Claus Oxvig

Claus Oxvig

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Claus Oxvig

Publications by authors named "Claus Oxvig"

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Transcription profile of the insulin-like growth factor signaling pathway during human ovarian follicular development.

J Assist Reprod Genet 2019 May 15;36(5):889-903. Epub 2019 Mar 15.

Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Rigshospitalet, Copenhagen University Hospital, Copenhagen University, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s10815-019-01432-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541695PMC
May 2019

A characteristic signature of insulin-like growth factor (IGF) axis expression during osteogenic differentiation of human dental pulp cells (hDPCs): Potential co-ordinated regulation of IGF action.

Growth Horm IGF Res 2018 Oct - Dec;42-43:14-21. Epub 2018 Jul 26.

Division of Oral Biology, Leeds School of Dentistry, Level 7 Wellcome Trust Brenner Building, University of Leeds, St James University Hospital, Leeds, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10966374183006
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http://dx.doi.org/10.1016/j.ghir.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259625PMC
March 2019

PAPP-A and cancer.

J Mol Endocrinol 2018 Jul;61(1):T1-T10

Department of Molecular Biology and GeneticsAarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1530/JME-17-0236DOI Listing
July 2018

Prognostic relevance and performance characteristics of serum IGFBP-2 and PAPP-A in women with breast cancer: a long-term Danish cohort study.

Cancer Med 2018 06 3;7(6):2391-2404. Epub 2018 May 3.

Medical Research Laboratory, Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1002/cam4.1504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010701PMC
June 2018

Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue.

Growth Horm IGF Res 2018 04 3;39:54-61. Epub 2018 Feb 3.

Edison Biotechnology Institute, Ohio University, Athens, OH 45701, USA; Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA; The Diabetes Institute, Ohio University, Athens, OH 45701, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ghir.2018.01.001DOI Listing
April 2018

Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction.

Cardiovasc Diabetol 2018 04 30;17(1):63. Epub 2018 Apr 30.

Heart Institute, Hospital Universitari Germans Trias i Pujol, Carretera de Canyet s/n, Badalona, 08916, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12933-018-0710-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925828PMC
April 2018

Effects of Prednisolone on Serum and Tissue Fluid IGF-I Receptor Activation and Post-Receptor Signaling in Humans.

J Clin Endocrinol Metab 2017 11;102(11):4031-4040

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1210/jc.2017-00696DOI Listing
November 2017

One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology.

EMBO Mol Med 2017 10;9(10):1338-1345

Department of Molecular Biology & Genetics, Aarhus University, Aarhus C, Denmark.

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http://dx.doi.org/10.15252/emmm.201707950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623872PMC
October 2017

Pregnancy-Associated Plasma Protein-A2 and Anthropometry, Lifestyle, and Biochemical Factors in a Human Adult Population.

Sci Rep 2017 09 5;7(1):10455. Epub 2017 Sep 5.

Molecular Epidemiology Group, Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-017-10629-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585218PMC
September 2017

The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.

Eur J Endocrinol 2017 May 8;176(5):521-531. Epub 2017 Feb 8.

Department of Clinical MedicineMedical Research Laboratory, Faculty of Health, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1530/EJE-16-0940DOI Listing
May 2017

PAPP-A: a promising therapeutic target for healthy longevity.

Aging Cell 2017 04 29;16(2):205-209. Epub 2016 Dec 29.

Department of Molecular Biology and Genetics, Aarhus Universitet, Aarhus, Denmark.

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http://dx.doi.org/10.1111/acel.12564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334524PMC
April 2017

Endogenous Natural Complement Inhibitor Regulates Cardiac Development.

J Immunol 2017 04 3;198(8):3118-3126. Epub 2017 Mar 3.

Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark;

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http://dx.doi.org/10.4049/jimmunol.1601958DOI Listing
April 2017

Rare and low-frequency coding variants alter human adult height.

