Claudio Franceschi

Claudio Franceschi

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Claudio Franceschi

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The peculiar aging of human liver: A geroscience perspective within transplant context.

Ageing Res Rev 2019 May 14;51:24-34. Epub 2019 Feb 14.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy; CIG-Interdepartmental Center "Galvani", University of Bologna, Bologna, Italy; CSR-Centro di Studio per la Ricerca dell'Invecchiamento, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/j.arr.2019.02.002DOI Listing
May 2019

The Genetic Variability of in Different Human Populations and Its Implications for Longevity.

Genes (Basel) 2019 Mar 15;10(3). Epub 2019 Mar 15.

Laboratory of Molecular Anthropology & Centre for Genome Biology, Department of Biological, Geological and Environmental Sciences, University of Bologna, 40126 Bologna, Italy.

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http://dx.doi.org/10.3390/genes10030222DOI Listing
March 2019

Muscle-specific Perilipin2 down-regulation affects lipid metabolism and induces myofiber hypertrophy.

J Cachexia Sarcopenia Muscle 2019 Feb 4;10(1):95-110. Epub 2018 Oct 4.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://doi.wiley.com/10.1002/jcsm.12355
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http://dx.doi.org/10.1002/jcsm.12355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438344PMC
February 2019

Cell-free DNA as a biomarker of aging.

Aging Cell 2019 Feb 20;18(1):e12890. Epub 2018 Dec 20.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island.

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http://doi.wiley.com/10.1111/acel.12890
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http://dx.doi.org/10.1111/acel.12890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351822PMC
February 2019

Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies.

Aging Cell 2019 Feb 15:e12903. Epub 2019 Feb 15.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1111/acel.12903DOI Listing
February 2019

The Dual Role of the Pervasive "Fattish" Tissue Remodeling With Age.

Front Endocrinol (Lausanne) 2019 26;10:114. Epub 2019 Feb 26.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fendo.2019.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400104PMC
February 2019

Identification of Pre-frailty Sub-Phenotypes in Elderly Using Metabolomics.

Front Physiol 2018 24;9:1903. Epub 2019 Jan 24.

Université Clermont Auvergne, Institut National de la Recherche Agronomique, Unité de Nutrition Humaine, Centre Auvergne Rhône Alpes, Clermont-Ferrand, France.

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http://dx.doi.org/10.3389/fphys.2018.01903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353829PMC
January 2019

Down Syndrome, Ageing and Epigenetics.

Subcell Biochem 2019;91:161-193

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

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http://dx.doi.org/10.1007/978-981-13-3681-2_7DOI Listing
January 2019

Inflammaging 2018: An update and a model.

Semin Immunol 2018 12 2;40:1-5. Epub 2018 Nov 2.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy; Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.

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http://dx.doi.org/10.1016/j.smim.2018.10.008DOI Listing
December 2018

Vaccination in the elderly: The challenge of immune changes with aging.

Semin Immunol 2018 12;40:83-94

Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100, Siena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2018.10.010DOI Listing
December 2018

Inflammaging: a new immune-metabolic viewpoint for age-related diseases.

Nat Rev Endocrinol 2018 Oct;14(10):576-590

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1038/s41574-018-0059-4DOI Listing
October 2018

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities.

J Neurosci Res 2018 Oct 11;96(10):1641-1662. Epub 2018 Aug 11.

Environmental Health Sciences Division, School of Public Health, University of Massachusetts, Amherst, Massachusetts, USA.

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http://dx.doi.org/10.1002/jnr.24244DOI Listing
October 2018

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework.

Circ Res 2018 Sep;123(7):745-772

IRCCS, Institute of Neurological Sciences of Bologna, Italy (C.F.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31256
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http://dx.doi.org/10.1161/CIRCRESAHA.118.312562DOI Listing
September 2018

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

Annu Rev Nutr 2018 08 31;38:329-356. Epub 2018 May 31.

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES) and Interdepartmental Centre "L. Galvani" (CIG), Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy; email: ,

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http://dx.doi.org/10.1146/annurev-nutr-082117-051637DOI Listing
August 2018

Sex Differences in Genetic Associations With Longevity.

JAMA Netw Open 2018 Aug 24;1(4). Epub 2018 Aug 24.

