Clive N Svendsen

Clive N Svendsen

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Clive N Svendsen

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Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support.

Front Neurosci 2019 28;13:669. Epub 2019 Jun 28.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fnins.2019.00669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610155PMC
June 2019

In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell-Induced Photoreceptor Survival.

Proteomics 2019 Feb 2;19(3):e1800213. Epub 2019 Jan 2.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA90048, California.

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http://dx.doi.org/10.1002/pmic.201800213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422354PMC
February 2019

Young bone marrow transplantation preserves learning and memory in old mice.

Commun Biol 2019 20;2:73. Epub 2019 Feb 20.

1Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 USA.

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http://dx.doi.org/10.1038/s42003-019-0298-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382867PMC
February 2019

Stem cell transplantation for amyotrophic lateral sclerosis.

Curr Opin Neurol 2018 10;31(5):655-661

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California.

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http://Insights.ovid.com/crossref?an=00019052-900000000-9910
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http://dx.doi.org/10.1097/WCO.0000000000000598DOI Listing
October 2018

Inducible Expression of GDNF in Transplanted iPSC-Derived Neural Progenitor Cells.

Stem Cell Reports 2018 06 26;10(6):1696-1704. Epub 2018 Apr 26.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989694PMC
June 2018

Ex vivo gene therapy for the treatment of neurological disorders.

Prog Brain Res 2017 17;230:99-132. Epub 2017 Jan 17.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Cedars-Sinai Medical Center, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.pbr.2016.11.003DOI Listing
May 2018

Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development.

Stem Cell Reports 2018 04 22;10(4):1222-1236. Epub 2018 Mar 22.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998748PMC
April 2018

Huntington modeling improves with age.

Nat Neurosci 2018 03;21(3):301-303

The Board of Governors Regenerative Medicine Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/s41593-018-0086-4DOI Listing
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

Concise Review: Stem Cells for Corneal Wound Healing.

Stem Cells 2017 10 26;35(10):2105-2114. Epub 2017 Jul 26.

Cedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/stem.2667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637932PMC
October 2017

Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.

Sci Rep 2017 09 6;7(1):10741. Epub 2017 Sep 6.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1038/s41598-017-05519-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587694PMC
September 2017

Patients with ALS show highly correlated progression rates in left and right limb muscles.

Neurology 2017 Jul 9;89(2):196-206. Epub 2017 Jun 9.

From the Board of Governors Regenerative Medicine Institute (D.J.R., P.A., R.H.B., C.N.S.), Department of Biomedical Sciences (D.J.R., C.N.S.), and Neurology (P.A., R.H.B.), Cedars-Sinai Medical Center, Los Angeles, CA; and Neurological Clinical Research Institute (P.L.A.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000004105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501935PMC
July 2017

Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.

Cell Rep 2017 05;19(7):1365-1377

Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; UCI MIND, University of California, Irvine, Irvine, CA 92697, USA; Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646270PMC
May 2017

Modeling Huntington׳s disease with patient-derived neurons.

Brain Res 2017 02 13;1656:76-87. Epub 2015 Oct 13.

The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, AHSP 8102, Los Angeles, CA 90048, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00068993150073
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http://dx.doi.org/10.1016/j.brainres.2015.10.001DOI Listing
February 2017

A model of recurrent concussion that leads to long-term motor deficits, CTE-like tauopathy and exacerbation of an ALS phenotype.

J Trauma Acute Care Surg 2016 12;81(6):1070-1079

From the Regenerative Medicine Institute (G.M.T., A.M., L.W., P.H., O.S., C.N.S.), Department of Biomedical Sciences (J-P.V., C.N.S.), and Biobehavioral Research Core (J-P.V.), Department of Surgery, Division of Trauma and Critical Care (A.K., M.Y.H., E.J.L.), Cedars-Sinai Medical Center, Los Angeles, California; and Division of Trauma, Critical Care, Burn and Emergency Surgery (P.R.), The University of Arizona Medical Center, Tucson, Arizona.

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http://dx.doi.org/10.1097/TA.0000000000001248DOI Listing
December 2016

Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model.

Methods Mol Biol 2016 ;1382:325-36

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.

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http://dx.doi.org/10.1007/978-1-4939-3271-9_24DOI Listing
October 2016

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks.

Nat Neurosci 2016 09 18;19(9):1256-67. Epub 2016 Jul 18.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nn.4345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003654PMC
September 2016

Human neural progenitors differentiate into astrocytes and protect motor neurons in aging rats.

Exp Neurol 2016 06 29;280:41-9. Epub 2016 Mar 29.

The Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States.

