Publications by authors named "Clinton D Orebaugh"

6Publications

Mapping Ribonucleotides Incorporated into DNA by Hydrolytic End-Sequencing.

Methods Mol Biol 2018 ;1672:329-345

Genome Integrity and Structural Biology Laboratory, National Institute for Environmental Health Sciences, National Institute of Health (NIH), 111 TW Alexander Drive, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_23DOI Listing
June 2018

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.

Nat Struct Mol Biol 2015 Mar 26;22(3):185-91. Epub 2015 Jan 26.

Genome Integrity &Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institute of Health (NIH), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1038/nsmb.2957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351163PMC
March 2015

The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.

J Biol Chem 2014 Apr 9;289(16):11556-65. Epub 2014 Mar 9.

From the Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157.

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http://dx.doi.org/10.1074/jbc.M114.559252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036290PMC
April 2014

The TREX1 C-terminal region controls cellular localization through ubiquitination.

J Biol Chem 2013 Oct 26;288(40):28881-92. Epub 2013 Aug 26.

From the Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157.

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http://dx.doi.org/10.1074/jbc.M113.503391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789983PMC
October 2013

The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.

J Biol Chem 2011 Nov 21;286(46):40246-54. Epub 2011 Sep 21.

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M111.297903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220555PMC
November 2011

Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.

J Biol Chem 2011 Sep 1;286(37):32373-82. Epub 2011 Aug 1.

Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1074/jbc.M111.276287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173215PMC
September 2011