Clemens R Scherzer

Clemens R Scherzer

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Clemens R Scherzer

Publications by authors named "Clemens R Scherzer"

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Potential two-step proteomic signature for Parkinson's disease: Pilot analysis in the Harvard Biomarkers Study.

Alzheimers Dement (Amst) 2019 Dec 2;11:374-382. Epub 2019 May 2.

Advanced Center for Parkinson's Disease Research of Brigham & Women's Hospital, and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.dadm.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502745PMC
December 2019

Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.

Neurol Genet 2019 Aug 9;5(4):e348. Epub 2019 Jul 9.

Laboratory of Neurogenetics (H.I., C.B., H.L.L., F.F., D.G.H., A.B.S., M.A.N.), National Institute on Aging, National Institutes of Health, Bethesda; Data Tecnica International (H.I., M.A.N.), Glen Echo, MD; Precision Neurology Program (G.L., C.R.S.), Harvard Medical School, Brigham and Women's Hospital; Neurogenomics Laboratory (G.L., C.R.S.), Harvard Medical School, Brigham and Women's Hospital; Ann Romney Center for Neurologic Diseases (G.L., C.R.S.), Brigham and Women's Hospital, Boston, MA; The Norwegian Centre for Movement Disorders (J.M.-G., G.A.), Stavanger University Hospital; Department of Chemistry (J.M.-G., G.A.), Bioscience and Environmental Engineering, University of Stavanger, Norway; Assistance-Publique Hôpitaux de Paris (J.-C.C.), ICM, INSERM UMRS 1127, CNRS 7225, ICM, Department of Neurology and CIC Neurosciences, Pitié-Salpêtrière Hospital, Paris, France; Department of Neurology (L.P., M.T.), Oslo University Hospital, Norway; Department of Neurology (M.N., B.R.B., B.P.W.), Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands; Michael J Fox Foundation (S.J.H.), New York; Translational Genome Sciences (K.-D.H.N, K.E.), Biogen, Cambridge, MA; Department of Neurology University of Pennsylvania (J.R.), Philadelphia, PA; Department of Biostatistics and Computational Biology (S.E.), University of Rochester, NY; Department of Computer Science (F.F.), University of Illinois Urbana-Champaign; Department of Neurology (P.A.), Center for Health + Technology, University of Rochester, NY; Department of Clinical Neurosciences (K.M.S., R.W.), University of Cambridge, John van Geest Centre for Brain Repair, UK; Department of Pathology and Laboratory Medicine (V.M.V.D.), Center for Neurodegenerative Disease Research, Parelman School of Medicine at the University of Pennsylvania, Philadelphia; Genetics and Pharmacogenomics (A.G.D.-W.), Merck Research Laboratory, Boston, MA; Statistical Genetics (A.G.D.-W.), Biogen, Cambridge, MA; Institut du cerveau et de la moelle épinière ICM (A.B., F.D.); Sorbonne Université SU (A.B.); INSERM UMR (A.B.), Paris, France; Department of Neurology (G.A.), Stavanger University Hospital, Norway; Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive Medicine, Queen Mary University of London; Department of Molecular Neuroscience (A.J.N.), UCL Institute of Neurology, London, UK; Department of Neurology (O.-B.T.), Haukeland University Hospital; University of Bergen (O.-B.T.), Bergen, Norway; Department of Neurology (J.R.E.), Nottingham University NHS Trust, UK; Centre for Clinical Brain Sciences (D.P.B.), University of Edinburgh; Anne Rowling Regenerative Neurology Clinic (D.P.B.), University of Edinburgh; Usher Institute of Population Health Sciences and Informatics (D.P.B.), University of Edinburgh, Scotland; Department of Medical and Molecular Genetics (C.E.W.), Indiana University, Indianapolis; Department of Neurology (D.K.S.), Beth Israel Deaconess Medical Center; Harvard Medical School (D.K.S.), Boston; Voyager Therapeutics (B.R.), Cambridge, MA; Department of Neurology (B.R.), University of Rochester School of Medicine, NY; Institute of Clinical Medicine (M.T.), University of Oslo, Norway; German Center for Neurodegenerative Diseases-Tubingen (P.H.); HIH Tuebingen (P.H.), Germany; Department of Psychiatry (D.W.), University of Pennsylvania School of Medicine; Department of Veterans Affairs (D.W.), Philadelphia, PA; and Department of Clinical Neurosciences (R.A.B., C.H.W.-G.), University of Cambridge, UK; Department of Neurology (J.J.V.H.), Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1212/NXG.0000000000000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659137PMC
August 2019

Discovering New Benefits From Old Drugs With Big Data-Promise for Parkinson Disease.

JAMA Neurol 2018 Aug;75(8):917-920

Precision Neurology Program, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaneurol.2018.0345DOI Listing
August 2018

Prediction of cognition in Parkinson's disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

Lancet Neurol 2017 08 16;16(8):620-629. Epub 2017 Jun 16.

Neurogenomics Laboratory and Parkinson Personalized Medicine Program of Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA; Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30122-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761650PMC
August 2017

Defining the contribution of neuroinflammation to Parkinson's disease in humanized immune system mice.

Mol Neurodegener 2017 02 14;12(1):17. Epub 2017 Feb 14.

Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, 58203, USA.

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http://dx.doi.org/10.1186/s13024-017-0158-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310074PMC
February 2017

α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities.

Cell Mol Neurobiol 2016 Apr 18;36(3):437-48. Epub 2016 Mar 18.

Departments of Neurology and Radiology, Massachusetts General Hospital and Center for NeuroDiscovery, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10571-015-0317-0DOI Listing
April 2016

A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain.

