Clement E Furlong

Clement E Furlong

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Clement E Furlong

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Paraoxonase-1 and Early-Life Environmental Exposures.

Ann Glob Health 2016 Jan-Feb;82(1):100-10

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA; Department of Genome Sciences, University of Washington, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.aogh.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916371PMC
January 2018

Metals and Paraoxonases.

Adv Neurobiol 2017 ;18:85-111

Department of Medicine (Division of Medical Genetics), University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA, 98105, USA.

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http://link.springer.com/10.1007/978-3-319-60189-2_5
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http://dx.doi.org/10.1007/978-3-319-60189-2_5DOI Listing
December 2017

Developmental expression of paraoxonase 2.

Chem Biol Interact 2016 Nov 7;259(Pt B):168-174. Epub 2016 Apr 7.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States; Dept. of Neuroscience, University of Parma, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5055469PMC
http://dx.doi.org/10.1016/j.cbi.2016.04.001DOI Listing
November 2016

Paraoxonases-1, -2 and -3: What are their functions?

Chem Biol Interact 2016 Nov 26;259(Pt B):51-62. Epub 2016 May 26.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Department of Neuroscience, University of Parma, Parma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2016.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391248PMC
November 2016

PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity.

J Lipid Res 2015 Jul 25;56(7):1351-62. Epub 2015 May 25.

Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WA Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA.

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http://dx.doi.org/10.1194/jlr.P058032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479339PMC
July 2015

Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.

PLoS One 2014 15;9(10):e110054. Epub 2014 Oct 15.

Department of Medicine (Division of Medical Genetics), University of Washington, Seattle, Washington, United States; Department of Genome Sciences, University of Washington, Seattle, Washington, United States.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110054PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198189PMC
June 2015

Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis.

J Proteome Res 2015 May 13;14(5):2046-54. Epub 2015 Mar 13.

¶Kidney Research Institute, University of Washington, 325 Ninth Avenue, Seattle, Washington 98104, United States.

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http://dx.doi.org/10.1021/pr5011586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434596PMC
May 2015

Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants.

Nutr Metab (Lond) 2014 15;11(1):44. Epub 2014 Sep 15.

Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Box 357720, Seattle, WA 98195-7720 USA ; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA USA.

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http://dx.doi.org/10.1186/1743-7075-11-44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177053PMC
September 2014

Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection.

Neurotoxicology 2014 Jul 4;43:3-9. Epub 2013 Sep 4.

Division of Medical Genetics and Department of Genome Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.neuro.2013.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942372PMC
July 2014

HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants.

J Am Heart Assoc 2014 Jun 25;3(3):e000902. Epub 2014 Jun 25.

Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WA (D.S.K., A.A.B., E.A.R., J.E.R., C.E.F., G.P.J.) Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA (D.S.K., C.E.F., G.P.J.).

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https://www.ahajournals.org/doi/10.1161/JAHA.114.000902
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http://dx.doi.org/10.1161/JAHA.114.000902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309059PMC
June 2014

Dietary fatty acid intake is associated with paraoxonase 1 activity in a cohort-based analysis of 1,548 subjects.

Lipids Health Dis 2013 Dec 12;12:183. Epub 2013 Dec 12.

Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Box 357720, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1186/1476-511X-12-183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878825PMC
December 2013

Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?

Neurochem Res 2013 Sep 7;38(9):1809-18. Epub 2013 Jun 7.

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1007/s11064-013-1085-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735620PMC
September 2013

Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease.

Pharmacogenomics 2013 Sep;14(12):1495-515

Departments of Genome Sciences & Medicine (Division of Medical Genetics), University of Washington School of Medicine, Box 357720, University of Washington, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.2217/pgs.13.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888096PMC
September 2013

Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity.

Toxicology 2013 May 31;307:115-22. Epub 2012 Jul 31.

Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X120028
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http://dx.doi.org/10.1016/j.tox.2012.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516631PMC
May 2013

Protein adducts as biomarkers of exposure to organophosphorus compounds.

Toxicology 2013 May 20;307:46-54. Epub 2012 Dec 20.

Departments of Medicine (Division of Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.tox.2012.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747771PMC
May 2013

Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol.

J Lipid Res 2013 May 11;54(5):1512-20. Epub 2013 Mar 11.

Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.1194/jlr.P035238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622343PMC
May 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

Authors:
Santhi K Ganesh Vinicius Tragante Wei Guo Yiran Guo Matthew B Lanktree Erin N Smith Toby Johnson Berta Almoguera Castillo John Barnard Jens Baumert Yen-Pei Christy Chang Clara C Elbers Martin Farrall Mary E Fischer Nora Franceschini Tom R Gaunt Johannes M I H Gho Christian Gieger Yan Gong Aaron Isaacs Marcus E Kleber Irene Mateo Leach Caitrin W McDonough Matthijs F L Meijs Olle Mellander Cliona M Molony Ilja M Nolte Sandosh Padmanabhan Tom S Price Ramakrishnan Rajagopalan Jonathan Shaffer Sonia Shah Haiqing Shen Nicole Soranzo Peter J van der Most Erik P A Van Iperen Jessica Van Setten Jessic A Van Setten Judith M Vonk Li Zhang Amber L Beitelshees Gerald S Berenson Deepak L Bhatt Jolanda M A Boer Eric Boerwinkle Ben Burkley Amber Burt Aravinda Chakravarti Wei Chen Rhonda M Cooper-Dehoff Sean P Curtis Albert Dreisbach David Duggan Georg B Ehret Richard R Fabsitz Myriam Fornage Ervin Fox Clement E Furlong Ron T Gansevoort Marten H Hofker G Kees Hovingh Susan A Kirkland Kandice Kottke-Marchant Abdullah Kutlar Andrea Z Lacroix Taimour Y Langaee Yun R Li Honghuang Lin Kiang Liu Steffi Maiwald Rainer Malik Gurunathan Murugesan Christopher Newton-Cheh Jeffery R O'Connell N Charlotte Onland-Moret Willem H Ouwehand Walter Palmas Brenda W Penninx Carl J Pepine Mary Pettinger Joseph F Polak Vasan S Ramachandran Jane Ranchalis Susan Redline Paul M Ridker Lynda M Rose Hubert Scharnag Nicholas J Schork Daichi Shimbo Alan R Shuldiner Sathanur R Srinivasan Ronald P Stolk Herman A Taylor Barbara Thorand Mieke D Trip Cornelia M van Duijn W Monique Verschuren Cisca Wijmenga Bernhard R Winkelmann Sharon Wyatt J Hunter Young Bernhard O Boehm Mark J Caulfield Daniel I Chasman Karina W Davidson Pieter A Doevendans Garret A Fitzgerald John G Gums Hakon Hakonarson Hans L Hillege Thomas Illig Gail P Jarvik Julie A Johnson John J P Kastelein Wolfgang Koenig Winfried März Braxton D Mitchell Sarah S Murray Albertine J Oldehinkel Daniel J Rader Muredach P Reilly Alex P Reiner Eric E Schadt Roy L Silverstein Harold Snieder Alice V Stanton André G Uitterlinden Pim van der Harst Yvonne T van der Schouw Nilesh J Samani Andrew D Johnson Patricia B Munroe Paul I W de Bakker Xiaofeng Zhu Daniel Levy Brendan J Keating Folkert W Asselbergs

Hum Mol Genet 2013 Apr 8;22(8):1663-78. Epub 2013 Jan 8.

Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, USA.

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http://hmg.oxfordjournals.org/content/22/8/1663.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds555
Publisher Site
http://dx.doi.org/10.1093/hmg/dds555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657476PMC
April 2013

Identifying safer anti-wear triaryl phosphate additives for jet engine lubricants.

Chem Biol Interact 2013 Mar 22;203(1):257-64. Epub 2012 Oct 22.

Department of Medicine-Division of Medical Genetics, University of Washington, Seattle, WA 98195, United States.

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http://dx.doi.org/10.1016/j.cbi.2012.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3618534PMC
March 2013

Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures.

Chem Biol Interact 2013 Mar 2;203(1):85-90. Epub 2012 Nov 2.

Dept of Medicine (Division of Medical Genetics), University of Washington, 98195 Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.cbi.2012.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108156PMC
March 2013

Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL.

J Lipid Res 2013 Feb 15;54(2):552-60. Epub 2012 Nov 15.

Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.1194/jlr.P033266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588879PMC
February 2013

Dietary cholesterol increases paraoxonase 1 enzyme activity.

J Lipid Res 2012 Nov 15;53(11):2450-8. Epub 2012 Aug 15.

