Clement C Zai

Clement C Zai

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Clement C Zai

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The complement system in schizophrenia: where are we now and what's next?

Mol Psychiatry 2020 Jan 22;25(1):114-130. Epub 2019 Aug 22.

Tanenbaum Centre for Pharmacogenetics, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

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http://dx.doi.org/10.1038/s41380-019-0479-0DOI Listing
January 2020

Towards precision medicine in generalized anxiety disorder: Review of genetics and pharmaco(epi)genetics.

J Psychiatr Res 2019 Dec 6;119:33-47. Epub 2019 Sep 6.

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2019.09.002DOI Listing
December 2019

Proof-of-concept study of a multi-gene risk score in adolescent bipolar disorder.

J Affect Disord 2019 Nov 5. Epub 2019 Nov 5.

Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.11.009DOI Listing
November 2019

Genome-wide association study on antipsychotic-induced weight gain in Europeans and African-Americans.

Schizophr Res 2019 Oct 22;212:204-212. Epub 2019 Aug 22.

Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.07.022DOI Listing
October 2019

Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.

World J Biol Psychiatry 2018 15;19(sup3):S97-S105. Epub 2016 Dec 15.

a Neurogenetics Section, Neuroscience Department , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/15622975.2016.1262061DOI Listing
September 2019

Copy number variant syndromes are frequent in schizophrenia: Progressing towards a CNV-schizophrenia model.

Schizophr Res 2019 Jul 10;209:171-178. Epub 2019 May 10.

Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, 250 College Street, Toronto M5T 1R8, Canada; The Fred A. Litwin Family Centre in Genetic Medicine, University Health Network & Mount Sinai Hospital, 60 Murray Street, Toronto M5T 3L9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.04.026DOI Listing
July 2019

BDNF Val66Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizoaffective disorder patients: a meta-analysis.

Pharmacogenomics J 2019 06 5;19(3):269-276. Epub 2018 Sep 5.

Psychiatric Neurogenetics Section, Campbell Family Research Institute Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41397-018-0041-5DOI Listing
June 2019

Copy number variant syndromes are frequent in schizophrenia: Progressing towards a CNV-schizophrenia model.

Schizophr Res 2019 Jul 10;209:171-178. Epub 2019 May 10.

Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, 250 College Street, Toronto M5T 1R8, Canada; The Fred A. Litwin Family Centre in Genetic Medicine, University Health Network & Mount Sinai Hospital, 60 Murray Street, Toronto M5T 3L9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.04.026DOI Listing
July 2019

Peripheral Biomarkers in Schizophrenia: A Meta-Analysis of Microarray Gene Expression Datasets.

Int J Neuropsychopharmacol 2019 03;22(3):186-193

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1093/ijnp/pyy103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403089PMC
March 2019

Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia.

World J Biol Psychiatry 2019 01 10;20(1):91-95. Epub 2017 Apr 10.

a Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/15622975.2017.1301681DOI Listing
January 2019

Genetic validation study of protein tyrosine phosphatase receptor type D (PTPRD) gene variants and risk for antipsychotic-induced weight gain.

J Neural Transm (Vienna) 2019 Jan 18;126(1):27-33. Epub 2018 Sep 18.

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, R-132, Toronto, ON, M5T1R8, Canada.

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http://dx.doi.org/10.1007/s00702-018-1921-1DOI Listing
January 2019

Association study of Disrupted-In-Schizophrenia-1 gene variants and tardive dyskinesia.

Neurosci Lett 2018 11 15;686:17-22. Epub 2018 Aug 15.

Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Canada; Institute of Medical Science, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Canada. Electronic address:

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https://www.sciencedirect.com/journal/neuroscience-letters/v
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https://academic.oup.com/ntr/article-abstract/11/4/404/11007
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https://academic.oup.com/schizophreniabulletin/article/21/2/
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https://linkinghub.elsevier.com/retrieve/pii/S03043940183053
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http://dx.doi.org/10.1016/j.neulet.2018.08.007DOI Listing
November 2018

Novel and de novo mutations in pediatric refractory epilepsy.