Authors:
Eirini Marouli Mariaelisa Graff Carolina Medina-Gomez Ken Sin Lo Andrew R Wood Troels R Kjaer Rebecca S Fine Yingchang Lu Claudia Schurmann Heather M Highland Sina Rüeger Gudmar Thorleifsson Anne E Justice David Lamparter Kathleen E Stirrups Valérie Turcot Kristin L Young Thomas W Winkler Tõnu Esko Tugce Karaderi Adam E Locke Nicholas G D Masca Maggie C Y Ng Poorva Mudgal Manuel A Rivas Sailaja Vedantam Anubha Mahajan Xiuqing Guo Goncalo Abecasis Katja K Aben Linda S Adair Dewan S Alam Eva Albrecht Kristine H Allin Matthew Allison Philippe Amouyel Emil V Appel Dominique Arveiler Folkert W Asselbergs Paul L Auer Beverley Balkau Bernhard Banas Lia E Bang Marianne Benn Sven Bergmann Lawrence F Bielak Matthias Blüher Heiner Boeing Eric Boerwinkle Carsten A Böger Lori L Bonnycastle Jette Bork-Jensen Michiel L Bots Erwin P Bottinger Donald W Bowden Ivan Brandslund Gerome Breen Murray H Brilliant Linda Broer Amber A Burt Adam S Butterworth David J Carey Mark J Caulfield John C Chambers Daniel I Chasman Yii-Der Ida Chen Rajiv Chowdhury Cramer Christensen Audrey Y Chu Massimiliano Cocca Francis S Collins James P Cook Janie Corley Jordi Corominas Galbany Amanda J Cox Gabriel Cuellar-Partida John Danesh Gail Davies Paul I W de Bakker Gert J de Borst Simon de Denus Mark C H de Groot Renée de Mutsert Ian J Deary George Dedoussis Ellen W Demerath Anneke I den Hollander Joe G Dennis Emanuele Di Angelantonio Fotios Drenos Mengmeng Du Alison M Dunning Douglas F Easton Tapani Ebeling Todd L Edwards Patrick T Ellinor Paul Elliott Evangelos Evangelou Aliki-Eleni Farmaki Jessica D Faul Mary F Feitosa Shuang Feng Ele Ferrannini Marco M Ferrario Jean Ferrieres Jose C Florez Ian Ford Myriam Fornage Paul W Franks Ruth Frikke-Schmidt Tessel E Galesloot Wei Gan Ilaria Gandin Paolo Gasparini Vilmantas Giedraitis Ayush Giri Giorgia Girotto Scott D Gordon Penny Gordon-Larsen Mathias Gorski Niels Grarup Megan L Grove Vilmundur Gudnason Stefan Gustafsson Torben Hansen Kathleen Mullan Harris Tamara B Harris Andrew T Hattersley Caroline Hayward Liang He Iris M Heid Kauko Heikkilä Øyvind Helgeland Jussi Hernesniemi Alex W Hewitt Lynne J Hocking Mette Hollensted Oddgeir L Holmen G Kees Hovingh Joanna M M Howson Carel B Hoyng Paul L Huang Kristian Hveem M Arfan Ikram Erik Ingelsson Anne U Jackson Jan-Håkan Jansson Gail P Jarvik Gorm B Jensen Min A Jhun Yucheng Jia Xuejuan Jiang Stefan Johansson Marit E Jørgensen Torben Jørgensen Pekka Jousilahti J Wouter Jukema Bratati Kahali René S Kahn Mika Kähönen Pia R Kamstrup Stavroula Kanoni Jaakko Kaprio Maria Karaleftheri Sharon L R Kardia Fredrik Karpe Frank Kee Renske Keeman Lambertus A Kiemeney Hidetoshi Kitajima Kirsten B Kluivers Thomas Kocher Pirjo Komulainen Jukka Kontto Jaspal S Kooner Charles Kooperberg Peter Kovacs Jennifer Kriebel Helena Kuivaniemi Sébastien Küry Johanna Kuusisto Martina La Bianca Markku Laakso Timo A Lakka Ethan M Lange Leslie A Lange