Colombo, Colombo, Sri Lanka iDepartment of Pediatrics, Division of Translational Therapeutics jCentre for Molecular Medicine and Therapeutics, Child and Family Research Institute kDepartment of Medicine, Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/FPC.0000000000000182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890825PMC
January 2016

Secondary neurotransmitter deficiencies in epilepsy caused by voltage-gated sodium channelopathies: A potential treatment target?

Mol Genet Metab 2016 Jan 17;117(1):42-8. Epub 2015 Nov 17.

Division of Biochemical Diseases, Dept of Pediatrics, B.C. Children's Hospital, University of British Columbia, Vancouver, Canada; Center for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2015.11.008DOI Listing
January 2016

Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry.

Mol Ther 2015 Nov 23;23(11):1759-1771. Epub 2015 Jul 23.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817952PMC
November 2015

Expansion of the QARS deficiency phenotype with report of a family with isolated supratentorial brain abnormalities.

Neurogenetics 2015 Apr 30;16(2):145-9. Epub 2014 Nov 30.

Division of Biochemical Diseases, Rm K3-201, Department of Pediatrics, B.C. Children's & Women's Hospital, 4480 Oak Street, Vancouver, BC, V6H 3 V4, Canada.

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http://link.springer.com/content/pdf/10.1007/s10048-014-0432
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http://link.springer.com/10.1007/s10048-014-0432-y
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http://dx.doi.org/10.1007/s10048-014-0432-yDOI Listing
April 2015

Use of pharmacogenomics in pediatric renal transplant recipients.

Front Genet 2015 18;6:41. Epub 2015 Feb 18.

Pharmaceutical Outcomes Programme, Pediatrics, BC Children's Hospital, University of British Columbia Vancouver, BC, Canada ; Division of Translational Therapeutics, Department of Paediatrics, Faculty of Medicine, University of British Columbia Vancouver, BC, Canada ; Child and Family Research Institute, University of British Columbia Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fgene.2015.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332348PMC
March 2015

A single bout of high-intensity aerobic exercise facilitates response to paired associative stimulation and promotes sequence-specific implicit motor learning.

J Appl Physiol (1985) 2014 Dec 25;117(11):1325-36. Epub 2014 Sep 25.

Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Graduate Program in Neuroscience, Faculty of Medicine, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1152/japplphysiol.00498.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254838PMC
December 2014

VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.

Pediatr Blood Cancer 2014 Jun 29;61(6):1055-62. Epub 2014 Jan 29.

Department of Pediatrics, Faculty of Medicine, University of British Columbia (UBC), Vancouver, BC, Canada; Pharmaceutical Outcomes Programme, B.C. Children's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/pbc.24932DOI Listing
June 2014

Codeine-related deaths: The role of pharmacogenetics and drug interactions.

Forensic Sci Int 2014 Jun 26;239:50-6. Epub 2014 Mar 26.

Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada; Toxicology Section, Centre of Forensic Sciences, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.forsciint.2014.03.018DOI Listing
June 2014

Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood.

Am J Hum Genet 2014 Mar 13;94(3):453-61. Epub 2014 Feb 13.

Division of Biochemical Diseases, BC Children's Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Treatable Intellectual Disability Endeavour in British Columbia, BC Children's Hospital, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1016/j.ajhg.2014.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951944PMC
March 2014

Pharmacogenomic investigation of adverse drug reactions(ADRs): the ADR prioritization tool, APT.

J Popul Ther Clin Pharmacol 2013 3;20(2):e110-27. Epub 2013 May 3.

Faculty of Medicine, University of British Columbia, Canada.

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December 2013

Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor.

Phys Ther 2013 Dec 1;93(12):1707-16. Epub 2013 Aug 1.

C.S. Mang, BPE, MSc, Department of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2522/ptj.20130053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870490PMC
December 2013

Putative association of ABCB1 2677G>T/A with oxycodone-induced central nervous system depression in breastfeeding mothers.

Ther Drug Monit 2013 Aug;35(4):466-72

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1097/FTD.0b013e318288f158DOI Listing
August 2013

From mutation identification to therapy: discovery and origins of the first approved gene therapy in the Western world.

