Publications by authors named "Clemens Ruppert"

66Publications

Mechanical ventilation-induced alterations of intracellular surfactant pool and blood-gas barrier in healthy and pre-injured lungs.

Histochem Cell Biol 2020 Nov 13. Epub 2020 Nov 13.

Institute of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00418-020-01938-xDOI Listing
November 2020

Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension.

Am J Respir Cell Mol Biol 2020 Oct 14. Epub 2020 Oct 14.

Justus Liebig University Giessen Faculty of Medicine, 60633, Pulmonary Pharmacotherapy, Giessen, Germany;

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http://dx.doi.org/10.1165/rcmb.2019-0431OCDOI Listing
October 2020

Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-β1 from ECM stores.

Matrix Biol 2020 06 11;88:69-88. Epub 2019 Dec 11.

Departments of Biochemistry and Internal Medicine, Universities of Giessen and Marburg Lung Center, Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2019.12.001DOI Listing
June 2020

WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.

Proc Natl Acad Sci U S A 2019 12 27;116(51):25697-25706. Epub 2019 Nov 27.

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany;

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http://dx.doi.org/10.1073/pnas.1911071116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926051PMC
December 2019

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.

Proc Natl Acad Sci U S A 2019 06 11;116(26):13016-13025. Epub 2019 Jun 11.

School of Cardiovascular Medicine & Sciences, British Heart Foundation Centre of Excellence, King's College London, London, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1904064116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601250PMC
June 2019

Data Discovery for Integration of Heterogeneous Medical Datasets in the German Center for Lung Research (DZL).

Stud Health Technol Inform 2018 ;253:65-69

Universities Gießen and Marburg Lung Center (UGMLC).

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November 2018

Is the fibroblast growth factor signaling pathway a victim of receptor tyrosine kinase inhibition in pulmonary parenchymal and vascular remodeling?

Am J Physiol Lung Cell Mol Physiol 2018 08 3;315(2):L248-L252. Epub 2018 May 3.

Justus-Liebig University Giessen, Excellence Cluster Cardio-Pulmonary System, Universities of Giessen and Marburg Lung Center, German Center for Lung Research , Giessen , Germany.

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https://www.physiology.org/doi/10.1152/ajplung.00140.2018
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http://dx.doi.org/10.1152/ajplung.00140.2018DOI Listing
August 2018

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis.

EMBO Mol Med 2018 02;10(2):276-293

Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Bad Nauheim, Germany

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http://dx.doi.org/10.15252/emmm.201606261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801513PMC
February 2018

Surfactant replacement therapy reduces acute lung injury and collapse induration-related lung remodeling in the bleomycin model.

Am J Physiol Lung Cell Mol Physiol 2017 08 27;313(2):L313-L327. Epub 2017 Apr 27.

Institute of Functional and Applied Anatomy, Hannover Medical School, Germany and Biomedical Research in Endstage and Obstructive Lung Disease Hannover, Member of the German Center for Lung Research, Hannover, Germany.

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http://dx.doi.org/10.1152/ajplung.00033.2017DOI Listing
August 2017

Tissue remodelling in pulmonary fibrosis.

Cell Tissue Res 2017 03 16;367(3):607-626. Epub 2016 Dec 16.

Institute of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg Strasse 1, 30625, Hannover, Germany.

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http://dx.doi.org/10.1007/s00441-016-2543-2DOI Listing
March 2017

Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis.

J Pathol Clin Res 2015 Oct 3;1(4):252-63. Epub 2015 Jun 3.

Department of Internal MedicineJustus-Liebig-UniversityGiessenGermany; Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL)GiessenGermany; Member of the European IPF Network; Lung Clinic Waldhof-ElgershausenGreifensteinGermany.

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http://dx.doi.org/10.1002/cjp2.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939895PMC
October 2015

MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro.

Am J Physiol Lung Cell Mol Physiol 2016 Mar 30;310(6):L519-31. Epub 2015 Dec 30.

Department of Internal Medicine, Justus-Liebig University, Giessen, Germany; Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Centre for Lung Research (DZL), Giessen, Germany;

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http://dx.doi.org/10.1152/ajplung.00213.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888554PMC
March 2016

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis.