Department of Medicine and University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.1194/jlr.P030601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466014PMC
November 2012

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

Authors:
Folkert W Asselbergs Yiran Guo Erik P A van Iperen Suthesh Sivapalaratnam Vinicius Tragante Matthew B Lanktree Leslie A Lange Berta Almoguera Yolande E Appelman John Barnard Jens Baumert Amber L Beitelshees Tushar R Bhangale Yii-Der Ida Chen Tom R Gaunt Yan Gong Jemma C Hopewell Toby Johnson Marcus E Kleber Taimour Y Langaee Mingyao Li Yun R Li Kiang Liu Caitrin W McDonough Matthijs F L Meijs Rita P S Middelberg Kiran Musunuru Christopher P Nelson Jeffery R O'Connell Sandosh Padmanabhan James S Pankow Nathan Pankratz Suzanne Rafelt Ramakrishnan Rajagopalan Simon P R Romaine Nicholas J Schork Jonathan Shaffer Haiqing Shen Erin N Smith Sam E Tischfield Peter J van der Most Jana V van Vliet-Ostaptchouk Niek Verweij Kelly A Volcik Li Zhang Kent R Bailey Kristian M Bailey Florianne Bauer Jolanda M A Boer Peter S Braund Amber Burt Paul R Burton Sarah G Buxbaum Wei Chen Rhonda M Cooper-Dehoff L Adrienne Cupples Jonas S deJong Christian Delles David Duggan Myriam Fornage Clement E Furlong Nicole Glazer John G Gums Claire Hastie Michael V Holmes Thomas Illig Susan A Kirkland Mika Kivimaki Ronald Klein Barbara E Klein Charles Kooperberg Kandice Kottke-Marchant Meena Kumari Andrea Z LaCroix Laya Mallela Gurunathan Murugesan Jose Ordovas Willem H Ouwehand Wendy S Post Richa Saxena Hubert Scharnagl Pamela J Schreiner Tina Shah Denis C Shields Daichi Shimbo Sathanur R Srinivasan Ronald P Stolk Daniel I Swerdlow Herman A Taylor Eric J Topol Elina Toskala Joost L van Pelt Jessica van Setten Salim Yusuf John C Whittaker A H Zwinderman Sonia S Anand Anthony J Balmforth Gerald S Berenson Connie R Bezzina Bernhard O Boehm Eric Boerwinkle Juan P Casas Mark J Caulfield Robert Clarke John M Connell Karen J Cruickshanks Karina W Davidson Ian N M Day Paul I W de Bakker Pieter A Doevendans Anna F Dominiczak Alistair S Hall Catharina A Hartman Christian Hengstenberg Hans L Hillege Marten H Hofker Steve E Humphries Gail P Jarvik Julie A Johnson Bernhard M Kaess Sekar Kathiresan Wolfgang Koenig Debbie A Lawlor Winfried März Olle Melander Braxton D Mitchell Grant W Montgomery Patricia B Munroe Sarah S Murray Stephen J Newhouse N Charlotte Onland-Moret Neil Poulter Bruce Psaty Susan Redline Stephen S Rich Jerome I Rotter Heribert Schunkert Peter Sever Alan R Shuldiner Roy L Silverstein Alice Stanton Barbara Thorand Mieke D Trip Michael Y Tsai Pim van der Harst Ellen van der Schoot Yvonne T van der Schouw W M Monique Verschuren Hugh Watkins Arthur A M Wilde Bruce H R Wolffenbuttel John B Whitfield G Kees Hovingh Christie M Ballantyne Cisca Wijmenga Muredach P Reilly Nicholas G Martin James G Wilson Daniel J Rader Nilesh J Samani Alex P Reiner Robert A Hegele John J P Kastelein Aroon D Hingorani Philippa J Talmud Hakon Hakonarson Clara C Elbers Brendan J Keating Fotios Drenos

Am J Hum Genet 2012 Nov 11;91(5):823-38. Epub 2012 Oct 11.

Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.ajhg.2012.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487124PMC
November 2012

Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon.

Neurotoxicol Teratol 2012 May-Jun;34(3):311-22. Epub 2012 Mar 7.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.ntt.2012.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367041PMC
October 2012

Immunosensor towards low-cost, rapid diagnosis of tuberculosis.

