Publications by authors named "Claudia Cavadas"

63 Publications

Neuropeptide Y (NPY) intranasal delivery alleviates Machado-Joseph disease.

Authors:
Joana Duarte-Neves Cláudia Cavadas Luís Pereira de Almeida

Sci Rep 2021 Feb 8;11(1):3345. Epub 2021 Feb 8.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Pólo 1, Universidade de Coimbra, 3004-504, Coimbra, Portugal.

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February 2021

Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?

Authors:
Laetitia S Gaspar Cátia Sousa Ana Rita Álvaro Cláudia Cavadas Alexandrina Ferreira Mendes

Pharmacol Res 2021 Feb 19;164:105369. Epub 2020 Dec 19.

Centre for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal; Centre for Innovation in Biomedicine and Biotechnology (CIBB), University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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February 2021

Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats.

Authors:
Sara Nunes Sofia D Viana Inês Preguiça André Alves Rosa Fernandes João S Teodoro Artur Figueirinha Lígia Salgueiro Sara Silva Ivana Jarak Rui A Carvalho Cláudia Cavadas Anabela P Rolo Carlos M Palmeira Maria M Pintado Flávio Reis

Pharmaceutics 2020 Nov 14;12(11). Epub 2020 Nov 14.

Institute of Pharmacology & Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

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November 2020

Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.

Authors:
Magda M Santana Susana Paixão Janete Cunha-Santos Teresa Pereira Silva Allyson Trevino-Garcia Laetitia S Gaspar Clévio Nóbrega Rui Jorge Nobre Cláudia Cavadas Hagar Greif Luís Pereira de Almeida

J Transl Med 2020 04 9;18(1):161. Epub 2020 Apr 9.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504, Coimbra, Portugal.

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April 2020

Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells.

Authors:
Célia A Aveleira Marisa Ferreira-Marques Luísa Cortes Jorge Valero Dina Pereira Luís Pereira de Almeida Cláudia Cavadas

J Gerontol A Biol Sci Med Sci 2020 05;75(6):1073-1078

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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May 2020

Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases.

Authors:
Pedro Gomes Helena Leal Alexandrina F Mendes Flávio Reis Cláudia Cavadas

Trends Pharmacol Sci 2019 12 6;40(12):1021-1039. Epub 2019 Nov 6.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

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December 2019

The importance of determining circadian parameters in pharmacological studies.

Authors:
Laetitia S Gaspar Ana Rita Álvaro Sara Carmo-Silva Alexandrina Ferreira Mendes Angela Relógio Cláudia Cavadas

Br J Pharmacol 2019 08 6;176(16):2827-2847. Epub 2019 Jul 6.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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August 2019

In vitro susceptibility of Trypanosoma brucei brucei to selected essential oils and their major components.

Authors:
Sonya Costa Cláudia Cavadas Carlos Cavaleiro Lígia Salgueiro Maria do Céu Sousa

Exp Parasitol 2018 Jul 18;190:34-40. Epub 2018 May 18.

CNC-Center for Neurosciences and Cell Biology, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Portugal. Electronic address:

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July 2018

Molecular Mechanisms and Cellular Pathways Implicated in Machado-Joseph Disease Pathogenesis.

Authors:
Clévio Nóbrega Ana Teresa Simões Joana Duarte-Neves Sónia Duarte Ana Vasconcelos-Ferreira Janete Cunha-Santos Dina Pereira Magda Santana Cláudia Cavadas Luís Pereira de Almeida

Adv Exp Med Biol 2018 ;1049:349-367

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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July 2018

Dipeptidyl peptidase IV (DPP-IV) inhibition prevents fibrosis in adipose tissue of obese mice.

Authors:
Ana Patrícia Marques Janete Cunha-Santos Helena Leal Lígia Sousa-Ferreira Luís Pereira de Almeida Cláudia Cavadas Joana Rosmaninho-Salgado

Biochim Biophys Acta Gen Subj 2018 Mar 22;1862(3):403-413. Epub 2017 Dec 22.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; Department of Medical Genetics, Pediatric Unit, Coimbra, Hospital and University Center (CHUC), 3000-602 Coimbra, Portugal. Electronic address:

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March 2018

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress.

Authors:
Regina Celia Spadari Claudia Cavadas Ana Elisa T Saturi de Carvalho Daniela Ortolani Andre Luiz de Moura Paula Frizera Vassalo

Cell Mol Neurobiol 2018 Jan 24;38(1):109-120. Epub 2017 Oct 24.

Department of Physiological Science, Universidade Federal Do Espírito Santo (HUCAM, UFES), Vitória, Brazil.

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January 2018

The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.

Authors:
Vera Lemos Rita M de Oliveira Luana Naia Éva Szegö Elisabete Ramos Sónia Pinho Fernando Magro Cláudia Cavadas A Cristina Rego Vítor Costa Tiago F Outeiro Pedro Gomes

Hum Mol Genet 2017 11;26(21):4105-4117

Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.

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November 2017

Hypothalamic Dysfunction in Obesity and Metabolic Disorders.

Authors:
Sara Carmo-Silva Cláudia Cavadas

Adv Neurobiol 2017 ;19:73-116

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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November 2018

Obstructive Sleep Apnea and Hallmarks of Aging.

Authors:
Laetitia S Gaspar Ana Rita Álvaro Joaquim Moita Cláudia Cavadas

Trends Mol Med 2017 08 21;23(8):675-692. Epub 2017 Jul 21.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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August 2017

Unraveling the Role of Ataxin-2 in Metabolism.

