Claudiu T Supuran

Claudiu T Supuran

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Claudiu T Supuran

Claudiu T Supuran

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The carbonic anhydrase IX inhibitor SLC-0111 sensitises cancer cells to conventional chemotherapy.

Authors:
Elena Andreucci Jessica Ruzzolini Silvia Peppicelli Francesca Bianchini Anna Laurenzana Fabrizio Carta Claudiu T Supuran Lido Calorini

J Enzyme Inhib Med Chem 2019 Dec;34(1):117-123

a Department of Clinical and Experimental Biomedical Sciences "Mario Serio", Section of Experimental Pathology and Oncology , University of Florence , Florence , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1532419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211231PMC
December 2019

Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line.

Authors:
Ismail Koyuncu Ataman Gonel Mustafa Durgun Abdurrahim Kocyigit Ozgur Yuksekdag Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):75-86

d Neurofarba Dept., Section of Pharmaceutical and Nutriceutical Sciences , Università degli Studi di Firenze , Sesto Fiorentino (Florence) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1524380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211230PMC
December 2019

Synthesis and cytotoxic activities of novel copper and silver complexes of 1,3-diaryltriazene-substituted sulfonamides.

Authors:
Dilek Canakci Ismail Koyuncu Nabih Lolak Mustafa Durgun Suleyman Akocak Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):110-116

e NEUROFARBA Department, Sezione di Scienze Farmaceutiche , Università degli Studi di Firenze , Florence , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1530994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211257PMC
December 2019

Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme.

Authors:
Esma Kocaoğlu Oktay Talaz Hüseyin Çavdar Murat Şentürk Claudiu T Supuran Deniz Ekinci

J Enzyme Inhib Med Chem 2019 Dec;34(1):51-54

e Ondokuz Mayis University , Faculty of Agriculture, Department of Agricultural Biotechnology , Samsun , Turkey.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1520228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211254PMC
December 2019

Comparison of blood carbonic anhydrase activity of athletes performing interval and continuous running exercise at high altitude.

Authors:
Murat Tas Esra Senturk Deniz Ekinci Ramazan Demirdag Veysal Comakli Metin Bayram Murat Akyuz Murat Senturk Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):218-224

f Section of Pharmaceutical Chemistry, Neurofarba Department , University of Florence , Firenze, Italy.

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http://dx.doi.org/10.1080/14756366.2018.1545768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292344PMC
December 2019

Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors.

Authors:
Alessandra Rogato Sonia Del Prete Alessio Nocentini Vincenzo Carginale Claudiu T Supuran Clemente Capasso

J Enzyme Inhib Med Chem 2019 Dec;34(1):510-518

a Institute of Bioscience and BioResources, CNR , Naples , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1559840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352938PMC
December 2019

An AGT-based protein-tag system for the labelling and surface immobilization of enzymes on E. coli outer membrane.

Authors:
Rosa Merlo Sonia Del Prete Anna Valenti Rosanna Mattossovich Vincenzo Carginale Claudiu T Supuran Clemente Capasso Giuseppe Perugino

J Enzyme Inhib Med Chem 2019 Dec;34(1):490-499

a Department of Biology Agriculture and Food Sciences , Institute of Bioscience and BioResources - National Research Council of Italy , Naples , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1559161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366409PMC
December 2019

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme.

Authors:
Atilla Akdemir Andrea Angeli Füsun Göktaş Pınar Eraslan Elma Nilgün Karalı Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):528-531

b Sezione di Scienza Farmaceutiche, Neurofarba Department , Universita degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1564045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366411PMC
December 2019

Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine.

Authors:
Andrea Angeli Mariana Pinteala Stelian S Maier Sonia Del Prete Clemente Capasso Bogdan C Simionescu Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):644-650

a Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2019.1571273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366436PMC
December 2019

Synthesis carbonic anhydrase enzyme inhibition and antioxidant activity of novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine moieties.

Authors:
Deniz Üzeroğlu Payaz F Zehra Küçükbay Hasan Küçükbay Andrea Angeli Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):343-349

c Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche e Laboratorio Di Chimica Bioinorganica, Universita` Degli Studi Di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1553040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327993PMC
December 2019

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity.

Authors:
Mariantonia Logozzi Clemente Capasso Rossella Di Raimo Sonia Del Prete Davide Mizzoni Mario Falchi Claudiu T Supuran Stefano Fais

J Enzyme Inhib Med Chem 2019 Dec;34(1):272-278

a Department of Oncology and Molecular Medicine , National Institute of Health , Rome , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1538980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327996PMC
December 2019

Organoruthenium(II) complexes of acetazolamide potently inhibit human carbonic anhydrase isoforms I, II, IX and XII.

Authors:
Sara Seršen Katja Traven Jakob Kljun Iztok Turel Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):388-393

b Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1547288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327979PMC
December 2019

Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies.

Authors:
Huseyin Cavdar Murat Senturk Murat Guney Serdar Durdagi Gulru Kayik Claudiu T Supuran Deniz Ekinci

J Enzyme Inhib Med Chem 2019 Dec;34(1):429-437

f Department of Agricultural Biotechnology , Agriculture Faculty, Ondokuz Mayis University , Samsun , Turkey.

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http://dx.doi.org/10.1080/14756366.2018.1543288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327988PMC
December 2019

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties.

Authors:
Andrea Angeli Mariana Pinteala Stelian S Maier Sonia Del Prete Clemente Capasso Bogdan C Simionescu Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):244-249

a Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1547287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327980PMC
December 2019

New sulfonamides containing organometallic-acylhydrazones: synthesis, characterisation and biological evaluation as inhibitors of human carbonic anhydrases.

Authors:
Yosselin Huentupil Luis Peña Néstor Novoa Emanuela Berrino Rodrigo Arancibia Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):451-458

b Dipartimento Neurofarba , Università degli Studi di Firenze , Firenze , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1555156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327986PMC
December 2019

Identification and characterization of the α-CA in the outer membrane vesicles produced by Helicobacter pylori.

