Publications by authors named "Clinton F Stewart"

100Publications

A phase I trial of talazoparib and irinotecan with and without temozolomide in children and young adults with recurrent or refractory solid malignancies.

Eur J Cancer 2020 Sep 11;137:204-213. Epub 2020 Aug 11.

Departments of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Departments of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; The Departments of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA.

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http://dx.doi.org/10.1016/j.ejca.2020.06.014DOI Listing
September 2020

The RACE to Develop New Targeted Therapies for Children With CNS Tumors.

Clin Pharmacol Ther 2020 Jul 7. Epub 2020 Jul 7.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1937DOI Listing
July 2020

LC-MS/MS method for quantitation of the CK2 inhibitor silmitasertib (CX-4945) in human plasma, CSF, and brain tissue, and application to a clinical pharmacokinetic study in children with brain tumors.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Sep 23;1152:122254. Epub 2020 Jun 23.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2020.122254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484447PMC
September 2020

A phase 1 trial of everolimus and bevacizumab in children with recurrent solid tumors.

Cancer 2020 Apr 22;126(8):1749-1757. Epub 2020 Jan 22.

Department of Pediatrics, Penn State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1002/cncr.32722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103504PMC
April 2020

Correction to: Pharmacokinetics and safety of erlotinib and its metabolite OSI-420 in infants and children with primary brain tumors.

Cancer Chemother Pharmacol 2020 Feb;85(2):475

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s00280-019-04026-7DOI Listing
February 2020

CNS penetration and pharmacodynamics of the CHK1 inhibitor prexasertib in a mouse Group 3 medulloblastoma model.

Eur J Pharm Sci 2020 Jan 25;142:105106. Epub 2019 Oct 25.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 28105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.105106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925336PMC
January 2020

An LC/ESI-MS/MS method to quantify the PI3K inhibitor GDC-0084 in human plasma and cerebrospinal fluid: Validation and clinical application.

Biomed Chromatogr 2020 Jan 21;34(1):e4697. Epub 2019 Oct 21.

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1002/bmc.4697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052798PMC
January 2020

Pharmacokinetics and safety of erlotinib and its metabolite OSI-420 in infants and children with primary brain tumors.

Cancer Chemother Pharmacol 2019 10 7;84(4):829-838. Epub 2019 Aug 7.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s00280-019-03921-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773504PMC
October 2019

CNS penetration of the CDK4/6 inhibitor ribociclib in non-tumor bearing mice and mice bearing pediatric brain tumors.

Cancer Chemother Pharmacol 2019 08 11;84(2):447-452. Epub 2019 May 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s00280-019-03864-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029794PMC
August 2019

Determining success rates of the current pharmacokinetically guided dosing approach of topotecan in pediatric oncology patients.

Pediatr Blood Cancer 2019 04 11;66(4):e27578. Epub 2018 Dec 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.27578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386591PMC
April 2019

Development and validation of a sensitive LC MS/MS method for the measurement of the checkpoint kinase 1 inhibitor prexasertib and its application in a cerebral microdialysis study.

J Pharm Biomed Anal 2018 Jul 17;156:97-103. Epub 2018 Apr 17.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.04.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984718PMC
July 2018

Bridging Adult Experience to Pediatrics in Oncology Drug Development.

J Clin Pharmacol 2017 Oct;57 Suppl 10:S129-S135

Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

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http://dx.doi.org/10.1002/jcph.910DOI Listing
October 2017

Development of Molecularly Targeted Therapies to Treat Pediatric Malignancies.

Clin Pharmacol Ther 2017 Nov 24;102(5):752-753. Epub 2017 Aug 24.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656826PMC
November 2017

Derivation of new equations to estimate glomerular filtration rate in pediatric oncology patients.

Pediatr Nephrol 2017 09 2;32(9):1575-1584. Epub 2017 Jun 2.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00467-017-3693-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712286PMC
September 2017

Development and validation of LC-MS/MS methods for the measurement of ribociclib, a CDK4/6 inhibitor, in mouse plasma and Ringer's solution and its application to a cerebral microdialysis study.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Jul 5;1057:110-117. Epub 2017 May 5.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512115PMC
July 2017

A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study.

