Publications by authors named "Claudia Cavadas"

63 Publications

Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease.

Sci Rep 2021 Feb 8;11(1):3345. Epub 2021 Feb 8.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Pólo 1, Universidade de Coimbra, 3004-504, Coimbra, Portugal.

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February 2021

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Pharmacol Res 2021 Feb 19;164:105369. Epub 2020 Dec 19.

Centre for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal; Centre for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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February 2021

Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats.

Pharmaceutics 2020 Nov 14;12(11). Epub 2020 Nov 14.

Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

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November 2020

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases.

Trends Pharmacol Sci 2019 12 6;40(12):1021-1039. Epub 2019 Nov 6.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

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December 2019

The importance of determining circadian parameters in pharmacological studies.

Br J Pharmacol 2019 08 6;176(16):2827-2847. Epub 2019 Jul 6.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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August 2019

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components.

Exp Parasitol 2018 Jul 18;190:34-40. Epub 2018 May 18.

CNC-Center for Neurosciences and Cell Biology, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Portugal. Electronic address:

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July 2018

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice.

Biochim Biophys Acta Gen Subj 2018 Mar 22;1862(3):403-413. Epub 2017 Dec 22.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; Department of Medical Genetics, Pediatric Unit, Coimbra, Hospital and University Center (CHUC), 3000-602 Coimbra, Portugal. Electronic address:

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March 2018

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.

Cell Mol Neurobiol 2018 Jan 24;38(1):109-120. Epub 2017 Oct 24.

Department of Physiological Science, Universidade Federal Do Espírito Santo (HUCAM, UFES), Vitória, Brazil.

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January 2018

Hypothalamic Dysfunction in Obesity and Metabolic Disorders.

Adv Neurobiol 2017 ;19:73-116

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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November 2018

Obstructive Sleep Apnea and Hallmarks of Aging.

Trends Mol Med 2017 08 21;23(8):675-692. Epub 2017 Jul 21.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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August 2017

Unraveling the Role of Ataxin-2 in Metabolism.

Trends Endocrinol Metab 2017 04 21;28(4):309-318. Epub 2017 Jan 21.

Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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April 2017

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line.

Biochim Biophys Acta Gen Subj 2017 Mar 9;1861(3):673-682. Epub 2016 Dec 9.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address:

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March 2017

The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing.

Nat Rev Endocrinol 2016 Dec 8;12(12):723-733. Epub 2016 Jul 8.

Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 1308-970, Brazil.

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December 2016

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases.

Neurobiol Dis 2016 Nov 25;95:210-24. Epub 2016 Jul 25.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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November 2016

Antileishmanial activity of antiretroviral drugs combined with miltefosine.

Parasitol Res 2016 Oct 1;115(10):3881-7. Epub 2016 Jun 1.

CNC -Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.

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October 2016

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

Nat Commun 2016 05 11;7:11445. Epub 2016 May 11.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Coimbra 3004-504, Portugal.

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May 2016

Neuropeptide Y: An Anti-Aging Player?

Trends Neurosci 2015 Nov;38(11):701-711

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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November 2015

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism.

Trends Pharmacol Sci 2015 Nov 1;36(11):756-768. Epub 2015 Nov 1.

CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

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November 2015

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.

ASN Neuro 2015 Jul-Aug;7(4). Epub 2015 Aug 26.

Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, Portugal CNC.IBILI, University of Coimbra, 3004-548 Coimbra, Portugal AIBILI, 3000-548 Coimbra, Portugal Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal

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March 2016

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.

Hum Mol Genet 2015 Oct 27;24(19):5451-63. Epub 2015 Jul 27.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal, Faculty of Pharmacy, University of Coimbra, Coimbra 3000-548, Portugal,

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October 2015

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress.

Eur Neuropsychopharmacol 2015 Oct 2;25(10):1753-66. Epub 2015 Jul 2.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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October 2015

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?

Autophagy 2015 ;11(8):1431-3

a CNC - Center for Neuroscience and Cell Biology; University of Coimbra ; Coimbra , Portugal.

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June 2016

Neuropeptide Y system in the retina: From localization to function.

Prog Retin Eye Res 2015 Jul 19;47:19-37. Epub 2015 Mar 19.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. Electronic address:

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July 2015

Neuropeptide Y stimulates autophagy in hypothalamic neurons.

Proc Natl Acad Sci U S A 2015 Mar 16;112(13):E1642-51. Epub 2015 Mar 16.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; and

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March 2015