Clifford J Woolf

Clifford J Woolf

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Clifford J Woolf

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Sepiapterin reductase inhibition selectively reduces inflammatory joint pain and increases urinary sepiapterin.

Arthritis Rheumatol 2019 Jul 27. Epub 2019 Jul 27.

Kirby Neurobiology Center, Boston Children's Hospital, Department of Neurobiology, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1002/art.41060DOI Listing
July 2019

Diltiazem Promotes Regenerative Axon Growth.

Mol Neurobiol 2019 Jun 19;56(6):3948-3957. Epub 2018 Sep 19.

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s12035-018-1349-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424671PMC
June 2019

Capturing Novel Non-opioid Pain Targets.

Authors:
Clifford J Woolf

Biol Psychiatry 2019 Jun 29. Epub 2019 Jun 29.

F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2019.06.017DOI Listing
June 2019

Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment.

Neuron 2019 03;101(5):783-800

Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, 02115 MA, USA.

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http://dx.doi.org/10.1016/j.neuron.2019.02.019DOI Listing
March 2019

Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.

Cell Rep 2018 Aug;24(7):1865-1879.e9

Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Boston Children's Hospital, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155462PMC
August 2018

Optical cuff for optogenetic control of the peripheral nervous system.

J Neural Eng 2018 02;15(1):015002

Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1202 Geneva, Switzerland. Department of Neurobiology, Harvard Medical School, Boston, MA 02115, United States of America. FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, United States of America.

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http://dx.doi.org/10.1088/1741-2552/aa9126DOI Listing
February 2018

Breaking barriers to novel analgesic drug development.

Nat Rev Drug Discov 2017 11 6;16(11):810. Epub 2017 Oct 6.

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http://www.nature.com/doifinder/10.1038/nrd.2017.202
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http://dx.doi.org/10.1038/nrd.2017.202DOI Listing
November 2017

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.

Cell 2017 Nov 5;171(4):836-848.e13. Epub 2017 Oct 5.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679747PMC
November 2017

Sense and Immunity: Context-Dependent Neuro-Immune Interplay.

Front Immunol 2017 3;8:1463. Epub 2017 Nov 3.

Département de Pharmacologie et Physiologie, Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.3389/fimmu.2017.01463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675863PMC
November 2017

Mouse embryonic stem cells can differentiate via multiple paths to the same state.

Elife 2017 10 9;6. Epub 2017 Oct 9.

Department of Systems Biology, Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.7554/eLife.26945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648529PMC
October 2017

Substance P activates Mas-related G protein-coupled receptors to induce itch.

J Allergy Clin Immunol 2017 Aug 20;140(2):447-453.e3. Epub 2017 Feb 20.

Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.12.980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546940PMC
August 2017

Breaking barriers to novel analgesic drug development.

Nat Rev Drug Discov 2017 Aug 9;16(8):545-564. Epub 2017 Jun 9.

Department of Neurobiology, Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrd.2017.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675565PMC
August 2017

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury.

Cell Rep 2017 08;20(5):1136-1147

Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565222PMC
August 2017

Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses.

Cell Rep 2017 07;20(1):89-98

Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568654PMC
July 2017

Decreased alertness due to sleep loss increases pain sensitivity in mice.

Nat Med 2017 Jun 8;23(6):768-774. Epub 2017 May 8.

Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798598PMC
June 2017

Time for nonaddictive relief of pain.

Science 2017 Mar 9;355(6329):1026-1027. Epub 2017 Mar 9.

Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1126/science.aan0088DOI Listing
March 2017

The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity.

Sci Rep 2017 03 27;7(1):446. Epub 2017 Mar 27.

Institute of Clinical Pharmacology, pharmazentrum frankfurt/ZAFES, University Hospital, Goethe-University, D-60590, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1038/s41598-017-00591-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428564PMC
March 2017

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.

Proc Natl Acad Sci U S A 2016 11 17;113(44):12544-12549. Epub 2016 Oct 17.

Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES (Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit), University Hospital, Goethe-University, D-60590 Frankfurt, Germany.

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http://dx.doi.org/10.1073/pnas.1613246113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098623PMC
November 2016

Toward a Mechanism-Based Approach to Pain Diagnosis.

J Pain 2016 09;17(9 Suppl):T50-69

FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jpain.2016.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012312PMC
September 2016

Pain and infection: pathogen detection by nociceptors.

Pain 2016 06;157(6):1192-3

aDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. bF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874496PMC
June 2016

Neuroimmunity: Physiology and Pathology.

Annu Rev Immunol 2016 05 22;34:421-47. Epub 2016 Feb 22.

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts 02115; email:

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http://dx.doi.org/10.1146/annurev-immunol-041015-055340DOI Listing
May 2016

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.