Neuro Oncol 2017 Aug;19(8):1135-1144

University of California San Francisco, San Francisco, California; Boston Children's Hospital, Boston, Massachusetts; Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; St Jude Children's Research Hospital, Memphis, Tennessee; Lurie Children's Hospital, Chicago, Illinois; Children's National Medical Center, Washington, DC; Duke University Medical Center, Durham, North Carolina; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1093/neuonc/now282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570236PMC
August 2017

Ocular Salvage and Vision Preservation Using a Topotecan-Based Regimen for Advanced Intraocular Retinoblastoma.

J Clin Oncol 2017 Jan 31;35(1):72-77. Epub 2016 Oct 31.

Rachel C. Brennan, Ibrahim Qaddoumi, Shenghua Mao, Jianrong Wu, Catherine A. Billups, Clinton F. Stewart, Carlos Rodriguez-Galindo, and Matthew W. Wilson, St Jude Children's Research Hospital; and Rachel C. Brennan, Ibrahim Qaddoumi, Clinton F. Stewart, Mary Ellen Hoehn, and Matthew W. Wilson, University of Tennessee Health Science Center, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2016.69.2996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455691PMC
January 2017

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant.

Drug Metab Dispos 2016 07 6;44(7):1116-22. Epub 2016 Apr 6.

Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.068676
Publisher Site
http://dx.doi.org/10.1124/dmd.115.068676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931885PMC
July 2016

Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.

Cancer Cell 2016 Apr 31;29(4):508-522. Epub 2016 Mar 31.

Li Ka Shing Centre, CRUK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, England. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829447PMC
April 2016

Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study.

Drug Metab Dispos 2016 Apr 22;44(4):591-4. Epub 2016 Jan 22.

Departments of Pharmaceutical Sciences (Y.T.P., M.O.J., A.D.D., D.C.T. C.F.S.), Hematology (N.B.), and Developmental Neurobiology (R.J.G.), Preclinical Pharmacokinetic Shared Resource (P.K.V., B.B.F.), St. Jude Children's Research Hospital, Memphis, Tennessee; Merck, Rahway, New Jersey (D.C.T.); and Cambridge Cancer Centre, Cambridge, United Kingdom (R.J.G.)

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http://dx.doi.org/10.1124/dmd.115.068445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810761PMC
April 2016

Neurocognitive and Patient-Reported Outcomes in Adult Survivors of Childhood Osteosarcoma.

JAMA Oncol 2016 Feb;2(2):201-8

Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee5Department of Psychology, St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1001/jamaoncol.2015.4398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752424PMC
February 2016

Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma.

Neuro Oncol 2015 Dec 4;17(12):1620-7. Epub 2015 Nov 4.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee (K.D.W., R.J.G., A.G.); Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee (V.M.D., D.C.T., C.F.S); Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee (A.O.-T.); Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee (N.B., R.J.G.); Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee (B.A.O.).

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http://neuro-oncology.oxfordjournals.org/content/17/12/1620.
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http://neuro-oncology.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/neuonc/nov181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633933PMC
December 2015

Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.

J Neurooncol 2016 Jan 30;126(2):225-34. Epub 2015 Oct 30.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s11060-015-1965-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718940PMC
January 2016

Pharmacokinetic Properties of Anticancer Agents for the Treatment of Central Nervous System Tumors: Update of the Literature.

Clin Pharmacokinet 2016 Mar;55(3):297-311

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://link.springer.com/10.1007/s40262-015-0319-6
Publisher Site
http://dx.doi.org/10.1007/s40262-015-0319-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761278PMC
March 2016

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

J Clin Oncol 2015 Aug 13;33(24):2646-54. Epub 2015 Jul 13.

Giles W. Robinson, Brent A. Orr, Gang Wu, Tong Lin, Ibrahim Qaddoumi, Sue C. Kaste, Michael Rusch, Sariah J. Allen, Arzu Onar-Thomas, Clinton F. Stewart, James M. Boyett, Richard J. Gilbertson, David W. Ellison, and Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Sridharan Gururangan and Annick Desjardins, Duke University Medical Center, Durham, NC; Roger J. Packer, Children's National Medical Center, Washington, DC; Stewart Goldman, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Michael D. Prados, University of California San Francisco, San Francisco, CA; Murali Chintagumpala, Texas Children's Cancer Center, Houston, TX; Naoko Takebe, National Cancer Institute, Bethesda, MD; Maryam Fouladi, Cincinnati Children's Hospital, Cincinnati, OH; and Tom Curran, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2014.60.1591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534527PMC
August 2015

Observational Evaluations of Mice during Cerebral Microdialysis for Pediatric Brain Tumor Research.