Authors:
Maurizio Ronci Sonia Del Prete Valentina Puca Simone Carradori Vincenzo Carginale Raffaella Muraro Gabriella Mincione Antonio Aceto Francesca Sisto Claudiu T Supuran Rossella Grande Clemente Capasso

J Enzyme Inhib Med Chem 2019 Dec;34(1):189-195

c CNR , Istituto di Bioscienze e Biorisorse , Napoli , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1539716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327981PMC
December 2019

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators.

Authors:
Marouan Rami Jean-Yves Winum Claudiu T Supuran Patricia Melnyk Saïd Yous

J Enzyme Inhib Med Chem 2019 Dec;34(1):224-229

a Université de Lille, Inserm, CHU Lille, UMR-S 1172-JPArc-Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer , Lille 59000 , France.

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http://dx.doi.org/10.1080/14756366.2018.1543292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327990PMC
December 2019

Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells.

Authors:
Ismail Koyuncu Yasin Tülüce Hewa Slahaddin Qadir Mustafa Durgun Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):703-711

d Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences , Università degli Studi di Firenze , Sesto Fiorentino (Florence) , Italy.

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http://dx.doi.org/10.1080/14756366.2019.1579805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394301PMC
December 2019

Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†.

Authors:
Yassine Aimene Romain Eychenne Sonia Mallet-Ladeira Nathalie Saffon Jean-Yves Winum Alessio Nocentini Claudiu T Supuran Eric Benoist Achour Seridi

J Enzyme Inhib Med Chem 2019 Dec;34(1):773-782

a Laboratoire de Chimie, physique Université du 8 Mai 1945 , Guelma , Algérie.

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http://dx.doi.org/10.1080/14756366.2019.1585835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407592PMC
December 2019

Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASL).

Authors:
Sonia Del Prete Rosa Merlo Anna Valenti Rosanna Mattossovich Mosè Rossi Vincenzo Carginale Claudiu T Supuran Giuseppe Perugino Clemente Capasso

J Enzyme Inhib Med Chem 2019 Dec;34(1):946-954

a Department of Biology Agriculture and Food Sciences , Institute of Bioscience and BioResources - National Research Council of Italy , Naples , Italy.

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http://dx.doi.org/10.1080/14756366.2019.1605991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493269PMC
December 2019

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies.

Authors:
Alessandra Ammazzalorso Simone Carradori Andrea Angeli Atilla Akdemir Barbara De Filippis Marialuigia Fantacuzzi Letizia Giampietro Cristina Maccallini Rosa Amoroso Claudiu T Supuran

J Enzyme Inhib Med Chem 2019 Dec;34(1):1051-1061

b Laboratorio di Chimica Bioinorganica , Università degli Studi di Firenze , Florence , Italy.

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http://dx.doi.org/10.1080/14756366.2019.1611801DOI Listing
December 2019

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

Authors:
Klaartje Somers Victoria W Wen Shiloh M C Middlemiss Brenna Osborne Helen Forgham MoonSun Jung Mawar Karsa Molly Clifton Angelika Bongers Jixuan Gao Chelsea Mayoh Newsha Raoufi-Rad Eric P Kusnadi Kate M Hannan David A Scott Alan Kwek Bing Liu Claudia Flemming Daria A Chudakova Ruby Pandher Tim W Failes James Lim Andrea Angeli Andrei L Osterman Toshihiko Imamura Ursula R Kees Claudiu T Supuran Richard B Pearson Ross D Hannan Thomas P Davis Joshua McCarroll Maria Kavallaris Nigel Turner Andrei V Gudkov Michelle Haber Murray D Norris Michelle J Henderson

Oncogene 2019 May 22;38(20):3824-3842. Epub 2019 Jan 22.

Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Randwick, NSW, Australia.

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http://dx.doi.org/10.1038/s41388-018-0666-5DOI Listing
May 2019

Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of β-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa.

Authors:
Silvia Bua Sameh M Osman Zeid AlOthman Claudiu T Supuran Alessio Nocentini

Bioorg Chem 2019 May 19;86:39-43. Epub 2019 Jan 19.

University of Florence, NEUROFARBA Department, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.030DOI Listing
May 2019

Click-tailed benzenesulfonamides as potent bacterial carbonic anhydrase inhibitors for targeting Mycobacterium tuberculosis and Vibrio cholerae.

Authors:
Silvia Bua Sameh M Osman Sonia Del Prete Clemente Capasso Zeid AlOthman Alessio Nocentini Claudiu T Supuran

Bioorg Chem 2019 May 29;86:183-186. Epub 2019 Jan 29.

University of Florence, Department of Neuroscience, Psychology, Drug Research and Child's Health, Section of Pharmaceutical and Nutraceutical Sciences, via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.065DOI Listing
May 2019

The management of diabetes mellitus-imperative role of natural products against dipeptidyl peptidase-4, α-glucosidase and sodium-dependent glucose co-transporter 2 (SGLT2).

Authors:
Ghulam Abbas Ahmed Al Harrasi Hidayat Hussain Ahmed Hamaed Claudiu T Supuran

Bioorg Chem 2019 May 4;86:305-315. Epub 2019 Feb 4.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.02.009DOI Listing
May 2019

Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes.

Authors:
Kaan Kucukoglu Halise Inci Gul Parham Taslimi Ilhami Gulcin Claudiu T Supuran

Bioorg Chem 2019 May 4;86:316-321. Epub 2019 Feb 4.

Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Universita degli Studi di Firenze, Florence, Italy.

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http://dx.doi.org/10.1016/j.bioorg.2019.02.008DOI Listing
May 2019

Discovery of new organoselenium compounds as antileishmanial agents.

