Clemens-Martin Wendtner

Clemens-Martin Wendtner

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Clemens-Martin Wendtner

Publications by authors named "Clemens-Martin Wendtner"

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Refining chemotherapy for chronic lymphocytic leukaemia with targeted drugs.

Lancet Haematol 2019 Aug 14;6(8):e389-e390. Epub 2019 Jun 14.

Munich Clinic Schwabing, Academic Teaching Hospital, Ludwig-Maximilians University, Munich 80804, Germany; University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(19)30105-XDOI Listing
August 2019

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions.

N Engl J Med 2019 06 4;380(23):2225-2236. Epub 2019 Jun 4.

From Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne and University of Cologne (K.F., O.A.-S., J.B., A.-M.F., S. Robrecht, B.E., K.-A.K., M.H.), the Oncogeriatric Unit, Department of Geriatric Medicine, St. Marien Hospital (V.G.), CECAD (Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases) (M.H.), Center for Molecular Medicine Cologne (M.H.), Cologne, Department III of Internal Medicine, University Hospital Rostock, Rostock (S.B.), Department III of Internal Medicine, Ulm University, Ulm (E.T., S.S.), the Departments of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases, and Tropical Medicine, Klinikum Schwabing, Munich (C.-M.W.), Department II of Internal Medicine, Campus Kiel, University of Schleswig-Holstein, Kiel (M.R.), and the Department of Hematology, Oncology, and Rheumatology, Saarland University Medical School, Homburg (S.S.) - all in Germany; Roche Products, Welwyn Garden City, United Kingdom (M.T., M.D., S.W., K.H.); Regional Clinical Hospital N.A. Semashko, Nizhny Novgorod, Russia (O.S.); the Division of Onco-Hematology, Santa Maria Terni Hospital, University of Perugia, Perugia, Italy (A.M.L.); the Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (J.P.-I.); the Haematology Department, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (S.O.); First Internal Department, Multiprofile Hospital for Active Treatment Hristo Botev, Vratsa, Bulgaria (L.S.); the Hematology Department, Clinique Victor Hugo, Le Mans, France (K.L.D.); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (L.M.F.); the Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen (C.U.N.); Wellington Blood and Cancer Centre, Capital and Coast District Health Board, and Malaghan Institute of Medical Research, Wellington, New Zealand (R.W.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (S. Robinson); Moores Cancer Center, University of California San Diego, San Diego (T.J.K.), and Genentech, South San Francisco (M.M.) - both in California; AbbVie, North Chicago, IL (R.H.); and the Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, the Netherlands (A.W.L.).

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http://dx.doi.org/10.1056/NEJMoa1815281DOI Listing
June 2019

CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia.

Leukemia 2019 05 19;33(5):1161-1172. Epub 2018 Dec 19.

Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, CECAD Cluster of Excellence at the University of Cologne, Clinical Research Unit (KFO) 286, German CLL Study Group, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41375-018-0313-8DOI Listing
May 2019

Ibrutinib: the home run for cure in CLL?

Blood 2019 May;133(19):2003-2004

Ludwig-Maximilians University; University of Cologne.

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http://dx.doi.org/10.1182/blood-2019-03-901090DOI Listing
May 2019

Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial.

J Clin Oncol 2018 07 1;36(19):1973-1980. Epub 2018 May 1.

Stephan Stilgenbauer and Johannes Bloehdorn, Ulm University, Ulm; Stephan Stilgenbauer, Klinik für Innere Medizin I, Universitätsklinikum des Saarlandes, Homburg; Barbara Eichhorst and Michael Hallek, Universitätsklinikum Köln, Köln; Johannes Schetelig, University Hospital, Technische Universität Dresden, Dresden; Clemens-Martin Wendtner, Klinikum Schwabing, Munich; Sebastian Böttcher, University Hospital of Schleswig-Holstein, Kiel, Germany; Peter Hillmen and Talha Munir, St James's University Hospital, Leeds; Anna Schuh, University of Oxford; Anna Schuh, Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford, United Kingdom; John F. Seymour, Peter MacCallum Cancer Centre; John F. Seymour, University of Melbourne; Andrew W. Roberts, Royal Melbourne Hospital, Parkville, Victoria; Stephen P. Mulligan, Royal North Shore Hospital, St Leonards, New South Wales, Australia; Steven Coutre, Stanford University Medical Center, Stanford, CA; Wojciech Jurczak, Jagiellonian University, Kraków, Poland; Sarit Assouline, McGill University, Montreal, Quebec, Canada; Matthew S. Davids, Dana-Farber Cancer Institute, Boston, MA; Lang Zhou, Ahmed Hamed Salem, Monali Desai, Brenda Chyla, Jennifer Arzt, Su Young Kim, Maria Verdugo, and Gary Gordon, AbbVie, North Chicago, IL; Ahmed Hamed Salem, Ain Shams University, Cairo, Egypt; and William G. Wierda, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2017.76.6840DOI Listing
July 2018

Bendamustine plus rituximab in chronic lymphocytic leukemia: is there life in the old dog yet?