J Am Assoc Lab Anim Sci 2015 May;54(3):304-10

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460944PMC
May 2015

Response to: comment on "Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections".

Cancer Chemother Pharmacol 2015 Apr 26;75(4):877-8. Epub 2015 Feb 26.

Division of Neuro-oncology, Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 260, Memphis, TN, 38105, USA,

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http://dx.doi.org/10.1007/s00280-015-2699-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401467PMC
April 2015

Comparable efficacy with varying dosages of glucarpidase in pediatric oncology patients.

Pediatr Blood Cancer 2015 Sep 28;62(9):1518-22. Epub 2015 Jan 28.

Pharmaceutical Department, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.25395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770903PMC
September 2015

Population pharmacokinetic analysis of oxaliplatin in adults and children identifies important covariates for dosing.

Cancer Chemother Pharmacol 2015 Mar 4;75(3):495-503. Epub 2015 Jan 4.

University of California San Diego, 9500 Gilman Drive, MC 0657, La Jolla, CA, 92093-0657, USA.

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http://dx.doi.org/10.1007/s00280-014-2667-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344382PMC
March 2015

Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells.

Cancer Res 2015 Jan 14;75(1):181-93. Epub 2014 Nov 14.

Tennessee Valley Healthcare System, Department of Veterans Affairs, Vanderbilt University Medical Center, Nashville, Tennessee. Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286469PMC
January 2015

Determination of crizotinib in human and mouse plasma by liquid chromatography electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Jun 28;960:151-7. Epub 2014 Apr 28.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2014.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062842PMC
June 2014

Population pharmacokinetics of bevacizumab in children with osteosarcoma: implications for dosing.

Clin Cancer Res 2014 May 17;20(10):2783-92. Epub 2014 Mar 17.

Authors' Affiliations: Departments of Pharmaceutical Sciences, Oncology, Biostatistics, and Surgery; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas; Department of Pediatrics, Stanford School of Medicine, Palo Alto, California; and Department of Oncology, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024352PMC
May 2014

Phase I dosage finding and pharmacokinetic study of intravenous topotecan and oral erlotinib in adults with refractory solid tumors.

Cancer Chemother Pharmacol 2014 Mar 22;73(3):561-8. Epub 2014 Jan 22.

Department of Pharmaceutical Sciences, MS 313, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA,

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http://link.springer.com/10.1007/s00280-014-2385-0
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http://dx.doi.org/10.1007/s00280-014-2385-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965853PMC
March 2014

Evaluation of amifostine for protection against cisplatin-induced serious hearing loss in children treated for average-risk or high-risk medulloblastoma.

Neuro Oncol 2014 Jun 10;16(6):848-55. Epub 2014 Jan 10.

Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis Tenneessee (J.G.G., G.T.A.); Department of Rehabilitation Service, St. Jude Children's Research Hospital, Memphis Tenneessee (J.K.B.); Department of Biostatistics, St. Jude Children's Research Hospital, Memphis Tenneessee (A.O.-T., J.H.); Department of Oncology, St. Jude Children's Research Hospital, Memphis Tenneessee (C.W., I.Q., G.T.A., A.B., A.G.); Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis Tenneessee, (A.P.P., T.E.M.); Department of Bone Marrow Transplantation, St. Jude Children's Research Hospital, Memphis, Tenneessee (A.S.); Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis Tenneessee (C.F.S.); Department of Pediatrics, Texas Children's Cancer Center, Houston, Texas (M.C.); Hospital for Sick Children, Toronto, Ontario, Canada (E.B.); Royal Children's Hospital Brisbane, Herston, Australia (T.H.); The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina (S.G.); The Royal Children's Hospital Melbourne, Victoria, Australia (J.A.H.); Children's Hospital at Westmead, Sydney, Australia (S.K.); Sydney Children's Hospital, Sydney, Australia (R.C.); Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (M.J.F.); School of Public Health, University of Memphis, Memphis, Tenneessee (J.G.G.).