Pain 2016 Apr;157(4):901-9

aDepartment of Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA bDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA cDepartment of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada dDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA ePain Research, Department of Surgery and Cancer, Imperial College, London, United Kingdom fCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom Departments of gAnesthesiology, hNeurology, and iPsychiatry, University of Rochester, Rochester, NY, USA jDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA kDepartment of Biostatistics, Harvard University, Boston, MA, USA lDepartment of Anesthesiology, University of Rochester, Rochester, NY, USA mClinical and Rehabilitative Medicine Research Program, United States Army Medical Research and Materiel Command, Fort Detrick, MD, USA nDepartment of Physiology and Pathophysiology, Friedrich-Alexander Universität, Erlangen-Nürnberg, Germany oInstitute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom pEli Lilly & Co., Indianapolis, IN, USA qDepartment of Rehabilitation Medicine, University of Washington, Seattle, WA, USA rNeuroscience Discovery Research, Eli Lilly & Co., Indianapolis, IN, USA sPolicy Department, Wellcome Trust, London, United Kingdom Departments of tMedicine and uOral Surgery, University of California San Francisco, San Francisco, CA, USA vNational Centre for Replacement, Refinement & Reduction of Animals in Research, London, United Kingdom wKent, United Kingdom xDepartment of Biostatistics and Computational Biology and Department of Neurology, University of Rochester, Rochester, NY, USA yNeurorestoration group, King's College, London, United Kingdom zSchool of Behavioral and Brain Sciences, University of Texas at Dallas, TX, USA aaDepartment of Neuro

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http://dx.doi.org/10.1097/j.pain.0000000000000458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794131PMC
April 2016

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program.

Neuron 2016 Mar 18;89(5):956-70. Epub 2016 Feb 18.

Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.01.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790095PMC
March 2016

CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.

Proc Natl Acad Sci U S A 2015 Dec 23;112(49):E6808-17. Epub 2015 Nov 23.

F. M. Kirby Neurobiology Center, Boston Children's Hospital & Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1501372112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679057PMC
December 2015

Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.

Neuron 2015 Nov 29;88(4):704-19. Epub 2015 Oct 29.

F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.10.005DOI Listing
November 2015

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Pain 2015 Jul;156(7):1184-97

aDepartment of Anesthesiology, University of Rochester, Rochester, NY, USA bUniversity of Washington, Seattle, WA, USA cUniversity of Pennsylvania, Philadelphia, PA, USA dUniversity of Florida, Gainesville, FL, USA eQueen's University, Kingston, ON, Canada fHarvard University, Boston, MS, USA gJohns Hopkins University, Baltimore, MD, USA hGerman Diabetes Center at Heinrich Heine University, Düsseldorf, Germany iLora Group, LLC, Royal Oak, MD, USA jAmerican Chronic Pain Association, Rocklin, CA, USA kPfizer and Duke University, Raleigh-Duram, NC, USA lGlaxoSmithKline, London, United Kingdom mEli Lilly, Indianapolis, IN, USA nVirtuous Pharma, Inc, Raleigh-Durham, NC, USA oYork University, Toronto, ON, Canada pRigshospitalet, Copenhagen University, Denmark qEndo Pharmaceuticals, Inc, Malvern, PA, USA rTeva Pharmaceuticals, North Wales, PA, USA sAcelRx, Redwood City, CA, USA tArlington, VA, USA uJohnson and Johnson, Titusville, NJ, USA vGrünenthal GMbH, Aachen, Germany wJazz Pharmaceuticals, Palo Alto, CA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769693PMC
July 2015

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.

Cell Stem Cell 2015 Jul;17(1):8-10

Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.06.013DOI Listing
July 2015

Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics.

Neuron 2015 May 30;86(4):1000-1014. Epub 2015 Apr 30.

F.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.03.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551425PMC
May 2015

CNS injury: IL-33 sounds the alarm.

Immunity 2015 Mar;42(3):403-5

FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.02.019DOI Listing
March 2015

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

Nat Neurosci 2015 Jan 24;18(1):17-24. Epub 2014 Nov 24.

1] F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nn.3886
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http://dx.doi.org/10.1038/nn.3886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429606PMC
January 2015

A three-dimensional human neural cell culture model of Alzheimer's disease.

Nature 2014 Nov 12;515(7526):274-8. Epub 2014 Oct 12.

Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature13800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366007PMC
November 2014

What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain?

Authors:
Clifford J Woolf

Pain 2014 Oct 30;155(10):1911-2. Epub 2014 Jul 30.

FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1016/j.pain.2014.07.021DOI Listing
October 2014

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

Cell Stem Cell 2014 Jun 3;14(6):781-95. Epub 2014 Apr 3.

The Howard Hughes Medical Institute, USA; Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653065PMC
June 2014

Skin β-endorphin mediates addiction to UV light.

Cell 2014 Jun;157(7):1527-34

Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117380PMC
June 2014

Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain.

JAMA Neurol 2014 May;71(5):640-5

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts7Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2014.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465580PMC
May 2014

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.

Cell Rep 2014 Apr 3;7(1):1-11. Epub 2014 Apr 3.

FM Kirby Neurobiology Center, Boston Children's Hospital and Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023477PMC
April 2014

Casting light on pain.

Nat Biotechnol 2014 Mar;32(3):240-1

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA, and the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2844DOI Listing
March 2014

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.

