Publications by authors named "Clemens Scheufler"

20Publications

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.

Bioorg Med Chem Lett 2017 12 20;27(23):5221-5224. Epub 2017 Oct 20.

Global Discovery Chemistry/Oncology & Exploratory Chemistry, Novartis Institutes for Biomedical Research, 5300 Chiron Way, Emeryville, CA 94608, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.10.047DOI Listing
December 2017

Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.

Bioorg Med Chem Lett 2016 Apr 26;26(8):2065-7. Epub 2016 Feb 26.

Novartis Institutes for Biomedical Research, Basel, Postfach, 4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2016.02.074DOI Listing
April 2016

Applications of Biophysics in High-Throughput Screening Hit Validation.

J Biomol Screen 2014 Jun 2;19(5):707-14. Epub 2014 Apr 2.

Novartis Pharma AG, Novartis Institutes for Biomedical Research Center for Proteomic Chemistry, Basel Screening Platform, Basel, Switzerland Screening Sciences Group, Basel, Switzerland.

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http://dx.doi.org/10.1177/1087057114529462DOI Listing
June 2014

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.

Bioorg Med Chem Lett 2010 Aug 11;20(15):4719-23. Epub 2010 Apr 11.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2010.04.023DOI Listing
August 2010

Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.

Bioorg Med Chem Lett 2010 Feb 3;20(3):1293-7. Epub 2009 Nov 3.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.138DOI Listing
February 2010

Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

Bioorg Med Chem Lett 2008 Dec 11;18(23):6142-6. Epub 2008 Oct 11.

Novartis Institutes for BioMedical Research, global Discovery Chemistry, WSJ-88.508, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2008.10.039DOI Listing
December 2008

Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes.

J Biol Chem 2002 May 4;277(22):19265-75. Epub 2002 Mar 4.

Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1074/jbc.M109002200DOI Listing
May 2002