Mol Brain 2018 09 5;11(1):48. Epub 2018 Sep 5.

Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-018-0392-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125990PMC
September 2018

Specific Alterations in Astrocyte Properties via the GluA2-GAPDH Complex Associated with Multiple Sclerosis.

Sci Rep 2018 08 27;8(1):12856. Epub 2018 Aug 27.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, M5T 1R8, Canada.

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http://dx.doi.org/10.1038/s41598-018-31318-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110783PMC
August 2018

Pharmacogenetic evaluation of a DISP1 gene variant in antidepressant treatment of obsessive-compulsive disorder.

Hum Psychopharmacol 2018 07 28;33(4):e2659. Epub 2018 Jun 28.

Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/hup.2659DOI Listing
July 2018

Genetics of tardive dyskinesia: Promising leads and ways forward.

J Neurol Sci 2018 06 5;389:28-34. Epub 2018 Feb 5.

Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2018.02.011DOI Listing
June 2018

Association study of Disrupted-In-Schizophrenia-1 gene variants and tardive dyskinesia.

Neurosci Lett 2018 11 15;686:17-22. Epub 2018 Aug 15.

Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Canada; Institute of Medical Science, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Canada. Electronic address:

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https://www.sciencedirect.com/journal/neuroscience-letters/v
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https://academic.oup.com/ntr/article-abstract/11/4/404/11007
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https://academic.oup.com/schizophreniabulletin/article/21/2/
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https://linkinghub.elsevier.com/retrieve/pii/S03043940183053
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http://dx.doi.org/10.1016/j.neulet.2018.08.007DOI Listing
November 2018

New findings in pharmacogenetics of schizophrenia.

Curr Opin Psychiatry 2018 05;31(3):200-212

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health.

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http://dx.doi.org/10.1097/YCO.0000000000000417DOI Listing
May 2018

A Comprehensive Analysis of Nuclear-Encoded Mitochondrial Genes in Schizophrenia.

Biol Psychiatry 2018 05 15;83(9):780-789. Epub 2018 Mar 15.

Department of Statistical Sciences, Faculty of Arts and Science, University of Toronto, Toronto, Ontario, Canada; Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.biopsych.2018.02.1175DOI Listing
May 2018

Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia.

Neurosci Lett 2018 04 31;671:1-6. Epub 2018 Jan 31.

Neurogenetics Section, Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183003
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http://dx.doi.org/10.1016/j.neulet.2018.01.033DOI Listing
April 2018

DNA methylation and clinical response to antidepressant medication in major depressive disorder: A review and recommendations.

Neurosci Lett 2018 03 4;669:14-23. Epub 2017 Jan 4.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940163101
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http://dx.doi.org/10.1016/j.neulet.2016.12.071DOI Listing
March 2018

Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain.

Neuropsychobiology 2016 23;74(3):169-175. Epub 2017 May 23.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1159/000457903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653224PMC
February 2018

Genetic testing as a supporting tool in prescribing psychiatric medication: Design and protocol of the IMPACT study.

J Psychiatr Res 2018 01 1;96:265-272. Epub 2018 Jan 1.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada; Molecular Brain Science Research Department, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2017.09.002DOI Listing
January 2018

Pattern of gene expression in different stages of schizophrenia: Down-regulation of NPTX2 gene revealed by a meta-analysis of microarray datasets.

Eur Neuropsychopharmacol 2017 10 18;27(10):1054-1063. Epub 2017 Jul 18.

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S0924977X173042
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http://dx.doi.org/10.1016/j.euroneuro.2017.07.002DOI Listing
October 2017

A comprehensive analysis of mitochondrial genes variants and their association with antipsychotic-induced weight gain.

Schizophr Res 2017 09 8;187:67-73. Epub 2017 Jul 8.