Thorax 2015 Nov 10;70(11):1022-32. Epub 2015 Sep 10.

Department of Internal Medicine, Justus-Liebig-University Giessen, Giessen, Germany Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL) Excellence Cluster Cardio-Pulmonary System (ECCPS), Giessen, Germany Agaplesion Lung Clinic Waldhof Elgershausen, Greifenstein, Germany European IPF Network and European IPF Registry.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206411DOI Listing
November 2015

Regulation of immunoproteasome function in the lung.

Sci Rep 2015 May 19;5:10230. Epub 2015 May 19.

Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.

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http://dx.doi.org/10.1038/srep10230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437306PMC
May 2015

Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model.

Am J Physiol Lung Cell Mol Physiol 2015 Jul 8;309(1):L63-75. Epub 2015 May 8.

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany; Member of the German Center for Lung Research (DZL), Germany;

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http://dx.doi.org/10.1152/ajplung.00279.2014DOI Listing
July 2015

Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.

Proc Natl Acad Sci U S A 2015 Apr 6;112(16):E2048-57. Epub 2015 Apr 6.

Institute for Anatomy and Cell Biology, Medical Cell Biology, Justus Liebig University, Giessen 35392, Germany;

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http://dx.doi.org/10.1073/pnas.1415111112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413321PMC
April 2015

Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.

Toxicol Sci 2014 Nov 27;142(1):285-97. Epub 2014 Aug 27.

Department of Internal Medicine, Justus-Liebig-University Giessen, Germany Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany Member of the European IPF Network Lung Clinic Waldhof-Elgershausen, Greifenstein, Germany.

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http://dx.doi.org/10.1093/toxsci/kfu177DOI Listing
November 2014

Biophysical inhibition of pulmonary surfactant function by polymeric nanoparticles: role of surfactant protein B and C.

Acta Biomater 2014 Nov 1;10(11):4678-4684. Epub 2014 Aug 1.

Medical Clinic II, Department of Internal Medicine, Justus-Liebig-Universität, Klinikstrasse 33, D-35392 Giessen, Germany.

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http://dx.doi.org/10.1016/j.actbio.2014.07.026DOI Listing
November 2014

Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles.

Biochim Biophys Acta 2014 Jan 1;1838(1 Pt B):474-81. Epub 2013 Nov 1.

Medical Clinic II, Department of Internal Medicine, Justus-Liebig-Universität, Giessen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2013.10.016DOI Listing
January 2014

Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis.

PLoS One 2013 2;8(9):e73279. Epub 2013 Sep 2.

University of Giessen & Marburg Lung Center (UGMLC), Giessen, Germany ; Department of Medicine, Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073279PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759404PMC
April 2014

Cancer cachexia alters intracellular surfactant metabolism but not total alveolar surface area.

Histochem Cell Biol 2012 Nov 19;138(5):803-13. Epub 2012 Jul 19.

Institute of Anatomy and Cell Biology, Justus-Liebig-University Giessen, Aulweg 123, 35385, Giessen, Germany.

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http://dx.doi.org/10.1007/s00418-012-0995-3DOI Listing
November 2012

Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.

Eur Respir Rev 2012 Jun;21(124):152-60

Universities of Giessen and Marburg Lung Center, Dept of Internal Medicine II, German Center for Lung Research, Germany.

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http://err.ersjournals.com/content/errev/21/124/152.full.pdf
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http://err.ersjournals.com/cgi/doi/10.1183/09059180.00001012
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http://dx.doi.org/10.1183/09059180.00001012DOI Listing
June 2012

Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury.

Am J Respir Crit Care Med 2011 Apr 10;183(8):1055-61. Epub 2010 Dec 10.

Veterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.

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http://dx.doi.org/10.1164/rccm.201009-1424OCDOI Listing
April 2011

Dry powder aerosolization of a recombinant surfactant protein-C-based surfactant for inhalative treatment of the acutely inflamed lung.

Crit Care Med 2010 Jul;38(7):1584-91

University of Giessen Lung Center, Justus-Liebig University, Department of Internal Medicine, Medical Clinic II, Giessen, Germany.

