Claudia Schoch

Claudia Schoch

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Claudia Schoch

Publications by authors named "Claudia Schoch"

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Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

Haematologica 2007 Apr;92(4):542-5

Medizinische Klinik II, Abt. Hämatologie/Onkologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, Frankfurt, Germany.

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http://dx.doi.org/10.3324/haematol.10758DOI Listing
April 2007

Impact of trisomy 8 on expression of genes located on chromosome 8 in different AML subgroups.

Genes Chromosomes Cancer 2006 Dec;45(12):1164-8

Munich Leukemia Laboratory (MLL), Munich 81377, Germany.

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http://dx.doi.org/10.1002/gcc.20380DOI Listing
December 2006

GAB2 is a novel target of 11q amplification in AML/MDS.

Genes Chromosomes Cancer 2006 Sep;45(9):798-807

Abteilung für Humangenetik, Klinisches Institut für Medizinische und Chemische Labor Diagnostik (KIMCL), Medizinische Universität Wien, Währinger Strasse 10, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1002/gcc.20344DOI Listing
September 2006

Acute myeloid leukemia (AML) with t(8;21)(q22;q22) relapsing as AML with t(3;21)(q26;q22).

Cancer Genet Cytogenet 2006 Jul;168(2):172-4

Department of Clinical Chemistry, Ludwig-Maximilians University of Munich, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2006.02.011DOI Listing
July 2006

Implications of NRAS mutations in AML: a study of 2502 patients.

Blood 2006 May 24;107(10):3847-53. Epub 2006 Jan 24.

Munich Leukemia Laboratory, Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians University, Max-Lebsche-Platz 31, 81377 Munich, Germany.

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http://dx.doi.org/10.1182/blood-2005-08-3522DOI Listing
May 2006

A comparison of donor lymphocyte infusions or imatinib mesylate for patients with chronic myelogenous leukemia who have relapsed after allogeneic stem cell transplantation.

Haematologica 2006 May 19;91(5):663-6. Epub 2006 Apr 19.

Department of Internal Medicine III, University of Munich, Klinikum Grosshadern, Munich, Germany.

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May 2006

D324N single-nucleotide polymorphism in the FLT3 gene is associated with higher risk of myeloid leukemias.

Genes Chromosomes Cancer 2006 Apr;45(4):332-7

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.20294DOI Listing
April 2006

KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival.

Blood 2006 Mar 27;107(5):1791-9. Epub 2005 Oct 27.

Laboratory of Leukemia Diagnostics and Clinical Cooperative Group Leukemia, Department of Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2005-04-1466DOI Listing
March 2006

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.

Blood 2005 Dec 2;106(12):3733-9. Epub 2005 Aug 2.

Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilian's University, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2005-06-2248DOI Listing
December 2005

Detailed analysis of FLT3 expression levels in acute myeloid leukemia.

Haematologica 2005 Dec;90(12):1617-25

Department of Internal Medicine III, Ludwig-Maximilians University of Munich, University Hospital Grosshadern, Munich, Germany.

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December 2005

Further correlations of morphology according to FAB and WHO classification to cytogenetics in de novo acute myeloid leukemia: a study on 2,235 patients.

Ann Hematol 2005 Nov 12;84(12):785-91. Epub 2005 Nov 12.

Laboratory for Leukemia Diagnostics, Department for Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistr. 15, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00277-005-1099-0DOI Listing
November 2005

Monitoring of minimal residual disease in acute myeloid leukemia.

Crit Rev Oncol Hematol 2005 Nov 5;56(2):283-309. Epub 2005 Oct 5.

Laboratory for Leukemia Diagnostics, Ludwig-Maximilians-University, University Hospital Grosshadern, Department of Internal Medicine III, 81366 Muenchen, Germany.

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http://dx.doi.org/10.1016/j.critrevonc.2004.06.004DOI Listing
November 2005

Modern diagnostics in acute leukemias.

Crit Rev Oncol Hematol 2005 Nov 5;56(2):223-34. Epub 2005 Oct 5.