Haematologica 2018 04;103(4):563-564

University of Cologne and Klinikum Schwabing, Academic Teaching Hospital of the University of Munich, Germany.

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http://dx.doi.org/10.3324/haematol.2018.188862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865432PMC
April 2018

CLL2-BXX Phase II trials: sequential, targeted treatment for eradication of minimal residual disease in chronic lymphocytic leukemia.

Future Oncol 2018 Mar 21;14(6):499-513. Epub 2018 Feb 21.

Department I of Internal Medicine & Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.2217/fon-2017-0442DOI Listing
March 2018

Current perspectives on the role of chemotherapy in chronic lymphocytic leukemia.

Leuk Lymphoma 2018 02 1;59(2):300-310. Epub 2017 Jun 1.

b Division of Hematology , Luzerner Kantonsspital , Lucerne , Switzerland.

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http://dx.doi.org/10.1080/10428194.2017.1330474DOI Listing
February 2018

Alemtuzumab consolidation in chronic lymphocytic leukaemia: a phase I/II multicentre trial.

Eur J Haematol 2017 Mar 1;98(3):254-262. Epub 2016 Dec 1.

Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study group, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/ejh.12825DOI Listing
March 2017

FCR front-line therapy and quality of life in patients with chronic lymphocytic leukemia.

Leuk Lymphoma 2017 02 29;58(2):399-407. Epub 2016 Jun 29.

a Department I of Internal Medicine and Center of Integrated Oncology Cologne Bonn , University Hospital of Cologne , Cologne , Germany.

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http://dx.doi.org/10.1080/10428194.2016.1190966DOI Listing
February 2017

Minimal Residual Disease Assessment Improves Prediction of Outcome in Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Partial Response: Comprehensive Analysis of Two Phase III Studies of the German CLL Study Group.

J Clin Oncol 2016 11;34(31):3758-3765

Gabor Kovacs, Sandra Robrecht, Anna Maria Fink, Jasmin Bahlo, Paula Cramer, Julia von Tresckow, Christian Maurer, Petra Langerbeins, Kirsten Fischer, Michael Hallek, and Barbara Eichhorst, University of Cologne and Center of Integrated Oncology Cologne/Bonn, Cologne; Matthias Ritgen, Michael Kneba, and Sebastian Böttcher, University of Schleswig-Holstein, Lubeck; Hartmut Döhner and Stephan Stilgenbauer, University of Ulm, Ulm; Wolfram Klapper, University of Kiel, Kiel; Clemens-Martin Wendtner, Klinikum Schwabing, Munich, Germany; and Günter Fingerle-Rowson, F. Hoffmann La-Roche, Basel, Switzerland.

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http://dx.doi.org/10.1200/JCO.2016.67.1305DOI Listing
November 2016

Basophils go wild when mosquitoes bite CLL.

Leuk Lymphoma 2016 10 16;57(10):2243-4. Epub 2016 May 16.

b Department of Hematology, Hadassah University Hospital and Hebrew University Medical School , Jerusalem , Israel.

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http://www.tandfonline.com/doi/full/10.1080/10428194.2016.11
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http://dx.doi.org/10.1080/10428194.2016.1180691DOI Listing
October 2016

Chimeric antigen receptor T cells targeting Fc μ receptor selectively eliminate CLL cells while sparing healthy B cells.

Blood 2016 09 17;128(13):1711-22. Epub 2016 Aug 17.

Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany; Department I Internal Medicine, University Hospital Cologne, Cologne, Germany;

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http://dx.doi.org/10.1182/blood-2016-01-692046DOI Listing
September 2016

[Treatment of metastatic malignant melanoma].

Dtsch Med Wochenschr 2016 Jul 12;141(14):1000. Epub 2016 Jul 12.

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http://dx.doi.org/10.1055/s-0042-111018DOI Listing
July 2016

[Treatment of metastatic malignant melanoma].

Dtsch Med Wochenschr 2016 Jun 2;141(11):768-71. Epub 2016 Jun 2.

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http://dx.doi.org/10.1055/s-0042-107202DOI Listing
June 2016

What should standard frontline therapy be in older patients with chronic lymphocytic leukemia? Chemoimmunotherapy should be standard frontline therapy.

Clin Adv Hematol Oncol 2016 May;14(5):336-8

Klinikum Schwabing, Munich, Germany.

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May 2016

The CLL12 trial protocol: a placebo-controlled double-blind Phase III study of ibrutinib in the treatment of early-stage chronic lymphocytic leukemia patients with risk of early disease progression.