Lab Chip 2012 Apr 6;12(8):1437-40. Epub 2012 Mar 6.

Department of Mechanical Engineering, University of Washington, Box 352600, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1039/c2lc21131aDOI Listing
April 2012

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.

Authors:
Richa Saxena Clara C Elbers Yiran Guo Inga Peter Tom R Gaunt Jessica L Mega Matthew B Lanktree Archana Tare Berta Almoguera Castillo Yun R Li Toby Johnson Marcel Bruinenberg Diane Gilbert-Diamond Ramakrishnan Rajagopalan Benjamin F Voight Ashok Balasubramanyam John Barnard Florianne Bauer Jens Baumert Tushar Bhangale Bernhard O Böhm Peter S Braund Paul R Burton Hareesh R Chandrupatla Robert Clarke Rhonda M Cooper-DeHoff Errol D Crook George Davey-Smith Ian N Day Anthonius de Boer Mark C H de Groot Fotios Drenos Jane Ferguson Caroline S Fox Clement E Furlong Quince Gibson Christian Gieger Lisa A Gilhuijs-Pederson Joseph T Glessner Anuj Goel Yan Gong Struan F A Grant Diederick E Grobbee Claire Hastie Steve E Humphries Cecilia E Kim Mika Kivimaki Marcus Kleber Christa Meisinger Meena Kumari Taimour Y Langaee Debbie A Lawlor Mingyao Li Maximilian T Lobmeyer Anke-Hilse Maitland-van der Zee Matthijs F L Meijs Cliona M Molony David A Morrow Gurunathan Murugesan Solomon K Musani Christopher P Nelson Stephen J Newhouse Jeffery R O'Connell Sandosh Padmanabhan Jutta Palmen Sanjey R Patel Carl J Pepine Mary Pettinger Thomas S Price Suzanne Rafelt Jane Ranchalis Asif Rasheed Elisabeth Rosenthal Ingo Ruczinski Sonia Shah Haiqing Shen Günther Silbernagel Erin N Smith Annemieke W M Spijkerman Alice Stanton Michael W Steffes Barbara Thorand Mieke Trip Pim van der Harst Daphne L van der A Erik P A van Iperen Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Bruce H R Wolffenbuttel Taylor Young M Hadi Zafarmand Joseph M Zmuda Michael Boehnke David Altshuler Mark McCarthy W H Linda Kao James S Pankow Thomas P Cappola Peter Sever Neil Poulter Mark Caulfield Anna Dominiczak Denis C Shields Deepak L Bhatt Deepak Bhatt Li Zhang Sean P Curtis John Danesh Juan P Casas Yvonne T van der Schouw N Charlotte Onland-Moret Pieter A Doevendans Gerald W Dorn Martin Farrall Garret A FitzGerald Anders Hamsten Robert Hegele Aroon D Hingorani Marten H Hofker Gordon S Huggins Thomas Illig Gail P Jarvik Julie A Johnson Olaf H Klungel William C Knowler Wolfgang Koenig Winfried März James B Meigs Olle Melander Patricia B Munroe Braxton D Mitchell Susan J Bielinski Daniel J Rader Muredach P Reilly Stephen S Rich Jerome I Rotter Danish Saleheen Nilesh J Samani Eric E Schadt Alan R Shuldiner Roy Silverstein Kandice Kottke-Marchant Philippa J Talmud Hugh Watkins Folkert W Asselbergs Folkert Asselbergs Paul I W de Bakker Jeanne McCaffery Cisca Wijmenga Marc S Sabatine James G Wilson Alex Reiner Donald W Bowden Hakon Hakonarson David S Siscovick Brendan J Keating

Am J Hum Genet 2012 Mar 9;90(3):410-25. Epub 2012 Feb 9.

Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, USA.

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http://dx.doi.org/10.1016/j.ajhg.2011.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309185PMC
March 2012

Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?

Toxicol Appl Pharmacol 2011 Nov 23;256(3):369-78. Epub 2011 Feb 23.

Dept. of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X110006
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http://dx.doi.org/10.1016/j.taap.2011.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155737PMC
November 2011

Exposure to tri-o-cresyl phosphate detected in jet airplane passengers.

Toxicol Appl Pharmacol 2011 Nov 24;256(3):337-47. Epub 2011 Jun 24.

