Claudia Martini

Claudia Martini

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Claudia Martini

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Synthesis of New GABA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold.

Int J Mol Sci 2019 Mar 21;20(6). Epub 2019 Mar 21.

Dipartimento Neurofarba, sezione Farmaceutica e Nutraceutica, Università di Firenze, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Firenze, Italy.

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http://dx.doi.org/10.3390/ijms20061438DOI Listing
March 2019

Antioxidant and Antisenescence Effects of Bergamot Juice.

Oxid Med Cell Longev 2018 12;2018:9395804. Epub 2018 Jul 12.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1155/2018/9395804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079356PMC
December 2018

Brain ageing and neurodegenerative disease: The role of cellular waste management.

Biochem Pharmacol 2018 Dec 28;158:207-216. Epub 2018 Oct 28.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.10.030DOI Listing
December 2018

MCAM knockdown impairs PPARγ expression and 3T3-L1 fibroblasts differentiation to adipocytes.

Mol Cell Biochem 2018 Nov 21;448(1-2):299-309. Epub 2018 Feb 21.

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina.

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http://link.springer.com/10.1007/s11010-018-3334-8
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http://dx.doi.org/10.1007/s11010-018-3334-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435271PMC
November 2018

Oxytocin receptor gene variation, behavioural inhibition, and adult separation anxiety: Role in complicated grief.

World J Biol Psychiatry 2018 09 5;19(6):471-479. Epub 2018 Feb 5.

b Department of Clinical and Experimental Medicine, Section of Psychiatry , University of Pisa , Pisa , Italy.

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http://dx.doi.org/10.1080/15622975.2018.1430374DOI Listing
September 2018

An in vitro comparative study of the antioxidant activity and SIRT1 modulation of natural compounds.

Biomed Pharmacother 2018 May 22;101:805-819. Epub 2018 Mar 22.

Department of Clinical and Experimental Medicine, University of Pisa, Italy.

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http://dx.doi.org/10.1016/j.biopha.2018.03.006DOI Listing
May 2018

A new class of pyrazolo[5,1-c][1,2,4]triazines as γ-aminobutyric type A (GABA) receptor subtype ligand: synthesis and pharmacological evaluation.

Bioorg Med Chem 2018 05 4;26(9):2475-2487. Epub 2018 Apr 4.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Italy.

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http://dx.doi.org/10.1016/j.bmc.2018.04.011DOI Listing
May 2018

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.

Eur J Med Chem 2018 May 25;152:283-297. Epub 2018 Apr 25.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.04.042DOI Listing
May 2018

Translocator protein and steroidogenesis.

Biochem J 2018 03 6;475(5):901-904. Epub 2018 Mar 6.

Department of Pharmacy, University of Pisa, via Bonanno 6, 56127 Pisa, Italy

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http://dx.doi.org/10.1042/BCJ20170766DOI Listing
March 2018

Lead enhancement of 3T3-L1 fibroblasts differentiation to adipocytes involves ERK, C/EBPβ and PPARγ activation.

Mol Cell Biochem 2018 Jan 23;437(1-2):37-44. Epub 2017 Jun 23.

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina.

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http://link.springer.com/10.1007/s11010-017-3093-y
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http://dx.doi.org/10.1007/s11010-017-3093-yDOI Listing
January 2018

Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABA) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity.

J Med Chem 2017 12 22;60(23):9691-9702. Epub 2017 Nov 22.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università degli Studi di Firenze , Via Ugo Schiff 6, Sesto Fiorentino, Firenze 50019, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01151DOI Listing
December 2017

Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety.

J Affect Disord 2017 08 27;218:365-373. Epub 2017 Mar 27.

Department of Pharmacy, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.jad.2017.03.056DOI Listing
August 2017

The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity.

ACS Chem Neurosci 2017 07 4;8(7):1448-1454. Epub 2017 Apr 4.

Department of Pharmacy, University of Pisa , via Bonanno, 6-56126 Pisa, Italy.

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http://dx.doi.org/10.1021/acschemneuro.7b00027DOI Listing
July 2017

Potential biomarkers and novel pharmacological targets in protein aggregation-related neurodegenerative diseases.

Biochem Pharmacol 2017 05 31;131:1-15. Epub 2017 Jan 31.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952173004
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http://dx.doi.org/10.1016/j.bcp.2017.01.017DOI Listing
May 2017

The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage.

Oxid Med Cell Longev 2017 12;2017:9536148. Epub 2017 Mar 12.

Department of Pharmacy, University of Pisa, Pisa, Italy; Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1155/2017/9536148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366223PMC
May 2017

Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABA-R ligands.