Neurogenetics Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.schres.2017.06.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660917PMC
September 2017

Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia.

World J Biol Psychiatry 2019 01 10;20(1):91-95. Epub 2017 Apr 10.

a Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/15622975.2017.1301681DOI Listing
January 2019

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Authors:
Christian R Marshall Daniel P Howrigan Daniele Merico Bhooma Thiruvahindrapuram Wenting Wu Douglas S Greer Danny Antaki Aniket Shetty Peter A Holmans Dalila Pinto Madhusudan Gujral William M Brandler Dheeraj Malhotra Zhouzhi Wang Karin V Fuentes Fajarado Michelle S Maile Stephan Ripke Ingrid Agartz Margot Albus Madeline Alexander Farooq Amin Joshua Atkins Silviu A Bacanu Richard A Belliveau Sarah E Bergen Marcelo Bertalan Elizabeth Bevilacqua Tim B Bigdeli Donald W Black Richard Bruggeman Nancy G Buccola Randy L Buckner Brendan Bulik-Sullivan William Byerley Wiepke Cahn Guiqing Cai Murray J Cairns Dominique Campion Rita M Cantor Vaughan J Carr Noa Carrera Stanley V Catts Kimberley D Chambert Wei Cheng C Robert Cloninger David Cohen Paul Cormican Nick Craddock Benedicto Crespo-Facorro James J Crowley David Curtis Michael Davidson Kenneth L Davis Franziska Degenhardt Jurgen Del Favero Lynn E DeLisi Dimitris Dikeos Timothy Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Peter Eichhammer Johan Eriksson Valentina Escott-Price Laurent Essioux Ayman H Fanous Kai-How Farh Martilias S Farrell Josef Frank Lude Franke Robert Freedman Nelson B Freimer Joseph I Friedman Andreas J Forstner Menachem Fromer Giulio Genovese Lyudmila Georgieva Elliot S Gershon Ina Giegling Paola Giusti-Rodríguez Stephanie Godard Jacqueline I Goldstein Jacob Gratten Lieuwe de Haan Marian L Hamshere Mark Hansen Thomas Hansen Vahram Haroutunian Annette M Hartmann Frans A Henskens Stefan Herms Joel N Hirschhorn Per Hoffmann Andrea Hofman Hailiang Huang Masashi Ikeda Inge Joa Anna K Kähler René S Kahn Luba Kalaydjieva Juha Karjalainen David Kavanagh Matthew C Keller Brian J Kelly James L Kennedy Yunjung Kim James A Knowles Bettina Konte Claudine Laurent Phil Lee S Hong Lee Sophie E Legge Bernard Lerer Deborah L Levy Kung-Yee Liang Jeffrey Lieberman Jouko Lönnqvist Carmel M Loughland Patrik K E Magnusson Brion S Maher Wolfgang Maier Jacques Mallet Manuel Mattheisen Morten Mattingsdal Robert W McCarley Colm McDonald Andrew M McIntosh Sandra Meier Carin J Meijer Ingrid Melle Raquelle I Mesholam-Gately Andres Metspalu Patricia T Michie Lili Milani Vihra Milanova Younes Mokrab Derek W Morris Bertram Müller-Myhsok Kieran C Murphy Robin M Murray Inez Myin-Germeys Igor Nenadic Deborah A Nertney Gerald Nestadt Kristin K Nicodemus Laura Nisenbaum Annelie Nordin Eadbhard O'Callaghan Colm O'Dushlaine Sang-Yun Oh Ann Olincy Line Olsen F Anthony O'Neill Jim Van Os Christos Pantelis George N Papadimitriou Elena Parkhomenko Michele T Pato Tiina Paunio Diana O Perkins Tune H Pers Olli Pietiläinen Jonathan Pimm Andrew J Pocklington John Powell Alkes Price Ann E Pulver Shaun M Purcell Digby Quested Henrik B Rasmussen Abraham Reichenberg Mark A Reimers Alexander L Richards Joshua L Roffman Panos Roussos Douglas M Ruderfer Veikko Salomaa Alan R Sanders Adam Savitz Ulrich Schall Thomas G Schulze Sibylle G Schwab Edward M Scolnick Rodney J Scott Larry J Seidman Jianxin Shi Jeremy M Silverman Jordan W Smoller Erik Söderman Chris C A Spencer Eli A Stahl Eric Strengman Jana Strohmaier T Scott Stroup Jaana Suvisaari Dragan M Svrakic Jin P Szatkiewicz Srinivas Thirumalai Paul A Tooney Juha Veijola Peter M Visscher John Waddington Dermot Walsh Bradley T Webb Mark Weiser Dieter B Wildenauer Nigel M Williams Stephanie Williams Stephanie H Witt Aaron R Wolen Brandon K Wormley Naomi R Wray Jing Qin Wu Clement C Zai Rolf Adolfsson Ole A Andreassen Douglas H R Blackwood Elvira Bramon Joseph D Buxbaum Sven Cichon David A Collier Aiden Corvin Mark J Daly Ariel Darvasi Enrico Domenici Tõnu Esko Pablo V Gejman Michael Gill Hugh Gurling Christina M Hultman Nakao Iwata Assen V Jablensky Erik G Jönsson Kenneth S Kendler George Kirov Jo Knight Douglas F Levinson Qingqin S Li Steven A McCarroll Andrew McQuillin Jennifer L Moran Bryan J Mowry Markus M Nöthen Roel A Ophoff Michael J Owen Aarno Palotie Carlos N Pato Tracey L Petryshen Danielle Posthuma Marcella Rietschel Brien P Riley Dan Rujescu Pamela Sklar David St Clair James T R Walters Thomas Werge Patrick F Sullivan Michael C O'Donovan Stephen W Scherer Benjamin M Neale Jonathan Sebat