Carl D Langefeld Claudia Langenberg Eric B Larson I-Te Lee Terho Lehtimäki Cora E Lewis Huaixing Li Jin Li Ruifang Li-Gao Honghuang Lin Li-An Lin Xu Lin Lars Lind Jaana Lindström Allan Linneberg Yeheng Liu Yongmei Liu Artitaya Lophatananon Jian'an Luan Steven A Lubitz Leo-Pekka Lyytikäinen David A Mackey Pamela A F Madden Alisa K Manning Satu Männistö Gaëlle Marenne Jonathan Marten Nicholas G Martin Angela L Mazul Karina Meidtner Andres Metspalu Paul Mitchell Karen L Mohlke Dennis O Mook-Kanamori Anna Morgan Andrew D Morris Andrew P Morris Martina Müller-Nurasyid Patricia B Munroe Mike A Nalls Matthias Nauck Christopher P Nelson Matt Neville Sune F Nielsen Kjell Nikus Pål R Njølstad Børge G Nordestgaard Ioanna Ntalla Jeffrey R O'Connel Heikki Oksa Loes M Olde Loohuis Roel A Ophoff Katharine R Owen Chris J Packard Sandosh Padmanabhan Colin N A Palmer Gerard Pasterkamp Aniruddh P Patel Alison Pattie Oluf Pedersen Peggy L Peissig Gina M Peloso Craig E Pennell Markus Perola James A Perry John R B Perry Thomas N Person Ailith Pirie Ozren Polasek Danielle Posthuma Olli T Raitakari Asif Rasheed Rainer Rauramaa Dermot F Reilly Alex P Reiner Frida Renström Paul M Ridker John D Rioux Neil Robertson Antonietta Robino Olov Rolandsson Igor Rudan Katherine S Ruth Danish Saleheen Veikko Salomaa Nilesh J Samani Kevin Sandow Yadav Sapkota Naveed Sattar Marjanka K Schmidt Pamela J Schreiner Matthias B Schulze Robert A Scott Marcelo P Segura-Lepe Svati Shah Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Albert Vernon Smith Jennifer A Smith Lorraine Southam Timothy D Spector Elizabeth K Speliotes John M Starr Valgerdur Steinthorsdottir Heather M Stringham Michael Stumvoll Praveen Surendran Leen M 't Hart Katherine E Tansey Jean-Claude Tardif Kent D Taylor Alexander Teumer Deborah J Thompson Unnur Thorsteinsdottir Betina H Thuesen Anke Tönjes Gerard Tromp Stella Trompet Emmanouil Tsafantakis Jaakko Tuomilehto Anne Tybjaerg-Hansen Jonathan P Tyrer Rudolf Uher André G Uitterlinden Sheila Ulivi Sander W van der Laan Andries R Van Der Leij Cornelia M van Duijn Natasja M van Schoor Jessica van Setten Anette Varbo Tibor V Varga Rohit Varma Digna R Velez Edwards Sita H Vermeulen Henrik Vestergaard Veronique Vitart Thomas F Vogt Diego Vozzi Mark Walker Feijie Wang Carol A Wang Shuai Wang Yiqin Wang Nicholas J Wareham Helen R Warren Jennifer Wessel Sara M Willems James G Wilson Daniel R Witte Michael O Woods Ying Wu Hanieh Yaghootkar Jie Yao Pang Yao Laura M Yerges-Armstrong Robin Young Eleftheria Zeggini Xiaowei Zhan Weihua Zhang Jing Hua Zhao Wei Zhao Wei Zhao He Zheng Wei Zhou Jerome I Rotter Michael Boehnke Sekar Kathiresan Mark I McCarthy Cristen J Willer Kari Stefansson Ingrid B Borecki Dajiang J Liu Kari E North Nancy L Heard-Costa Tune H Pers Cecilia M Lindgren Claus Oxvig Zoltán Kutalik Fernando Rivadeneira Ruth J F Loos Timothy M Frayling Joel N Hirschhorn Panos Deloukas Guillaume Lettre