Parkinsons Dis 2016 3;2016:2405176. Epub 2016 Mar 3.

Neurogenomics Lab and Harvard Parkinson Personalized Medicine Initiative, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA; Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA; Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1155/2016/2405176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818948PMC
April 2016

Network analysis identifies SOD2 mRNA as a potential biomarker for Parkinson's disease.

PLoS One 2014 3;9(10):e109042. Epub 2014 Oct 3.

The Cellular and Molecular Pharmacology Department, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109042PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184821PMC
December 2015

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Brain 2015 Sep 28;138(Pt 9):2659-71. Epub 2015 Jul 28.

1 Neurogenomics Lab and Parkinson Personalized Medicine Program, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA 2 Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA 4 Ann Romney Centre for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA 5 Biomarkers Program, Harvard NeuroDiscovery Center, Boston, MA 02115, USA 7 Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA

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http://dx.doi.org/10.1093/brain/awv202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643625PMC
September 2015

Motor impulsivity in Parkinson disease: associations with COMT and DRD2 polymorphisms.

Scand J Psychol 2014 Jun 21;55(3):278-86. Epub 2014 Apr 21.

Department of Neurology and the Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA; Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1111/sjop.12113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751699PMC
June 2014

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.

Nat Commun 2014 Apr 16;5:3633. Epub 2014 Apr 16.

1] Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA [2] Department of Psychiatry, Columbia University Medical Center, New York, New York 10032, USA [3] Department of Pharmacology, Columbia University Medical Center, New York, New York 10032, USA.

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http://www.nature.com/articles/ncomms4633
Publisher Site
http://dx.doi.org/10.1038/ncomms4633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024461PMC
April 2014

Metallothioneins as dynamic markers for brain disease in lysosomal disorders.

Ann Neurol 2014 Jan;75(1):127-37

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy; Neurogenomics Laboratory, Harvard Medical School and Brigham & Women's Hospital, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/ana.24053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237725PMC
January 2014

Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.

Neurology 2013 Oct 25;81(17):1531-7. Epub 2013 Sep 25.

From the Neurogenomics Laboratory (H.D., K.D., K.C.L., A.N.H., K.D., A.T.-L., C.R.S.), Harvard Medical School and Brigham & Women's Hospital, Cambridge; Biomarkers Program (K.D., K.C.L., A.N.H., K.D., A.T.-L., M.T.H., U.S.S., B.M., N.M., V.K., S.N.G., D.J.S., M.A.S., M.G.S., B.T.H., J.H.G., C.R.S.), Harvard NeuroDiscovery Center, Boston; Department of Neurology (J.J.L., U.S.S., A.-M.W., A.W.F., A.Y.H., N.M., V.K., S.N.G., M.A.S., B.T.H., J.H.G., C.R.S.), Massachusetts General Hospital, Boston; Department of Neurology (M.T.H., A.Y.H., D.J.S., L.R.S., C.R.S.), Brigham and Women's Hospital, Boston, MA; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; and Division of Neurology, the Ottawa Hospital, University of Ottawa (M.G.S.), Canada.

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http://dx.doi.org/10.1212/WNL.0b013e3182a95818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888173PMC
October 2013

Specific splice variants are associated with Parkinson's disease.

Mov Disord 2013 Oct 20;28(12):1724-7. Epub 2013 Sep 20.

Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/mds.25635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812386PMC
October 2013

Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.

Proc Natl Acad Sci U S A 2011 Oct 3;108(41):17141-6. Epub 2011 Oct 3.

Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1104409108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193232PMC
October 2011

Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.

J Biol Chem 2010 Oct 17;285(41):31217-32. Epub 2010 Jun 17.

Neurochemistry Laboratory, Department of Psychiatry-Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://www.jbc.org/content/285/41/31217.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M110.149161
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.149161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951196PMC
October 2010

Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease.

Biochim Biophys Acta 2010 Jul-Aug;1802(7-8):673-81. Epub 2010 May 9.

Geriatric Research Education Clinical Center, New England Veterans Administration VISN 1, Bedford, MA 01730, USA.

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http://dx.doi.org/10.1016/j.bbadis.2010.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893277PMC
August 2010

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

PLoS Genet 2010 Jul 15;6(7):e1001026. Epub 2010 Jul 15.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904797PMC
July 2010

Chipping away at diagnostics for neurodegenerative diseases.

Neurobiol Dis 2009 Aug 10;35(2):148-56. Epub 2009 Mar 10.

Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.nbd.2009.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753504PMC
August 2009

GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein.

Proc Natl Acad Sci U S A 2008 Aug 31;105(31):10907-12. Epub 2008 Jul 31.

Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0802437105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504800PMC
August 2008

RNA biomarkers of Parkinson's disease: developing tools for novel therapies.

Biomark Med 2008 Feb;2(1):41-53

Harvard Medical School and Brigham and Women's Hospital, Laboratory for Neurogenomics, Center for Neurologic Diseases, 65 Landsdowne Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.2217/17520363.2.1.41DOI Listing
February 2008

Molecular markers of early Parkinson's disease based on gene expression in blood.

Proc Natl Acad Sci U S A 2007 Jan 10;104(3):955-60. Epub 2007 Jan 10.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0610204104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766335PMC
January 2007

Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.

Neurobiol Dis 2006 Feb 29;21(2):256-75. Epub 2005 Sep 29.

Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.nbd.2005.07.004DOI Listing
February 2006

Yeast genetics targets lipids in Parkinson's disease.

Trends Genet 2004 Jul;20(7):273-7

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.tig.2004.05.005DOI Listing
July 2004

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease.

Hum Mol Genet 2003 Oct 5;12(19):2457-66. Epub 2003 Aug 5.

Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/hmg/ddg265DOI Listing
October 2003