Nat Genet 2017 01 21;49(1):27-35. Epub 2016 Nov 21.

Beyster Center for Psychiatric Genomics, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ng.3725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737772PMC
January 2017

Association study between the neurexin-1 gene and tardive dyskinesia.

Hum Psychopharmacol 2017 01;32(1)

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/hup.2568DOI Listing
January 2017

Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015.

Psychiatr Genet 2016 12;26(6):229-257

aNeurogenetics Section bCampbell Family Mental Health Research Institute cClinical Genetics Research Program dKrembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health eDepartment of Psychiatry fInstitute of Medical Science gDepartment of Psychology, University of Toronto hFrederick W. Thompson Anxiety Disorders Centre, Department of Psychiatry, Sunnybrook Health Sciences Centre iThe Dalglish Family 22q Clinic jUniversity Health Network kThe Centre for Applied Genomics, Genetics and Genome Biology, The Hospital for Sick Children, Toronto lMolecular Genetics Unit mBiomedical Sciences Division, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada nMax Planck Institute of Psychiatry oInstitute of Psychiatric Phenomics and Genomics, University of Munich, Munich pDepartment of Translational Research in Psychiatry, Institute of Computational Biology, Helmholtz Zentrum München qDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg rCharité Universitätsmedizin Berlin, Berlin, Germany sDepartment of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary tSchool of Social Work uDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan vStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, New York wDepartment of Psychiatry, University of Iowa, Iowa City, Iowa xVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia yDepartment of Chemistry and Biochemistry zDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA †Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands ‡Institute and Department of Psychiatry, University of São Paulo Medical School, São Paulo §Department of Genetics, Instituto de Biociências ¶ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil ∥Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden #Department of Psychiatry, University of Calabar Teaching Hospital, Calabar, Nigeria **Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland ††Department of Psychiatry, Hakkari State Hospital, Turkey ‡‡Department of Genetics, University of Delhi, South Campus, New Delhi §§Molecular Genetics Lab, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India ¶¶Genetics Unit, IRCCS Centro S. Giovanni di Dio, Fatebenefratelli, Brescia, Italy ∥∥Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia ##Clinic for Psychiatry, Clinical Center of Serbia, Belgrade, Serbia ***Molecular Psychiatric Laboratory, Division of Psychiatry, University College London, London, UK †††Department of Clinical Medicine, Aarhus University, Aarhus ‡‡‡Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark §§§Human Genetics Lab, Department of Genetics ¶¶¶Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa ∥∥∥Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece ###Nagoya University, Nagoya, Japan ****School of Psychology, Shaanxi Normal University, Xi'an, China ††††School of Psychology, National University of Ireland, Galway, Ireland.