Nature 2017 02 1;542(7640):186-190. Epub 2017 Feb 1.

Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.

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http://dx.doi.org/10.1038/nature21039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302847PMC
February 2017

PAPP-A, IGFBP-4 and IGF-II are secreted by human adipose tissue cultures in a depot-specific manner.

Eur J Endocrinol 2016 Dec 1;175(6):509-519. Epub 2016 Sep 1.

Medical Research LaboratoryDepartment of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus C, Denmark

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http://dx.doi.org/10.1530/EJE-16-0569DOI Listing
December 2016

Effect of pregnancy-associated plasma protein-A (PAPP-A) single-nucleotide polymorphisms on the level and activity of PAPP-A and the hormone profile in fluid from normal human small antral follicles.

Fertil Steril 2016 Dec 25;106(7):1778-1786.e8. Epub 2016 Oct 25.

Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital, Copenhagen University, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.fertnstert.2016.09.008DOI Listing
December 2016

Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.

J Clin Endocrinol Metab 2016 Nov 20;101(11):3879-3883. Epub 2016 Sep 20.

Department of Pediatrics and Pediatric Endocrinology (M.T.M.-C., V.B., J.P., J.A.C., G.A.M.-M., J.A.) Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Universidad Autónoma de Madrid, Department of Pediatrics, Centro de Investigación Biomédica en Red (CIBEROBN), Instituto de Salud Carlos III, 28009 Madrid, Spain; Department of Endocrinology (F.H.), Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, 28040 Madrid, Spain; Cincinnati Center for Growth Disorders (A.D.), Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229; Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE) (H.M.D.), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), FEI, División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina; Department of Basic Science and Craniofacial Biology (S.Y.), New York University College of Dentistry, New York, New York 10010; Oregon Health and Science University (R.G.R.), Portland, Oregon 97239; Stat5 LLC (R.G.R.), Los Altos, California 94022; Genetics Unit (L.A.P.-J.), Universitat Pompeu Fabra, Hospital del Mar Research Institute (IMIM), and CIBER de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 08003 Barcelona, Spain; Department of Molecular Biology and Genetics (C.O.), Aarhus University, 8000 Aarhus, Denmark; and Medical Research Laboratory (J.F.), Department of Clinical Medicine, Faculty of Health, Aarhus University and Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.

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http://dx.doi.org/10.1210/jc.2016-2751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393598PMC
November 2016

PAPP-A and the IGF system.

Ann Endocrinol (Paris) 2016 Jun 5;77(2):90-6. Epub 2016 May 5.

Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ando.2016.04.015DOI Listing
June 2016

Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice.

Atherosclerosis 2016 May 3;248:36-43. Epub 2016 Mar 3.

Department of Molecular Biology and Genetics, Aarhus University, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.02.026DOI Listing
May 2016

The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development.

Hum Reprod 2016 Apr 13;31(4):866-74. Epub 2016 Feb 13.

Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark

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http://dx.doi.org/10.1093/humrep/dew013DOI Listing
April 2016

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.

EMBO Mol Med 2016 04;8(4):363-74

Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús Instituto de Investigación La Princesa Universidad Autónoma de Madrid, Madrid, Spain Program of Pediatric Obesity, CIBEROBN Instituto de Salud Carlos III, Madrid, Spain

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http://dx.doi.org/10.15252/emmm.201506106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818753PMC
April 2016

Lactation opposes pappalysin-1-driven pregnancy-associated breast cancer.

EMBO Mol Med 2016 04;8(4):388-406

Division of Hematology/Oncology of the Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA

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http://dx.doi.org/10.15252/emmm.201606273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818749PMC
April 2016

Targeted Inhibition of Pregnancy-Associated Plasma Protein-A Activity Reduces Atherosclerotic Plaque Burden in Mice.

J Cardiovasc Transl Res 2016 Feb 5;9(1):77-9. Epub 2016 Jan 5.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1007/s12265-015-9666-9DOI Listing
February 2016

Identification of transglutaminase reactive residues in human osteopontin and their role in polymerization.

PLoS One 2014 24;9(11):e113650. Epub 2014 Nov 24.

Department of Molecular Biology and Genetics, Science Park, Aarhus University, Aarhus, Denmark; Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113650PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242673PMC
January 2016

Transglutaminase 2-Catalyzed Intramolecular Cross-Linking of Osteopontin.

Biochemistry 2016 Jan 4;55(2):294-303. Epub 2016 Jan 4.

Department of Molecular Biology and Genetics, Aarhus University , 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1021/acs.biochem.5b01153DOI Listing
January 2016

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs.

J Cardiovasc Transl Res 2015 Dec 6;8(9):528-35. Epub 2015 Oct 6.

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

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http://dx.doi.org/10.1007/s12265-015-9656-yDOI Listing
December 2015

Pregnancy-associated plasma protein A in human ovarian follicles and its association with intrafollicular hormone levels.

