Publications by authors named "Cody J Peer"

97Publications

Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors.

Cancer Chemother Pharmacol 2020 Oct 8;86(4):475-486. Epub 2020 Sep 8.

Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10/Room 5A03, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-020-04134-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515962PMC
October 2020

Slow-, Tight-Binding Inhibition of CYP17A1 by Abiraterone Redefines Its Kinetic Selectivity and Dosing Regimen.

J Pharmacol Exp Ther 2020 Sep 17;374(3):438-451. Epub 2020 Jun 17.

Department of Pharmacy, Faculty of Science (E.J.Y.C., R.W.Y.N., H.T.T., C.L.L.C., E.C.Y.C.) and Department of Biological Sciences (H.F.), National University of Singapore, Singapore, Singapore; Department of Clinical Pharmacology and Flinders Centre for Innovation in Cancer, College of Medicine and Public Health, Flinders University, Adelaide, Australia (P.C.N., J.O.M.); Bioinformatics Institute, Biotransformation Innovation Platform (BioTrans) (F.L.) and Bioinformatics Institute (H.F.), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Surgery, National University Health System, Singapore, Singapore (E.C., K.E.); Department of Urology, National University Hospital, Singapore, Singapore (E.C., K.E.); Centre for Computational Biology, DUKE-NUS Medical School, Singapore, Singapore (H.F.); The University of Chicago, Chicago, Illinois (R.Z.S.); National Cancer Institute, Rockville, Maryland (C.J.P., W.D.F.); and National University Cancer Institute, Singapore (NCIS), NUH Medical Centre (NUHMC), Singapore, Singapore (E.C.Y.C.)

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http://dx.doi.org/10.1124/jpet.120.265868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469252PMC
September 2020

Opportunities for using in silico-based extended dosing regimens for monoclonal antibody immune checkpoint inhibitors.

Br J Clin Pharmacol 2020 May 18. Epub 2020 May 18.

Department of Medicine, Center for Personalized Therapeutics, and Comprehensive Cancer Center, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/bcp.14369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444775PMC
May 2020

Phase 2 Study of Seviteronel (INO-464) in Patients With Metastatic Castration-Resistant Prostate Cancer After Enzalutamide Treatment.

Clin Genitourin Cancer 2020 08 29;18(4):258-267.e1. Epub 2020 Mar 29.

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2019.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415516PMC
August 2020

Plasma and cerebrospinal fluid pharmacokinetics of the DNA methyltransferase inhibitor, 5-azacytidine, alone and with inulin, in nonhuman primate models.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa005. Epub 2020 Jan 1.

Pediatric Neuro-Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/noajnl/vdaa005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146732PMC
January 2020

Cerebrospinal fluid penetration of the colony-stimulating factor-1 receptor (CSF-1R) inhibitor, pexidartinib.

Cancer Chemother Pharmacol 2020 May 18;85(5):1003-1007. Epub 2020 Apr 18.

Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s00280-020-04071-7DOI Listing
May 2020

Selumetinib in Children with Inoperable Plexiform Neurofibromas.

N Engl J Med 2020 04 18;382(15):1430-1442. Epub 2020 Mar 18.

From the Pediatric Oncology Branch (A.M.G., P.L.W., E.D., P.W., S.M., M.C.R., D.C.P., A.C., J.T., O.K., J.G., B.C.W.) and the Clinical Pharmacology Program (C.J.P., W.D.F.), Center for Cancer Research, National Cancer Institute, and the Rehabilitation Medicine Department, Clinical Center (S.M.P), National Institutes of Health, Bethesda, the Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick (A.B., K.H.), the Cancer Therapy Evaluation Program (M.S., L.A.D.) and the Biostatistics and Data Management Section, Center for Cancer Research (S.M.S., D.J.V.), National Cancer Institute, National Institutes of Health, Shady Grove, and Johns Hopkins University School of Medicine, Baltimore (J.O.B.) - all in Maryland; Children's Hospital of Philadelphia, Philadelphia (M.J.F., A.C.S.); Cincinnati Children's Hospital, Cincinnati (B.W.); Children's National Hospital, Washington, DC (A.K., M.B.); and Indiana University School of Medicine, Indianapolis (D.W.C., C.Z.).