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http://dx.doi.org/10.1097/YPG.0000000000000148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134913PMC
December 2016

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic Studies.

Curr Neuropharmacol 2015 ;13(6):802-14

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8 Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759319PMC
http://dx.doi.org/10.2174/1570159x13666150612225836DOI Listing
September 2016

Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response.

Pharmacogenomics 2016 15;17(2):103-9. Epub 2015 Dec 15.

250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.

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http://dx.doi.org/10.2217/pgs.15.155DOI Listing
September 2016

Pharmacogenetics of tardive dyskinesia: an updated review of the literature.

Pharmacogenomics 2016 08 29;17(12):1339-51. Epub 2016 Jul 29.

Centre for Addiction & Mental Health, Campbell Family Mental Health Research Institute, Toronto, Canada.

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http://dx.doi.org/10.2217/pgs.16.26DOI Listing
August 2016

Increased Nigral SLC6A3 Activity in Schizophrenia Patients: Findings From the Toronto-McLean Cohorts.

Schizophr Bull 2016 May 26;42(3):772-81. Epub 2015 Dec 26.

Laboratory of Psychiatric Neurogenomics, McLean Hospital, Belmont, MA; Department of Psychiatry, Harvard Medical School, Boston, MA;

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http://dx.doi.org/10.1093/schbul/sbv191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838105PMC
May 2016

Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis.

Int J Neuropsychopharmacol 2016 05 29;19(5). Epub 2016 Apr 29.

Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada (Mr Huang, Dr Zai, Ms Lisoway, Dr Maciukiewicz, Mr Felsky, Dr Tiwari, Dr Müller, and Dr Kennedy); Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN (Dr Bishop); Department of Psychiatry, Fujita Health University, Toyoake, Aichi, Japan (Dr Ikeda); Departamento de Psiquiatria, Clinica Universidad de Navarra, Pamplona, Spain (Drs Molero and Ortuno); Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy (Dr Porcelli); Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland (Dr Samochowiec); Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, Poland (Dr Mierzejewski); Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, China (Dr Gao); Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla- IDIVAL, School of Medicine, University of Cantabria, Santander, Spain (Dr Pelayo-Terán); Institute of Genomics and Integrative Biology, Delhi, India (Drs Kaur and Kukreti); Feinberg School of Medicine, Northwestern University, Chicago, IL (Dr Meltzer); Department of Psychiatry, Columbia University Medical Center, New York, NY (Dr Lieberman); Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA (Dr Potkin).

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http://dx.doi.org/10.1093/ijnp/pyv132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886669PMC
May 2016

Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.

World J Biol Psychiatry 2016 04 8;17(3):221-9. Epub 2015 Oct 8.

a Pharmacogenetics Research Clinic, Neurogenetics Section , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada .

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http://dx.doi.org/10.3109/15622975.2015.1076173DOI Listing
April 2016

Possible association between the prolactin receptor gene and callous-unemotional traits among aggressive children.

Psychiatr Genet 2016 Feb;26(1):48-51

aNeurogenetics Section bChild Psychiatry Section, Child, Youth, and Family Program, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/YPG.0000000000000108DOI Listing
February 2016

Corrigendum to "Age at onset of schizophrenia: Cannabis, COMT gene, and their interactions" [Volume 151, Issues 1-3, December 2013, Pages 289-290].