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http://dx.doi.org/10.1016/j.expneurol.2016.03.023DOI Listing
June 2016

Regenerative cellular therapies for neurologic diseases.

Brain Res 2016 May 31;1638(Pt A):88-96. Epub 2015 Jul 31.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.06.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733583PMC
May 2016

Cell freezing protocol suitable for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells.

Sci Rep 2016 05 5;6:25474. Epub 2016 May 5.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, United States of America.

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http://dx.doi.org/10.1038/srep25474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857123PMC
May 2016

In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa.

Mol Ther 2016 Mar 15;24(3):556-63. Epub 2015 Dec 15.

Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/mt.2015.220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786918PMC
March 2016

Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells.

PLoS One 2015 23;10(2):e0118188. Epub 2015 Feb 23.

Laboratory of Molecular and Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118188PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338147PMC
November 2015

Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord.

Neurosurgery 2015 Oct;77(4):604-12; discussion 612

*Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia; ‡Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, Georgia; §Department of Neurosurgery, School of Medicine, University of Alabama, Birmingham, Alabama; ¶Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1227/NEU.0000000000000882DOI Listing
October 2015

Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model

eNeuro 2015 May-Jun;2(3). Epub 2015 Jul 3.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center , Los Angeles, CA 90048 ; Department of Biomedical Sciences, Cedars-Sinai Medical Center , Los Angeles, CA 90048.

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http://dx.doi.org/10.1523/ENEURO.0059-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586929PMC
October 2015

Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.

Stem Cells Transl Med 2015 Sep 16;4(9):998-1010. Epub 2015 Jul 16.

Board of Governors, Regenerative Medicine Institute, Department of Biomedical Sciences, iPSC Core, The David and Janet Polak Foundation Stem Cell Core Laboratory, Genomics Core Facility, Department of Surgery, and Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://dx.doi.org/10.5966/sctm.2015-0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542875PMC
September 2015

Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons.

Mol Ther Methods Clin Dev 2015 16;2:15030. Epub 2015 Sep 16.

Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), and Networked Biomedical Research Centre for NeuroDegenerative Disorders (CIBERNED), University of Barcelona , Barcelona, Spain.

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http://dx.doi.org/10.1038/mtm.2015.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571731PMC
September 2015

Human iPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model.

Stem Cells 2015 Aug 2;33(8):2537-49. Epub 2015 Jun 2.

Department of Biomedical Sciences, Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/stem.2032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477659PMC
August 2015

Stimulation of GABA-induced Ca2+ influx enhances maturation of human induced pluripotent stem cell-derived neurons.

PLoS One 2013 22;8(11):e81031. Epub 2013 Nov 22.

Divisions of Pathophysiology & Repair and Neuroscience, School of Biosciences, Cardiff University, Cardiff, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081031PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838360PMC
May 2015

Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS.

Neurobiol Aging 2015 Feb 28;36(2):1130-9. Epub 2014 Sep 28.

Cedars-Sinai Medical Center, The Regenerative Medicine Institute, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.09.020DOI Listing
February 2015

A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy.

Transl Vis Sci Technol 2015 Feb 10;4(1). Epub 2015 Feb 10.

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1167/tvst.4.1.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324446PMC
February 2015

The past, present and future of stem cell clinical trials for ALS.

Exp Neurol 2014 Dec 6;262 Pt B:127-37. Epub 2014 Mar 6.

Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.02.021DOI Listing
December 2014

Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines.

Stem Cells Transl Med 2014 Dec 8;3(12):1429-34. Epub 2014 Oct 8.

Regenerative Medicine Institute, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA

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http://dx.doi.org/10.5966/sctm.2014-0121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250214PMC
December 2014

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Sci Transl Med 2014 Dec;6(268):268ra178

Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. UCLA Brain Research Institute, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010523DOI Listing
December 2014

Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium.

Stem Cells Transl Med 2014 Sep 28;3(9):1002-12. Epub 2014 Jul 28.

Regenerative Medicine Institute, Eye Program, and Departments of Biomedical Sciences, Neurosurgery, Genomics Core, and Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA; Norris Comprehensive Cancer Center Bioinformatics Core and Division of Hematology, University of Southern California, Los Angeles, California, USA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

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http://dx.doi.org/10.5966/sctm.2014-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149305PMC
September 2014

Stem cells for cell replacement therapy: a therapeutic strategy for HD?

Mov Disord 2014 Sep;29(11):1446-54

Cardiff Brain Repair Group, Schools of Medicine and Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, United Kingdom.

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http://dx.doi.org/10.1002/mds.26026DOI Listing
September 2014

Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord.