Eppley Institute, University of Nebraska Medical Center, Omaha, NE 68198-5950, USA.

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http://dx.doi.org/10.1016/j.taap.2011.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205265PMC
November 2011

Biomarkers of organophosphorus (OP) exposures in humans.

Neurotoxicology 2011 Oct 8;32(5):656-60. Epub 2011 Jul 8.

Department of Medicine, Division Medical Genetics, University of Washington, Seattle, WA 98195-7720, United States.

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http://dx.doi.org/10.1016/j.neuro.2011.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279568PMC
October 2011

Paraoxonase 1 status as a risk factor for disease or exposure.

Adv Exp Med Biol 2010 ;660:29-35

Departments of Medicine (Division of Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1007/978-1-60761-350-3_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868909PMC
September 2011

Engineering human PON1 in an E. coli expression system.

Adv Exp Med Biol 2010 ;660:37-45

Departments of Medicine (Div. of Medical Genetics) and Genome Sciences, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1007/978-1-60761-350-3_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056878PMC
September 2011

Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression.

Toxicol Sci 2011 Sep 14;123(1):155-69. Epub 2011 Jun 14.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1093/toxsci/kfr157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164442PMC
September 2011

Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.

Biochem Pharmacol 2011 Feb 18;81(3):337-44. Epub 2010 Nov 18.

Dept. of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000629521000805
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http://dx.doi.org/10.1016/j.bcp.2010.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077125PMC
February 2011

Exposure to triaryl phosphates: metabolism and biomarkers of exposure.

J Biol Phys Chem 2011 ;11

Departments of Medicine, Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, WA 98195-7760, USA.

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http://dx.doi.org/10.4024/28FU11A.jbpc.11.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839637PMC
January 2011

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

Authors:
Matthew B Lanktree Yiran Guo Muhammed Murtaza Joseph T Glessner Swneke D Bailey N Charlotte Onland-Moret Guillaume Lettre Halit Ongen Ramakrishnan Rajagopalan Toby Johnson Haiqing Shen Christopher P Nelson Norman Klopp Jens Baumert Sandosh Padmanabhan Nathan Pankratz James S Pankow Sonia Shah Kira Taylor John Barnard Bas J Peters Cliona M Maloney Maximilian T Lobmeyer Alice Stanton M Hadi Zafarmand Simon P R Romaine Amar Mehta Erik P A van Iperen Yan Gong Tom S Price Erin N Smith Cecilia E Kim Yun R Li Folkert W Asselbergs Larry D Atwood Kristian M Bailey Deepak Bhatt Florianne Bauer Elijah R Behr Tushar Bhangale Jolanda M A Boer Bernhard O Boehm Jonathan P Bradfield Morris Brown Peter S Braund Paul R Burton Cara Carty Hareesh R Chandrupatla Wei Chen John Connell Chrysoula Dalgeorgou Anthonius de Boer Fotios Drenos Clara C Elbers James C Fang Caroline S Fox Edward C Frackelton Barry Fuchs Clement E Furlong Quince Gibson Christian Gieger Anuj Goel Diederik E Grobbee Claire Hastie Philip J Howard Guan-Hua Huang W Craig Johnson Qing Li Marcus E Kleber Barbara E K Klein Ronald Klein Charles Kooperberg Bonnie Ky Andrea Lacroix Paul Lanken Mark Lathrop Mingyao Li Vanessa Marshall Olle Melander Frank D Mentch Nuala J Meyer Keri L Monda Alexandre Montpetit Gurunathan Murugesan Karen Nakayama Dave Nondahl Abiodun Onipinla Suzanne Rafelt Stephen J Newhouse F George Otieno Sanjey R Patel Mary E Putt Santiago Rodriguez Radwan N Safa Douglas B Sawyer Pamela J Schreiner Claire Simpson Suthesh Sivapalaratnam Sathanur R Srinivasan Christine Suver Gary Swergold Nancy K Sweitzer Kelly A Thomas Barbara Thorand Nicholas J Timpson Sam Tischfield Martin Tobin Maciej Tomaszewski Maciej Tomaszweski W M Monique Verschuren Chris Wallace Bernhard Winkelmann Haitao Zhang Dongling Zheng Li Zhang Joseph M Zmuda Robert Clarke Anthony J Balmforth John Danesh Ian N Day Nicholas J Schork Paul I W de Bakker Christian Delles David Duggan Aroon D Hingorani Joel N Hirschhorn Marten H Hofker Steve E Humphries Mika Kivimaki Debbie A Lawlor Kandice Kottke-Marchant Jessica L Mega Braxton D Mitchell David A Morrow Jutta Palmen Susan Redline Denis C Shields Alan R Shuldiner Patrick M Sleiman George Davey Smith Martin Farrall Yalda Jamshidi David C Christiani Juan P Casas Alistair S Hall Pieter A Doevendans Jason D Christie Gerald S Berenson Sarah S Murray Thomas Illig Gerald W Dorn Thomas P Cappola Eric Boerwinkle Peter Sever Daniel J Rader Muredach P Reilly Mark Caulfield Philippa J Talmud Eric Topol James C Engert Kai Wang Anna Dominiczak Anders Hamsten Sean P Curtis Roy L Silverstein Leslie A Lange Marc S Sabatine Mieke Trip Danish Saleheen John F Peden Karen J Cruickshanks Winfried März Jeffrey R O'Connell Olaf H Klungel Cisca Wijmenga Anke Hilse Maitland-van der Zee Eric E Schadt Julie A Johnson Gail P Jarvik George J Papanicolaou Struan F A Grant Patricia B Munroe Kari E North Nilesh J Samani Wolfgang Koenig Tom R Gaunt Sonia S Anand Yvonne T van der Schouw Nicole Soranzo Garret A Fitzgerald Alex Reiner Robert A Hegele Hakon Hakonarson Brendan J Keating