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http://dx.doi.org/10.1056/NEJMoa1912735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305659PMC
April 2020

Targeting Pancreatic Cancer Cells and Stellate Cells Using Designer Nanotherapeutics in vitro.

Int J Nanomedicine 2020 13;15:991-1003. Epub 2020 Feb 13.

Department of Pathology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

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http://dx.doi.org/10.2147/IJN.S234112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025663PMC
June 2020

Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma.

J Pharm Biomed Anal 2020 Mar 27;181:113073. Epub 2019 Dec 27.

Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2019.113073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068816PMC
March 2020

Characterizing the pharmacokinetics of panobinostat in a non-human primate model for the treatment of diffuse intrinsic pontine glioma.

Cancer Chemother Pharmacol 2020 Apr 1;85(4):827-830. Epub 2020 Jan 1.

Pediatric Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-019-04021-yDOI Listing
April 2020

Local and Systemic Antitumor Effects of Photo-activatable Paclitaxel Prodrug on Rat Breast Tumor Models.

Photochem Photobiol 2020 05 9;96(3):668-679. Epub 2020 Mar 9.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY.

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http://dx.doi.org/10.1111/php.13202DOI Listing
May 2020

A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer.

Cancer Chemother Pharmacol 2019 10 31;84(4):759-770. Epub 2019 Jul 31.

Clinical Pharmacology Program, CCR, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-019-03908-0DOI Listing
October 2019

PBPK modeling-based optimization of site-specific chemo-photodynamic therapy with far-red light-activatable paclitaxel prodrug.

J Control Release 2019 08 9;308:86-97. Epub 2019 Jul 9.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City 73117, OK, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193039
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http://dx.doi.org/10.1016/j.jconrel.2019.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710169PMC
August 2019

Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters.

Mol Pharmacol 2019 08 7;96(2):158-167. Epub 2019 Jun 7.

Clinical Pharmacology Program (T.M.S., C.J.P., W.D.F.), Molecular Pharmacology Section (P.A.H., R.J.H., E.M.M., R.H.B., J.D.S., A.M.L., W.D.F.), Biostatistics and Data Management Section (M.Z., J.A.H., D.V.), Pediatric Oncology Branch (P.G., J.G., B.C.W.), Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute (D.S.S.), and Translational Hepatology Section (T.H.), Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; and BioIVT, ADME-Tox Division, Durham, North Carolina (J.P.J., K.R.B.)

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http://dx.doi.org/10.1124/mol.118.114827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608607PMC
August 2019

Tissue preservation with mass spectroscopic analysis: Implications for cancer diagnostics.

Cancer Biol Ther 2018 31;19(11):953-955. Epub 2018 May 31.

a Clinical Pharmacology Program , National Cancer Institute , Bethesda , MD.

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https://www.tandfonline.com/doi/full/10.1080/15384047.2018.1
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http://dx.doi.org/10.1080/15384047.2018.1456610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301822PMC
May 2018

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.

Mol Cancer Ther 2018 08 10;17(8):1694-1704. Epub 2018 May 10.

Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-18-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072611PMC
August 2018

A sensitive and rapid ultra high-performance liquid chromatography with tandem mass spectrometric assay for the simultaneous quantitation of cyclophosphamide and the 4-hydroxycyclophosphamide metabolite in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Jun 10;1086:56-62. Epub 2018 Apr 10.

Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927828PMC
June 2018

Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer.

J Clin Oncol 2018 05 28;36(14):1389-1395. Epub 2018 Mar 28.

Russell Z. Szmulewitz, Abiola Ibraheem, Elia Martinez, Mark F. Kozloff, Chadi Nabhan, Theodore Karrison, Walter M. Stadler, and Mark J. Ratain, The University of Chicago, Chicago; Mark F. Kozloff, Ingalls Hospital, Harvey; Paul Fishkin, Illinois Cancer Care, Peoria, IL; Cody J. Peer and William D. Figg, National Cancer Institute, Rockville, MD; Bradley Carthon and R. Donald Harvey, Winship Cancer Institute of Emory University, Atlanta, GA; and Wei Peng Yong and Edmund Chiong, National University Cancer Institute, Singapore, Singapore.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.4381
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http://dx.doi.org/10.1200/JCO.2017.76.4381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941614PMC
May 2018

Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques.

Cytokine 2018 08 7;108:213-224. Epub 2018 May 7.

Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657354PMC
August 2018

Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology.

J Control Release 2017 Dec 18;268:147-158. Epub 2017 Oct 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Institute of Quantitative Systems Pharmacology, Carlsbad, CA 92008, USA; Optimum Therapeutics LLC, Carlsbad, CA 92008, USA; College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722714PMC
December 2017

Jumping the Barrier: Modeling Drug Penetration across the Blood-Brain Barrier.

Clin Cancer Res 2017 12 10;23(24):7437-7439. Epub 2017 Oct 10.

Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732885PMC
December 2017

Quantitative modeling of the dynamics and intracellular trafficking of far-red light-activatable prodrugs: implications in stimuli-responsive drug delivery system.

J Pharmacokinet Pharmacodyn 2017 Dec 14;44(6):521-536. Epub 2017 Sep 14.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.

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http://dx.doi.org/10.1007/s10928-017-9543-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688019PMC
December 2017

Population pharmacokinetic analyses of the effect of carboplatin pretreatment on olaparib in recurrent or refractory women's cancers.

Cancer Chemother Pharmacol 2017 Jul 2;80(1):165-175. Epub 2017 Jun 2.

Clinical Pharmacology Program, CCR, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-017-3346-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361113PMC
July 2017

Carfilzomib and lenalidomide response related to VEGF and VEGFR2 germline polymorphisms.

Cancer Chemother Pharmacol 2017 Jul 9;80(1):217-221. Epub 2017 May 9.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, 9000 Rockville Pike, Building 10, Rm 5A01, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-017-3323-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387687PMC
July 2017

Diagnosis, staging, and risk stratification in prostate cancer: Utilizing diagnostic tools to avoid unnecessary therapies and side effects.

Cancer Biol Ther 2017 Jul 5;18(7):470-472. Epub 2017 May 5.

a Clinical Pharmacology Program , Office of the Clinical Director, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2017.1323600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639830PMC
July 2017

Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.

J Clin Oncol 2017 Jul 4;35(19):2193-2202. Epub 2017 May 4.

Jung-Min Lee, Cody J. Peer, Alexandra Zimmer, Stanley Lipkowitz, Christina M. Annunziata, Liang Cao, Nicole Houston, Dana-Adriana Botesteanu, Jeffers Nguyen, William D. Figg, and Elise C. Kohn, Center for Cancer Research, National Cancer Institute, Bethesda; Ashley Cimino-Mathews, Janis M. Taube, Elizabeth Thompson, Aleksandra Ogurtsova, and Haiying Xu, The Johns Hopkins Medical Institution, Baltimore; and Tony W. Ho, AstraZeneca, Gaithersburg, MD; and Maria I. Harrell and Elizabeth M. Swisher, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2016.72.1340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493052PMC
July 2017

Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.

Pharmacogenet Genomics 2017 04;27(4):159-163

aSchool of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program for Personalized and Genomic Medicine, University of Maryland, Baltimore bGeriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore cClinical Pharmacology Program, National Cancer Institute, Bethesda dApplied and Developmental Research, SAIC-Frederick Inc., National Cancer Institute, Frederick, Maryland, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346037PMC
April 2017

Pharmacokinetics of Pomalidomide in a Patient Receiving Hemodialysis Using a High-Cutoff Filter.

Am J Kidney Dis 2017 Apr 4;69(4):553-554. Epub 2017 Jan 4.

Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1053/j.ajkd.2016.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667183PMC
April 2017

Pharmacokinetics of lenalidomide during high cut-off dialysis in a patient with multiple myeloma and renal failure.

Cancer Chemother Pharmacol 2017 Jan 17;79(1):215-218. Epub 2016 Dec 17.

Service of Nephrology, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00280-016-3219-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410697PMC
January 2017

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study.

J Clin Oncol 2016 12 31;34(34):4125-4131. Epub 2016 Oct 31.

Mark N. Polizzotto, Thomas S. Uldrick, Kathleen M. Wyvill, Karen Aleman, Cody J. Peer, Frank Maldarelli, Priscila H. Goncalves, William D. Figg, Seth M. Steinberg, and Robert Yarchoan, National Cancer Institute; Margaret Bevans, National Institutes of Health; Irini Sereti, National Institute of Allergy and Infectious Diseases, Bethesda, MD; Denise Whitby and Vickie Marshall, Frederick National Cancer Laboratory for Cancer Research, Frederick, MD; and Vikram Khetani and Jerome B. Zeldis, Celgene Corporation, Summit, NJ.