Bioorg Med Chem 2017 03 11;25(6):1901-1906. Epub 2017 Feb 11.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università di Firenze, Via Ugo Schiff, 6 - 50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1016/j.bmc.2017.02.013DOI Listing
March 2017

The Citrus Flavanone Naringenin Produces Cardioprotective Effects in Hearts from 1 Year Old Rat, through Activation of mitoBK Channels.

Front Pharmacol 2017 27;8:71. Epub 2017 Feb 27.

Department of Pharmacy, University of PisaPisa, Italy; Interdepartmental Research Center "Nutraceuticals and Food for Health"Pisa, Italy.

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http://dx.doi.org/10.3389/fphar.2017.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326774PMC
February 2017

Glyphosate Inhibits PPAR Gamma Induction and Differentiation of Preadipocytes and is able to Induce Oxidative Stress.

J Biochem Mol Toxicol 2016 Aug 4;30(8):404-13. Epub 2016 Apr 4.

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina.

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http://doi.wiley.com/10.1002/jbt.21804
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http://dx.doi.org/10.1002/jbt.21804DOI Listing
August 2016

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma.

Eur J Med Chem 2016 Aug 20;118:47-63. Epub 2016 Apr 20.

Department of Pharmacy, University of Pisa, Via Bonanno, 6, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.04.003DOI Listing
August 2016

Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.

ACS Chem Neurosci 2016 08 8;7(8):1041-6. Epub 2016 Jul 8.

Department of Pharmacy, University of Pisa , via Bonanno, 6-56126 Pisa, Italy.

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http://dx.doi.org/10.1021/acschemneuro.6b00149DOI Listing
August 2016

Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine.

ACS Chem Neurosci 2016 07 31;7(7):952-63. Epub 2016 May 31.

Department of Pharmacy, University of Pisa , Pisa 56126, Italy.

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http://dx.doi.org/10.1021/acschemneuro.6b00078DOI Listing
July 2016

A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights.

Cell Signal 2016 Jun 10;28(6):631-42. Epub 2016 Mar 10.

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy; Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di Milano, Via Gian Battista Grassi 74, 20157 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.03.001DOI Listing
June 2016

TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis.

Eur J Pharm Sci 2016 Jun 14;88:124-31. Epub 2016 Apr 14.

Department of Pharmacy, University of Naples Federico II, 80131 Naples, University of Pisa, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.04.006DOI Listing
June 2016

An Effective Virtual Screening Protocol To Identify Promising p53-MDM2 Inhibitors.

J Chem Inf Model 2016 06 7;56(6):1216-27. Epub 2016 Jun 7.

Dipartimento di Farmacia, Università "G. d'Annunzio" Chieti , Via dei Vestini 31, 66100 Chieti, Italy.

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http://dx.doi.org/10.1021/acs.jcim.5b00747DOI Listing
June 2016

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being.

Int J Mol Sci 2016 Jun 29;17(7). Epub 2016 Jun 29.

Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.3390/ijms17071028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964404PMC
June 2016

New insights into the anticancer activity of carnosol: p53 reactivation in the U87MG human glioblastoma cell line.

Int J Biochem Cell Biol 2016 May 3;74:95-108. Epub 2016 Mar 3.

Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy; Interdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, via del Borghetto 80, 56124 Pisa, Italy.

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http://dx.doi.org/10.1016/j.biocel.2016.02.019DOI Listing
May 2016

Toward PET imaging of A2B adenosine receptors: a carbon-11 labeled triazinobenzimidazole tracer: Synthesis and imaging of a new A2B PET tracer.

Nucl Med Biol 2016 05 27;43(5):309-17. Epub 2016 Feb 27.

Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche (CNR), Via Moruzzi, 1, I-56124 Pisa, Italy; Fondazione Toscana G. Monasterio, Via Moruzzi, 1, I-56124, Pisa, Italy.

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http://dx.doi.org/10.1016/j.nucmedbio.2016.02.005DOI Listing
May 2016

Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes.

J Neuroinflammation 2015 Dec 1;12:225. Epub 2015 Dec 1.

Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, Pisa, 56126, PI, Italy.

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http://dx.doi.org/10.1186/s12974-015-0446-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666178PMC
December 2015

Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-κB, p38 and JNK.

Cell Signal 2015 Aug 21;27(8):1609-29. Epub 2015 Apr 21.

Department of Pharmacy, University of Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.04.006DOI Listing
August 2015

AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells.