Authors:
Abdul-Malek S Al-Tamimi Mikel Etxebeste-Mitxeltorena Carmen Sanmartín Antonio Jiménez-Ruiz Leo Syrjänen Seppo Parkkila Silvia Selleri Fabrizio Carta Andrea Angeli Claudiu T Supuran

Bioorg Chem 2019 May 31;86:339-345. Epub 2019 Jan 31.

Department of Neuroscience, Psychology, Drug Research and Child's Health (NEUROFARBA), Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.069DOI Listing
May 2019

Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors.

Authors:
Pavitra S Thacker Mallika Alvala Mohammed Arifuddin Andrea Angeli Claudiu T Supuran

Bioorg Chem 2019 May 5;86:386-392. Epub 2019 Feb 5.

Università degli Studi di Firenze, Neurofarba Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.02.004DOI Listing
May 2019

Polypharmacology of epacadostat: a potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII.

Authors:
Andrea Angeli Marta Ferraroni Alessio Nocentini Silvia Selleri Paola Gratteri Claudiu T Supuran Fabrizio Carta

Chem Commun (Camb) 2019 May;55(40):5720-5723

University of Florence, NEUROFARBA Dept., Sezione di Farmaceutica e Nutraceutica, Via Ugo Schiff 6, Sesto Fiorentino, 50019, Florence, Italy.

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http://xlink.rsc.org/?DOI=C8CC09568J
Publisher Site
http://dx.doi.org/10.1039/c8cc09568jDOI Listing
May 2019

Extrinsic acidosis suppresses glycolysis and migration while increasing network formation in pulmonary microvascular endothelial cells.

Authors:
Ji Young Lee Mher Onanyan Ian Garrison Roderica White Maura Crook Mikhail F Alexeyev Natalya Kozhukhar Viktoriya Pastukh Erik Richard Swenson Claudiu T Supuran Troy Stevens

Am J Physiol Lung Cell Mol Physiol 2019 May 1. Epub 2019 May 1.

Physiology and Cell Biology and Medicine, Center for Lung Biology, University of South Alabama, United States.

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https://www.physiology.org/doi/10.1152/ajplung.00544.2018
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http://dx.doi.org/10.1152/ajplung.00544.2018DOI Listing
May 2019

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells.

Authors:
Mam Y Mboge Zhijuan Chen Daniel Khokhar Alyssa Wolff Lingbao Ai Coy D Heldermon Murat Bozdag Fabrizio Carta Claudiu T Supuran Kevin D Brown Robert McKenna Christopher J Frost Susan C Frost

Biochem J 2019 May 9. Epub 2019 May 9.

University of Florida, Gainesville, Florida, United States

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http://www.biochemj.org/lookup/doi/10.1042/BCJ20190177
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http://dx.doi.org/10.1042/BCJ20190177DOI Listing
May 2019

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia.

Authors:
Paul C McDonald Shawn C Chafe Wells S Brown Saeed Saberi Mridula Swayampakula Geetha Venkateswaran Oksana Nemirovsky Jordan A Gillespie Joanna M Karasinska Steven E Kalloger Claudiu T Supuran David F Schaeffer Ali Bashashati Sohrab P Shah James T Topham Donald T Yapp Jinyang Li Daniel J Renouf Ben Z Stanger Shoukat Dedhar

Gastroenterology 2019 May 9. Epub 2019 May 9.

Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, British Columbia, V5Z 1L3, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.05.004DOI Listing
May 2019

Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII.

Authors:
Kübra Demir-Yazıcı Silvia Bua Nurgül Mutlu Akgüneş Atilla Akdemir Claudiu T Supuran Özlen Güzel-Akdemir

Int J Mol Sci 2019 May 12;20(9). Epub 2019 May 12.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey.

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http://dx.doi.org/10.3390/ijms20092354DOI Listing
May 2019

Cloning, Purification, and Characterization of a β-Carbonic Anhydrase from , an Opportunistic Pathogen Involved in Dandruff and Seborrheic Dermatitis.

Authors:
Sonia Del Prete Daniela Vullo Cynthia Ghobril Julien Hitce Cécile Clavaud Xavier Marat Clemente Capasso Claudiu T Supuran

Int J Mol Sci 2019 May 17;20(10). Epub 2019 May 17.

Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.3390/ijms20102447DOI Listing
May 2019

Syntesis of thio- and seleno-acetamides bearing benzenesulfonamide as potent inhibitors of human carbonic anhydrase II and XII.

Authors:
Damiano Tanini Antonella Capperucci Martina Scopelliti Andrea Milaneschi Andrea Angeli Claudiu T Supuran

Bioorg Chem 2019 May 15;89:102984. Epub 2019 May 15.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.102984DOI Listing
May 2019

Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.

Authors:
Mam Y Mboge Zhijuan Chen Alyssa Wolff John V Mathias Chingkuang Tu Kevin D Brown Murat Bozdag Fabrizio Carta Claudiu T Supuran Robert McKenna Susan C Frost

PLoS One 2018 19;13(11):e0207417. Epub 2018 Nov 19.

Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207417PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242694PMC
April 2019

Synthesis of novel benzenesulfonamide bearing 1,2,3-triazole linked hydroxy-trifluoromethylpyrazolines and hydrazones as selective carbonic anhydrase isoforms IX and XII inhibitors.

Authors:
Vikas Sharma Rajiv Kumar Silvia Bua Claudiu T Supuran Pawan K Sharma

Bioorg Chem 2019 Apr 3;85:198-208. Epub 2019 Jan 3.

Department of Chemistry, Kurukshetra University, Kurukshetra 136119, India. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.01.002DOI Listing
April 2019

Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines.

Authors:
Mikhail Krasavin Anton Shetnev Sergey Baykov Stanislav Kalinin Alessio Nocentini Vladimir Sharoyko Giulio Poli Tiziano Tuccinardi Mikhail Korsakov Tatiana B Tennikova Claudiu T Supuran

Eur J Med Chem 2019 Apr 15;168:301-314. Epub 2019 Feb 15.

Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.02.044DOI Listing
April 2019

Discovery of new ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as carbonic anhydrase I, II, IX and XII inhibitors.

Authors:
Nabih Lolak Suleyman Akocak Silvia Bua Rajesh K K Sanku Claudiu T Supuran

Bioorg Med Chem 2019 Apr 1;27(8):1588-1594. Epub 2019 Mar 1.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.03.001DOI Listing
April 2019

Carbonic Anhydrase XII Inhibitors Overcome Temozolomide Resistance in Glioblastoma.

Authors:
Prashant Mujumdar Joanna Kopecka Silvia Bua Claudiu T Supuran Chiara Riganti Sally-Ann Poulsen

J Med Chem 2019 Apr 10;62(8):4174-4192. Epub 2019 Apr 10.

Griffith Institute for Drug Discovery , Griffith University , Don Young Road , Nathan, Brisbane , Queensland 4111 , Australia.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00282DOI Listing
April 2019

Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors.

Authors:
Sridhar Goud Narella Mohammed Ghouse Shaik Arifuddin Mohammed Mallika Alvala Andrea Angeli Claudiu T Supuran

Bioorg Chem 2019 Apr 5;87:765-772. Epub 2019 Apr 5.

Università degli Studi di Firenze, Neurofarba Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.04.004DOI Listing
April 2019

Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity and molecular modeling studies.

Authors:
Mahmoud F Abo-Ashour Wagdy M Eldehna Alessio Nocentini Hany S Ibrahim Silvia Bua Hatem A Abdel-Aziz Sahar M Abou-Seri Claudiu T Supuran

Bioorg Chem 2019 Apr 3;87:794-802. Epub 2019 Apr 3.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.04.002DOI Listing
April 2019

-Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis.

Authors:
Alessandro Bonardi Alane Beatriz Vermelho Veronica da Silva Cardoso Mirian Claudia de Souza Pereira Leonardo da Silva Lara Silvia Selleri Paola Gratteri Claudiu T Supuran Alessio Nocentini

ACS Med Chem Lett 2019 Apr 27;10(4):413-418. Epub 2018 Nov 27.

Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino (Firenze), Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466549PMC
April 2019

α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.

Authors:
Alessio Nocentini Alessia Lucidi Francesca Perut Annamaria Massa Daniela Tomaselli Paola Gratteri Nicola Baldini Dante Rotili Antonello Mai Claudiu T Supuran

ACS Med Chem Lett 2019 Apr 19;10(4):661-665. Epub 2019 Feb 19.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466837PMC
April 2019

Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Authors:
Laura Micheli Murat Bozdag Ozlem Akgul Fabrizio Carta Clizia Guccione Maria Camilla Bergonzi Anna Rita Bilia Lorenzo Cinci Elena Lucarini Carmen Parisio Claudiu T Supuran Carla Ghelardini Lorenzo Di Cesare Mannelli

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139 Florence, Italy.

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http://dx.doi.org/10.3390/ijms20081923DOI Listing
April 2019

Activation Studies of the γ-Carbonic Anhydrases from the Antarctic Marine Bacteria and with Amino Acids and Amines.

Authors:
Andrea Angeli Sonia Del Prete Sameh M Osman Zeid AlOthman William A Donald Clemente Capasso Claudiu T Supuran

Mar Drugs 2019 Apr 22;17(4). Epub 2019 Apr 22.

Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via U. Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.

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http://dx.doi.org/10.3390/md17040238DOI Listing
April 2019

5-Arylisothiazol-3(2H)-one-1,(1)-(di)oxides: A new class of selective tumor-associated carbonic anhydrases (hCA IX and XII) inhibitors.

Authors:
Benedetta Cornelio Marie Laronze-Cochard Raimundo Miambo Michela De Grandis Rossana Riccioni Boryana Borisova Dimitar Dontchev Carine Machado Mariangela Ceruso Antonella Fontana Claudiu T Supuran Janos Sapi

Eur J Med Chem 2019 Apr 30;175:40-48. Epub 2019 Apr 30.

Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, Université de Reims Champagne-Ardenne, UFR Pharmacie, 51 Rue Cognacq-Jay, F-51096, Reims Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.04.072DOI Listing
April 2019

4-Substituted benzenesulfonamides featuring cyclic imides moieties exhibit potent and isoform-selective carbonic anhydrase II/IX inhibition.

Authors:
Alaa A-M Abdel-Aziz Adel S El-Azab Adel H Ghiaty Paola Gratteri Claudiu T Supuran Alessio Nocentini

Bioorg Chem 2019 Mar 19;83:198-204. Epub 2018 Oct 19.

NEUROFARBA Department - Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy; NEUROFARBA Department - Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.10.037DOI Listing
March 2019

Synthesis and carbonic anhydrase inhibitory properties of novel 4-(2-aminoethyl)benzenesulfonamide-dipeptide conjugates.

Authors:
Hasan Küçükbay Nesrin Buğday F Zehra Küçükbay Emanuela Berrino Gianluca Bartolucci Sonia Del Prete Clemente Capasso Claudiu T Supuran

Bioorg Chem 2019 Mar 3;83:414-423. Epub 2018 Nov 3.

Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche e Laboratorio Di Chimica Bioinorganica, Universita' Degli Studi Di Firenze, Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.11.003DOI Listing
March 2019

SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.

Authors:
Wagdy M Eldehna Mahmoud F Abo-Ashour Emanuela Berrino Daniela Vullo Hazem A Ghabbour Sara T Al-Rashood Ghada S Hassan Hamad M Alkahtani Abdulrahman A Almehizia Amal Alharbi Hatem A Abdel-Aziz Claudiu T Supuran

Bioorg Chem 2019 Mar 14;83:549-558. Epub 2018 Nov 14.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.11.014DOI Listing
March 2019

Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions.