Fertil Steril 2015 Nov 18;104(5):1294-301.e1. Epub 2015 Aug 18.

Laboratory of Reproductive Biology, Juliane Marie Center for Women, Children, and Reproduction, Copenhagen University Hospital, Copenhagen University, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.fertnstert.2015.07.1152DOI Listing
November 2015

Disturbed Laminar Blood Flow Vastly Augments Lipoprotein Retention in the Artery Wall: A Key Mechanism Distinguishing Susceptible From Resistant Sites.

Arterioscler Thromb Vasc Biol 2015 Sep 16;35(9):1928-35. Epub 2015 Jul 16.

From the Department of Cardiology, and Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Denmark (L.B.S., M.B.M., M.K., M.K.H., J.F.B.); Department of Molecular Biology and Genetics (L.B.S., C.O.) and Department of Biomedicine (M.K.), Aarhus University, Aarhus, Denmark; and Department of Molecular Biology and Genetics (L.B.S., C.O.) and DANDRITE and Danish Diabetes Academy, Department of Biomedicine (M.K.), Aarhus University, Denmark.

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http://dx.doi.org/10.1161/ATVBAHA.115.305874DOI Listing
September 2015

The role of PAPP-A in the IGF system: location, location, location.

Authors:
Claus Oxvig

J Cell Commun Signal 2015 Jun 25;9(2):177-87. Epub 2015 Jan 25.

Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000, Aarhus C, Denmark,

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http://dx.doi.org/10.1007/s12079-015-0259-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458251PMC
June 2015

PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI.

Clin Biochem 2015 Mar 6;48(4-5):322-8. Epub 2014 Dec 6.

Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.clinbiochem.2014.11.022DOI Listing
March 2015

Papp-a2 modulates development of cranial cartilage and angiogenesis in zebrafish embryos.

J Cell Sci 2014 Dec 18;127(Pt 23):5027-37. Epub 2014 Sep 18.

Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark

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http://dx.doi.org/10.1242/jcs.152587DOI Listing
December 2014

Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoforms α1, α2, α3 and the ATP1A3 promoter.

PLoS One 2013 13;8(11):e79127. Epub 2013 Nov 13.

Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark ; Department of Biomedicine, Aarhus University, Aarhus C, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079127PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827302PMC
September 2014

Development of a recombinant antibody towards PAPP-A for immunohistochemical use in multiple animal species.

J Immunol Methods 2014 Feb 12;404:33-40. Epub 2013 Dec 12.

Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00221759130036
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http://dx.doi.org/10.1016/j.jim.2013.12.002DOI Listing
February 2014

Zebrafish as a novel model to assess Na+/K(+)-ATPase-related neurological disorders.

Neurosci Biobehav Rev 2013 Dec 1;37(10 Pt 2):2774-87. Epub 2013 Oct 1.

Centre for Membrane Pumps in Cells and Disease-PUMPKIN, Danish National Research Foundation, Copenhagen, Denmark; Aarhus University, Department of Biomedicine, Ole Worms Allé 3, Building 1171, DK-8000 Aarhus, Denmark; Aarhus University, Department of Molecular Biology and Genetics, Gustav Wieds Vej 10, Building 3135, DK-8000 Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.neubiorev.2013.09.013DOI Listing
December 2013

Porcine synapsin 1: SYN1 gene analysis and functional characterization of the promoter.

FEBS Open Bio 2013 7;3:411-20. Epub 2013 Oct 7.

Department of Molecular Biology and Genetics, Aarhus University, Blichers Alle 20, Tjele DK-8830, Denmark.

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http://dx.doi.org/10.1016/j.fob.2013.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821028PMC
November 2013

Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy.

J Endocrinol 2013 Oct 6;219(1):51-8. Epub 2013 Sep 6.

Endocrine Research Unit, Division of Endocrinology, Mayo Clinic, 200 First Street SW, 5-194 Joseph, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1530/JOE-13-0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820014PMC
October 2013

α3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish.

J Biol Chem 2013 Mar 11;288(13):8862-74. Epub 2013 Feb 11.

Centre for Membrane Pumps in Cells and Disease-PUMPKIN, Danish National Research Foundation, DK-1057 Copenhagen, Denmark.

