Colin C Pritchard

Colin C Pritchard

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Colin C Pritchard

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Lynch Syndrome: From Screening to Diagnosis to Treatment in the Era of Modern Molecular Oncology.

Annu Rev Genomics Hum Genet 2019 Aug 8;20:293-307. Epub 2019 Mar 8.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195, USA.

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https://www.annualreviews.org/doi/10.1146/annurev-genom-0831
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http://dx.doi.org/10.1146/annurev-genom-083118-015406DOI Listing
August 2019

New name for breast-cancer syndrome could help to save lives.

Nature 2019 07;571(7763):27-29

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http://dx.doi.org/10.1038/d41586-019-02015-7DOI Listing
July 2019

Targeted Sequencing of Malignant Supratentorial Pediatric Brain Tumors Demonstrates a High Frequency of Clinically Relevant Mutations.

Pediatr Dev Pathol 2018 Jul-Aug;21(4):380-388. Epub 2017 Nov 27.

4 Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington.

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http://dx.doi.org/10.1177/1093526617743905DOI Listing
May 2019

DNA damage repair alterations are frequent in prostatic adenocarcinomas with focal pleomorphic giant-cell features.

Histopathology 2019 May 1;74(6):836-843. Epub 2019 Apr 1.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://doi.wiley.com/10.1111/his.13806
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http://dx.doi.org/10.1111/his.13806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476659PMC
May 2019

The effects of genomic germline variant reclassification on clinical cancer care.

Oncotarget 2019 Jan 11;10(4):417-423. Epub 2019 Jan 11.

Department of Medical Oncology and Therapeutics Research, Division of Clinical Cancer Genomics, City of Hope, Duarte, CA, USA.

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http://www.oncotarget.com/fulltext/26501
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http://dx.doi.org/10.18632/oncotarget.26501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355179PMC
January 2019

Two-stain immunohistochemical screening for Lynch syndrome in colorectal cancer may fail to detect mismatch repair deficiency.

Mod Pathol 2018 12 2;31(12):1891-1900. Epub 2018 Jul 2.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.1038/s41379-018-0058-yDOI Listing
December 2018

Efficient Detection of Copy Number Mutations in PMS2 Exons with a Close Homolog.

J Mol Diagn 2018 07 22;20(4):512-521. Epub 2018 May 22.

Department of Laboratory Medicine, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1016/j.jmoldx.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119818PMC
July 2018

BRCA2-Associated Prostate Cancer in a Patient With Spinal and Bulbar Muscular Atrophy.

JCO Precis Oncol 2018 29;2. Epub 2018 Jun 29.

Weill Cornell Medicine; Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY.

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http://dx.doi.org/10.1200/PO.18.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317373PMC
June 2018

Significance and implications of FDA approval of pembrolizumab for biomarker-defined disease.

J Immunother Cancer 2018 05 14;6(1):35. Epub 2018 May 14.

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/s40425-018-0342-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950135PMC
May 2018

DNA Repair Pathway Alterations in Metastatic Castration-resistant Prostate Cancer Responders to Radium-223.

Clin Genitourin Cancer 2018 04 6;16(2):106-110. Epub 2017 Dec 6.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, Division of Oncology, University of Washington, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.11.009DOI Listing
April 2018

Personalizing Therapy for Metastatic Prostate Cancer: The Role of Solid and Liquid Tumor Biopsies.

Am Soc Clin Oncol Educ Book 2017 ;37:358-369

From the Division of Hematology and Medical Oncology, University of California, San Francisco, San Francisco, CA; Department of Laboratory Medicine, University of Washington, Seattle, WA; Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/EDBK_175510DOI Listing
December 2017

Prostate Cancer Screening in a New Era of Genetics.

Clin Genitourin Cancer 2017 12 31;15(6):625-628. Epub 2017 May 31.

Department of Medicine, University of Washington, Seattle, WA; Fred Hutchinson Cancer Research Center, Seattle, WA.

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http://dx.doi.org/10.1016/j.clgc.2017.05.024DOI Listing
December 2017

DNA Repair in Prostate Cancer: Biology and Clinical Implications.

Eur Urol 2017 03 31;71(3):417-425. Epub 2016 Aug 31.

Division of Cancer Therapeutics and Division of Clinical Studies, The Institute of Cancer Research, London, UK; Drug Development Unit, The Royal Marsden NHS Foundation Trust, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.08.037DOI Listing
March 2017

Family-Specific Variants and the Limits of Human Genetics.

Trends Mol Med 2016 Nov 11;22(11):925-934. Epub 2016 Oct 11.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.molmed.2016.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197474PMC
November 2016

Classification and characterization of microsatellite instability across 18 cancer types.

Nat Med 2016 11 3;22(11):1342-1350. Epub 2016 Oct 3.

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nm.4191DOI Listing
November 2016

DNA-Repair Gene Mutations in Metastatic Prostate Cancer.