Authors:
Alaa A-M Abdel-Aziz Andrea Angeli Adel S El-Azab Mohammed E A Hammouda Magda A El-Sherbeny Claudiu T Supuran

Bioorg Chem 2019 Mar 22;84:260-268. Epub 2018 Nov 22.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.11.033DOI Listing
March 2019

Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity.

Authors:
Dilan Ozmen Ozgun Halise Inci Gul Cem Yamali Hiroshi Sakagami Ilhami Gulcin Murat Sukuroglu Claudiu T Supuran

Bioorg Chem 2019 Mar 20;84:511-517. Epub 2018 Dec 20.

Neurofarba Department e Laboratorio di Chimica Bioinorganica, Universita Degli Studi di Firenze, Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.1016/j.bioorg.2018.12.028DOI Listing
March 2019

Novel approaches for designing drugs that interfere with pH regulation.

Authors:
Emanuela Berrino Claudiu T Supuran

Expert Opin Drug Discov 2019 Mar 25;14(3):231-248. Epub 2019 Jan 25.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche , University of Florence , Sesto Fiorentino (Florence) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1567488DOI Listing
March 2019

α-Carbonic anhydrases are strongly activated by spinaceamine derivatives.

Authors:
Suleyman Akocak Nabih Lolak Silvia Bua Alessio Nocentini Gulcin Karakoc Claudiu T Supuran

Bioorg Med Chem 2019 Mar 21;27(5):800-804. Epub 2019 Jan 21.

Università degli Studi di Firenze, Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.01.017DOI Listing
March 2019

Comparison of the Sulfonamide Inhibition Profiles of the α-Carbonic Anhydrase Isoforms (SpiCA1, SpiCA2 and SpiCA3) Encoded by the Genome of the Scleractinian Coral .

Authors:
Sonia Del Prete Silvia Bua Fatmah A S Alasmary Zeid AlOthman Sylvie Tambutté Didier Zoccola Claudiu T Supuran Clemente Capasso

Mar Drugs 2019 Mar 1;17(3). Epub 2019 Mar 1.

Istituto di Bioscienze e Biorisorse, National Research Council (CNR), Via Pietro Castellino 111, 80131 Napoli, Italy.

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http://dx.doi.org/10.3390/md17030146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471618PMC
March 2019

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII.

Authors:
Kerem Buran Silvia Bua Giulio Poli F Esra Önen Bayram Tiziano Tuccinardi Claudiu T Supuran

Int J Mol Sci 2019 03 10;20(5). Epub 2019 Mar 10.

NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Italy.

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http://dx.doi.org/10.3390/ijms20051208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429297PMC
March 2019

Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors.

Authors:
Adel S El-Azab Alaa A-M Abdel-Aziz Sivia Bua Alessio Nocentini Manal A El-Gendy Menshawy A Mohamed Taghreed Z Shawer Nawaf A AlSaif Claudiu T Supuran

Bioorg Chem 2019 Mar 6;87:78-90. Epub 2019 Mar 6.

Università degli Studi di Firenze, Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.03.007DOI Listing
March 2019

Design, synthesis, and carbonic anhydrase inhibition activity of benzenesulfonamide-linked novel pyrazoline derivatives.

Authors:
Alaa A-M Abdel-Aziz Adel S El-Azab Silvia Bua Alessio Nocentini Mohamed A Abu El-Enin Mohammed M Alanazi Nawaf A AlSaif Mohamed M Hefnawy Claudiu T Supuran

Bioorg Chem 2019 Mar 19;87:425-431. Epub 2019 Mar 19.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.03.052DOI Listing
March 2019

Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators.

Authors:
Damiano Tanini Antonella Capperucci Claudiu T Supuran Andrea Angeli

Bioorg Chem 2019 Mar 25;87:516-522. Epub 2019 Mar 25.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.03.062DOI Listing
March 2019

Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma.

Authors:
Belma Zengin Kurt Aydan Dag Berna Doğan Serdar Durdagi Andrea Angeli Alessio Nocentini Claudiu T Supuran Fatih Sonmez

Bioorg Chem 2019 Mar 7;87:838-850. Epub 2019 Mar 7.

Sakarya University of Applied Sciences, Pamukova Vocational Highschool, Pamukova, Turkey.

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http://dx.doi.org/10.1016/j.bioorg.2019.03.003DOI Listing
March 2019

1,2,4-Trisubstituted imidazolinones with dual carbonic anhydrase and p38 mitogen-activated protein kinase inhibitory activity.

Authors:
Hanan H Georgey Fatma M Manhi Walaa R Mahmoud Nehad A Mohamed Emanuela Berrino Claudiu T Supuran

Bioorg Chem 2019 Feb 1;82:109-116. Epub 2018 Oct 1.

Università degli Studi di Firenze, Department NEUROFARBA, Pharmaceutical and Nutraceutical Chemistry Section, University of Florence, via Ugo Schiff 6, I-50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1016/j.bioorg.2018.09.037DOI Listing
February 2019

Design, synthesis and biological evaluation of novel ureido benzenesulfonamides incorporating 1,3,5-triazine moieties as potent carbonic anhydrase IX inhibitors.

Authors:
Nabih Lolak Suleyman Akocak Silvia Bua Claudiu T Supuran

Bioorg Chem 2019 Feb 5;82:117-122. Epub 2018 Oct 5.

Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.10.005DOI Listing
February 2019

3-Aminobenzenesulfonamides incorporating acylthiourea moieties selectively inhibit the tumor-associated carbonic anhydrase isoform IX over the off-target isoforms I, II and IV.

Authors:
Tanzeela Abdul Fattah Silvia Bua Aamer Saeed Ghulam Shabir Claudiu T Supuran

Bioorg Chem 2019 Feb 4;82:123-128. Epub 2018 Oct 4.