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http://dx.doi.org/10.1200/JCO.2016.69.3812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477825PMC
December 2016

A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma.

J Pharm Biomed Anal 2017 Jan 5;132:223-226. Epub 2016 Oct 5.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085163079
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http://dx.doi.org/10.1016/j.jpba.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357958PMC
January 2017

Pharmacogenomics and histone deacetylase inhibitors.

Pharmacogenomics 2016 11 21;17(16):1807-1815. Epub 2016 Oct 21.

Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2217/pgs-2016-0113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558504PMC
November 2016

Synthesis of a stable and orally bioavailable englerin analogue.

Bioorg Med Chem Lett 2016 06 8;26(11):2641-4. Epub 2016 Apr 8.

Department of Chemistry, University of Hawaii at Manoa, 2545 McCarthy Mall, Honolulu, HI 96822, United States; The University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862412PMC
June 2016

Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues.

Mol Cancer Ther 2015 Oct 12;14(10):2228-37. Epub 2015 Aug 12.

Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland. Clinical Pharmacology Program, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596783PMC
October 2015

Targeted PI3Kδ inhibition by the small molecule idelalisib as a novel therapy in indolent non-Hodgkin lymphoma.

Cancer Biol Ther 2015 ;16(2):204-6

a Clinical Pharmacology Program; Center for Cancer Research ; National Cancer Institute , Bethesda , MD USA.

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http://dx.doi.org/10.1080/15384047.2014.1002369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622714PMC
May 2015

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer.

J Clin Oncol 2015 Jan 17;33(1):74-82. Epub 2014 Nov 17.

Kevin C. Conlon, Steven A. Rosenberg, Antonio Tito Fojo, John C. Morris, Thomas A. Fleisher, Sigrid P. Dubois, Liyanage P. Perera, Donn M. Stewart, Carolyn K. Goldman, Bonita R. Bryant, Jean M. Decker, Jing Chen, Tat'Yana A. Worthy, William D. Figg Sr, Cody J. Peer, and Thomas A. Waldmann, National Cancer Institute; Enrico Lugli, Hugh C. Welles, Michael C. Sneller, H. Clifford Lane, and Mario Roederer, National Institute of Allergy and Infectious Diseases, Bethesda; Jason L. Yovandich and Stephen P. Creekmore, National Cancer Institute, Frederick, MD; and Hugh C. Welles, Columbian College of Arts and Sciences, George Washington University, Washington, DC.

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http://dx.doi.org/10.1200/JCO.2014.57.3329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268254PMC
January 2015

Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC-MS/MS method for clinical pharmacokinetic application.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Nov 6;970:95-101. Epub 2014 Sep 6.

Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15700232140053
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http://dx.doi.org/10.1016/j.jchromb.2014.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188709PMC
November 2014

Prolonged low intensity EPOCH-rituximab has improved toxicity in Burkitt lymphoma compared with standard short, high intensity therapy.

Cancer Biol Ther 2014 Sep 11;15(9):1117-9. Epub 2014 Jun 11.

Clinical Pharmacology Program; Medical Oncology Branch; National Cancer Institute; Bethesda, MD USA.

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http://dx.doi.org/10.4161/cbt.29504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128854PMC
September 2014

Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers.

J Clin Pharmacol 2014 Aug 7;54(8):865-73. Epub 2014 Apr 7.

Program in Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/jcph.293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113831PMC
August 2014

Clinical pharmacology of an atrasentan and docetaxel regimen in men with hormone-refractory prostate cancer.

Cancer Chemother Pharmacol 2014 May 12;73(5):991-7. Epub 2014 Mar 12.

Mary Babb Randolph (MBR) Cancer Center, West Virginia University, PO Box 9300, Morgantown, WV, 26506, USA.

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http://dx.doi.org/10.1007/s00280-014-2432-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010098PMC
May 2014

The androgen receptor transcriptional program in castration-resistant prostate cancer: cell lines vs. tissue samples.

Cancer Biol Ther 2014 Jan 19;15(1):16-8. Epub 2013 Nov 19.

