Claudiu T Supuran

Claudiu T Supuran

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Claudiu T Supuran

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The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy.

J Enzyme Inhib Med Chem 2019 Dec;34(1):117-123

a Department of Clinical and Experimental Biomedical Sciences "Mario Serio", Section of Experimental Pathology and Oncology , University of Florence , Florence , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1532419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211231PMC
December 2019

Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line.

J Enzyme Inhib Med Chem 2019 Dec;34(1):75-86

d Neurofarba Dept., Section of Pharmaceutical and Nutriceutical Sciences , Università degli Studi di Firenze , Sesto Fiorentino (Florence) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1524380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211230PMC
December 2019

Synthesis and cytotoxic activities of novel copper and silver complexes of 1,3-diaryltriazene-substituted sulfonamides.

J Enzyme Inhib Med Chem 2019 Dec;34(1):110-116

e NEUROFARBA Department, Sezione di Scienze Farmaceutiche , Università degli Studi di Firenze , Florence , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1530994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211257PMC
December 2019

Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme.

J Enzyme Inhib Med Chem 2019 Dec;34(1):51-54

e Ondokuz Mayis University , Faculty of Agriculture, Department of Agricultural Biotechnology , Samsun , Turkey.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1520228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211254PMC
December 2019

An AGT-based protein-tag system for the labelling and surface immobilization of enzymes on E. coli outer membrane.

J Enzyme Inhib Med Chem 2019 Dec;34(1):490-499

a Department of Biology Agriculture and Food Sciences , Institute of Bioscience and BioResources - National Research Council of Italy , Naples , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1559161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366409PMC
December 2019

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme.

J Enzyme Inhib Med Chem 2019 Dec;34(1):528-531

b Sezione di Scienza Farmaceutiche, Neurofarba Department , Universita degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1564045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366411PMC
December 2019

Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine.

J Enzyme Inhib Med Chem 2019 Dec;34(1):644-650

a Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2019.1571273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366436PMC
December 2019

Synthesis carbonic anhydrase enzyme inhibition and antioxidant activity of novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine moieties.

J Enzyme Inhib Med Chem 2019 Dec;34(1):343-349

c Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche e Laboratorio Di Chimica Bioinorganica, Universita` Degli Studi Di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1553040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327993PMC
December 2019

Organoruthenium(II) complexes of acetazolamide potently inhibit human carbonic anhydrase isoforms I, II, IX and XII.

J Enzyme Inhib Med Chem 2019 Dec;34(1):388-393

b Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1547288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327979PMC
December 2019

Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies.

J Enzyme Inhib Med Chem 2019 Dec;34(1):429-437

f Department of Agricultural Biotechnology , Agriculture Faculty, Ondokuz Mayis University , Samsun , Turkey.

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http://dx.doi.org/10.1080/14756366.2018.1543288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327988PMC
December 2019

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties.

J Enzyme Inhib Med Chem 2019 Dec;34(1):244-249

a Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1547287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327980PMC
December 2019

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators.

J Enzyme Inhib Med Chem 2019 Dec;34(1):224-229

a Université de Lille, Inserm, CHU Lille, UMR-S 1172-JPArc-Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer , Lille 59000 , France.

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http://dx.doi.org/10.1080/14756366.2018.1543292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327990PMC
December 2019

Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells.

J Enzyme Inhib Med Chem 2019 Dec;34(1):703-711

d Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences , Università degli Studi di Firenze , Sesto Fiorentino (Florence) , Italy.

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http://dx.doi.org/10.1080/14756366.2019.1579805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394301PMC
December 2019

Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASL).

J Enzyme Inhib Med Chem 2019 Dec;34(1):946-954

a Department of Biology Agriculture and Food Sciences , Institute of Bioscience and BioResources - National Research Council of Italy , Naples , Italy.

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http://dx.doi.org/10.1080/14756366.2019.1605991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493269PMC
December 2019

Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of β-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa.

Bioorg Chem 2019 May 19;86:39-43. Epub 2019 Jan 19.

University of Florence, NEUROFARBA Department, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.030DOI Listing
May 2019

Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae.

Bioorg Chem 2019 May 29;86:183-186. Epub 2019 Jan 29.

University of Florence, Department of Neuroscience, Psychology, Drug Research and Child's Health, Section of Pharmaceutical and Nutraceutical Sciences, via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.065DOI Listing
May 2019

The management of diabetes mellitus-imperative role of natural products against dipeptidyl peptidase-4, α-glucosidase and sodium-dependent glucose co-transporter 2 (SGLT2).

Bioorg Chem 2019 May 4;86:305-315. Epub 2019 Feb 4.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.02.009DOI Listing
May 2019

Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes.