Hum Gene Ther 2013 May;24(5):472-8

Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1089/hum.2013.063DOI Listing
May 2013

Cancer pharmacogenomics in children: research initiatives and progress to date.

Paediatr Drugs 2013 Apr;15(2):71-81

Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s40272-013-0021-9DOI Listing
April 2013

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: the devil is in the details.

Ther Drug Monit 2012 Aug;34(4):378-80

Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/FTD.0b013e31825da19fDOI Listing
August 2012

Suspected opioid overdose case resolved by CYP2D6 genotyping.

Ther Drug Monit 2012 Apr;34(2):121-3

Division of Translational Therapeutics, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Canada.

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http://www.thblack.com/links/RSD/TherDrugMonit2012_34_121.pd
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/FTD.0b013e31824a1e21DOI Listing
April 2012

Amelioration of hypertriglyceridemia with hypo-alpha-cholesterolemia in LPL deficient mice by hematopoietic cell-derived LPL.

PLoS One 2011 29;6(9):e25620. Epub 2011 Sep 29.

Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025620PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183060PMC
January 2012

Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics.

J Cardiovasc Pharmacol 2011 Sep;58(3):228-39

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/FJC.0b013e3182163b82DOI Listing
September 2011

Pharmacogenomics of serious adverse drug reactions in pediatric oncology.

J Popul Ther Clin Pharmacol 2011 21;18:e134-51. Epub 2011 Mar 21.

Department of Medical Genetics, University of British Columbia (UBC), Centre for Molecular Medicine and Therapeutics,

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August 2011

HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia.

Eur J Hum Genet 2011 May 19;19(5):561-6. Epub 2011 Jan 19.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/ejhg.2010.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083615PMC
May 2011

Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.

Pediatrics 2010 Oct 13;126(4):e986-9. Epub 2010 Sep 13.

Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8.

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http://dx.doi.org/10.1542/peds.2009-1907DOI Listing
October 2010

Pharmacogenomics and active surveillance for serious adverse drug reactions in children.

Pharmacogenomics 2010 Sep;11(9):1269-85

Faculty of Medicine, Department of Paediatrics, UBC, Vancouver, Canada.

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http://dx.doi.org/10.2217/pgs.10.111DOI Listing
September 2010

The Canadian Pharmacogenomics Network for Drug Safety: a model for safety pharmacology.

Thyroid 2010 Jul;20(7):681-7

Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1089/thy.2010.1642DOI Listing
July 2010

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

Nat Genet 2009 Dec 8;41(12):1345-9. Epub 2009 Nov 8.

Department of Medical Genetics, University of British Columbia, Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/ng.478DOI Listing
December 2009

Genotypic approaches to therapy in children: a national active surveillance network (GATC) to study the pharmacogenomics of severe adverse drug reactions in children.

Ann N Y Acad Sci 2007 Sep;1110:177-92

Department of Medical Genetics, University of British Columbia, Centre for Molecular Medicine and Therapeutics, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1196/annals.1423.020DOI Listing
September 2007

Pharmacogenomics and its implications for autoimmune disease.

J Autoimmun 2007 Mar-May;28(2-3):122-8. Epub 2007 Apr 5.

Department of Medical Genetics, University of British Columbia (UBC), Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1016/j.jaut.2007.02.008DOI Listing
July 2007

Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma.

Neurobiol Dis 2006 Oct 8;24(1):114-27. Epub 2006 Aug 8.

Department of Pathology and Laboratory Medicine, University of British Columbia, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.nbd.2006.06.007DOI Listing
October 2006

Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation.

Arterioscler Thromb Vasc Biol 2006 Jun 30;26(6):1236-45. Epub 2006 Mar 30.

Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.1161/01.ATV.0000219283.10832.43DOI Listing
June 2006

Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia.

Biochem Biophys Res Commun 2006 Mar 25;341(4):1066-71. Epub 2006 Jan 25.

Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing 100083, China.

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http://dx.doi.org/10.1016/j.bbrc.2006.01.067DOI Listing
March 2006