University of Florence, NEUROFARBA Department, Pharmaceutical and Nutraceutical Sciences Section, via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183092
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http://dx.doi.org/10.1016/j.bioorg.2018.10.006DOI Listing
February 2019

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Authors:
Maria Rosa Buemi Anna Di Fiore Laura De Luca Andrea Angeli Francesca Mancuso Stefania Ferro Simona Maria Monti Martina Buonanno Emilio Russo Giovanbattista De Sarro Giuseppina De Simone Claudiu T Supuran Rosaria Gitto

Eur J Med Chem 2019 Feb 1;163:443-452. Epub 2018 Dec 1.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali (CHIBIOFARAM), Università degli Studi di Messina, Viale Palatucci, Polo didattico SS, Annunziata, 98168, Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.11.073DOI Listing
February 2019

Continued exploration of 1,2,4-oxadiazole periphery for carbonic anhydrase-targeting primary arene sulfonamides: Discovery of subnanomolar inhibitors of membrane-bound hCA IX isoform that selectively kill cancer cells in hypoxic environment.

Authors:
Mikhail Krasavin Anton Shetnev Tatyana Sharonova Sergey Baykov Stanislav Kalinin Alessio Nocentini Vladimir Sharoyko Giulio Poli Tiziano Tuccinardi Sofia Presnukhina Tatiana B Tennikova Claudiu T Supuran

Eur J Med Chem 2019 Feb 21;164:92-105. Epub 2018 Dec 21.

Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.12.049DOI Listing
February 2019

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan with Amino Acids and Amines.

Authors:
Silvia Bua Susanna Haapanen Marianne Kuuslahti Seppo Parkkila Claudiu T Supuran

Metabolites 2019 Feb 1;9(2). Epub 2019 Feb 1.

Sezione di Scienze Farmaceutiche e Nutraceutiche, Dipartimento Neurofarba, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, 50019 Florence, Italy.

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http://dx.doi.org/10.3390/metabo9020026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409850PMC
February 2019

Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand-Protein Binding Affinities.

Authors:
Giang T H Nguyen Thinh N Tran Matthew N Podgorski Stephen G Bell Claudiu T Supuran William A Donald

ACS Cent Sci 2019 Feb 14;5(2):308-318. Epub 2019 Jan 14.

School of Chemistry, University of New South Wales, Dalton Building, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1021/acscentsci.8b00787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396573PMC
February 2019

The Possible Role of in Gastric Cancer and Its Management.

Authors:
Khalid O Alfarouk Adil H H Bashir Ahmed N Aljarbou AbdelRahman M Ramadan Abdel Khalig Muddathir Sari T S AlHoufie Abdelhamid Hifny Gamal O Elhassan Muntaser E Ibrahim Saad S Alqahtani Shakir D AlSharari Claudiu T Supuran Cyril Rauch Rosa Angela Cardone Stephan J Reshkin Stefano Fais Salvador Harguindey

Front Oncol 2019 22;9:75. Epub 2019 Feb 22.

Institute for Clinical Biology and Metabolism, Vitoria, Spain.

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http://dx.doi.org/10.3389/fonc.2019.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395443PMC
February 2019

Phosphorus versus Sulfur: Discovery of Benzenephosphonamidates as Versatile Sulfonamide-Mimic Chemotypes Acting as Carbonic Anhydrase Inhibitors.

Authors:
Alessio Nocentini Paola Gratteri Claudiu T Supuran

Chemistry 2019 Jan 14;25(5):1188-1192. Epub 2018 Dec 14.

Department NEUROFARBA-Pharmaceutical and nutraceutical section, University of Firenze, via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy.

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http://doi.wiley.com/10.1002/chem.201805039
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January 2019

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents.

Authors:
Wagdy M Eldehna Mahmoud F Abo-Ashour Alessio Nocentini Radwan S El-Haggar Silvia Bua Alessandro Bonardi Sara T Al-Rashood Ghada S Hassan Paola Gratteri Hatem A Abdel-Aziz Claudiu T Supuran

Eur J Med Chem 2019 Jan 2;162:147-160. Epub 2018 Nov 2.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183094
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http://dx.doi.org/10.1016/j.ejmech.2018.10.068DOI Listing
January 2019

Selenols: a new class of carbonic anhydrase inhibitors.

Authors:
Andrea Angeli Damiano Tanini Alessio Nocentini Antonella Capperucci Marta Ferraroni Paola Gratteri Claudiu T Supuran

Chem Commun (Camb) 2019 Jan;55(5):648-651

University of Florence, NEUROFARBA Department, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.1039/c8cc08562eDOI Listing
January 2019

Carbonic Anhydrase Inhibitors of Different Structures Dilate Pre-Contracted Porcine Retinal Arteries.

Authors:
Thor Eysteinsson Hrönn Gudmundsdottir Arnar Oessur Hardarson Emanuela Berrino Silvia Selleri Claudiu T Supuran Fabrizio Carta

Int J Mol Sci 2019 Jan 22;20(3). Epub 2019 Jan 22.

NEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche e Nutraceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.3390/ijms20030467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387369PMC
January 2019

Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX.

Authors:
Peter Mikuš Dominika Krajčiová Mária Mikulová Branislav Horváth Daniel Pecher Vladimír Garaj Silvia Bua Andrea Angeli Claudiu T Supuran

Bioorg Chem 2018 12 16;81:241-252. Epub 2018 Aug 16.

Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, University of Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.08.005DOI Listing
December 2018

Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties.

Authors:
Nesrin Buğday F Zehra Küçükbay Hasan Küçükbay Silvia Bua Gianluca Bartolucci Janis Leitans Andris Kazaks Kaspars Tars Claudiu T Supuran

Bioorg Chem 2018 12 27;81:311-318. Epub 2018 Aug 27.