Center for the Study of Aging and Human Development, Medical School of Duke University, Durham, North Carolina (Zeng, H. Chen); Center for Healthy Aging and Development Studies, National School of Development, Raissun Institute for Advanced Studies, Peking University, Beijing, China (Zeng, Bai); BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China (Nie);BGI-Shenzhen, Shenzhen, China (Nie, Xiaomin Liu, Ye, Z. Chen, Bolund, Hou, Xiao Liu, Xu, H. Yang); The First Affiliated Hospital, Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China (Min, E. Xie); Business School of Xiangtan University, Xiangtan, China (H. Chen); Division of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing, China (Yin); National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China (Lv, Shi); Department of Sociology, Peking University, Beijing, China (Lu, Li); School of Life Sciences, Fudan University, Shanghai, China (Ni); Department of Biomedicine, Aarhus University, Aarhus, Denmark (Bolund); Duke Population Research Institute, Duke University, Durham, North Carolina (Land, Yashin, O'Rand); The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China (Sun, Z. Yang); School of Life Sciences, Peking University, Beijing, China (Tao, Gu); Boston University, Boston, Massachusetts (Gurinovich, Sebastiani, Perls); University of Bologna, Bologna, Italy (Franceschi); Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina (J. Xie); French National Institute on Health and Medical Research and Ecole Pratique des Hautes Etudes, University of Montpellier, Montpellier, France (Robine); Max Planck Institute for Biology of Ageing, Cologne, Germany (Deelen); Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands (Slagboom); Molecular Physiology Institute, Medical Center, Duke University, Durham, North Carolina (Hauser); Department of Neurology, Medical Center, Duke University, Durham, North Carolina (Gottschalk, Lutz); University of Southern Denmark, Odense, Denmark (Tan, Christensen); Human Aging Research Institute and School of Life Science, Nanchang University, Jiangxi, China (Tian); James D. Watson Institute of Genome Sciences, Hangzhou, China (H. Yang); Max Planck Institute for Demographic Research, Rostock, Germany (Vaupel).

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2018.1670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173523PMC
August 2018

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice.

J Nutr Biochem 2018 Jun 20;56:152-164. Epub 2018 Mar 20.

Division of Human Nutrition, Wageningen University & Research, 6708 WE, Wageningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2018.01.001DOI Listing
June 2018

Epigenetic DNA methylation changes in episodic and chronic migraine.

Neurol Sci 2018 Jun;39(Suppl 1):67-68

Department of Biomedical and Neuromotor Sciences, University of Bologna, 40123, Bologna, Italy.

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http://dx.doi.org/10.1007/s10072-018-3348-8DOI Listing
June 2018

Human aging and longevity are characterized by high levels of mitokines.

J Gerontol A Biol Sci Med Sci 2018 Jun 27. Epub 2018 Jun 27.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1093/gerona/gly153DOI Listing
June 2018

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing.

Ageing Res Rev 2018 Mar 5;42:1-13. Epub 2017 Dec 5.

CNR Institute of Molecular Genetics, Unit of Bologna, Via di Barbiano 1/10, I-40136, Bologna, Italy; Rizzoli Orthopedic Institute, Via di Barbiano 1/10, I-40136, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2017.12.001DOI Listing
March 2018

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates.

Front Med (Lausanne) 2018 12;5:61. Epub 2018 Mar 12.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fmed.2018.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890129PMC
March 2018

Biological age of transplanted livers.

Aging (Albany NY) 2018 Feb;10(2):156-157

Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

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http://www.aging-us.com/article/101378/text
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http://dx.doi.org/10.18632/aging.101378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842843PMC
February 2018

Gut microbiota changes in the extreme decades of human life: a focus on centenarians.

Cell Mol Life Sci 2018 01 14;75(1):129-148. Epub 2017 Oct 14.

Institute of Neurological Sciences (IRCCS), Via Altura 3, 40139, Bologna, Italy.

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http://link.springer.com/10.1007/s00018-017-2674-y
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http://dx.doi.org/10.1007/s00018-017-2674-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752746PMC
January 2018

Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly.

Genes (Basel) 2018 Jan 16;9(1). Epub 2018 Jan 16.

Department of Specialty, Diagnostic and Experimental Medicine (DIMES), Via San Giacomo 12, 40126 Bologna, Italy.