N Engl J Med 2016 11;375(18):1804-5

Fred Hutchinson Cancer Research Center, Seattle, WA

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http://dx.doi.org/10.1056/NEJMc1611137DOI Listing
November 2016

Germline, hematopoietic, mosaic, and somatic variation: interplay between inherited and acquired genetic alterations in disease assessment.

Genome Med 2016 10 5;8(1):100. Epub 2016 Oct 5.

Department of Laboratory Medicine, University of Washington Medical Center, Box 357110, 1959 NE Pacific St, Seattle, WA, 98195-7110, USA.

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http://genomemedicine.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13073-016-0350-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050638PMC
October 2016

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

N Engl J Med 2016 Aug 6;375(5):443-53. Epub 2016 Jul 6.

From the University of Washington (C.C.P., M. Beightol, C.M., B.N., H.H.C., B.M., T.W., S. Casadei, P.S.N.) and Fred Hutchinson Cancer Research Center (N.D.S., R.G., P.S.N.) - both in Seattle; the Institute of Cancer Research and Royal Marsden Hospital, London (J.M., S. Carreira, R.E., J.B.); Memorial Sloan Kettering Cancer Center (M.F.W., W.A., M. Berger, L.Z., A.Z., J. Vijai, H.I.S., C.S., N.S., P.W.K., D.S., M.R., K.O.), Weill Cornell Medical College (H.B., O.E., M.A.R.), and the Prostate Cancer Clinical Trials Consortium (J. Vinson, J.F.) - all in New York; the University of Michigan, Ann Arbor (D.R., R.L., M.H., A.C.); Howard Hughes Medical Institute, Chevy Chase, MD (A.C., C.S.); and Dana-Farber Cancer Institute, Boston (A.G., L.G., M.-E.T., S.A., G.C.H., E.M.V.A.).

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http://dx.doi.org/10.1056/NEJMoa1603144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986616PMC
August 2016

Tissue Is the Issue for Diagnosis of EGFR T790M Mutation.

J Thorac Oncol 2016 07;11(7):e91-2

Department of Medicine, Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington.

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http://dx.doi.org/10.1016/j.jtho.2016.03.017DOI Listing
July 2016

Next Generation Sequencing in the Clinic: a Patterns of Care Study in a Retrospective Cohort of Subjects Referred to a Genetic Medicine Clinic for Suspected Lynch Syndrome.

J Genet Couns 2016 06 5;25(3):515-9. Epub 2015 Dec 5.

Department of Medicine, Division of Medical Genetics, University of Washington, 1705 NE Pacific Street, K228, UW Box 357720, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1007/s10897-015-9902-0DOI Listing
June 2016

Biallelic Inactivation of BRCA2 in Platinum-sensitive Metastatic Castration-resistant Prostate Cancer.

Eur Urol 2016 06 24;69(6):992-5. Epub 2015 Dec 24.

Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2015.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909531PMC
June 2016

Applying Ancestry and Sex Computation as a Quality Control Tool in Targeted Next-Generation Sequencing.

Am J Clin Pathol 2016 Mar 20;145(3):308-15. Epub 2016 Feb 20.

From the Department of Laboratory Medicine, University of Washington, Seattle.

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http://ajcp.oxfordjournals.org/content/ajcpath/145/3/308.ful
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http://dx.doi.org/10.1093/ajcp/aqv098DOI Listing
March 2016

DNA Yield From Tissue Samples in Surgical Pathology and Minimum Tissue Requirements for Molecular Testing.

Arch Pathol Lab Med 2016 Feb 22;140(2):130-3. Epub 2015 Jun 22.

From the Department of Laboratory Medicine, University of Washington Medical Center, Seattle. Dr Austin is now with the Department of Pathology, Walter Reed National Military Medical Center, Bethesda, Maryland.

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http://www.archivesofpathology.org/doi/10.5858/arpa.2015-008
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http://dx.doi.org/10.5858/arpa.2015-0082-OADOI Listing
February 2016

Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study.

J Clin Oncol 2015 Dec 9;33(36):4301-8. Epub 2015 Nov 9.

Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.

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http://dx.doi.org/10.1200/JCO.2015.63.9518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678181PMC
December 2015

MSIplus for Integrated Colorectal Cancer Molecular Testing by Next-Generation Sequencing.

J Mol Diagn 2015 Nov 29;17(6):705-14. Epub 2015 Aug 29.

Department of Laboratory Medicine, University of Washington, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2015.05.008DOI Listing
November 2015

Durable Response to Tyrosine Kinase Inhibitor Therapy in a Lung Cancer Patient Harboring Epidermal Growth Factor Receptor Tandem Kinase Domain Duplication.

J Thorac Oncol 2015 Oct;10(10):e97-9

*Department of Medicine, University of Washington, Seattle, Washington; and †Department of Laboratory Medicine, University of Washington, Seattle.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153352
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http://dx.doi.org/10.1097/JTO.0000000000000586DOI Listing
October 2015

Integrative clinical genomics of advanced prostate cancer.