J Comp Neurol 2014 Aug 12;522(12):2707-28. Epub 2014 Apr 12.

Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048.

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http://dx.doi.org/10.1002/cne.23578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070510PMC
August 2014

A simple alkaline method for decellularizing human amniotic membrane for cell culture.

PLoS One 2013 13;8(11):e79632. Epub 2013 Nov 13.

Eye Program, Cedars-Sinai Medical Center, Los Angeles, California, United States of America ; Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America ; Departments of Biomedical Sciences, Surgery, and Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079632PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827346PMC
July 2014

In vivo tracking of human neural progenitor cells in the rat brain using bioluminescence imaging.

J Neurosci Methods 2014 May 24;228:67-78. Epub 2014 Mar 24.

University of Wisconsin-Madison, 5009 Wisconsin Institute for Medical Research, 1111 Highland Ave., Madison, WI 53705, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054746PMC
http://dx.doi.org/10.1016/j.jneumeth.2014.03.005DOI Listing
May 2014

Ocular changes in TgF344-AD rat model of Alzheimer's disease.

Invest Ophthalmol Vis Sci 2014 Jan 29;55(1):523-34. Epub 2014 Jan 29.

Cedars-Sinai Regenerative Medicine Institute, Los Angeles, California.

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http://dx.doi.org/10.1167/iovs.13-12888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907137PMC
January 2014

Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.

Mol Ther 2013 Aug 28;21(8):1602-10. Epub 2013 May 28.

Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1038/mt.2013.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734670PMC
August 2013

The in vitro survival of human monosomies and trisomies as embryonic stem cells.

Stem Cell Res 2012 Nov 22;9(3):218-24. Epub 2012 Jul 22.

Regenerative Medicine Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1016/j.scr.2012.07.002DOI Listing
November 2012

Gene expression changes in the MAPK pathway in both Fragile X and Down syndrome human neural progenitor cells.

Am J Stem Cells 2012 Jun 3;1(2):154-162. Epub 2012 Jun 3.

Stem Cell Research Program, Waisman Center, University of Wisconsin-Madison, WI 53705, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399245PMC
June 2012

Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2012 May 13;13(3):311-4. Epub 2012 Mar 13.

Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.3109/17482968.2012.654393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644484PMC
May 2012

Clinical translation of stem cells in neurodegenerative disorders.

Cell Stem Cell 2012 Feb;10(2):151-5

Wallenberg Neuroscience Center, University Hospital, SE-221 84 Lund, Sweden.

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http://dx.doi.org/10.1016/j.stem.2012.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982832PMC
February 2012

BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid β-induced toxicity in cultured rat septal neurons.

Neurochem Res 2012 Jan 11;37(1):143-52. Epub 2011 Sep 11.

Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom 73170, Thailand.

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http://link.springer.com/10.1007/s11064-011-0592-1
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http://dx.doi.org/10.1007/s11064-011-0592-1DOI Listing
January 2012

Blood-brain barrier modeling with co-cultured neural progenitor cell-derived astrocytes and neurons.

J Neurochem 2011 Nov 21;119(3):507-20. Epub 2011 Sep 21.

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07434.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192906PMC
November 2011

Stem cell transplantation for motor neuron disease: current approaches and future perspectives.

Neurotherapeutics 2011 Oct;8(4):591-606

Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

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http://dx.doi.org/10.1007/s13311-011-0068-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210365PMC
October 2011

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.

Brain 2011 Jun;134(Pt 6):1777-89

Department of Neurosurgery, Stanford Stroke Centre, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305-5487, USA.

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http://dx.doi.org/10.1093/brain/awr094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102243PMC
June 2011

Induced pluripotent stem cells: a new revolution for clinical neurology?

Lancet Neurol 2011 Apr;10(4):383-94

Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/S1474-4422(11)70022-9DOI Listing
April 2011

Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia.

Cytotherapy 2011 Jan 24;13(1):61-8. Epub 2010 Aug 24.

Neuroscience Research Laboratories, Department of Neurosurgery, Medical College of Wisconsin/VAMC, 5000 W. National Ave. 151, Milwaukee, WI 53295, USA.

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http://dx.doi.org/10.3109/14653249.2010.510504DOI Listing
January 2011

Real time imaging of human progenitor neurogenesis.

PLoS One 2010 Oct 7;5(10):e13187. Epub 2010 Oct 7.

Department of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951355PMC
October 2010

Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease.

Exp Neurol 2010 Jul 19;224(1):155-62. Epub 2010 Mar 19.

Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1111 Highland Ave., Madison, WI 53705, USA.

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http://dx.doi.org/10.1016/j.expneurol.2010.03.005DOI Listing
July 2010

Stem cell model of spinal muscular atrophy.