Schizophr Res 2015 Dec 14;169(1-3):507. Epub 2015 Nov 14.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2015.09.031DOI Listing
December 2015

Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.

World J Biol Psychiatry 2016 04 8;17(3):221-9. Epub 2015 Oct 8.

a Pharmacogenetics Research Clinic, Neurogenetics Section , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada .

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http://dx.doi.org/10.3109/15622975.2015.1076173DOI Listing
April 2016

Association study of GABAA α2 receptor subunit gene variants in antipsychotic-associated weight gain.

J Clin Psychopharmacol 2015 Feb;35(1):7-12

From the *Neurogenetics Section, Centre for Addiction and Mental Health; †Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; ‡Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany; §Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, Lieber Center for Schizophrenia Research, New York Presbyterian Hospital & Columbia University Medical Center, New York, NY; and ║Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.

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February 2015

Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder.

Psychiatr Genet 2015 Apr;25(2):95-6

aNeurogenetics Section, Centre for Addiction and Mental Health bDepartment of Psychiatry and Institute of Medical Science, University of Toronto cDepartment of Psychiatry and Program in Genetics and Genome Biology, Hospital for Sick Children dFrederick W. Thompson Anxiety Disorders Centre and Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/YPG.0000000000000077DOI Listing
April 2015

The role of genetic variants in genes regulating the oxytocin-vasopressin neurohumoral system in childhood-onset aggression.

Psychiatr Genet 2014 Oct;24(5):201-10

aDepartment of Psychiatry bInstitute of Medical Science, University of Toronto cChild, Youth and Family Program dNeurogenetics, Centre for Addiction and Mental Health, Toronto eUniversity of Western Ontario (UWO), London, Ontario, Canada.

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October 2014

Association study of GABAA α2 receptor subunit gene variants in antipsychotic-associated weight gain.

J Clin Psychopharmacol 2015 Feb;35(1):7-12

From the *Neurogenetics Section, Centre for Addiction and Mental Health; †Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; ‡Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany; §Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, Lieber Center for Schizophrenia Research, New York Presbyterian Hospital & Columbia University Medical Center, New York, NY; and ║Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1097/JCP.0000000000000261DOI Listing
February 2015

Fat mass- and obesity-associated (FTO) gene and antipsychotic-induced weight gain: an association study.

Neuropsychobiology 2014 30;69(1):59-63. Epub 2014 Jan 30.

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000356231DOI Listing
January 2015

The role of genetic variants in genes regulating the oxytocin-vasopressin neurohumoral system in childhood-onset aggression.

Psychiatr Genet 2014 Oct;24(5):201-10

aDepartment of Psychiatry bInstitute of Medical Science, University of Toronto cChild, Youth and Family Program dNeurogenetics, Centre for Addiction and Mental Health, Toronto eUniversity of Western Ontario (UWO), London, Ontario, Canada.

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http://dx.doi.org/10.1097/YPG.0000000000000044DOI Listing
October 2014

No evidence for a role of the peroxisome proliferator-activated receptor gamma (PPARG) and adiponectin (ADIPOQ) genes in antipsychotic-induced weight gain.

Psychiatry Res 2014 Oct 28;219(2):255-60. Epub 2014 May 28.

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2014.05.031DOI Listing
October 2014

A hypothesis-driven association study of 28 nuclear-encoded mitochondrial genes with antipsychotic-induced weight gain in schizophrenia.

Neuropsychopharmacology 2014 May 7;39(6):1347-54. Epub 2013 Nov 7.

1] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [2] Neuroscience Section, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/npp.2013.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988538PMC
May 2014

Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain.

Pharmacogenomics 2014 Mar;15(4):423-31

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health, Toronto, ON, Canada.

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https://www.futuremedicine.com/doi/10.2217/pgs.13.247
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March 2014

Age at onset of schizophrenia: cannabis, COMT gene, and their interactions.

