Publications by authors named "Claudia L Kleinman"

46Publications

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.

Cell 2020 Nov 20. Epub 2020 Nov 20.

Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.11.012DOI Listing
November 2020

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands.

iScience 2020 Aug 10;23(9):101447. Epub 2020 Aug 10.

Lady Davis Institute-Jewish General Hospital, McGill University, 3755 Côte St. Catherine, E-535, Montreal, QC H3T 1E2, Canada; Department of Pharmacology, McGill University, Montreal, QC, Canada; Department of Ophthalmology and Visual Science, McGill University, Montreal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.101447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452315PMC
August 2020

Differential expression of tissue-restricted antigens among mTEC is associated with distinct autoreactive T cell fates.

Nat Commun 2020 07 24;11(1):3734. Epub 2020 Jul 24.

Maisonneuve-Rosemont Hospital Research Center, 5415 Boulevard de l'Assomption, Montreal, QC, H1T 2M4, Canada.

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http://dx.doi.org/10.1038/s41467-020-17544-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381629PMC
July 2020

Epigenomic programming in early fetal brain development.

Epigenomics 2020 Jun 17;12(12):1053-1070. Epub 2020 Jul 17.

Department of Microbiology & Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

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http://dx.doi.org/10.2217/epi-2019-0319DOI Listing
June 2020

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay.

Elife 2020 06 8;9. Epub 2020 Jun 8.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

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http://dx.doi.org/10.7554/eLife.54995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279887PMC
June 2020

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 07;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors.

Cancer Res 2019 05 15;79(10):2761-2774. Epub 2019 Mar 15.

Departments of Oncology and Experimental Medicine, McGill University, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-1545DOI Listing
May 2019

Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and Myelination.

Dev Cell 2018 08 26;46(4):426-440.e5. Epub 2018 Jul 26.

Segal Cancer Center, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, QC H3T 1E2, Canada; Departments of Oncology and Medicine, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.06.025DOI Listing
August 2018

chromswitch: a flexible method to detect chromatin state switches.

Bioinformatics 2018 07;34(13):2286-2288

Department of Human Genetics, McGill University, Montreal, QC, Canada and Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada.

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http://dx.doi.org/10.1093/bioinformatics/bty075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022667PMC
July 2018

Transcriptome profiling in preadipocytes identifies long noncoding RNAs as Sam68 targets.

Oncotarget 2017 Oct 11;8(47):81994-82005. Epub 2017 May 11.

Segal Cancer Center, Sir Mortimer B Davis Jewish General Hospital, Lady Davis Institute for Medical Research, Montréal, Québec H3T 1E2, Canada.

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http://dx.doi.org/10.18632/oncotarget.17813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669865PMC
October 2017

A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer.

Cell Rep 2017 Oct;21(5):1140-1149

Department of Human Genetics, McGill University, Montréal, QC H3A 0C7, Canada; McGill University and Genome Québec Innovation Centre, Montréal, QC H3A 1A4, Canada; Center of Innovation in Personalized Medicine, Cancer and Mutagen Unit, King Fahd Center for Medical Research, Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.015DOI Listing
October 2017

Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing.

Sci Rep 2017 08 8;7(1):7554. Epub 2017 Aug 8.

Segal Cancer Centre, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Montréal, Québec, Canada.

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http://www.nature.com/articles/s41598-017-06211-1
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http://dx.doi.org/10.1038/s41598-017-06211-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548867PMC
August 2017

A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability.

EMBO Rep 2017 01 14;18(1):28-38. Epub 2016 Dec 14.

Department of Human Genetics, Montreal Neurological Institute, McGill University, Montreal, QC, Canada

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http://dx.doi.org/10.15252/embr.201643391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210091PMC
January 2017

Live single-cell laser tag.

Nat Commun 2016 05 20;7:11636. Epub 2016 May 20.

Research Center of the Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1038/ncomms11636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876456PMC
May 2016

NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia.

Cell Rep 2016 Mar 17;14(12):2938-49. Epub 2016 Mar 17.

Division of Experimental Medicine, Department of Oncology, Segal Cancer Centre and Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, QC H3T 1E2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814328PMC
March 2016

Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1.

PLoS Genet 2012 15;8(11):e1003078. Epub 2012 Nov 15.

RNA Group, Department of Biochemistry, Université de Sherbrooke, Sherbrooke, Québec, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1003078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499365PMC
May 2013

RNA editing of protein sequences: a rare event in human transcriptomes.

RNA 2012 Sep 25;18(9):1586-96. Epub 2012 Jul 25.

Department of Human Genetics, McGill University–Genome Quebec Innovation Centre, Montreal, Quebec H3A 1A4, Canada.

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http://dx.doi.org/10.1261/rna.033233.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425774PMC
September 2012

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome".

Science 2012 Mar;335(6074):1302; author reply 1302

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1126/science.1209658DOI Listing
March 2012

RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression.

Genome Res 2011 Apr 20;21(4):545-54. Epub 2010 Dec 20.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1101/gr.111211.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065702PMC
April 2011

Statistical potentials for improved structurally constrained evolutionary models.

Mol Biol Evol 2010 Jul 16;27(7):1546-60. Epub 2010 Feb 16.

Département de Biochimie, Centre Robert Cedergren, Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1093/molbev/msq047DOI Listing
July 2010

Fast optimization of statistical potentials for structurally constrained phylogenetic models.

BMC Evol Biol 2009 Sep 9;9:227. Epub 2009 Sep 9.

Département d'Informatique, LIRMM, 161 rue Ada, 34392 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1186/1471-2148-9-227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754480PMC
September 2009

Computational methods for evaluating phylogenetic models of coding sequence evolution with dependence between codons.

Mol Biol Evol 2009 Jul 21;26(7):1663-76. Epub 2009 Apr 21.

Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1093/molbev/msp078DOI Listing
July 2009

A maximum likelihood framework for protein design.

BMC Bioinformatics 2006 Jun 29;7:326. Epub 2006 Jun 29.

Canadian Institute for Advanced Research, Département de Biochimie, Université de Montréal, Montréal, Québec, Canada.

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http://dx.doi.org/10.1186/1471-2105-7-326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570151PMC
June 2006