Arch Neurol 2010 Jun;67(6):665-9

Wisconsin Institutes for Medical Research, 1111 Highland Ave, Room 5033, Madison, WI 53705, USA.

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http://dx.doi.org/10.1001/archneurol.2010.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140872PMC
June 2010

Human stem cells and drug screening: opportunities and challenges.

Nat Rev Drug Discov 2010 05 26;9(5):367-72. Epub 2010 Mar 26.

Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1111 Highland Avenue, Wisconsin 53705, USA.

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http://dx.doi.org/10.1038/nrd3000DOI Listing
May 2010

Stem cell biologists sure play a mean pinball.

Nat Biotechnol 2010 Apr;28(4):333-5

Regenerative Medicine Institute at the Cedars-Sinai Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/nbt0410-333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142542PMC
April 2010

A critical period in cortical interneuron neurogenesis in down syndrome revealed by human neural progenitor cells.

Dev Neurosci 2009 9;31(6):497-510. Epub 2009 Sep 9.

Stem Cell Research Group, The Waisman Center, University of Wisconsin, Madison, Wisc. 53705, USA.

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http://dx.doi.org/10.1159/000236899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818457PMC
January 2010

Chromosome 7 and 19 trisomy in cultured human neural progenitor cells.

PLoS One 2009 Oct 29;4(10):e7630. Epub 2009 Oct 29.

Department of Neurology, University of Wisconsin School of Medicine and Public Health, Wisconsin Institutes for Medical Research (WIMR), Madison, Wisconsin, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765070PMC
October 2009

Induced pluripotent stem cells from a spinal muscular atrophy patient.

Nature 2009 Jan 21;457(7227):277-80. Epub 2008 Dec 21.

The Waisman Center, The Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA.

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http://www.nature.com/doifinder/10.1038/nature07677
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659408PMC
January 2009

Isolating, expanding, and infecting human and rodent fetal neural progenitor cells.

Curr Protoc Stem Cell Biol 2008 Sep;Chapter 2:Unit 2D.2

Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1002/9780470151808.sc02d02s6DOI Listing
September 2008

Combining growth factor and stem cell therapy for amyotrophic lateral sclerosis.

Trends Neurosci 2008 Apr 10;31(4):192-8. Epub 2008 Mar 10.

The Waisman Center and Departments of Anatomy and Neurology, University of Wisconsin-Madison, Madison, WI 53707-2280, USA.

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http://dx.doi.org/10.1016/j.tins.2008.01.006DOI Listing
April 2008

A high concentration of epidermal growth factor increases the growth and survival of neurogenic radial glial cells within human neurosphere cultures.

Stem Cells 2008 Feb 21;26(2):348-55. Epub 2007 Nov 21.

Department of Anatomy and Neurology, Waisman Center, University of Wisconsin-Madison, 1500 Highland Avenue, Madison, Wisconsin 53705-2280, USA.

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http://dx.doi.org/10.1634/stemcells.2007-0299DOI Listing
February 2008

Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells.

Stem Cells Dev 2008 Feb;17(1):107-17

The Waisman Center, University of Wisconsin, Madison, WI 53705, USA.

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http://dx.doi.org/10.1089/scd.2007.0073DOI Listing
February 2008

A novel serum-free method for culturing human prenatal retinal pigment epithelial cells.

Invest Ophthalmol Vis Sci 2008 Feb;49(2):788-99

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, T607 Waisman Center, Madison, WI 53705, USA.

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http://dx.doi.org/10.1167/iovs.07-0777DOI Listing
February 2008

Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease.

Exp Neurol 2008 Jan 4;209(1):213-23. Epub 2007 Oct 4.

The Waisman Center and Department of Anatomy, University of Wisconsin Madison, Madison, WI 53705-2280, USA.

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http://dx.doi.org/10.1016/j.expneurol.2007.09.022DOI Listing
January 2008

Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy.

J Neurosci Methods 2007 Jul 3;163(2):338-49. Epub 2007 Mar 3.

Stem Cell Research Program, Waisman Center, University of Wisconsin-Madison, 1500 Highland Ave, Madison, WI 53705, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2007.02.022DOI Listing
July 2007

Sexual dimorphism in disease onset and progression of a rat model of ALS.

Amyotroph Lateral Scler 2007 Feb;8(1):20-5

Stem Cell Research Program in Neuroscience, The Waisman Center and Department of Anatomy, University of Wisconsin-Madison, Madison, WI 53705-2280, USA.

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http://dx.doi.org/10.1080/17482960600982447DOI Listing
February 2007