Publications by authors named "Claudia Betschart"

19Publications

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.

Front Neurosci 2013 3;7:230. Epub 2013 Dec 3.

Department of Pharmacology and Therapeutics, Faculty of Medicine, Dentistry and Health Sciences, School of Medicine, The University of Melbourne Parkville, VIC, Australia ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne Parkville, VIC, Australia ; Department of Neuroscience, Novartis Institutes for Biomedical Research Basel, Switzerland.

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December 2013

Distinct effects of IPSU and suvorexant on mouse sleep architecture.

Front Neurosci 2013 10;7:235. Epub 2013 Dec 10.

Neuroscience, Novartis Institutes for BioMedical Research Basel, Switzerland ; Center for Molecular Neuroscience Hamburg, Institute for Synaptic Physiology Hamburg, Germany.

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December 2013

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.

J Med Chem 2013 Oct 18;56(19):7590-607. Epub 2013 Sep 18.

Global Discovery Chemistry, ‡Neuroscience, and §Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , CH-4002 Basel, Switzerland.

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October 2013

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors.

Bioorg Med Chem Lett 2009 Mar 19;19(5):1361-5. Epub 2009 Jan 19.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, PO Box, CH-4002 Basel, Switzerland.

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March 2009

New chemotypes for cathepsin K inhibitors.

Bioorg Med Chem Lett 2008 Apr 16;18(8):2599-603. Epub 2008 Mar 16.

Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan.

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April 2008

Dipeptide nitrile inhibitors of cathepsin K.

Bioorg Med Chem Lett 2006 May 9;16(9):2549-54. Epub 2006 Feb 9.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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May 2006