Laboratory for Leukemia Diagnostics, Medical Department III, University Hospital Grosshadern, Ludwig-Maximilians-University, Marchioninistreet 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.critrevonc.2004.04.008DOI Listing
November 2005

Population-based age-specific incidences of cytogenetic subgroups of acute myeloid leukemia.

Haematologica 2005 Nov;90(11):1502-10

Department for Internal Medicine III, Klinikum, Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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November 2005

Global approach to the diagnosis of leukemia using gene expression profiling.

Blood 2005 Aug 5;106(4):1189-98. Epub 2005 May 5.

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig-Maximilians-University, Marchioninistr 15, 81377 Munich.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2004-12-49
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http://dx.doi.org/10.1182/blood-2004-12-4938DOI Listing
August 2005

Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile.

Genes Chromosomes Cancer 2005 Jul;43(3):227-38

Laboratory for Leukemia Diagnostics, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.20193DOI Listing
July 2005

Gain of 9p due to an unbalanced rearrangement der(9;18): a recurrent clonal abnormality in chronic myeloproliferative disorders.

Cancer Genet Cytogenet 2005 Jul;160(2):179-83

Department for Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.12.015DOI Listing
July 2005

Risk assessment by monitoring expression levels of partial tandem duplications in the MLL gene in acute myeloid leukemia during therapy.

Haematologica 2005 Jul;90(7):881-9

Laboratory for Leukemia Diagnostics, Medical Department III, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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July 2005

Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia.

Br J Haematol 2005 Jul;130(2):196-202

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig-Maximilians University of Munich, University Hospital Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2005.05595.xDOI Listing
July 2005

AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes.

Genes Chromosomes Cancer 2005 Jun;43(2):113-27

Laboratory for Leukemia Diagnostics, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.20175DOI Listing
June 2005

Role of gene expression profiling for diagnosing acute leukemias.

Rev Clin Exp Hematol 2005 Jun 1;9(1):E1. Epub 2005 Jun 1.

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Munich, Germany.

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June 2005

Conventional cytogenetics of myeloproliferative diseases other than CML contribute valid information.

Ann Hematol 2005 Apr 4;84(4):250-7. Epub 2005 Feb 4.

Laboratory for Leukemia Diagnostics, Department for Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1007/s00277-004-0977-1DOI Listing
April 2005

Four-fold staining including CD45 gating improves the sensitivity of multiparameter flow cytometric assessment of minimal residual disease in patients with acute myeloid leukemia.

Hematol J 2004 ;5(5):410-8

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig-Maximilians-University, University Hospital Grosshadern, 81366 Muenchen, Germany.

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http://dx.doi.org/10.1038/sj.thj.6200538DOI Listing
March 2005

Pattern robustness of diagnostic gene expression signatures in leukemia.

Genes Chromosomes Cancer 2005 Mar;42(3):299-307

Laboratory for Leukemia Diagnostics, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.20126DOI Listing
March 2005

Blast count and cytogenetics correlate and are useful parameters for the evaluation of different phases in chronic myeloid leukemia.

Leuk Lymphoma 2005 Mar;46(3):357-66

Laboratory for Leukemia Diagnostics, Department for Internal Medicine III, Klinikum Grossharden, Ludwig-Maximilians-University, Marchioninistr, Munich, Germany.

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http://dx.doi.org/10.1080/10428190400013068DOI Listing
March 2005

Detection of t(14;18)(q32;q21) in B-cell chronic lymphocytic leukemia.

Arch Pathol Lab Med 2005 Mar;129(3):410-1

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Muenchen, Germany.

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http://dx.doi.org/10.1043/1543-2165(2005)129<410:DOQIBC>2.0.CO;2DOI Listing
March 2005

Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype.

Oncogene 2005 Feb;24(9):1580-8

Division of Molecular Genetics (B060), Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/sj.onc.1208344DOI Listing
February 2005

Additional clonal abnormalities in Philadelphia-positive ALL and CML demonstrate a different cytogenetic pattern at diagnosis and follow different pathways at progression.

Cancer Genet Cytogenet 2005 Feb;157(1):53-61

Laboratory for Leukemia Diagnostics, Department for Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, D-81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.06.011DOI Listing
February 2005

Diagnostic tool for the identification of MLL rearrangements including unknown partner genes.