Cell 2015 May;161(5):1215-1228

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484602PMC
May 2015

Actionable exomic incidental findings in 6503 participants: challenges of variant classification.

Genome Res 2015 Mar 30;25(3):305-15. Epub 2015 Jan 30.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington 98195, USA; Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;

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http://dx.doi.org/10.1101/gr.183483.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352885PMC
March 2015

Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.

Nat Genet 2015 Feb 12;47(2):180-5. Epub 2015 Jan 12.

1] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, Washington, USA. [3] Department of Pediatrics, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/ng.3177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540357PMC
February 2015

Genomic analysis of bone marrow failure and myelodysplastic syndromes reveals phenotypic and diagnostic complexity.

Haematologica 2015 Jan 19;100(1):42-8. Epub 2014 Sep 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA Department of Pediatric Hematology/Oncology, Seattle Children's Hospital, WA Department of Pediatrics, University of Washington, Seattle, WA, USA

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http://dx.doi.org/10.3324/haematol.2014.113456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281311PMC
January 2015

Microsatellite instability detection by next generation sequencing.

Clin Chem 2014 Sep 30;60(9):1192-9. Epub 2014 Jun 30.

Department of Laboratory Medicine, University of Washington, Seattle WA;

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http://dx.doi.org/10.1373/clinchem.2014.223677DOI Listing
September 2014

Molecular profiling of soft tissue sarcomas using next-generation sequencing: a pilot study toward precision therapeutics.

Hum Pathol 2014 Aug 24;45(8):1563-71. Epub 2014 Apr 24.

University of Washington Medical Center, Department of Anatomic Pathology, Seattle, WA, 98195, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00468177140016
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http://dx.doi.org/10.1016/j.humpath.2014.04.012DOI Listing
August 2014

Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.

Clin Cancer Res 2014 Feb 15;20(3):764-75. Epub 2013 Nov 15.

Authors' Affiliations: Division of Gynecologic Oncology; Division of Medical Genetics; Departments of Pathology and Laboratory Medicine, University of Washington Medical Center, Seattle, Washington.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944197PMC
February 2014

Molecular alterations and biomarkers in colorectal cancer.

Toxicol Pathol 2014 Jan 31;42(1):124-39. Epub 2013 Oct 31.

1Clinical Research Division, Fred Hutchison Cancer Research Center, Seattle, Washington, USA.

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http://journals.sagepub.com/doi/10.1177/0192623313505155
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http://dx.doi.org/10.1177/0192623313505155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947043PMC
January 2014

A mosaic PTEN mutation causing Cowden syndrome identified by deep sequencing.

Genet Med 2013 Dec 25;15(12):1004-7. Epub 2013 Apr 25.

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/gim.2013.51DOI Listing
December 2013

Actionable, pathogenic incidental findings in 1,000 participants' exomes.

Am J Hum Genet 2013 Oct 19;93(4):631-40. Epub 2013 Sep 19.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.ajhg.2013.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791261PMC
October 2013

Single molecule molecular inversion probes for targeted, high-accuracy detection of low-frequency variation.

Genome Res 2013 May 4;23(5):843-54. Epub 2013 Feb 4.

Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1101/gr.147686.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638140PMC
May 2013

EGFR mutations in squamous cell lung cancer in never-smokers.

J Thorac Oncol 2013 Jan;8(1):e6-7

Thoracic, Head and Neck Program, Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1097/JTO.0b013e3182762d49DOI Listing
January 2013

MicroRNA profiling: approaches and considerations.

Nat Rev Genet 2012 Apr 18;13(5):358-69. Epub 2012 Apr 18.

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nrg3198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517822PMC
April 2012

Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies.

Cancer Prev Res (Phila) 2012 Mar 12;5(3):492-497. Epub 2011 Dec 12.

Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186243PMC
March 2012

Colorectal cancer molecular biology moves into clinical practice.

Gut 2011 Jan 4;60(1):116-29. Epub 2010 Oct 4.

Department of Laboratory Medicine, University of Washington, Washington, USA.

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http://dx.doi.org/10.1136/gut.2009.206250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006043PMC
January 2011

COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma.

BMC Clin Pathol 2010 Nov 26;10. Epub 2010 Nov 26.

Department of Laboratory Medicine, University of Washington, Seattle, USA.

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http://dx.doi.org/10.1186/1472-6890-10-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001699PMC
November 2010

Gene expression profiling in the developing prostate.

Differentiation 2008 Jul 7;76(6):624-40. Epub 2008 May 7.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

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http://dx.doi.org/10.1111/j.1432-0436.2008.00274.xDOI Listing
July 2008

Bayesian integrated functional analysis of microarray data.

Bioinformatics 2004 Nov 4;20(17):2943-53. Epub 2004 Jun 4.

Rolf Nevanlinna Institute, Department of Mathematics and Statistics, University of Helsinki, P.O. Box 68, FIN 00014, Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/bth338DOI Listing
November 2004