Clinical Pharmacology Program; Office of the Clinical Director; National Cancer Institute; Bethesda, MD USA.

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http://www.tandfonline.com/doi/abs/10.4161/cbt.27149
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http://dx.doi.org/10.4161/cbt.27149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938517PMC
January 2014

A novel uHPLC-MS/MS method for the quantitation of AZD7451 (AZ12607092) in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Dec 22;942-943:107-12. Epub 2013 Oct 22.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, United States.

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http://dx.doi.org/10.1016/j.jchromb.2013.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864870PMC
December 2013

Uncovering the genetic landscape driving castration-resistant prostate cancer.

Cancer Biol Ther 2013 May;14(5):399-400

Clinical Pharmacology Program, Medical Oncology Branch, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cbt.24426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672183PMC
May 2013

A rapid ultra HPLC-MS/MS method for the quantitation and pharmacokinetic analysis of 3-deazaneplanocin A in mice.

J Chromatogr B Analyt Technol Biomed Life Sci 2013 May 9;927:142-6. Epub 2013 Jan 9.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.jchromb.2013.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640617PMC
May 2013

Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite.

Xenobiotica 2012 Dec 22;42(12):1170-7. Epub 2012 Jun 22.

Department of Basic Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA.

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http://dx.doi.org/10.3109/00498254.2012.696740DOI Listing
December 2012

Development and utilization of a combined LC-UV and LC-MS/MS method for the simultaneous analysis of tegafur and 5-fluorouracil in human plasma to support a phase I clinical study of oral UFT®/leucovorin.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Jun 20;898:32-7. Epub 2012 Apr 20.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, USA.

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http://dx.doi.org/10.1016/j.jchromb.2012.04.010DOI Listing
June 2012

Sorafenib is an inhibitor of UGT1A1 but is metabolized by UGT1A9: implications of genetic variants on pharmacokinetics and hyperbilirubinemia.

Clin Cancer Res 2012 Apr 3;18(7):2099-107. Epub 2012 Feb 3.

Clinical Pharmacology Program, Pharmacology and Experimental Therapeutics Section, Molecular Pharmacology Section, Biostatistics and Data Management Branch, Medical Oncology Branch, and HIV/AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432766PMC
April 2012

A sensitive and rapid ultra HPLC-MS/MS method for the simultaneous detection of clopidogrel and its derivatized active thiol metabolite in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Jan 26;880(1):132-9. Epub 2011 Nov 26.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.jchromb.2011.11.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246081PMC
January 2012

Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma.

Blood 2011 Jun 25;117(22):5827-34. Epub 2011 Feb 25.

Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health/DHHS, 6130 Executive Blvd., Rockville, MD 20852, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-10-31
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http://dx.doi.org/10.1182/blood-2010-10-312603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112033PMC
June 2011

CHIP and gp78-mediated ubiquitination of CYP3A4: Implications for the pharmacology of anticancer agents.

Cancer Biol Ther 2011 Mar 15;11(6):549-51. Epub 2011 Mar 15.

National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cbt.11.6.14834DOI Listing
March 2011

Analysis of free-radical scavenging of Yerba Mate (Ilex paraguriensis) using electron spin resonance and radical-induced DNA damage.

J Food Sci 2010 Jan-Feb;75(1):C14-20

Health Effects Laboratory Div., Natl. Inst. for Occupational Safety and Health, Morgantown, WV, USA.

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http://dx.doi.org/10.1111/j.1750-3841.2009.01394.xDOI Listing
September 2010

Subcellular localization of the amide class herbicide 3,4-dichloropropionanilide (DCPA) in T cells and hepatocytes.

J Toxicol Environ Health A 2010 ;73(1):1-4

Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia 26506-9177, USA.

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http://dx.doi.org/10.1080/15287390903249131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888467PMC
January 2010

Diabetic cardiomyopathy-associated dysfunction in spatially distinct mitochondrial subpopulations.

Am J Physiol Heart Circ Physiol 2009 Feb 5;296(2):H359-69. Epub 2008 Dec 5.

Division of Exercise Physiology, Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA.

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http://dx.doi.org/10.1152/ajpheart.00467.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643887PMC
February 2009

Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases.

J Anal Toxicol 2007 Oct;31(8):515-21

Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA.

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http://dx.doi.org/10.1093/jat/31.8.515DOI Listing
October 2007