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http://dx.doi.org/10.3390/genes9010039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793190PMC
January 2018

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Front Immunol 2017 10;8:1960. Epub 2018 Jan 10.

Italian National Research Center on Aging, Department of Experimental Pathology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fimmu.2017.01960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767595PMC
January 2018

Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement.

Oncotarget 2018 Jan 18;9(2):2279-2294. Epub 2017 Dec 18.

DIMES-Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.18632/oncotarget.23406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788639PMC
January 2018

Massive parallel sequencing of human whole mitochondrial genomes with Ion Torrent technology: an optimized workflow for Anthropological and Population Genetics studies.

Mitochondrial DNA A DNA Mapp Seq Anal 2017 11 8;28(6):843-850. Epub 2016 Nov 8.

a Laboratory of Molecular Anthropology, Department of Biological, Geological & Environmental Sciences (BiGeA) , University of Bologna , Bologna , Italy.

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https://www.tandfonline.com/doi/full/10.1080/24701394.2016.1
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http://dx.doi.org/10.1080/24701394.2016.1197218DOI Listing
November 2017

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition.

Ageing Res Rev 2017 Nov 9;40:95-119. Epub 2017 Sep 9.

Department of Molecular Medicine, University of Padova, 35121 Padova, Italy; IMDEA-Food, 28049 Madrid, Spain.

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http://dx.doi.org/10.1016/j.arr.2017.09.001DOI Listing
November 2017

The epigenetic landscape of age-related diseases: the geroscience perspective.

Biogerontology 2017 08 28;18(4):549-559. Epub 2017 Mar 28.

Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 12, Bologna, 40126, Italy.

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http://dx.doi.org/10.1007/s10522-017-9695-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514215PMC
August 2017

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity.

Front Immunol 2017 15;8:982. Epub 2017 Aug 15.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.3389/fimmu.2017.00982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559470PMC
August 2017

Inflammaging and human longevity in the omics era.

Mech Ageing Dev 2017 07 27;165(Pt B):129-138. Epub 2016 Dec 27.

IRCCS, Institute of Neurological Sciences of Bologna, Via Altura 3, 40139 Bologna, Italy.

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http://dx.doi.org/10.1016/j.mad.2016.12.008DOI Listing
July 2017

The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity.

Mech Ageing Dev 2017 07 20;165(Pt B):156-161. Epub 2017 Jan 20.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2017.01.006DOI Listing
July 2017

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.

Mech Ageing Dev 2017 07 27;165(Pt B):195-201. Epub 2017 Feb 27.

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy; Interdepartmental Center "L. Galvani" (CIG), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/j.mad.2017.02.007DOI Listing
July 2017

Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess.

Mech Ageing Dev 2017 07 9;165(Pt B):185-194. Epub 2017 Mar 9.

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1016/j.mad.2017.02.010DOI Listing
July 2017

The genetics of human longevity: an intricacy of genes, environment, culture and microbiome.

Mech Ageing Dev 2017 07 5;165(Pt B):147-155. Epub 2017 Apr 5.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Rende, Italy.

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http://dx.doi.org/10.1016/j.mad.2017.03.011DOI Listing
July 2017

Demographic, genetic and phenotypic characteristics of centenarians in Italy: Focus on gender differences.

Mech Ageing Dev 2017 07 29;165(Pt B):68-74. Epub 2017 Apr 29.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Rende, Italy.

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http://dx.doi.org/10.1016/j.mad.2017.04.008DOI Listing
July 2017

Centenarians as a 21st century healthy aging model: A legacy of humanity and the need for a world-wide consortium (WWC100+).

Mech Ageing Dev 2017 07 23;165(Pt B):55-58. Epub 2017 Jun 23.

IRCCS, Institute of Neurological Sciences of Bologna, 40139 Bologna, Italy; Department of Biology, Ecology and Earth Science, University of Calabria, Rende, CS, Italy; Geriatric Unit, Department of Medical Sciences and Community Health, University of Milan, Via Pace 9, 20122 Milan, Italy; Fondazione Ca' Granda, IRCCS Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy.

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http://dx.doi.org/10.1016/j.mad.2017.06.002DOI Listing
July 2017

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.