Future Oncol 2015 ;11(13):1895-903

Department I of Internal Medicine, Center of Integrated Oncology (CIO), & CECAD - Cluster of Excellence 'Cellular Stress Responses in Aging-Associated Diseases,' University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.2217/fon.15.95DOI Listing
April 2016

Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial.

Blood 2016 Jan 20;127(2):208-15. Epub 2015 Oct 20.

Department I for Internal Medicine and Center of Integrated Oncology, University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-06-651125DOI Listing
January 2016

Subtotal spleen necrosis.

Am J Hematol 2015 Dec;90(12):1189

Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, Klinikum Schwabing, Academic Teaching Hospital of the University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/ajh.24206DOI Listing
December 2015

Past, present and future role of chlorambucil in the treatment of chronic lymphocytic leukemia.

Leuk Lymphoma 2015 Jun 20;56(6):1585-92. Epub 2014 Nov 20.

German CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne , Cologne , Germany.

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http://www.tandfonline.com/doi/full/10.3109/10428194.2014.96
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http://dx.doi.org/10.3109/10428194.2014.963077DOI Listing
June 2015

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

Blood 2015 May 10;125(19):2948-57. Epub 2015 Feb 10.

Department I of Internal Medicine and Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany;

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-07-58
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http://dx.doi.org/10.1182/blood-2014-07-586511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654424PMC
May 2015

[Chronic lymphatic leukemia].

Dtsch Med Wochenschr 2015 Apr 31;140(7):479-82. Epub 2015 Mar 31.

Klinikum Schwabing, Klinik für Hämatologie, Onkologie, Immunologie, Palliativmedizin, Infektiologie und Tropenmedizin, München.

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http://dx.doi.org/10.1055/s-0041-101160DOI Listing
April 2015

Poor efficacy and tolerability of R-CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformation.

Am J Hematol 2014 Dec 26;89(12):E239-43. Epub 2014 Sep 26.

Department I of Internal Medicine, Center of Integrated Oncology (CIO), and CECAD-Cluster of Excellence "Cellular Stress Responses in Aging-Associated Diseases," University of Cologne, Germany.

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http://dx.doi.org/10.1002/ajh.23841DOI Listing
December 2014

Meningeal spread of blastic plasmacytoid dendritic cell neoplasm.

Eur J Haematol 2014 Aug 26;93(2):175-6. Epub 2014 Feb 26.

Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, Klinikum Schwabing, Academic Teaching Hospital of University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/ejh.12280DOI Listing
August 2014

Performance and clinical validation of the RealStar MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA.

J Clin Virol 2014 Jun 28;60(2):168-71. Epub 2014 Mar 28.

Institute of Virology, University of Bonn Medical Centre, 53127 Bonn, Germany.

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http://dx.doi.org/10.1016/j.jcv.2014.03.012DOI Listing
June 2014

Otlertuzumab more than a TRU(E) toddler in CLL?

Blood 2014 Feb;123(9):1282-4

KLINIKUM SCHWABING;

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http://dx.doi.org/10.1182/blood-2014-01-548560DOI Listing
February 2014

Use of eculizumab in refractory gemcitabine-induced thrombotic microangiopathy.

Br J Haematol 2013 Dec 4. Epub 2013 Dec 4.

Department of Haematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, Klinikum Schwabing, Academic Teaching Hospital of the University of Munich, Munich, Germany.

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http://dx.doi.org/10.1111/bjh.12686DOI Listing
December 2013

There is life in the old dog yet: thymidine kinase as predictive marker in diffuse large B-cell lymphoma.

Leuk Lymphoma 2013 Nov 16;54(11):2343-4. Epub 2013 Jul 16.

Department of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, Klinikum Schwabing, Academic Teaching Hospital of University of Munich , Munich , Germany.

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http://dx.doi.org/10.3109/10428194.2013.807513DOI Listing
November 2013

Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization.

Ann Hematol 2013 Jun 15;92(6):747-58. Epub 2013 Feb 15.

Department of Hematology, Oncology and Tumor Immunology, Charité University Hospital Berlin, Hindenburgdamm 30, 12203, Campus Benjamin Franklin, Berlin, Germany.

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http://dx.doi.org/10.1007/s00277-013-1694-4DOI Listing
June 2013

Rare case of a dislocated spleen in a patient with B-cell lymphoma.

J Clin Oncol 2013 Apr 18;31(12):e206-7. Epub 2013 Mar 18.

Department of Hematology, Klinikum Schwabing, Koelner Platz 1, 80804 Munich, Germany.

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http://ascopubs.org/doi/10.1200/JCO.2012.44.4877
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http://dx.doi.org/10.1200/JCO.2012.44.4877DOI Listing
April 2013

Comparison of the effects of two kinase inhibitors, sorafenib and dasatinib, on chronic lymphocytic leukemia cells.

Onkologie 2012 6;35(7-8):420-6. Epub 2012 Jul 6.