Proc Natl Acad Sci U S A 2005 Jan 30;102(2):449-54. Epub 2004 Dec 30.

Institute of Pharmaceutical Biology/Center for Drug Research, Development and Safety (ZAFES), Biocenter, University of Frankfurt, D-60439 Frankfurt/Main, Germany.

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http://dx.doi.org/10.1073/pnas.0406994102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544299PMC
January 2005

Determination of relapse risk based on assessment of minimal residual disease during complete remission by multiparameter flow cytometry in unselected patients with acute myeloid leukemia.

Blood 2004 Nov 29;104(10):3078-85. Epub 2004 Jul 29.

Laboratory for Leukemia Diagnostics, Ludwig-Maximilians-University, University Hospital Grosshadern, Department of Internal Medicine III, 81366 Muenchen, Germany.

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http://dx.doi.org/10.1182/blood-2004-03-1036DOI Listing
November 2004

Gene expression profiling as a diagnostic tool in acute myeloid leukemia.

Am J Pharmacogenomics 2004 ;4(4):225-37

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Munich, Germany.

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http://dx.doi.org/10.2165/00129785-200404040-00002DOI Listing
November 2004

Stability of leukemia-associated aberrant immunophenotypes in patients with acute myeloid leukemia between diagnosis and relapse: comparison with cytomorphologic, cytogenetic, and molecular genetic findings.

Cytometry B Clin Cytom 2004 Nov;62(1):25-38

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1002/cyto.b.20025DOI Listing
November 2004

Cytogenetic profile in de novo acute myeloid leukemia with FAB subtypes M0, M1, and M2: a study based on 652 cases analyzed with morphology, cytogenetics, and fluorescence in situ hybridization.

Cancer Genet Cytogenet 2004 Nov;155(1):47-56

Department of Internal Medicine III, Laboratory for Leukemia Diagnostics, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2004.03.008DOI Listing
November 2004

The influence of age on prognosis of de novo acute myeloid leukemia differs according to cytogenetic subgroups.

Haematologica 2004 Sep;89(9):1082-90

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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September 2004

Functional analysis of apoptosis induction in acute myeloid leukaemia-relevance of karyotype and clinical treatment response.

Br J Haematol 2004 Aug;126(3):338-47

Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany.

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http://doi.wiley.com/10.1111/j.1365-2141.2004.05039.x
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http://dx.doi.org/10.1111/j.1365-2141.2004.05039.xDOI Listing
August 2004

FLT3 length mutations as marker for follow-up studies in acute myeloid leukaemia.

Acta Haematol 2004 ;112(1-2):68-78

Laboratory for Leukaemia Diagnostics, Department of Internal Medicine III, Ludwig Maximilians University of Munich, University Hospital Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1159/000077561DOI Listing
July 2004

Prognostic impact of early response to induction therapy as assessed by multiparameter flow cytometry in acute myeloid leukemia.

Haematologica 2004 May;89(5):528-40

Laboratory for Leukemia Diagnostics,Dept. of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, 81366 Muenchen, Germany.

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May 2004

A new prognostic score for patients with acute myeloid leukemia based on cytogenetics and early blast clearance in trials of the German AML Cooperative Group.

Haematologica 2004 Apr;89(4):408-18

Ludwig-Maximilians-University, University Hospital Grosshadern, Dept. of Internal Medicine III, München, Germany.

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April 2004

Rapid diagnostic approach to PML-RARalpha-positive acute promyelocytic leukemia.

Hematol J 2002 ;3(5):259-63

Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1038/sj.thj.6200181DOI Listing
October 2003

AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases.

Blood 2003 Oct 12;102(7):2395-402. Epub 2003 Jun 12.

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr 15, 81377 München, Germany.

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http://dx.doi.org/10.1182/blood-2003-02-0434DOI Listing
October 2003

New score predicting for prognosis in PML-RARA+, AML1-ETO+, or CBFBMYH11+ acute myeloid leukemia based on quantification of fusion transcripts.