Dipartimento Neurofarba, Sezione Di Scienze Farmaceutiche E Nutraceutiche e Laboratorio Di Chimica Bioinorganica, Universita' Degli Studi Di Firenze, Sesto Fiorentino, Florence, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183077
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http://dx.doi.org/10.1016/j.bioorg.2018.08.032DOI Listing
December 2018

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer.

Authors:
Wagdy M Eldehna Alessio Nocentini Sara T Al-Rashood Ghada S Hassan Hamad M Alkahtani Abdulrahman A Almehizia Ahmed M Reda Hatem A Abdel-Aziz Claudiu T Supuran

Bioorg Chem 2018 12 7;81:425-432. Epub 2018 Sep 7.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.09.007DOI Listing
December 2018

Target-based drug discovery through inversion of quantitative structure-drug-property relationships and molecular simulation: CA IX-sulphonamide complexes.

Authors:
Petar Žuvela J Jay Liu Myunggi Yi Paweł P Pomastowski Gulyaim Sagandykova Mariusz Belka Jonathan David Tomasz Bączek Krzysztof Szafrański Beata Żołnowska Jarosław Sławiński Claudiu T Supuran Ming Wah Wong Bogusław Buszewski

J Enzyme Inhib Med Chem 2018 Dec;33(1):1430-1443

b Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry , Nicolaus Copernicus University , Toruń , Poland.

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http://dx.doi.org/10.1080/14756366.2018.1511551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151961PMC
December 2018

Steroids interfere with human carbonic anhydrase activity by using alternative binding mechanisms.

Authors:
Alessio Nocentini Alessandro Bonardi Paola Gratteri Bruno Cerra Antimo Gioiello Claudiu T Supuran

J Enzyme Inhib Med Chem 2018 Dec;33(1):1453-1459

b Department of NEUROFARBA, Pharmaceutical and Nutraceutical Section , University of Florence , Firenze , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1512597DOI Listing
December 2018

New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones.

Authors:
Mehtap Tugrak Halise Inci Gul Hiroshi Sakagami Ilhami Gulcin Claudiu T Supuran

Bioorg Chem 2018 12 8;81:433-439. Epub 2018 Sep 8.

Neurofarba Department, Sezione di Scienza Farmaceutiche e Nutraceutiche, Universita egli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.

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http://dx.doi.org/10.1016/j.bioorg.2018.09.013DOI Listing
December 2018

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.

Authors:
Özlen Güzel-Akdemir Andrea Angeli Kübra Demir Claudiu T Supuran Atilla Akdemir

J Enzyme Inhib Med Chem 2018 Dec;33(1):1299-1308

c Computer-Aided Drug Discovery Laboratory, Department of Pharmacology, Faculty of Pharmacy , Bezmialem Vakif University , Istanbul , Turkey.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1499628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161604PMC
December 2018

Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism.

Authors:
Andrea Angeli Damiano Tanini Antonella Capperucci Gianni Malevolti Francesca Turco Marta Ferraroni Claudiu T Supuran

Bioorg Chem 2018 12 20;81:642-648. Epub 2018 Sep 20.

Department of University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino (Florence), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2018.09.028DOI Listing
December 2018

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates.

Authors:
Marwa G El-Gazzar Nessma H Nafie Alessio Nocentini Mostafa M Ghorab Helmi I Heiba Claudiu T Supuran

J Enzyme Inhib Med Chem 2018 Dec;33(1):1565-1574

b NEUROFARBA Department, Pharmaceutical and Nutraceutical Sciences Section , University of Florence , Firenze , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1513927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171417PMC
December 2018

Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases.

Authors:
Giannamaria Annunziato Laura Giovati Andrea Angeli Marialaura Pavone Sonia Del Prete Marco Pieroni Clemente Capasso Agostino Bruno Stefania Conti Walter Magliani Claudiu T Supuran Gabriele Costantino

J Enzyme Inhib Med Chem 2018 Dec;33(1):1537-1544

a Department of Food and Drugs , University of Parma , Parma , Italy.

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http://dx.doi.org/10.1080/14756366.2018.1516652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179086PMC
December 2018

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors.

Authors:
Suleyman Akocak Nabih Lolak Silvia Bua Claudiu T Supuran

J Enzyme Inhib Med Chem 2018 Dec;33(1):1575-1580

b NEUROFARBA Dept., Sezione di Scienze Farmaceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Florence) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1
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http://dx.doi.org/10.1080/14756366.2018.1515933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179046PMC
December 2018

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors.

Authors:
Claudiu T Supuran

Expert Opin Investig Drugs 2018 12 22;27(12):963-970. Epub 2018 Nov 22.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Firenze) , Italy.

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https://www.tandfonline.com/doi/full/10.1080/13543784.2018.1
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http://dx.doi.org/10.1080/13543784.2018.1548608DOI Listing
December 2018

4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.

Authors:
Alessio Nocentini Elena Trallori Srishti Singh Carrie L Lomelino Gianluca Bartolucci Lorenzo Di Cesare Mannelli Carla Ghelardini Robert McKenna Paola Gratteri Claudiu T Supuran

J Med Chem 2018 Dec 28;61(23):10860-10874. Epub 2018 Nov 28.

NEUROFARBA Dept., Sezione di Scienze Farmaceutiche , Università degli Studi di Firenze , Via Ugo Schiff 6 , 50019 Sesto Fiorentino Florence , Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.8b01504DOI Listing
December 2018

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan .

Authors:
Silvia Bua Susanna Haapanen Marianne Kuuslahti Seppo Parkkila Claudiu T Supuran

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Sezione di Scienze Farmaceutiche e Nutraceutiche, Neurofarba Dept., Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.3390/ijms19123946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321117PMC
December 2018

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on and Studies.

Authors:
Ashok Aspatwar Jean-Yves Winum Fabrizio Carta Claudiu T Supuran Milka Hammaren Mataleena Parikka Seppo Parkkila

Molecules 2018 Nov 8;23(11). Epub 2018 Nov 8.