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http://dx.doi.org/10.1074/jbc.M112.421529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610961PMC
March 2013

Formation of high-molecular-weight angiotensinogen during pregnancy is a result of competing redox reactions with the proform of eosinophil major basic protein.

Biochem J 2013 Jan;449(1):209-17

Department of Molecular Biology and Genetics, University of Aarhus, DK-8000 Aarhus, Denmark.

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http://dx.doi.org/10.1042/BJ20120801DOI Listing
January 2013

Effects of mutated pregnancy-associated plasma protein-a on atherosclerotic lesion development in mice.

Endocrinology 2013 Jan 16;154(1):246-52. Epub 2012 Nov 16.

Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1210/en.2012-1552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529381PMC
January 2013

The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish.

J Cell Sci 2012 Dec 24;125(Pt 24):6166-75. Epub 2012 Oct 24.

Centre for Membrane Pumps in Cells and Disease-PUMPKIN, Danish National Research Foundation, Aarhus, Denmark.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.115808
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http://dx.doi.org/10.1242/jcs.115808DOI Listing
December 2012

Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview.

Acta Obstet Gynecol Scand 2010 Sep;89(9):1118-25

Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark.

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http://doi.wiley.com/10.3109/00016349.2010.505639
Publisher Site
http://dx.doi.org/10.3109/00016349.2010.505639DOI Listing
September 2010

Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development.

Am J Physiol Heart Circ Physiol 2010 Aug 14;299(2):H284-91. Epub 2010 May 14.

Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1152/ajpheart.00904.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930380PMC
August 2010

Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish.

PLoS One 2008 Aug 28;3(8):e3091. Epub 2008 Aug 28.

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003091PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518108PMC
August 2008

Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding.

J Biol Chem 2008 Jun 23;283(24):16772-80. Epub 2008 Apr 23.

Department of Molecular Biology, University of Aarhus, DK-8000 Aarhus, Denmark.

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http://dx.doi.org/10.1074/jbc.M802429200DOI Listing
June 2008

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein.

J Cell Sci 2008 Mar 19;121(Pt 6):773-83. Epub 2008 Feb 19.

King's College London, Wolfson Centre for Age Related Disease, Guy's Campus, London SE1 1UL, UK.

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http://dx.doi.org/10.1242/jcs.021816DOI Listing
March 2008

The structural basis of calcium transport by the calcium pump.

Nature 2007 Dec;450(7172):1036-42

Centre for Membrane Pumps in Cells and Disease-PUMPKIN, Danish National Research Foundation, University of Aarhus, Ole Worms Alle, blg. 1185, DK - 8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1038/nature06418DOI Listing
December 2007

Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5.

Mol Endocrinol 2007 May 20;21(5):1246-57. Epub 2007 Feb 20.

Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1210/me.2006-0522DOI Listing
May 2007

Quantification of proteolytically active pregnancy-associated plasma protein-A with an assay based on quenched fluorescence.

Clin Chem 2007 May 15;53(5):947-54. Epub 2007 Mar 15.

Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2006.080614
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http://dx.doi.org/10.1373/clinchem.2006.080614DOI Listing
May 2007

Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages.

Am J Physiol Heart Circ Physiol 2007 Feb 13;292(2):H994-H1000. Epub 2006 Oct 13.

Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1152/ajpheart.00798.2006DOI Listing
February 2007

Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy-associated plasma protein-A.

Biochemistry 2007 Feb 24;46(7):1972-80. Epub 2007 Jan 24.

Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.

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http://pubs.acs.org/doi/abs/10.1021/bi062229i
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http://dx.doi.org/10.1021/bi062229iDOI Listing
February 2007

The GH-IGF-IGFBP axis is changed in Turner syndrome: partial normalization by HRT.

Growth Horm IGF Res 2006 Oct-Dec;16(5-6):332-9. Epub 2006 Oct 25.

Medical Department M (Endocrinology and Diabetes) and Medical Research Laboratories, Aarhus Sygehus NBG, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, Denmark.

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http://linkinghub.elsevier.com/retrieve/pii/S109663740600117
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http://dx.doi.org/10.1016/j.ghir.2006.09.001DOI Listing
January 2007

Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.