Am J Hum Genet 2011 Jan 30;88(1):6-18. Epub 2010 Dec 30.

Department of Medicine and Biochemistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada.

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http://dx.doi.org/10.1016/j.ajhg.2010.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014369PMC
January 2011

Development of diagnostics in the search for an explanation of aerotoxic syndrome.

Anal Biochem 2010 Sep 4;404(1):64-74. Epub 2010 May 4.

Eppley Institute, University of Nebraska Medical Center, Omaha, 68198, USA.

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http://dx.doi.org/10.1016/j.ab.2010.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900449PMC
September 2010

Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds.

Toxicol Appl Pharmacol 2009 Apr 9;236(2):142-53. Epub 2009 Feb 9.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.taap.2009.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717945PMC
April 2009

Surface plasmon resonance detection using antibody-linked magnetic nanoparticles for analyte capture, purification, concentration, and signal amplification.

Anal Chem 2009 Mar;81(6):2357-63

Department of Medicine-Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1021/ac900007cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880624PMC
March 2009

Paraoxonase 1 (PON1) status and substrate hydrolysis.

Toxicol Appl Pharmacol 2009 Feb 13;235(1):1-9. Epub 2008 Nov 13.

Department of Medicine-Division of Medical Genetics, Box 357720, University of Washington, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1016/j.taap.2008.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045428PMC
February 2009

Determination of paraoxonase 1 status without the use of toxic organophosphate substrates.

Circ Cardiovasc Genet 2008 Dec;1(2):147-52

Department, of Medicine-Division of Medical Genetics and Genome Sciences, University of Washington, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.108.811638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035628PMC
December 2008

Detection of cortisol in saliva with a flow-filtered, portable surface plasmon resonance biosensor system.

Anal Chem 2008 Sep 26;80(17):6747-51. Epub 2008 Jul 26.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington 98195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056881PMC
September 2008

Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning.

Proc Natl Acad Sci U S A 2008 Sep 18;105(35):12780-4. Epub 2008 Aug 18.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0805865105
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529096PMC
September 2008

Genetic variability in the cytochrome P450-paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds.

J Biochem Mol Toxicol 2007 ;21(4):197-205

Department of Medicine, Division of Medical Genetics, and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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November 2007

Paraoxonase (PON1): from toxicology to cardiovascular medicine.

Acta Biomed 2005 ;76 Suppl 2:50-7

Dept of Human Anatomy, Pharmacology and Forensic Science, University of Parma Medical School, Parma, Italy.

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March 2006

PON1 status of farmworker mothers and children as a predictor of organophosphate sensitivity.

Pharmacogenet Genomics 2006 Mar;16(3):183-90

Department of Genome Sciences, Division of Medical Genetics, University of Washington, Seattle, Washington 98195-7720, USA.