Faculty of Medicine and Health Technology, University of Tampere, 33014 Tampere, Finland.

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http://www.mdpi.com/1420-3049/23/11/2911
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http://dx.doi.org/10.3390/molecules23112911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278287PMC
November 2018

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan .

Authors:
Susanna Haapanen Silvia Bua Marianne Kuuslahti Seppo Parkkila Claudiu T Supuran

Molecules 2018 Nov 28;23(12). Epub 2018 Nov 28.

Neurofarba Dept., Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Via U. Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.

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http://dx.doi.org/10.3390/molecules23123112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321543PMC
November 2018

Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).

Authors:
Alessio Nocentini Claudiu T Supuran

Expert Opin Ther Pat 2018 10 9;28(10):729-740. Epub 2018 Aug 9.

a Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences , University of Florence , Sesto Fiorentino (Firenze) , Italy.

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http://dx.doi.org/10.1080/13543776.2018.1508453DOI Listing
October 2018

Structural Mapping of Anion Inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa.

Authors:
Akilah B Murray Mayank Aggarwal Melissa Pinard Daniela Vullo Marianna Patrauchan Claudiu T Supuran Robert McKenna

ChemMedChem 2018 Oct 13;13(19):2024-2029. Epub 2018 Sep 13.

Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

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http://dx.doi.org/10.1002/cmdc.201800375DOI Listing
October 2018

Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases.

Authors:
Claudiu T Supuran

Expert Opin Ther Pat 2018 10 10;28(10):713-721. Epub 2018 Sep 10.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Firenze) , Italy.

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http://dx.doi.org/10.1080/13543776.2018.1519023DOI Listing
October 2018

Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas.

Authors:
Claudiu T Supuran

Expert Opin Ther Pat 2018 Oct 19;28(10):709-712. Epub 2018 Sep 19.

a NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Sesto Fiorentino (Firenze) , Italy.

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http://dx.doi.org/10.1080/13543776.2018.1523897DOI Listing
October 2018

Famotidine, an Antiulcer Agent, Strongly Inhibits and Human Carbonic Anhydrases.

Authors:
Andrea Angeli Marta Ferraroni Claudiu T Supuran

ACS Med Chem Lett 2018 Oct 4;9(10):1035-1038. Epub 2018 Sep 4.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187404PMC
October 2018

Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.

Authors:
Rita Meleddu Simona Distinto Filippo Cottiglia Rossella Angius Marco Gaspari Domenico Taverna Claudia Melis Andrea Angeli Giulia Bianco Serenella Deplano Benedetta Fois Sonia Del Prete Clemente Capasso Stefano Alcaro Francesco Ortuso Matilde Yanez Claudiu T Supuran Elias Maccioni

ACS Med Chem Lett 2018 Oct 17;9(10):1045-1050. Epub 2018 Sep 17.

Department of Life and Environmental Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00352
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http://dx.doi.org/10.1021/acsmedchemlett.8b00352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187410PMC
October 2018

Novel hydrazido benzenesulfonamides-isatin conjugates: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.

Authors:
Mahmoud F Abo-Ashour Wagdy M Eldehna Alessio Nocentini Hany S Ibrahim Silvia Bua Sahar M Abou-Seri Claudiu T Supuran

Eur J Med Chem 2018 Sep 24;157:28-36. Epub 2018 Jul 24.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019, Sesto Fiorentino, Firenze, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.07.054DOI Listing
September 2018

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit.

Authors:
Gilberto Spadoni Annalida Bedini Lucia Furiassi Michele Mari Marco Mor Laura Scalvini Alessio Lodola Andrea Ghidini Valeria Lucini Silvana Dugnani Francesco Scaglione Daniele Piomelli Kwang-Mook Jung Claudiu T Supuran Laura Lucarini Mariaconcetta Durante Silvia Sgambellone Emanuela Masini Silvia Rivara

J Med Chem 2018 Sep 4;61(17):7902-7916. Epub 2018 Sep 4.

Dipartimento di Scienze degli Alimenti e del Farmaco , Università degli Studi di Parma , Parco Area delle Scienze 27/A I-43124 Parma , Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00893DOI Listing
September 2018

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding.

Authors:
Giuseppina De Simone Andrea Angeli Murat Bozdag Claudiu T Supuran Jean-Yves Winum Simona Maria Monti Vincenzo Alterio

Chem Commun (Camb) 2018 Sep;54(73):10312-10315

Istituto di Biostrutture e Bioimmagini-CNR, Naples, Italy.

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http://dx.doi.org/10.1039/c8cc05755aDOI Listing
September 2018

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.

Authors:
Andrea Angeli Elena Trallori Marta Ferraroni Lorenzo Di Cesare Mannelli Carla Ghelardini Claudiu T Supuran

Eur J Med Chem 2018 Sep 3;157:1214-1222. Epub 2018 Sep 3.

Department of University of Florence, NEUROFARBA Dept, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, Sesto Fiorentino, 50019, Florence, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.096DOI Listing
September 2018

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.

Authors:
Derek P Logsdon Fenil Shah Fabrizio Carta Claudiu T Supuran Malgorzata Kamocka Max H Jacobsen George E Sandusky Mark R Kelley Melissa L Fishel

Sci Rep 2018 Sep 13;8(1):13759. Epub 2018 Sep 13.

Indiana University School of Medicine, Department of Pharmacology and Toxicology, Indianapolis, IN, USA.

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http://www.nature.com/articles/s41598-018-32034-9
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http://dx.doi.org/10.1038/s41598-018-32034-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137035PMC
September 2018

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.

Authors:
Andrea Angeli Elena Trallori Fabrizio Carta Lorenzo Di Cesare Mannelli Carla Ghelardini Claudiu T Supuran

ACS Med Chem Lett 2018 Sep 29;9(9):947-951. Epub 2018 Aug 29.

University of Florence, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142056PMC
September 2018