Schizophr Res 2013 Dec 20;151(1-3):289-90. Epub 2013 Nov 20.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.schres.2013.10.037DOI Listing
December 2013

Analysis of 34 candidate genes in bupropion and placebo remission.

Int J Neuropsychopharmacol 2013 May 4;16(4):771-81. Epub 2012 Sep 4.

Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1017/S1461145712000843DOI Listing
May 2013

Abnormal interneuron development in disrupted-in-schizophrenia-1 L100P mutant mice.

Mol Brain 2013 Apr 30;6:20. Epub 2013 Apr 30.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1186/1756-6606-6-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648430PMC
April 2013

The pharmacogenetics of antipsychotic-induced adverse events.

Curr Opin Psychiatry 2013 Mar;26(2):144-50

Pharmacogenetics Research Clinic, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/YCO.0b013e32835dc9daDOI Listing
March 2013

Possible genetic association between vasopressin receptor 1B and child aggression.

Psychiatry Res 2012 Dec 19;200(2-3):784-8. Epub 2012 Aug 19.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.psychres.2012.07.031DOI Listing
December 2012

Association of a functional polymorphism in neuropeptide Y with antipsychotic-induced weight gain in schizophrenia patients.

J Clin Psychopharmacol 2013 Feb;33(1):11-7

Neurogenetics Section, Neuroscience Department, Centre forAddiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0b013e31827d145aDOI Listing
February 2013

Study of the catechol-o-methyltransferase (COMT) gene with high aggression in children.

Aggress Behav 2013 Jan 12;39(1):45-51. Epub 2012 Sep 12.

Department of Psychiatry, Neurogenetics Section, Centre for Addiction and Mental Health, University of Toronto, ON, Canada.

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http://dx.doi.org/10.1002/ab.21448DOI Listing
January 2013

Role of 5-HT(2C) receptor gene variants in antipsychotic-induced weight gain.

Pharmgenomics Pers Med 2011 18;4:83-93. Epub 2011 Aug 18.

Neurogenetics Section, Center for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.2147/PGPM.S11866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513221PMC
December 2012

Possible genetic association between vasopressin receptor 1B and child aggression.

Psychiatry Res 2012 Dec 19;200(2-3):784-8. Epub 2012 Aug 19.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.psychres.2012.07.031DOI Listing
December 2012

The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.

Prog Neuropsychopharmacol Biol Psychiatry 2012 Oct 27;39(1):96-101. Epub 2012 May 27.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2012.05.014DOI Listing
October 2012

Antipsychotics, dopamine D₂ receptor occupancy and clinical improvement in schizophrenia: a meta-analysis.

Schizophr Res 2012 Sep 12;140(1-3):214-20. Epub 2012 Jul 12.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.schres.2012.06.027DOI Listing
September 2012

The AmpliChip® CYP450 test and response to treatment in schizophrenia and obsessive compulsive disorder: a pilot study and focus on cases with abnormal CYP2D6 drug metabolism.

Genet Test Mol Biomarkers 2012 Aug 9;16(8):897-903. Epub 2012 Jul 9.

Pharmacogenetics Research Clinic, Neurogenetics Section, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1089/gtmb.2011.0327DOI Listing
August 2012

Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies.

Hum Psychopharmacol 2012 Jul 22;27(4):345-51. Epub 2012 Jun 22.

Neurogenetics Section, Center for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/hup.2233DOI Listing
July 2012

Possible association of the DRD4 gene with a history of attention-deficit/hyperactivity disorder in women with bulimia nervosa.

Int J Eat Disord 2012 May 24;45(4):622-5. Epub 2012 Jan 24.

Institute of Medical Science, University of Toronto, Toronto, Canada.

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http://doi.wiley.com/10.1002/eat.20986
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May 2012

Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: replication and exploration.

Prog Neuropsychopharmacol Biol Psychiatry 2012 Apr 8;37(1):62-75. Epub 2011 Dec 8.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2011.11.018DOI Listing
April 2012

Childhood aggression, callous-unemotional traits and oxytocin genes.