Blood 2003 Oct 3;102(8):2746-55. Epub 2003 Jul 3.

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1182/blood-2003-03-0880DOI Listing
October 2003

Gene expression profiling as a tool for the diagnosis of acute leukemias.

Semin Hematol 2003 Oct;40(4):281-95

Department of Internal Medicine III, University Hospital Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1016/s0037-1963(03)00193-8DOI Listing
October 2003

Correlation of protein expression and gene expression in acute leukemia.

Cytometry B Clin Cytom 2003 Sep;55(1):29-36

Laboratory for Leukemia Diagnostics, Ludwig-Maximilians-University, University Hospital Grosshadern, Department of Internal Medicine III, Munich, Germany.

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http://dx.doi.org/10.1002/cyto.b.10025DOI Listing
September 2003

Molecular characterization of acute leukemias by use of microarray technology.

Genes Chromosomes Cancer 2003 Aug;37(4):396-405

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1002/gcc.10225DOI Listing
August 2003

Impact of integrating clinical and genetic information.

In Silico Biol 2002 ;2(3):383-91

Department of Medical Informatics, Biometrics and Epidemiology (IBE), University of Munich, Marchioninistr. 15, D-81377 Munich, Germany.

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July 2003

CS-1, a novel c-kithi+ acute myeloid leukemia cell line with dendritic cell differentiation capacity and absent immunogenicity.

Int J Cancer 2003 Jun;105(2):232-40

Department of Hematology, Oncology and Transfusion Medicine, University Hospital Benjamin Franklin, Free University, Berlin, Germany.

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http://dx.doi.org/10.1002/ijc.11053DOI Listing
June 2003

Analysis of site-specific transgene integration following cotransduction with recombinant adeno-associated virus and a rep encodingplasmid.

J Gene Med 2003 Feb;5(2):120-9

Gene Center of the Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 25, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/jgm.324DOI Listing
February 2003

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.

Blood 2003 Jan 29;101(1):270-7. Epub 2002 Aug 29.

Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University Munich and GSF-National Research Center for Environment and Health, Germany.

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http://dx.doi.org/10.1182/blood-2002-04-1288DOI Listing
January 2003

Alveolar rhabdomyosarcoma with bone marrow infiltration mimicking haematological neoplasia.

Br J Haematol 2002 Dec;119(3):583

III Medizinische Universitätsklinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03860.xDOI Listing
December 2002

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia.

Blood 2002 Nov;100(9):3423-5

Clinical Cooperative Group Leukemia, GSF, National Research Center for Environment and Health, University Hospital Grosshadern, Ludwig-Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1182/blood-2002-03-0953DOI Listing
November 2002

Cytogenetics in acute myeloid leukemia.

Curr Oncol Rep 2002 Sep;4(5):390-7

Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1007/s11912-002-0032-0DOI Listing
September 2002

CD40L stimulation enhances the ability of conventional metaphase cytogenetics to detect chromosome aberrations in B-cell chronic lymphocytic leukaemia cells.

Br J Haematol 2002 Sep;118(4):968-75

GSF, National Research Center for Environment and Health, Genzentrum and Medizinische Klinik III, Klinikum der Universitaet Muenchen Grosshadern, Germany.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03719.xDOI Listing
September 2002

Distinct genetic patterns can be identified in acute monoblastic and acute monocytic leukaemia (FAB AML M5a and M5b): a study of 124 patients.

Br J Haematol 2002 Aug;118(2):426-31

Department of Internal Medicine III, Laboratory for Leukaemia Diagnostics, University Hospital Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03599.xDOI Listing
August 2002

Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles.

Proc Natl Acad Sci U S A 2002 Jul 8;99(15):10008-13. Epub 2002 Jul 8.

Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, 81366 Munich, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.142103599
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http://dx.doi.org/10.1073/pnas.142103599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126615PMC
July 2002

21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop.

Genes Chromosomes Cancer 2002 Apr;33(4):379-94

Department of Cytogenetics, City of Hope National Medical Center, Duarte, California 91010, USA.

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http://dx.doi.org/10.1002/gcc.10042DOI Listing
April 2002