Bioorg Chem 2019 May 4;86:316-321. Epub 2019 Feb 4.

Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Universita degli Studi di Firenze, Florence, Italy.

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http://dx.doi.org/10.1016/j.bioorg.2019.02.008DOI Listing
May 2019

Discovery of new organoselenium compounds as antileishmanial agents.

Bioorg Chem 2019 May 31;86:339-345. Epub 2019 Jan 31.

Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.069DOI Listing
May 2019

Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors.

Bioorg Chem 2019 May 5;86:386-392. Epub 2019 Feb 5.

Università degli Studi di Firenze, Neurofarba Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.02.004DOI Listing
May 2019

Polypharmacology of epacadostat: a potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII.

Chem Commun (Camb) 2019 May;55(40):5720-5723

University of Florence, NEUROFARBA Dept., Sezione di Farmaceutica e Nutraceutica, Via Ugo Schiff 6, Sesto Fiorentino, 50019, Florence, Italy.

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http://xlink.rsc.org/?DOI=C8CC09568J
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http://dx.doi.org/10.1039/c8cc09568jDOI Listing
May 2019

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.

Gastroenterology 2019 May 9. Epub 2019 May 9.

Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, V5Z 1L3, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.05.004DOI Listing
May 2019

Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII.

Int J Mol Sci 2019 May 12;20(9). Epub 2019 May 12.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey.

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http://dx.doi.org/10.3390/ijms20092354DOI Listing
May 2019

Cloning, Purification, and Characterization of a β-Carbonic Anhydrase from , an Opportunistic Pathogen Involved in Dandruff and Seborrheic Dermatitis.

Int J Mol Sci 2019 May 17;20(10). Epub 2019 May 17.

Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.3390/ijms20102447DOI Listing
May 2019

Syntesis of thio- and seleno-acetamides bearing benzenesulfonamide as potent inhibitors of human carbonic anhydrase II and XII.

Bioorg Chem 2019 May 15;89:102984. Epub 2019 May 15.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.102984DOI Listing
May 2019

Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors.

Bioorg Chem 2019 Apr 3;85:198-208. Epub 2019 Jan 3.

Department of Chemistry, Kurukshetra University, Kurukshetra 136119, India. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.002DOI Listing
April 2019

Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.

Bioorg Med Chem 2019 Apr 1;27(8):1588-1594. Epub 2019 Mar 1.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.03.001DOI Listing
April 2019

Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.

J Med Chem 2019 Apr 10;62(8):4174-4192. Epub 2019 Apr 10.

Griffith Institute for Drug Discovery , Griffith University , Don Young Road , Nathan, Brisbane , Queensland 4111 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00282DOI Listing
April 2019

Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors.

Bioorg Chem 2019 Apr 5;87:765-772. Epub 2019 Apr 5.

Università degli Studi di Firenze, Neurofarba Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.04.004DOI Listing
April 2019

Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies.

Bioorg Chem 2019 Apr 3;87:794-802. Epub 2019 Apr 3.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.04.002DOI Listing
April 2019

-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis.

ACS Med Chem Lett 2019 Apr 27;10(4):413-418. Epub 2018 Nov 27.

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino (Firenze), Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466549PMC
April 2019

α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.

ACS Med Chem Lett 2019 Apr 19;10(4):661-665. Epub 2019 Feb 19.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466837PMC
April 2019

Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139 Florence, Italy.

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http://dx.doi.org/10.3390/ijms20081923DOI Listing
April 2019

Activation Studies of the γ-Carbonic Anhydrases from the Antarctic Marine Bacteria and with Amino Acids and Amines.

Mar Drugs 2019 Apr 22;17(4). Epub 2019 Apr 22.

Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via U. Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.

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http://dx.doi.org/10.3390/md17040238DOI Listing
April 2019

5-Arylisothiazol-3(2H)-one-1,(1)-(di)oxides: A new class of selective tumor-associated carbonic anhydrases (hCA IX and XII) inhibitors.

Eur J Med Chem 2019 Apr 30;175:40-48. Epub 2019 Apr 30.

Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Université de Reims Champagne-Ardenne, UFR Pharmacie, 51 Rue Cognacq-Jay, F-51096, Reims Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.04.072DOI Listing
April 2019

4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition.

Bioorg Chem 2019 Mar 19;83:198-204. Epub 2018 Oct 19.

NEUROFARBA Department - Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy; NEUROFARBA Department - Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183094
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http://dx.doi.org/10.1016/j.bioorg.2018.10.037DOI Listing
March 2019

Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates.

Bioorg Chem 2019 Mar 3;83:414-423. Epub 2018 Nov 3.

Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche e Laboratorio Di Chimica Bioinorganica, Universita' Degli Studi Di Firenze, Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.11.003DOI Listing
March 2019

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.

Bioorg Chem 2019 Mar 14;83:549-558. Epub 2018 Nov 14.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.11.014DOI Listing
March 2019

Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions.

Bioorg Chem 2019 Mar 22;84:260-268. Epub 2018 Nov 22.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.11.033DOI Listing
March 2019

Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity.

Bioorg Chem 2019 Mar 20;84:511-517. Epub 2018 Dec 20.

Neurofarba Department e Laboratorio di Chimica Bioinorganica, Universita Degli Studi di Firenze, Sesto Fiorentino (Florence), Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183132
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http://dx.doi.org/10.1016/j.bioorg.2018.12.028DOI Listing
March 2019

Novel approaches for designing drugs that interfere with pH regulation.

Expert Opin Drug Discov 2019 Mar 25;14(3):231-248. Epub 2019 Jan 25.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche , University of Florence , Sesto Fiorentino (Florence) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1567488DOI Listing
March 2019

α-Carbonic anhydrases are strongly activated by spinaceamine derivatives.

Bioorg Med Chem 2019 Mar 21;27(5):800-804. Epub 2019 Jan 21.

Università degli Studi di Firenze, Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.01.017DOI Listing
March 2019

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII.

Int J Mol Sci 2019 03 10;20(5). Epub 2019 Mar 10.

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Italy.

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http://dx.doi.org/10.3390/ijms20051208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429297PMC
March 2019

Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors.

Bioorg Chem 2019 Mar 6;87:78-90. Epub 2019 Mar 6.

Università degli Studi di Firenze, Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.03.007DOI Listing
March 2019

Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives.

Bioorg Chem 2019 Mar 19;87:425-431. Epub 2019 Mar 19.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.03.052DOI Listing
March 2019

Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators.

Bioorg Chem 2019 Mar 25;87:516-522. Epub 2019 Mar 25.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.03.062DOI Listing
March 2019

1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity.

Bioorg Chem 2019 Feb 1;82:109-116. Epub 2018 Oct 1.

Università degli Studi di Firenze, Department NEUROFARBA, Pharmaceutical and Nutraceutical Chemistry Section, University of Florence, via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1016/j.bioorg.2018.09.037DOI Listing
February 2019

Design, synthesis and biological evaluation of novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as potent carbonic anhydrase IX inhibitors.

Bioorg Chem 2019 Feb 5;82:117-122. Epub 2018 Oct 5.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.10.005DOI Listing
February 2019

3-Aminobenzenesulfonamides incorporating acylthiourea moieties selectively inhibit the tumor-associated carbonic anhydrase isoform IX over the off-target isoforms I, II and IV.

Bioorg Chem 2019 Feb 4;82:123-128. Epub 2018 Oct 4.

University of Florence, NEUROFARBA Department, Pharmaceutical and Nutraceutical Sciences Section, via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183092
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http://dx.doi.org/10.1016/j.bioorg.2018.10.006DOI Listing
February 2019

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Eur J Med Chem 2019 Feb 1;163:443-452. Epub 2018 Dec 1.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Palatucci, Polo didattico SS, Annunziata, 98168, Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.11.073DOI Listing
February 2019

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines.

Metabolites 2019 Feb 1;9(2). Epub 2019 Feb 1.

Sezione di Scienze Farmaceutiche e Nutraceutiche, Dipartimento Neurofarba, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, 50019 Florence, Italy.

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http://dx.doi.org/10.3390/metabo9020026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409850PMC
February 2019

Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand-Protein Binding Affinities.

ACS Cent Sci 2019 Feb 14;5(2):308-318. Epub 2019 Jan 14.

School of Chemistry, University of New South Wales, Dalton Building, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1021/acscentsci.8b00787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396573PMC
February 2019

Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide-Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors.

Chemistry 2019 Jan 14;25(5):1188-1192. Epub 2018 Dec 14.

Department NEUROFARBA-Pharmaceutical and nutraceutical section, University of Firenze, via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy.

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http://doi.wiley.com/10.1002/chem.201805039
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http://dx.doi.org/10.1002/chem.201805039DOI Listing
January 2019

Selenols: a new class of carbonic anhydrase inhibitors.

Chem Commun (Camb) 2019 Jan;55(5):648-651

University of Florence, NEUROFARBA Department, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.1039/c8cc08562eDOI Listing
January 2019

Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries.

Int J Mol Sci 2019 Jan 22;20(3). Epub 2019 Jan 22.

NEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.3390/ijms20030467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387369PMC
January 2019

Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX.