Cell Metab 2017 Jun 25;25(6):1374-1389.e6. Epub 2017 May 25.

Venetian Institute of Molecular Medicine, via Orus 2, 35129 Padova, Italy; Department of Biomedical Science, University of Padova, via G. Colombo 3, 35100 Padova, Italy; Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462533PMC
June 2017

Mediterranean diet and inflammaging within the hormesis paradigm.

Nutr Rev 2017 06;75(6):442-455

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1093/nutrit/nux013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914347PMC
June 2017

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans.

Ageing Res Rev 2017 May 19;35:322-335. Epub 2016 Nov 19.

Department of Experimental, Diagnostic and Specialty Medicine, Interdepartmental Centre "L.Galvani" for Bioinformatics, Biophysics and Biocomplexity, Via San Giacomo, 12, University of Bologna, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.arr.2016.11.005DOI Listing
May 2017

Increased brain-predicted aging in treated HIV disease.

Neurology 2017 Apr 3;88(14):1349-1357. Epub 2017 Mar 3.

From the Computational, Cognitive & Clinical Neuroimaging Laboratory, Division of Brain Sciences, Department of Medicine (J.H.C., R.L., D.J.S.), and Division of Infectious Diseases (J.U., A.W.), Imperial College London, UK; Departments of Radiology (M.W.A.C., C.B.L.M.M.), Global Health, Amsterdam Institute for Global Health and Development (AIGHD) (R.A.v.Z., F.W.N.M.W., P.R.), Neurology (P.P., B.A.S.), and Medical Psychology (G.J.G., B.A.S.), Academic Medical Center, Amsterdam, the Netherlands; Department of Infection & Population Health (D.D.F., C.A.S.), University College London, UK; Dutch HIV Monitoring Foundation (F.W.N.M.W., P.R.); Department of Neurology (P.P.), OLVG Hospital; Public Health Service of Amsterdam (M.F.S.v.d.L.), the Netherlands; and Alma Mater Studiorum (C.F.), University of Bologna, Italy.

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http://dx.doi.org/10.1212/WNL.0000000000003790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379929PMC
April 2017

Inflammaging and 'Garb-aging'.

Trends Endocrinol Metab 2017 03 24;28(3):199-212. Epub 2016 Oct 24.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.tem.2016.09.005DOI Listing
March 2017

Healthy ageing in 2016: Obesity in geroscience - is cellular senescence the culprit?

Nat Rev Endocrinol 2017 02 6;13(2):76-78. Epub 2017 Jan 6.

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Institute of Neurological Sciences of Bologna, Bellaria Hospital, Via Altura 3, 40139 Bologna, Italy.

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http://dx.doi.org/10.1038/nrendo.2016.213DOI Listing
February 2017

Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective.

Trends Endocrinol Metab 2016 12 19;27(12):893-903. Epub 2016 Sep 19.

Department of Experimental, Diagnostic, and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy; Interdepartmental Centre 'L. Galvani' (CIG), University of Bologna, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.tem.2016.09.001DOI Listing
December 2016

Senescence associated macrophages and "macroph-aging": are they pieces of the same puzzle?

Aging (Albany NY) 2016 12;8(12):3159-3160

IRCCS, Institute of Neurological Sciences of Bologna, Bellaria Hospital, Bologna, Italy.

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http://dx.doi.org/10.18632/aging.101133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270660PMC
December 2016

Suggestions from Geroscience for the Genetics of Age-Related Diseases.

PLoS Genet 2016 11 10;12(11):e1006399. Epub 2016 Nov 10.

DIMES, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1006399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104376PMC
November 2016

Epigenetic Variability across Human Populations: A Focus on DNA Methylation Profiles of the KRTCAP3, MAD1L1 and BRSK2 Genes.

Genome Biol Evol 2016 09 19;8(9):2760-73. Epub 2016 Sep 19.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Italy Interdepartmental Center "L. Galvani" (C.I.G.), University of Bologna, Italy Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, Bologna, Italy.

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http://dx.doi.org/10.1093/gbe/evw186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630933PMC
September 2016

Gut Microbiota and Extreme Longevity.

Curr Biol 2016 06 12;26(11):1480-5. Epub 2016 May 12.

Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Bologna 40126, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.04.016DOI Listing
June 2016