Nat Neurosci 2013 Jul 19;16(7):910-8. Epub 2013 May 19.

FM Kirby Neurobiology Center and Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.3404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695070PMC
July 2013

Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314.

J Neurophysiol 2013 Apr 9;109(7):1704-12. Epub 2013 Jan 9.

Dept. of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1152/jn.00012.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628012PMC
April 2013

Photochemical activation of TRPA1 channels in neurons and animals.

Nat Chem Biol 2013 Apr 10;9(4):257-63. Epub 2013 Feb 10.

Department of Medicine, Cardiovascular Research Center and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604056PMC
April 2013

Pain: morphine, metabolites, mambas, and mutations.

Authors:
Clifford J Woolf

Lancet Neurol 2013 Jan;12(1):18-20

FM Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S1474-4422(12)70287-9DOI Listing
January 2013

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.

Nat Neurosci 2012 Jul 26;15(8):1063-7. Epub 2012 Jul 26.

FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nn.3144
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http://dx.doi.org/10.1038/nn.3144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520068PMC
July 2012

Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.

Pain 2012 Apr 15;153(4):876-84. Epub 2012 Feb 15.

Program in Neurobiology, F.M. Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.pain.2012.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319437PMC
April 2012

Analgesia by inhibiting tetrahydrobiopterin synthesis.

Curr Opin Pharmacol 2012 Feb 15;12(1):92-9. Epub 2011 Dec 15.

FM Kirby Neurobiology Center, Children's Hospital Boston, and Department of Neurobiology, Harvard Medical School, 3 Blackfan Circle, CLS 12260, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.coph.2011.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288148PMC
February 2012

Deconstructing the neuropathic pain phenotype to reveal neural mechanisms.

Neuron 2012 Feb;73(4):638-52

FM Kirby Neurobiology Center, Children's Hospital Boston, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319438PMC
February 2012

TrpA1 regulates thermal nociception in Drosophila.

PLoS One 2011 31;6(8):e24343. Epub 2011 Aug 31.

Neuroscience Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164203PMC
January 2012

Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice.

J Clin Invest 2011 Nov 3;121(11):4332-47. Epub 2011 Oct 3.

Program in Neurobiology and F.M. Kirby Neurobiology Center, Children’s Hospital Boston, and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

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http://content-assets.jci.org/manuscripts/58000/58675/JCI586
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http://www.jci.org/articles/view/58675
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http://dx.doi.org/10.1172/JCI58675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223863PMC
November 2011

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.

Mol Pain 2011 Oct 4;7:78. Epub 2011 Oct 4.

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1186/1744-8069-7-78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195722PMC
October 2011

Considerations for extrapolating evidence of acute and chronic pain analgesic efficacy.

Pain 2011 Aug 10;152(8):1705-8. Epub 2011 Mar 10.

Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1016/j.pain.2011.02.026DOI Listing
August 2011

Central sensitization: implications for the diagnosis and treatment of pain.

Authors:
Clifford J Woolf

Pain 2011 Mar 18;152(3 Suppl):S2-15. Epub 2010 Oct 18.

FM Kirby Neurobiology Center, Children's Hospital Boston, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.pain.2010.09.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268359PMC
March 2011

Overcoming obstacles to developing new analgesics.

Authors:
Clifford J Woolf

Nat Med 2010 Nov 14;16(11):1241-7. Epub 2010 Oct 14.

Neurobiology Center and Program in Neurobiology, Department of Neurology, Children's Hospital Boston, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.2230DOI Listing
November 2010

What is this thing called pain?

Authors:
Clifford J Woolf

J Clin Invest 2010 Nov 1;120(11):3742-4. Epub 2010 Nov 1.

Department of Neurology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI45178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965006PMC
November 2010

Future directions in neuropathic pain therapy: closing the translational loop.

Oncologist 2010 ;15 Suppl 2:24-9

University of Wisconsin-Madison, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1634/theoncologist.2009-S502DOI Listing
September 2010

Selectively targeting pain in the trigeminal system.

Pain 2010 Jul 16;150(1):29-40. Epub 2010 Mar 16.

National Research Laboratory for Pain, Dental Research Institute and Department of Physiology School of Dentistry, Seoul National University, Seoul 110-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.pain.2010.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704110PMC
July 2010

Neuropathic pain: a maladaptive response of the nervous system to damage.

Annu Rev Neurosci 2009 ;32:1-32

Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.neuro.05150
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http://dx.doi.org/10.1146/annurev.neuro.051508.135531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768555PMC
October 2009

Central sensitization: a generator of pain hypersensitivity by central neural plasticity.

J Pain 2009 Sep;10(9):895-926

Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jpain.2009.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750819PMC
September 2009

Mu and delta opioid receptors diverge.

Authors:
Clifford J Woolf

Cell 2009 Jun;137(6):987-8

Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740900636
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http://dx.doi.org/10.1016/j.cell.2009.05.033DOI Listing
June 2009

A novel tool for the assessment of pain: validation in low back pain.

PLoS Med 2009 Apr 7;6(4):e1000047. Epub 2009 Apr 7.

Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1000047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661253PMC
April 2009