Bioorg Chem 2018 12 16;81:241-252. Epub 2018 Aug 16.

Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, University of Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.08.005DOI Listing
December 2018

Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties.

Bioorg Chem 2018 12 27;81:311-318. Epub 2018 Aug 27.

Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche e Laboratorio Di Chimica Bioinorganica, Universita' Degli Studi Di Firenze, Sesto Fiorentino, Florence, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183077
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http://dx.doi.org/10.1016/j.bioorg.2018.08.032DOI Listing
December 2018

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer.

Bioorg Chem 2018 12 7;81:425-432. Epub 2018 Sep 7.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.09.007DOI Listing
December 2018

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms.

J Enzyme Inhib Med Chem 2018 Dec;33(1):1453-1459

b Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section , University of Florence , Firenze , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1512597DOI Listing
December 2018

New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones.

Bioorg Chem 2018 12 8;81:433-439. Epub 2018 Sep 8.

Neurofarba Department, Sezione di Scienza Farmaceutiche e Nutraceutiche, Universita egli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.1016/j.bioorg.2018.09.013DOI Listing
December 2018

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.

J Enzyme Inhib Med Chem 2018 Dec;33(1):1299-1308

c Computer-Aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy , Bezmialem Vakif University , Istanbul , Turkey.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1499628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161604PMC
December 2018

Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism.

Bioorg Chem 2018 12 20;81:642-648. Epub 2018 Sep 20.

Department of University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.09.028DOI Listing
December 2018

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates.

J Enzyme Inhib Med Chem 2018 Dec;33(1):1565-1574

b NEUROFARBA Department, Pharmaceutical and Nutraceutical Sciences Section , University of Florence , Firenze , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1513927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171417PMC
December 2018

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors.

J Enzyme Inhib Med Chem 2018 Dec;33(1):1575-1580

b NEUROFARBA Dept., Sezione di Scienze Farmaceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Florence) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1515933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179046PMC
December 2018

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors.

Expert Opin Investig Drugs 2018 12 22;27(12):963-970. Epub 2018 Nov 22.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Firenze) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/13543784.2018.1
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http://dx.doi.org/10.1080/13543784.2018.1548608DOI Listing
December 2018

4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.

J Med Chem 2018 Dec 28;61(23):10860-10874. Epub 2018 Nov 28.

NEUROFARBA Dept., Sezione di Scienze Farmaceutiche , Università degli Studi di Firenze , Via Ugo Schiff 6 , 50019 Sesto Fiorentino Florence , Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01504DOI Listing
December 2018

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan .

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Sezione di Scienze Farmaceutiche e Nutraceutiche, Neurofarba Dept., Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.3390/ijms19123946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321117PMC
December 2018

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan .

Molecules 2018 Nov 28;23(12). Epub 2018 Nov 28.

Neurofarba Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via U. Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.

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http://dx.doi.org/10.3390/molecules23123112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321543PMC
November 2018

Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).

Expert Opin Ther Pat 2018 10 9;28(10):729-740. Epub 2018 Aug 9.

a Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Sesto Fiorentino (Firenze) , Italy.

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http://dx.doi.org/10.1080/13543776.2018.1508453DOI Listing
October 2018

Structural Mapping of Anion Inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa.

ChemMedChem 2018 Oct 13;13(19):2024-2029. Epub 2018 Sep 13.

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1002/cmdc.201800375DOI Listing
October 2018

Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases.

Expert Opin Ther Pat 2018 10 10;28(10):713-721. Epub 2018 Sep 10.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Firenze) , Italy.

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http://dx.doi.org/10.1080/13543776.2018.1519023DOI Listing
October 2018

Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas.

Expert Opin Ther Pat 2018 Oct 19;28(10):709-712. Epub 2018 Sep 19.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Firenze) , Italy.

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http://dx.doi.org/10.1080/13543776.2018.1523897DOI Listing
October 2018

Famotidine, an Antiulcer Agent, Strongly Inhibits and Human Carbonic Anhydrases.

ACS Med Chem Lett 2018 Oct 4;9(10):1035-1038. Epub 2018 Sep 4.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187404PMC
October 2018

Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.

Eur J Med Chem 2018 Sep 24;157:28-36. Epub 2018 Jul 24.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.07.054DOI Listing
September 2018

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.

Eur J Med Chem 2018 Sep 3;157:1214-1222. Epub 2018 Sep 3.

Department of University of Florence, NEUROFARBA Dept, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, Sesto Fiorentino, 50019, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.096DOI Listing
September 2018

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.

ACS Med Chem Lett 2018 Sep 29;9(9):947-951. Epub 2018 Aug 29.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142056PMC
September 2018