Authors:
Sara Carmo-Silva Clevio Nobrega Luís Pereira de Almeida Claudia Cavadas

Trends Endocrinol Metab 2017 04 21;28(4):309-318. Epub 2017 Jan 21.

Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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April 2017

Hypoxia mimetic induces lipid accumulation through mitochondrial dysfunction and stimulates autophagy in murine preadipocyte cell line.

Authors:
Ana Patrícia Marques Joana Rosmaninho-Salgado Marta Estrada Vera Cortez Rui Jorge Nobre Cláudia Cavadas

Biochim Biophys Acta Gen Subj 2017 Mar 9;1861(3):673-682. Epub 2016 Dec 9.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address:

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March 2017

The pathophysiology of defective proteostasis in the hypothalamus - from obesity to ageing.

Authors:
Cláudia Cavadas Célia A Aveleira Gabriela F P Souza Lício A Velloso

Nat Rev Endocrinol 2016 Dec 8;12(12):723-733. Epub 2016 Jul 8.

Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 1308-970, Brazil.

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December 2016

Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases.

Authors:
Joana Duarte-Neves Luís Pereira de Almeida Cláudia Cavadas

Neurobiol Dis 2016 Nov 25;95:210-24. Epub 2016 Jul 25.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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November 2016

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.

Authors:
Marisa Ferreira-Marques Célia A Aveleira Sara Carmo-Silva Mariana Botelho Luís Pereira de Almeida Cláudia Cavadas

Aging (Albany NY) 2016 07;8(7):1470-84

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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July 2016

Antileishmanial activity of antiretroviral drugs combined with miltefosine.

Authors:
Sonya Costa Marisa Machado Cláudia Cavadas Maria do Céu Sousa

Parasitol Res 2016 Oct 1;115(10):3881-7. Epub 2016 Jun 1.

CNC -Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.

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October 2016

Corrigendum to "Intracellular mechanisms coupled to NPY Y and Y receptor activation and lipid accumulation in murine adipocytes" [neuropeptides 46/6 (2012) 359-366].

Authors:
Joana Rosmaninho-Salgado Vera Cortez Marta Estrada Magda M Santana Alexandra Gonçalves Ana Patrícia Marques Cláudia Cavadas

Neuropeptides 2016 Jun 10;57:101. Epub 2015 Dec 10.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Portugal.

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June 2016

Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.

Authors:
Janete Cunha-Santos Joana Duarte-Neves Vitor Carmona Leonard Guarente Luís Pereira de Almeida Cláudia Cavadas

Nat Commun 2016 05 11;7:11445. Epub 2016 May 11.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Coimbra 3004-504, Portugal.

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May 2016

Neuropeptide Y: An Anti-Aging Player?

Authors:
Mariana Botelho Cláudia Cavadas

Trends Neurosci 2015 Nov;38(11):701-711

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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November 2015

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism.

Authors:
Pedro Gomes Tiago Fleming Outeiro Cláudia Cavadas

Trends Pharmacol Sci 2015 Nov 1;36(11):756-768. Epub 2015 Nov 1.

CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.

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November 2015

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.

Authors:
João Martins Filipe Elvas Dan Brudzewsky Tânia Martins Bogdan Kolomiets Pedro Tralhão Casper R Gøtzsche Cláudia Cavadas Miguel Castelo-Branco David P D Woldbye Serge Picaud Ana R Santiago António F Ambrósio

ASN Neuro 2015 Jul-Aug;7(4). Epub 2015 Aug 26.

Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3004-548 Coimbra, Portugal CNC.IBILI, University of Coimbra, 3004-548 Coimbra, Portugal AIBILI, 3000-548 Coimbra, Portugal Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal

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March 2016

Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.

Authors:
Joana Duarte-Neves Nélio Gonçalves Janete Cunha-Santos Ana Teresa Simões Wilfred F A den Dunnen Hirokazu Hirai Sebastian Kügler Cláudia Cavadas Luís Pereira de Almeida

Hum Mol Genet 2015 Oct 27;24(19):5451-63. Epub 2015 Jul 27.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal, Faculty of Pharmacy, University of Coimbra, Coimbra 3000-548, Portugal,

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October 2015

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress.

Authors:
Magda M Santana Joana Rosmaninho-Salgado Vera Cortez Frederico C Pereira Manuella P Kaster Célia A Aveleira Marisa Ferreira Ana Rita Álvaro Cláudia Cavadas

Eur Neuropsychopharmacol 2015 Oct 2;25(10):1753-66. Epub 2015 Jul 2.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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October 2015

NPY/neuropeptide Y enhances autophagy in the hypothalamus: a mechanism to delay aging?

Authors:
Célia A Aveleira Mariana Botelho Cláudia Cavadas

Autophagy 2015 ;11(8):1431-3

a CNC - Center for Neuroscience and Cell Biology; University of Coimbra ; Coimbra , Portugal.

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June 2016

Neuropeptide Y system in the retina: From localization to function.

Authors:
Ana Santos-Carvalho António Francisco Ambrósio Cláudia Cavadas

Prog Retin Eye Res 2015 Jul 19;47:19-37. Epub 2015 Mar 19.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. Electronic address:

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July 2015

Neuropeptide Y stimulates autophagy in hypothalamic neurons.

Authors:
Célia A Aveleira Mariana Botelho Sara Carmo-Silva Jorge F Pascoal Marisa Ferreira-Marques Clévio Nóbrega Luísa Cortes Jorge Valero Lígia Sousa-Ferreira Ana R Álvaro Magda Santana Sebastian Kügler Luís Pereira de Almeida Cláudia Cavadas

Proc Natl Acad Sci U S A 2015 Mar 16;112(13):E1642-51. Epub 2015 Mar 16.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal; and

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March 2015