Department I of Internal Medicine, Center of Integrated Oncology Cologne Bonn, Germany.

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http://dx.doi.org/10.1159/000341081DOI Listing
January 2013

Targeted therapy of soft tissue sarcomas.

Onkologie 2012 20;35 Suppl 1:21-7. Epub 2012 Jan 20.

Institute of Pathology, University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1159/000334958DOI Listing
May 2012

Intensive chemotherapy without stem cell transplant for indolent lymphomas.

Leuk Lymphoma 2011 Nov 18;52(11):2039-40. Epub 2011 Aug 18.

University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.3109/10428194.2011.606385DOI Listing
November 2011

Malignant peripheral nerve sheath tumor of the scalp: case report and review of the literature.

Dermatol Surg 2011 Nov 26;37(11):1684-8. Epub 2011 Jul 26.

Department of Dermatology and Allergology, Center of Integrated Oncology (CIO) Cologne Bonn, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/j.1524-4725.2011.02113.xDOI Listing
November 2011

Critical role of microRNAs in chronic lymphocytic leukemia: overexpression of the oncogene PLAG1 by deregulated miRNAs.

Leuk Lymphoma 2010 Aug;51(8):1379-81

Department I of Internal Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.3109/10428194.2010.496016DOI Listing
August 2010

First-line treatment of chronic lymphocytic leukemia: role of alemtuzumab.

Onco Targets Ther 2010 Jun 24;3:53-67. Epub 2010 Jun 24.

Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895774PMC
June 2010

Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade.

Leuk Res 2009 Mar 5;33(3):460-4. Epub 2008 Oct 5.

Laboratory of Cellular Immunotherapy, Clinic I of Internal Medicine, University of Cologne, Germany.

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http://dx.doi.org/10.1016/j.leukres.2008.08.021DOI Listing
March 2009

Overexpression of the Fas-inhibitory molecule TOSO: a novel antiapoptotic factor in chronic lymphocytic leukemia.

Leuk Lymphoma 2009 Mar;50(3):498-501

Laboratory of Cellular Immunotherapy, Clinic I of Internal Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1080/10428190902763491DOI Listing
March 2009

Use of alemtuzumab and rituximab consolidation in CLL: Pros and cons.

Curr Hematol Malig Rep 2009 Jan;4(1):43-6

Department I of Internal Medicine, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.

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http://dx.doi.org/10.1007/s11899-009-0006-5DOI Listing
January 2009

Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease.

Blood 2008 Nov 15;112(10):4213-9. Epub 2008 Aug 15.

Laboratory of Cellular Immunotherapy, Clinic I of Internal Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2008-05-157255DOI Listing
November 2008

Eradication of minimal residual disease in chronic lymphocytic leukemia.

Curr Hematol Malig Rep 2008 Jan;3(1):54-60

Department of Internal Medicine I, University of Cologne, Köln, Germany.

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http://dx.doi.org/10.1007/s11899-008-0009-7DOI Listing
January 2008

CD23 is recognized as tumor-associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes.

Exp Hematol 2007 Jun;35(6):920-30

KKG Gene Therapy, GSF-National Research Center for Environment and Health, Munich, Germany.

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http://dx.doi.org/10.1016/j.exphem.2007.03.001DOI Listing
June 2007

Human Ly9 (CD229) as novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (B-CLL) recognized by autologous CD8+ T cells.

Exp Hematol 2006 Jul;34(7):860-9

KKG Gene Therapy, GSF-National Research Center for Environment and Health, Munich, Germany.

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http://dx.doi.org/10.1016/j.exphem.2006.04.010DOI Listing
July 2006

Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.

Blood 2006 Jan 22;107(2):742-51. Epub 2005 Sep 22.

Gesellschaft für Strahlenforschung (GSF)-National Research Center for Environment and Health, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2005-05-2093DOI Listing
January 2006

MDM2 is recognized as a tumor-associated antigen in chronic lymphocytic leukemia by CD8+ autologous T lymphocytes.

Exp Hematol 2006 Jan;34(1):44-53

KKG Gene Therapy, GSF-National Research Center for Environment and Health, Munich, Germany.

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http://dx.doi.org/10.1016/j.exphem.2005.09.016DOI Listing
January 2006

Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells.

Blood 2005 Nov 12;106(9):3223-6. Epub 2005 Jul 12.

KKG Gene Therapy, GSF-National Research Center for Environment and Health, Munich, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-04-17
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http://dx.doi.org/10.1182/blood-2005-04-1742DOI Listing
November 2005

High level of transgene expression in primary chronic lymphocytic leukemia cells using helper-virus-free recombinant Epstein-Barr virus vectors.

Exp Hematol 2003 Feb;31(2):99-108

Medical Clinic III, University Hospital Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, D-81377 Munich, Germany.

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February 2003