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http://dx.doi.org/10.1097/01.fpc.0000189796.21770.d3DOI Listing
March 2006

A portable surface plasmon resonance sensor system for real-time monitoring of small to large analytes.

J Ind Microbiol Biotechnol 2005 Dec 11;32(11-12):669-74. Epub 2005 Nov 11.

Department of Genome Science, Division of Medical Genetics, University of Washington, P.O. Box 357720, Seattle, WA 98195-7720, USA.

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http://link.springer.com/10.1007/s10295-005-0044-5
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December 2005

Discussion and conclusions.

J Biochem Mol Toxicol 2005 ;19(3):192-3

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA.

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http://doi.wiley.com/10.1002/jbt.20083
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October 2005

Paraoxonase 1 (PON1) status and risk of insecticide exposure.

J Biochem Mol Toxicol 2005 ;19(3):182-3

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1002/jbt.20079DOI Listing
October 2005

Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism.

Pharmacogenet Genomics 2005 Aug;15(8):589-98

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195-7720, USA.

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August 2005

Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants.

Neurotoxicology 2005 Aug;26(4):651-9

Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Box 357720, Seattle, WA 98195-7720, USA.

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http://dx.doi.org/10.1016/j.neuro.2004.08.002DOI Listing
August 2005

Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates.

Neurotoxicology 2005 Mar;26(2):199-209

Center for Children's Environmental Health Research, School of Public Health, UC Berkeley, 2150 Shattuck Ave, Suite 600, Berkeley, CA 94720-7380, USA.

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http://dx.doi.org/10.1016/j.neuro.2004.10.004DOI Listing
March 2005

Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity.

Clin Chim Acta 2005 Feb;352(1-2):37-47

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100 Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.cccn.2004.09.019DOI Listing
February 2005

Modulation of paraoxonase (PON1) activity.

Biochem Pharmacol 2005 Feb;69(4):541-50

Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA.

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February 2005

Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population.

Environ Health Perspect 2004 Jul;112(10):1116-24

Center for Children's Environmental Health Research, School of Public Health, University of California Berkeley, 94720-7380, USA.

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http://dx.doi.org/10.1289/ehp.6789DOI Listing
July 2004

Determination of paraoxonase 1 status and genotypes at specific polymorphic sites.

Curr Protoc Toxicol 2004 May;Chapter 4:Unit4.12

University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/0471140856.tx0412s19DOI Listing
May 2004

Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease.

Arterioscler Thromb Vasc Biol 2003 Aug 12;23(8):1465-71. Epub 2003 Jun 12.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Wash, USA.

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http://dx.doi.org/10.1161/01.ATV.0000081635.96290.D3DOI Listing
August 2003

Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity.

Biomarkers 2003 Jan-Feb;8(1):1-12

Department of Environmental Health, University of Washington, Seattle, Washington 98105-6099, USA.

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June 2003

Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism.

Annu Rev Med 2003 3;54:371-92. Epub 2001 Dec 3.

Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA.

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June 2003

Expression of human paraoxonase (PON1) during development.

Pharmacogenetics 2003 Jun;13(6):357-64

Departments of Environmental Health, University of Washington, Seattle 98195-7720, USA.

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http://dx.doi.org/10.1097/01.fpc.0000054092.48725.30DOI Listing
June 2003

Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status.

Pharmacogenetics 2003 May;13(5):291-5

Department of Medicine, Division of Medical Genetics, The University of Washington, Seattle, Washington 98195-7720, USA.

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http://dx.doi.org/10.1097/01.fpc.0000054086.48725.90DOI Listing
May 2003

Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates.

J Toxicol Clin Toxicol 2003 ;41(1):37-45

Department of Environmental Health, University of Washington, Seattle, Washington 98105-6099, USA.

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April 2003

Vitamin C and E intake is associated with increased paraoxonase activity.

Arterioscler Thromb Vasc Biol 2002 Aug;22(8):1329-33

Department of Medicine, Division of Medical Genetics, University of Washington 98195, USA.

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August 2002

Pharmacogenomic considerations of the paraoxonase polymorphisms.

Pharmacogenomics 2002 May;3(3):341-8

Department of genome Services, University of Washington, Seattle, WA 98195, USA.

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https://www.futuremedicine.com/doi/abs/10.1517/14622416.3.3.
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May 2002