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http://dx.doi.org/10.1093/neuonc/not241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022215PMC
June 2014

Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study.

Clin Cancer Res 2013 Nov 27;19(22):6305-12. Epub 2013 Sep 27.

Authors' Affiliations: Departments of Oncology, Pharmaceutical Sciences, Pathology, Radiological Sciences, Biostatistics, and Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee; Center for Neuroscience Research, Children's National Medical Center, Washington, DC; Division of Hematology-Oncology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois; Department of Pediatrics, Texas Children's Hospital, Houston, Texas; Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland; and Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856244PMC
November 2013

Combination metronomic oral topotecan and pazopanib: a pharmacokinetic study in patients with gynecological cancer.

Anticancer Res 2013 Sep;33(9):3823-9

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386652PMC
September 2013

Phase II study of cilengitide in the treatment of refractory or relapsed high-grade gliomas in children: a report from the Children's Oncology Group.

Neuro Oncol 2013 Oct 5;15(10):1438-44. Epub 2013 Sep 5.

Corresponding Author: Tobey J. MacDonald, MD, Emory Children's Center, Aflac Cancer and Blood Disorders Center, 2015 Uppergate Drive NE, Suite 442, Atlanta, GA 30322.

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http://dx.doi.org/10.1093/neuonc/not058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779033PMC
October 2013

Determination of crenolanib in human serum and cerebrospinal fluid by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2013 Jun 11;929:1-5. Epub 2013 Apr 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.jchromb.2013.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665945PMC
June 2013

Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis.

Invest Ophthalmol Vis Sci 2012 Apr 30;53(4):2439-45. Epub 2012 Apr 30.

Departments of Ophthalmology, Anatomy and Neurobiology, Pharmaceutical Sciences, Radiology, and Comparative Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1167/iovs.12-9466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995559PMC
April 2012

Magnetic resonance imaging-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model.

J Pharm Sci 2011 Oct 11;100(10):4210-4. Epub 2011 Aug 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105; Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163.

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http://dx.doi.org/10.1002/jps.22723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750095PMC
October 2011

Determination of vandetanib in human plasma and cerebrospinal fluid by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2011 Sep 18;879(25):2561-6. Epub 2011 Jul 18.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.jchromb.2011.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162072PMC
September 2011

MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport.

Biochem Pharmacol 2011 Jul 1;82(1):24-34. Epub 2011 Apr 1.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.bcp.2011.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108438PMC
July 2011

Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid.

Cancer Chemother Pharmacol 2011 Sep 16;68(3):721-31. Epub 2010 Dec 16.

Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/s00280-010-1542-3DOI Listing
September 2011

Role of ATP-binding cassette and solute carrier transporters in erlotinib CNS penetration and intracellular accumulation.

Clin Cancer Res 2011 Jan 18;17(1):89-99. Epub 2010 Nov 18.

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, University of Tennessee Health Science Center, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017236PMC
January 2011

Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2010 Sep 30;878(25):2348-52. Epub 2010 Jul 30.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S157002321000463
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http://dx.doi.org/10.1016/j.jchromb.2010.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926936PMC
September 2010

Clinical pharmacology in the adolescent oncology patient.

J Clin Oncol 2010 Nov 3;28(32):4790-9. Epub 2010 May 3.

Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2010.28.3473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018345PMC
November 2010

Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma.

Clin Cancer Res 2010 Feb 26;16(3):1049-57. Epub 2010 Jan 26.

Department of Clinical Pharmacy and Pharmaceutical Sciences, University of Tennessee, TN, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-1997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818675PMC
February 2010

Stability of cyclophosphamide in extemporaneous oral suspensions.

Ann Pharmacother 2010 Feb 26;44(2):295-301. Epub 2010 Jan 26.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1345/aph.1M578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835970PMC
February 2010

Determination of nutlin-3a in murine plasma by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS).

J Pharm Biomed Anal 2010 Mar 30;51(4):915-20. Epub 2009 Oct 30.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.jpba.2009.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814893PMC
March 2010