Eur Child Adolesc Psychiatry 2012 Mar 1;21(3):125-32. Epub 2012 Feb 1.

Child, Youth and Family Program, Centre for Addiction and Mental Health, 250 College Street, Room 125, Toronto, Canada.

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http://dx.doi.org/10.1007/s00787-012-0240-6DOI Listing
March 2012

Dopaminergic system genes in childhood aggression: possible role for DRD2.

World J Biol Psychiatry 2012 Jan 19;13(1):65-74. Epub 2011 Jan 19.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada.

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http://dx.doi.org/10.3109/15622975.2010.543431DOI Listing
January 2012

ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.

World J Biol Psychiatry 2011 Aug 18;12(5):392-7. Epub 2011 Jul 18.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada.

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http://dx.doi.org/10.3109/15622975.2011.564655DOI Listing
August 2011

COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa.

Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun 12;35(4):948-52. Epub 2011 Feb 12.

Institute of Medical Science, University of Toronto, 7213 Medical Science Building, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://linkinghub.elsevier.com/retrieve/pii/S027858461100021
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http://dx.doi.org/10.1016/j.pnpbp.2011.01.012DOI Listing
June 2011

Association between the DAOA/G72 gene and bipolar disorder and meta-analyses in bipolar disorder and schizophrenia.

Bipolar Disord 2011 Mar;13(2):198-207

Neurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 250 College Street, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1111/j.1399-5618.2011.00905.x
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http://dx.doi.org/10.1111/j.1399-5618.2011.00905.xDOI Listing
March 2011

Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients.

Prog Neuropsychopharmacol Biol Psychiatry 2010 Dec 20;34(8):1484-90. Epub 2010 Aug 20.

Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2010.08.009DOI Listing
December 2010

Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response.

Pharmacogenomics 2011 Feb;12(2):277-91

Neurogenetics Section, Centre for Addiction & Mental Health, 250 College Street, Toronto, Ontario, 5T1R8, Canada.

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http://dx.doi.org/10.2217/pgs.10.182DOI Listing
February 2011

Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients.

Prog Neuropsychopharmacol Biol Psychiatry 2010 Dec 20;34(8):1484-90. Epub 2010 Aug 20.

Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2010.08.009DOI Listing
December 2010

Genetics in schizophrenia: where are we and what next?

Dialogues Clin Neurosci 2010 ;12(3):289-303

Neurogenetics section, Neuroscience department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181975PMC
November 2010

Polymorphisms of the HTR2C gene and antipsychotic-induced weight gain: an update and meta-analysis.

Pharmacogenomics 2010 Nov;11(11):1561-71

Neurogenetics Section, Centre for Addiction & Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

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http://dx.doi.org/10.2217/pgs.10.123DOI Listing
November 2010

Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes.

Eur Neuropsychopharmacol 2010 Sep 8;20(9):663-70. Epub 2010 May 8.

Laboratory of Molecular Genetics, Department of Neurosciences B.B. Brodie, University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1016/j.euroneuro.2010.04.001DOI Listing
September 2010

Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes.

Prog Neuropsychopharmacol Biol Psychiatry 2010 Feb 22;34(1):50-6. Epub 2009 Sep 22.

Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8.

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http://dx.doi.org/10.1016/j.pnpbp.2009.09.020DOI Listing
February 2010

Association study of the gamma-aminobutyric acid type a receptor gamma2 subunit gene with schizophrenia.

Schizophr Res 2009 Oct 13;114(1-3):33-8. Epub 2009 Aug 13.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.schres.2009.07.010DOI Listing
October 2009

Association study of tardive dyskinesia and twelve DRD2 polymorphisms in schizophrenia patients.

Int J Neuropsychopharmacol 2007 Oct 7;10(5):639-51. Epub 2006 Sep 7.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1017/S1461145706007152DOI Listing
October 2007