Anticancer Drugs 2015 Aug;26(7):754-62

Departments of aPharmacy bTranslational Research and New Technologies in Medicine and Surgery cVeterinary Sciences, University of Pisa dMedical Oncology Unit, University Hospital of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1097/CAD.0000000000000246DOI Listing
August 2015

Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection.

Biochem Soc Trans 2015 Aug 3;43(4):559-65. Epub 2015 Aug 3.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy

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http://dx.doi.org/10.1042/BST20150028DOI Listing
August 2015

♦Copper (II) ions modulate Angiogenin activity in human endothelial cells.

Int J Biochem Cell Biol 2015 Mar 14;60:185-96. Epub 2015 Jan 14.

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.biocel.2015.01.005DOI Listing
March 2015

Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).

Eur J Med Chem 2015 Mar 7;93:392-400. Epub 2015 Feb 7.

School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia; Faculty of Health Sciences, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.02.004DOI Listing
March 2015

Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.

Eur J Med Chem 2015 Jan 12;89:32-41. Epub 2014 Oct 12.

Dipartimento NEUROFARBA, Sezione Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2014.10.020DOI Listing
January 2015

1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A₃ receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.

Bioorg Med Chem 2015 Jan 27;23(1):9-21. Epub 2014 Nov 27.

Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Sezione di Farmaceutica e Nutraceutica, Università di Firenze, Polo Scientifico, Via Ugo Schiff 6, 50019 Sesto Fiorentino, FI, Italy.

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http://dx.doi.org/10.1016/j.bmc.2014.11.033DOI Listing
January 2015

Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation.

Cell Signal 2014 Dec 22;26(12):2614-20. Epub 2014 Aug 22.

Laboratorio di Biochimica e Biofisica Computazionale, Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.cellsig.2014.08.003DOI Listing
December 2014

Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators.

Biochim Biophys Acta 2014 Dec 18;1843(12):2957-66. Epub 2014 Sep 18.

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2014.09.013DOI Listing
December 2014

Prevention of excessive endothelin-1 release in sclerotherapy: in vitro and in vivo studies.

Dermatol Surg 2014 Jul;40(7):769-75

*Studio Medico Flebologico, Figline Valdarno-Florence, Italy; †Department of Pharmacy, University of Pisa, Italy; ‡Department of Surgical, Medical and Molecular pathology and Critic area, University of Pisa, Italy; §Fondazione Toscana G. Monasterio, Pisa, Italy.

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http://dx.doi.org/10.1111/dsu.0000000000000038DOI Listing
July 2014

Effect of hexavalent chromium on proliferation and differentiation to adipocytes of 3T3-L1 fibroblasts.

Toxicol In Vitro 2014 Jun 25;28(4):700-6. Epub 2014 Feb 25.

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2014.02.003DOI Listing
June 2014

Allosteric modulators of human A2B adenosine receptor.

Biochim Biophys Acta 2014 Mar 19;1840(3):1194-203. Epub 2013 Dec 19.

Dipartimento di Farmacia, Università di Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.

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http://dx.doi.org/10.1016/j.bbagen.2013.12.021DOI Listing
March 2014

Exchange protein activated by cyclic AMP is involved in the regulation of adipogenic genes during 3T3-L1 fibroblasts differentiation.

Dev Growth Differ 2014 Feb 20;56(2):143-51. Epub 2014 Jan 20.

Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, 1428, Argentina.

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http://doi.wiley.com/10.1111/dgd.12114
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http://dx.doi.org/10.1111/dgd.12114DOI Listing
February 2014

Protective effect of high-dose montelukast on salbutamol-induced homologous desensitisation in airway smooth muscle.

Pulm Pharmacol Ther 2013 Dec 27;26(6):693-9. Epub 2013 Jun 27.

Department of Pharmacy, University of Pisa, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2013.06.006DOI Listing
December 2013

BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects.

Prog Neuropsychopharmacol Biol Psychiatry 2013 Jun 23;43:185-7. Epub 2012 Dec 23.

Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht (UMCU), Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.pnpbp.2012.12.017DOI Listing
June 2013

Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor.

Bioorg Med Chem 2013 Apr 26;21(8):2186-2198. Epub 2013 Feb 26.

Centro di Cristallografia, Università degli Studi di Firenze, Via della Lastruccia, 3, 50019 Polo Scientifico, Sesto Fiorentino, Firenze, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896130016
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http://dx.doi.org/10.1016/j.bmc.2013.02.027DOI Listing
April 2013

Gender effect on the relationship between stress hormones and panic-agoraphobic spectrum dimensions in healthy subjects.

CNS Spectr 2012 Dec;17(4):214-20

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1017/S1092852912000685DOI Listing
December 2012