Blood 2006 Oct 15;108(8):2846-9. Epub 2006 Jun 15.

Department of Medical Biochemistry, University of Aarhus, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1182/blood-2006-05-022327DOI Listing
October 2006

The proform of the eosinophil major basic protein binds the cell surface through a site distinct from its C-type lectin ligand-binding region.

J Biol Chem 2006 Oct 28;281(42):31509-16. Epub 2006 Aug 28.

Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M605824200
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http://dx.doi.org/10.1074/jbc.M605824200DOI Listing
October 2006

Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina.

Eur Heart J 2006 Jul 22;27(14):1678-84. Epub 2006 May 22.

Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1093/eurheartj/ehl042DOI Listing
July 2006

Stress-activated signaling pathways mediate the stimulation of pregnancy-associated plasma protein-A expression in cultured human fibroblasts.

Endocrinology 2006 Feb 3;147(2):885-90. Epub 2005 Nov 3.

Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1210/en.2005-0908DOI Listing
February 2006

Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris.

Eur Heart J 2005 Oct 29;26(20):2093-8. Epub 2005 Jul 29.

Department of Cardiac and Vascular Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.

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http://dx.doi.org/10.1093/eurheartj/ehi433DOI Listing
October 2005

Real-time measurement in living cells of insulin-like growth factor activity using bioluminescence resonance energy transfer.

Biochem Pharmacol 2005 Jun;69(12):1723-32

Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/j.bcp.2005.04.005DOI Listing
June 2005

Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP) is a multistep process of intra- and intermolecular disulfide rearrangements.

J Biol Chem 2005 Mar 12;280(11):9823-32. Epub 2005 Jan 12.

Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1074/jbc.M413228200DOI Listing
March 2005

IGFBP-4 degradation by pregnancy-associated plasma protein-A in MC3T3 osteoblasts.

Biochem Biophys Res Commun 2004 Dec;325(3):698-706

Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0402430
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http://dx.doi.org/10.1016/j.bbrc.2004.10.092DOI Listing
December 2004

The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity.

J Biol Chem 2004 Sep 15;279(37):38525-31. Epub 2004 Jul 15.

Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1074/jbc.M405222200DOI Listing
September 2004

Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells.

Int J Cancer 2004 Jul;110(5):633-40

Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1002/ijc.20185DOI Listing
July 2004

Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines.

Endocrinology 2004 Mar 4;145(3):1124-9. Epub 2003 Dec 4.

Division of Endocrinology, Metabolism, and Nutrition, Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1210/en.2003-1313DOI Listing
March 2004

Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development.

Development 2004 Mar;131(5):1187-94

The Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.00997
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http://dx.doi.org/10.1242/dev.00997DOI Listing
March 2004

Inhibition of proteolysis by the proform of eosinophil major basic protein (proMBP) requires covalent binding to its target proteinase.

FEBS Lett 2004 Feb;560(1-3):147-52

Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.

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http://dx.doi.org/10.1016/S0014-5793(04)00095-XDOI Listing
February 2004

Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin.

J Clin Endocrinol Metab 2003 Sep;88(9):4465-71

Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1210/jc.2003-030193DOI Listing
September 2003

Transforming growth factor-beta regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts.

J Bone Miner Res 2003 Jun;18(6):1066-72

Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 5590, USA.

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http://dx.doi.org/10.1359/jbmr.2003.18.6.1066DOI Listing
June 2003

[Unstable carotid plaque: biochemical and cellular marker of vulnerability].

Ital Heart J Suppl 2003 May;4(5):398-406

Laboratorio di Emodinamica, Istituto Policlinico San Donato, San Donato Milanese, MI.

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May 2003

Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment.

J Biol Chem 2003 Jan 5;278(4):2106-17. Epub 2002 Nov 5.

Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, Denmark.

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http://dx.doi.org/10.1074/jbc.M208777200DOI Listing
January 2003

Pregnancy-associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane.

J Clin Endocrinol Metab 2002 Nov;87(11):5235-40

Department of Gynecology and Obstetrics, Center for Research on Women's Health and Reproductive Medicine, Stanford University Medical Center, Stanford, CA 94305-5317, USA.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2002-020561DOI Listing
November 2002