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http://dx.doi.org/10.1097/CCM.0b013e3181dfcb3bDOI Listing
July 2010

Epithelial stress and apoptosis underlie Hermansky-Pudlak syndrome-associated interstitial pneumonia.

Am J Respir Crit Care Med 2010 Jul 8;182(2):207-19. Epub 2010 Apr 8.

Department of Internal Medicine II, University of Giessen Lung Center (UGLC), Klinikstrasse 36, 35392 Giessen, Germany.

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http://dx.doi.org/10.1164/rccm.200909-1414OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913235PMC
July 2010

Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.

Am J Respir Crit Care Med 2010 Jun 1;181(12):1355-66. Epub 2010 Mar 1.

Department of Specialty Care Services, The Texas Lung Injury Institute, University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200901-0015O
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http://dx.doi.org/10.1164/rccm.200901-0015OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894411PMC
June 2010

Safety and tolerability of inhaled heparin in idiopathic pulmonary fibrosis.

J Aerosol Med Pulm Drug Deliv 2010 Jun;23(3):161-72

Department of Internal Medicine, Faculty of Medicine, Justus Liebig University, Giessen, Germany.

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http://dx.doi.org/10.1089/jamp.2009.0780DOI Listing
June 2010

Liver carboxylesterase cleaves surfactant protein (SP-) B and promotes surfactant subtype conversion.

Biochem Biophys Res Commun 2006 Oct 10;348(4):1449-54. Epub 2006 Aug 10.

University of Giessen Lung Center (UGLC), Department of Internal Medicine, Medical Clinic II, Justus-Liebig University, Giessen, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2006.08.013DOI Listing
October 2006

Positive end-expiratory pressure modifies response to recombinant and natural exogenous surfactant in ventilated immature newborn rabbits.

Biol Neonate 2006 6;90(3):210-6. Epub 2005 Sep 6.

Department of Pediatrics and Neonatology, Justus-Liebig-University Giessen, Giessen, Germany.

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http://dx.doi.org/10.1159/000093820DOI Listing
October 2006

Ischemic and endotoxin pre-conditioning reduce lung reperfusion injury-induced surfactant alterations.

J Heart Lung Transplant 2005 Oct;24(10):1680-9

Department of Internal Medicine, Med. Klinik II, Justus-Liebig University, Giessen, Germany.

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http://dx.doi.org/10.1016/j.healun.2005.01.017DOI Listing
October 2005

Compartment- and cell-specific expression of coagulation and fibrinolysis factors in the murine lung undergoing inhalational versus intravenous endotoxin application.

Thromb Haemost 2004 Sep;92(3):529-40

Department of Internal Medicine, Faculty of Medicine, Justus-Liebig-University Giessen, Klinikstr. 36, 35392 Giessen, Germany.

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http://dx.doi.org/10.1160/TH04-02-0126DOI Listing
September 2004

Impact of surface tension on the conversion rate of large to small surfactant aggregates.

Biophys Chem 2003 May;104(1):229-38

Department of Internal Medicine, Medizinische Klinik II, Justus-Liebig University Giessen, 35385 Giessen, Germany.

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http://dx.doi.org/10.1016/s0301-4622(02)00370-8DOI Listing
May 2003

Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.

Thromb Haemost 2003 Jan;89(1):53-64

Department of Internal Medicine, Justus-Liebeg University Giessen, Germany.

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January 2003

Fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C.

Am J Physiol Lung Cell Mol Physiol 2003 Jan 6;284(1):L69-76. Epub 2002 Sep 6.

Department of Internal Medicine, Justus-Liebig-University-Giessen, Klinikstrasse 36, D-35385 Giessen, Germany.

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http://dx.doi.org/10.1152/ajplung.00037.2002DOI Listing
January 2003

An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid.

Am J Respir Crit Care Med 2002 Feb;165(4):470-4

Department of Internal Medicine, Justus-Liebig-University, Giessen, Germany.

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http://dx.doi.org/10.1164/ajrccm.165.4.2102080DOI Listing
February 2002