Publications by authors named "Claudio Dalloul"

2 Publications

  • Page 1 of 1

Effectiveness and Safety of Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema: A Real-World Experience.

Ophthalmologica 2019 8;241(1):9-16. Epub 2018 Nov 8.

Retina Private Office, Buenos Aires, Argentina.

Introduction: There are few real-life studies on the intravitreal 0.7-mg dexamethasone implant for the treatment of diabetic macular edema (DME) conducted in Latin America. We aimed to assess the effectiveness and safety of this implant in clinical practice.

Methods: Twenty-seven centers from Brazil and one from Argentina provided information on patients with DME treated with Ozurdex. The efficacy outcome variables were best-corrected visual acuity (BCVA) in Snellen and central retinal thickness (CRT). Safety was assessed by the elevation in intraocular pressure (IOP), occurrence of cataracts, and adverse events.

Results: A total of 329 eyes (both treated cases and naïve eyes) from 282 patients underwent treatment. The time since diagnosis of DME ranged from 1 to 156 months. The median BCVA was 0.7 logMAR/50 letters at baseline and 0.3 logMAR/70 letters after treatment (both p < 0.001). Median CRT values decreased from 425 µm at baseline to 270 µm after treatment (p < 0.001). Increases in IOP of at least 10 mm Hg were observed in 7.4% of eyes, and 4% of eyes had cataract evolution. No cases of endophthalmitis were reported.

Conclusion: These real-life results suggest that the intravitreal dexamethasone implant is effective and safe for eyes with DME.
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http://dx.doi.org/10.1159/000492132DOI Listing
February 2019

Vitrectomy with and without scleral buckling for retinal detachment.

Arq Bras Oftalmol 2007 Mar-Apr;70(2):298-302

Hospital do Olho, São José do Rio Preto, SP, Brasil.

Purpose: To compare the surgical results of vitrectomy with and without scleral buckling for rhegmatogenous retinal detachment (RD).

Methods: Fifty-one patients with rhegmatogenous retinal detachment with proliferative vitreoretinopathy (PVR) at different stages were submitted to pars plana vitrectomy as the primary surgery, 23 patients (45.09%) with scleral buckle (group I) and 28 (54.90%) without scleral buckle (group II). Visual acuity, anterior segment complications, intraocular pressure, strabismus and retina reattachment rate were evaluated in both groups.

Results: The anatomical success and postoperative complications were similar in both groups. Retinal reattachment was achieved in 20 of 23 eyes (87%) of group I and in 24 of 28 eyes (85.7%) of group II after the initial surgery (p=1.000). Elevated intraocular pressure was noted in 2 eyes (8.7%) of group I and 1 eye (3.6%) of group II (p=0.583). Corneal abnormalities were seen in 3 eyes (13%) of group I and 2 eyes (7.19%) of the group II (p=0.647). Visual acuity improved from a preoperative median of 20/200 to a median of 20/100 in group 1 and from 20/400 to 20/100 in group 2; the difference between the two groups was statistically significant (p<0.05). The mean follow-up period was 10 months, ranging from 6 to 18 months.

Conclusions: Both surgical procedures had similar reattachment rates. Intra- and postoperative complications were similar considering both procedures. Visual acuity improved significantly in group 2 (vitrectomy without scleral buckling).
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http://dx.doi.org/10.1590/s0004-27492007000200020DOI Listing
February 2008